CYP2J2

Functionⁱ

This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.

Catalytic activityⁱ

RH + [reduced NADPH--hemoprotein reductase] + O₂ = ROH + [oxidized NADPH--hemoprotein reductase] + H₂O.

Cofactorⁱ

hemeBy similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	448	Iron (heme axial ligand)By similarity		1

GO - Molecular functionⁱ

arachidonic acid 11,12-epoxygenase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 11901223
arachidonic acid 14,15-epoxygenase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 11901223
arachidonic acid epoxygenase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 11901223
aromatase activity Source: UniProtKB-EC
heme binding Source: InterPro
iron ion binding Source: InterPro
linoleic acid epoxygenase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 11901223
monooxygenase activity Source: Reactome

Complete GO annotation...

GO - Biological processⁱ

epoxygenase P450 pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 11901223
icosanoid metabolic process
Source: ProtInc
Traceable author statementⁱ
- 8631948
linoleic acid metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 11901223
regulation of heart contraction
Source: ProtInc
Traceable author statementⁱ
- 8631948
xenobiotic metabolic process
Source: BHF-UCL
Traceable author statementⁱ
- 11901223

Complete GO annotation...

Keywordsⁱ

Molecular function	Monooxygenase, Oxidoreductase
Ligand	Heme, Iron, Metal-binding, NADP

Enzyme and pathway databases

BRENDAⁱ	1.14.13.159. 2681.
Reactomeⁱ	R-HSA-211935. Fatty acids. R-HSA-211981. Xenobiotics. R-HSA-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).

Chemistry databases

SwissLipidsⁱ	SLP:000001594.

SwissLipidsⁱ

SLP:000001594.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytochrome P450 2J2 (EC:1.14.14.1) Alternative name(s): Arachidonic acid epoxygenase CYPIIJ2
Gene namesⁱ	Name:CYP2J2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2634. CYP2J2.

HGNCⁱ

HGNC:2634. CYP2J2.

Subcellular locationⁱ

GO - Cellular componentⁱ

endoplasmic reticulum membrane Source: Reactome
extracellular exosome
Source: UniProtKB
Inferred from direct assayⁱ
- 18570454
organelle membrane Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1573.
Open Targets More...OpenTargetsⁱ	ENSG00000134716.
PharmGKBⁱ	PA27112.

Chemistry databases

ChEMBLⁱ	CHEMBL3491.
Drug and drug target database More...DrugBankⁱ	DB06605. Apixaban. DB00637. Astemizole. DB00169. Cholecalciferol. DB09148. Florbetaben (18F). DB08918. Levomilnacipran. DB04725. Licofelone. DB00179. Masoprocol. DB08931. Riociguat. DB06228. Rivaroxaban. DB00342. Terfenadine.
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1332.

Polymorphism and mutation databases

BioMutaⁱ	CYP2J2.
DMDMⁱ	21264413.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051769	1 – 502	Cytochrome P450 2J2Add BLAST		502

Proteomic databases

EPDⁱ	P51589.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P51589.
PaxDbⁱ	P51589.
PeptideAtlas More...PeptideAtlasⁱ	P51589.
PRIDEⁱ	P51589.

PTM databases

iPTMnetⁱ	P51589.
PhosphoSitePlusⁱ	P51589.

Expressionⁱ

Tissue specificityⁱ

Highly expressed in heart, present at lower levels in liver, ileum, jejunum, colon, and kidney.

Gene expression databases

Bgeeⁱ	ENSG00000134716.
CleanExⁱ	HS_CYP2J2.
Genevisibleⁱ	P51589. HS.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	107946. 3 interactors.
IntActⁱ	P51589. 2 interactors.
STRINGⁱ	9606.ENSP00000360247.

