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UniProtKB - P51589 (CP2J2_HUMAN)

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Protein

Cytochrome P450 2J2

Gene

CYP2J2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi448Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • arachidonic acid 11,12-epoxygenase activity Source: BHF-UCL
  • arachidonic acid 14,15-epoxygenase activity Source: BHF-UCL
  • arachidonic acid epoxygenase activity Source: BHF-UCL
  • aromatase activity Source: UniProtKB-EC
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro
  • linoleic acid epoxygenase activity Source: BHF-UCL
  • monooxygenase activity Source: Reactome
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • epoxygenase P450 pathway Source: BHF-UCL
  • icosanoid metabolic process Source: ProtInc
  • linoleic acid metabolic process Source: BHF-UCL
  • regulation of heart contraction Source: ProtInc
  • xenobiotic metabolic process Source: BHF-UCL
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS05902-MONOMER.
BRENDAi1.14.13.159. 2681.
ReactomeiR-HSA-211935. Fatty acids.
R-HSA-211981. Xenobiotics.
R-HSA-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).

Chemistry databases

SwissLipidsiSLP:000001594.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2J2 (EC:1.14.14.1)
Alternative name(s):
Arachidonic acid epoxygenase
CYPIIJ2
Gene namesi
Name:CYP2J2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000134716.9.
HGNCiHGNC:2634. CYP2J2.
MIMi601258. gene.
neXtProtiNX_P51589.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi1573.
OpenTargetsiENSG00000134716.
PharmGKBiPA27112.

Chemistry databases

ChEMBLiCHEMBL3491.
DrugBankiDB06605. Apixaban.
DB00637. Astemizole.
DB00169. Cholecalciferol.
DB09148. Florbetaben (18F).
DB08918. Levomilnacipran.
DB04725. Licofelone.
DB00179. Masoprocol.
DB08931. Riociguat.
DB06228. Rivaroxaban.
DB00342. Terfenadine.
GuidetoPHARMACOLOGYi1332.

Polymorphism and mutation databases

BioMutaiCYP2J2.
DMDMi21264413.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517691 – 502Cytochrome P450 2J2Add BLAST502

Proteomic databases

MaxQBiP51589.
PaxDbiP51589.
PeptideAtlasiP51589.
PRIDEiP51589.

PTM databases

iPTMnetiP51589.
PhosphoSitePlusiP51589.

Expressioni

Tissue specificityi

Highly expressed in heart, present at lower levels in liver, ileum, jejunum, colon, and kidney.

Gene expression databases

BgeeiENSG00000134716.
CleanExiHS_CYP2J2.
GenevisibleiP51589. HS.

Interactioni

Protein-protein interaction databases

BioGridi107946. 27 interactors.
IntActiP51589. 2 interactors.
STRINGi9606.ENSP00000360247.

Chemistry databases

BindingDBiP51589.

Structurei

3D structure databases

ProteinModelPortaliP51589.
SMRiP51589.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00900000140799.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiP51589.
KOiK07418.
OMAiRTIFSCN.
OrthoDBiEOG091G0BT8.
PhylomeDBiP51589.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
IPR036396. Cyt_P450_sf.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR01688. EP450ICYP2J.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

P51589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAAMGSLAA ALWAVVHPRT LLLGTVAFLL AADFLKRRRP KNYPPGPWRL 
        60         70         80         90        100
PFLGNFFLVD FEQSHLEVQL FVKKYGNLFS LELGDISAVL ITGLPLIKEA 
       110        120        130        140        150
LIHMDQNFGN RPVTPMREHI FKKNGLIMSS GQAWKEQRRF TLTALRNFGL 
       160        170        180        190        200
GKKSLEERIQ EEAQHLTEAI KEENGQPFDP HFKINNAVSN IICSITFGER 
       210        220        230        240        250
FEYQDSWFQQ LLKLLDEVTY LEASKTCQLY NVFPWIMKFL PGPHQTLFSN 
       260        270        280        290        300
WKKLKLFVSH MIDKHRKDWN PAETRDFIDA YLKEMSKHTG NPTSSFHEEN 
       310        320        330        340        350
LICSTLDLFF AGTETTSTTL RWALLYMALY PEIQEKVQAE IDRVIGQGQQ 
       360        370        380        390        400
PSTAARESMP YTNAVIHEVQ RMGNIIPLNV PREVTVDTTL AGYHLPKGTM 
       410        420        430        440        450
ILTNLTALHR DPTEWATPDT FNPDHFLENG QFKKREAFMP FSIGKRACLG 
       460        470        480        490        500
EQLARTELFI FFTSLMQKFT FRPPNNEKLS LKFRMGITIS PVSHRLCAVP 

QV
Length:502
Mass (Da):57,611
Last modified:May 27, 2002 - v2
Checksum:iB5F006581E249EC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti264K → E in BAG37780 (PubMed:14702039).Curated1
Sequence conflicti318T → A in BAG37780 (PubMed:14702039).Curated1
Sequence conflicti339A → V in BAB85489 (PubMed:12386130).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02915949R → S1 PublicationCorresponds to variant dbSNP:rs11572190Ensembl.1
Natural variantiVAR_029160113V → M. Corresponds to variant dbSNP:rs11572242Ensembl.1
Natural variantiVAR_022084124N → S. Corresponds to variant dbSNP:rs2228113Ensembl.1
Natural variantiVAR_014317143T → A in allele CYP2J2*2; significantly reduced metabolism of both arachidonic acid and linoleic acid. 1 PublicationCorresponds to variant dbSNP:rs55753213Ensembl.1
Natural variantiVAR_014318158R → C in allele CYP2J2*3; significantly reduced metabolism of both arachidonic acid and linoleic acid. 1 PublicationCorresponds to variant dbSNP:rs56307989Ensembl.1
Natural variantiVAR_014319192I → N in allele CYP2J2*4; significantly reduced metabolism of arachidonic acid only. 1 PublicationCorresponds to variant dbSNP:rs66515830Ensembl.1
Natural variantiVAR_014320342D → N in allele CYP2J2*5; no change in activity. 1 PublicationCorresponds to variant dbSNP:rs56053398Ensembl.1
Natural variantiVAR_014321404N → Y in allele CYP2J2*6; significantly reduced metabolism of both arachidonic acid and linoleic acid. 1 PublicationCorresponds to variant dbSNP:rs72547598Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37143 mRNA. Translation: AAC50370.2.
AB080265 mRNA. Translation: BAB85489.1.
AF272142 Genomic DNA. Translation: AAM44456.1.
AY426985 Genomic DNA. Translation: AAQ93356.1.
AK315387 mRNA. Translation: BAG37780.1.
BC032594 mRNA. Translation: AAH32594.1.
CCDSiCCDS613.1.
RefSeqiNP_000766.2. NM_000775.3.
UniGeneiHs.152096.

Genome annotation databases

EnsembliENST00000371204; ENSP00000360247; ENSG00000134716.
GeneIDi1573.
KEGGihsa:1573.
UCSCiuc001czq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCP2J2_HUMAN
AccessioniPrimary (citable) accession number: P51589
Secondary accession number(s): B2RD33, Q8TF13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 27, 2002
Last modified: March 28, 2018
This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome