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P51590

- CP2J3_RAT

UniProt

P51590 - CP2J3_RAT

Protein

Cytochrome P450 2J3

Gene

Cyp2j3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation mainly to 14,15-, 11,12-, and 8,9-epoxyeicosatrienoic acids (EET). It also acts as an omega-1-hydroxylase by metabolizing arachidonic acid to 19-hydroxyeicosatetraenoic acid (19-OH-AA).

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi448 – 4481Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2J3 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIJ3
    Gene namesi
    Name:Cyp2j3
    Synonyms:Cyp2j9
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi631442. Cyp2j3.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 502502Cytochrome P450 2J3PRO_0000051770Add
    BLAST

    Proteomic databases

    PaxDbiP51590.
    PRIDEiP51590.

    Expressioni

    Tissue specificityi

    Abundantly expressed in heart and liver.

    Gene expression databases

    GenevestigatoriP51590.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4577944.
    STRINGi10116.ENSRNOP00000013087.

    Structurei

    3D structure databases

    ProteinModelPortaliP51590.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036991.
    HOVERGENiHBG015789.
    InParanoidiP51590.
    KOiK07418.
    PhylomeDBiP51590.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01688. EP450ICYP2J.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51590-1 [UniParc]FASTAAdd to Basket

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    MLVTAGSLLG AIWTVLHLRI LLLAAVTFLF LADFLKHRRP KNYPPGPWRL    50
    PLVGCLFHLD PKQPHLSLQQ FVKKYGNVLS LDFANIPSVV VTGMPLIKEI 100
    FTQMEHNFLN RPVTLLRKHL FNKNGLIFSS GQTWKEQRRF ALMTLRNFGL 150
    GKKSLEQRIQ EEAYHLVEAI KDEGGLPFDP HFNINKAVSN IICSVTFGER 200
    FEYHDSQFQE MLRLLDEAMC LESSMMCQLY NIFPRILQYL PGSHQTLFSN 250
    WRKLKLFISD IIKNHRRDWD PDEPRDFIDA FLKEMAKYPD KTTTSFNEEN 300
    LICSTLDLFF AGTETTSTTL RWALLCMALY PEVQEKMQAE IDRVIGQGRQ 350
    PNLADRDSMP YTNAVIHEVQ RIGNIIPFNV PREVAVDTYL AGFNLPKGTM 400
    ILTNLTALHR DPKEWATPDT FNPEHFLENG QFKKRESFLP FSMGKRACLG 450
    EQLARSELFI FITSLIQKFT FKPPVNEKLS LQFRMSVTIS PVSHRLCAIP 500
    RL 502
    Length:502
    Mass (Da):57,969
    Last modified:October 1, 1996 - v1
    Checksum:iCCC0AE67977FFF31
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U39943 mRNA. Translation: AAB48545.1.
    BC089766 mRNA. Translation: AAH89766.1.
    RefSeqiNP_786942.1. NM_175766.3.
    UniGeneiRn.28757.

    Genome annotation databases

    GeneIDi313375.
    KEGGirno:313375.
    UCSCiRGD:631442. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U39943 mRNA. Translation: AAB48545.1 .
    BC089766 mRNA. Translation: AAH89766.1 .
    RefSeqi NP_786942.1. NM_175766.3.
    UniGenei Rn.28757.

    3D structure databases

    ProteinModelPortali P51590.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4577944.
    STRINGi 10116.ENSRNOP00000013087.

    Proteomic databases

    PaxDbi P51590.
    PRIDEi P51590.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 313375.
    KEGGi rno:313375.
    UCSCi RGD:631442. rat.

    Organism-specific databases

    CTDi 313375.
    RGDi 631442. Cyp2j3.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036991.
    HOVERGENi HBG015789.
    InParanoidi P51590.
    KOi K07418.
    PhylomeDBi P51590.

    Miscellaneous databases

    NextBioi 666056.

    Gene expression databases

    Genevestigatori P51590.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01688. EP450ICYP2J.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, expression, and functional significance of a cytochrome P450 highly expressed in rat heart myocytes."
      Wu S., Chen W., Murphy E., Gabel S., Tomer K.B., Foley J., Steenbergen C., Falck J.R., Moomaw C.R., Zeldin D.C.
      J. Biol. Chem. 272:12551-12559(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Fischer 344.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.

    Entry informationi

    Entry nameiCP2J3_RAT
    AccessioniPrimary (citable) accession number: P51590
    Secondary accession number(s): Q5EBD7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3