Chemistry databases

BindingDBⁱ

P51589.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P51589.
SMRⁱ	P51589.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0156. Eukaryota. COG2124. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137854.
HOGENOMⁱ	HOG000036991.
HOVERGENⁱ	HBG015789.
InParanoidⁱ	P51589.
KEGG Orthology (KO) More...KOⁱ	K07418.
OMAⁱ	MSKHTGN.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BT8.
PhylomeDBⁱ	P51589.
TreeFamⁱ	TF352043.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067. p450. 1 hit.
PRINTSⁱ	PR00463. EP450I. PR01688. EP450ICYP2J. PR00385. P450.
SUPFAMⁱ	SSF48264. SSF48264. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00086. CYTOCHROME_P450. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P51589-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLAAMGSLAA ALWAVVHPRT LLLGTVAFLL AADFLKRRRP KNYPPGPWRL 
        60         70         80         90        100
PFLGNFFLVD FEQSHLEVQL FVKKYGNLFS LELGDISAVL ITGLPLIKEA 
       110        120        130        140        150
LIHMDQNFGN RPVTPMREHI FKKNGLIMSS GQAWKEQRRF TLTALRNFGL 
       160        170        180        190        200
GKKSLEERIQ EEAQHLTEAI KEENGQPFDP HFKINNAVSN IICSITFGER 
       210        220        230        240        250
FEYQDSWFQQ LLKLLDEVTY LEASKTCQLY NVFPWIMKFL PGPHQTLFSN 
       260        270        280        290        300
WKKLKLFVSH MIDKHRKDWN PAETRDFIDA YLKEMSKHTG NPTSSFHEEN 
       310        320        330        340        350
LICSTLDLFF AGTETTSTTL RWALLYMALY PEIQEKVQAE IDRVIGQGQQ 
       360        370        380        390        400
PSTAARESMP YTNAVIHEVQ RMGNIIPLNV PREVTVDTTL AGYHLPKGTM 
       410        420        430        440        450
ILTNLTALHR DPTEWATPDT FNPDHFLENG QFKKREAFMP FSIGKRACLG 
       460        470        480        490        500
EQLARTELFI FFTSLMQKFT FRPPNNEKLS LKFRMGITIS PVSHRLCAVP 

QV

Length:502

Mass (Da):57,611

Last modified:May 27, 2002 - v2

Checksum:ⁱB5F006581E249EC0

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	264	K → E in BAG37780 (PubMed:14702039).Curated	1
Sequence conflictⁱ	318	T → A in BAG37780 (PubMed:14702039).Curated	1
Sequence conflictⁱ	339	A → V in BAB85489 (PubMed:12386130).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_029159	49	R → S1 PublicationCorresponds to variant dbSNP:rs11572190Ensembl.	1
Natural variantⁱVAR_029160	113	V → M. Corresponds to variant dbSNP:rs11572242Ensembl.	1
Natural variantⁱVAR_022084	124	N → S. Corresponds to variant dbSNP:rs2228113Ensembl.	1
Natural variantⁱVAR_014317	143	T → A in allele CYP2J2*2; significantly reduced metabolism of both arachidonic acid and linoleic acid. 1 PublicationCorresponds to variant dbSNP:rs55753213Ensembl.	1
Natural variantⁱVAR_014318	158	R → C in allele CYP2J2*3; significantly reduced metabolism of both arachidonic acid and linoleic acid. 1 PublicationCorresponds to variant dbSNP:rs56307989Ensembl.	1
Natural variantⁱVAR_014319	192	I → N in allele CYP2J2*4; significantly reduced metabolism of arachidonic acid only. 1 PublicationCorresponds to variant dbSNP:rs66515830Ensembl.	1
Natural variantⁱVAR_014320	342	D → N in allele CYP2J2*5; no change in activity. 1 PublicationCorresponds to variant dbSNP:rs56053398Ensembl.	1
Natural variantⁱVAR_014321	404	N → Y in allele CYP2J2*6; significantly reduced metabolism of both arachidonic acid and linoleic acid. 1 PublicationCorresponds to variant dbSNP:rs72547598Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U37143 mRNA. Translation: AAC50370.2. AB080265 mRNA. Translation: BAB85489.1. AF272142 Genomic DNA. Translation: AAM44456.1. AY426985 Genomic DNA. Translation: AAQ93356.1. AK315387 mRNA. Translation: BAG37780.1. BC032594 mRNA. Translation: AAH32594.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS613.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_000766.2. NM_000775.3.
UniGeneⁱ	Hs.152096.

Genome annotation databases

Ensemblⁱ	ENST00000371204; ENSP00000360247; ENSG00000134716.
GeneIDⁱ	1573.
KEGGⁱ	hsa:1573.
UCSC genome browser More...UCSCⁱ	uc001czq.4. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Web resourcesⁱ

Cytochrome P450 Allele Nomenclature Committee

CYP2J2 alleles

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U37143 mRNA. Translation: AAC50370.2. AB080265 mRNA. Translation: BAB85489.1. AF272142 Genomic DNA. Translation: AAM44456.1. AY426985 Genomic DNA. Translation: AAQ93356.1. AK315387 mRNA. Translation: BAG37780.1. BC032594 mRNA. Translation: AAH32594.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS613.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_000766.2. NM_000775.3.
UniGeneⁱ	Hs.152096.

3D structure databases

ProteinModelPortalⁱ	P51589.
SMRⁱ	P51589.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107946. 3 interactors.
IntActⁱ	P51589. 2 interactors.
STRINGⁱ	9606.ENSP00000360247.

Chemistry databases

BindingDBⁱ	P51589.
ChEMBLⁱ	CHEMBL3491.
Drug and drug target database More...DrugBankⁱ	DB06605. Apixaban. DB00637. Astemizole. DB00169. Cholecalciferol. DB09148. Florbetaben (18F). DB08918. Levomilnacipran. DB04725. Licofelone. DB00179. Masoprocol. DB08931. Riociguat. DB06228. Rivaroxaban. DB00342. Terfenadine.
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1332.
SwissLipidsⁱ	SLP:000001594.

PTM databases

iPTMnetⁱ	P51589.
PhosphoSitePlusⁱ	P51589.

Polymorphism and mutation databases

BioMutaⁱ	CYP2J2.
DMDMⁱ	21264413.

Proteomic databases

EPDⁱ	P51589.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P51589.
PaxDbⁱ	P51589.
PeptideAtlas More...PeptideAtlasⁱ	P51589.
PRIDEⁱ	P51589.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1573.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000371204; ENSP00000360247; ENSG00000134716.
GeneIDⁱ	1573.
KEGGⁱ	hsa:1573.
UCSC genome browser More...UCSCⁱ	uc001czq.4. human.

Organism-specific databases

CTDⁱ	1573.
DisGeNET More...DisGeNETⁱ	1573.
GeneCardsⁱ	CYP2J2.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2634. CYP2J2.
MIMⁱ	601258. gene.
neXtProtⁱ	NX_P51589.
Open Targets More...OpenTargetsⁱ	ENSG00000134716.
PharmGKBⁱ	PA27112.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0156. Eukaryota. COG2124. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137854.
HOGENOMⁱ	HOG000036991.
HOVERGENⁱ	HBG015789.
InParanoidⁱ	P51589.
KEGG Orthology (KO) More...KOⁱ	K07418.
OMAⁱ	MSKHTGN.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BT8.
PhylomeDBⁱ	P51589.
TreeFamⁱ	TF352043.

Enzyme and pathway databases

BRENDAⁱ	1.14.13.159. 2681.
Reactomeⁱ	R-HSA-211935. Fatty acids. R-HSA-211981. Xenobiotics. R-HSA-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).

Miscellaneous databases

GeneWikiⁱ	CYP2J2.
GenomeRNAiⁱ	1573.
Protein Ontology More...PROⁱ	PR:P51589.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000134716.
CleanExⁱ	HS_CYP2J2.
Genevisibleⁱ	P51589. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067. p450. 1 hit.
PRINTSⁱ	PR00463. EP450I. PR01688. EP450ICYP2J. PR00385. P450.
SUPFAMⁱ	SSF48264. SSF48264. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00086. CYTOCHROME_P450. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CP2J2_HUMAN
Accessionⁱ	P51589Primary (citable) accession number: P51589 Secondary accession number(s): B2RD33, Q8TF13
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	May 27, 2002
	Last modified:	June 7, 2017
	This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P51589 (CP2J2_HUMAN)

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Cytochrome P450 2J2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