UniProtKB - P51589 (CP2J2_HUMAN)
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Protein
Cytochrome P450 2J2
Gene
CYP2J2
Organism
Homo sapiens (Human)
Status
Functioni
This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.
Catalytic activityi
RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.
Cofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 448 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- arachidonic acid 11,12-epoxygenase activity Source: BHF-UCL
- arachidonic acid 14,15-epoxygenase activity Source: BHF-UCL
- arachidonic acid epoxygenase activity Source: BHF-UCL
- aromatase activity Source: UniProtKB-EC
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- linoleic acid epoxygenase activity Source: BHF-UCL
- monooxygenase activity Source: Reactome
GO - Biological processi
- epoxygenase P450 pathway Source: BHF-UCL
- icosanoid metabolic process Source: ProtInc
- linoleic acid metabolic process Source: BHF-UCL
- regulation of heart contraction Source: ProtInc
- xenobiotic metabolic process Source: BHF-UCL
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:HS05902-MONOMER. |
BRENDAi | 1.14.13.159. 2681. |
Reactomei | R-HSA-211935. Fatty acids. R-HSA-211981. Xenobiotics. R-HSA-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET). |
Chemistry databases
SwissLipidsi | SLP:000001594. |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome P450 2J2 (EC:1.14.14.1)Alternative name(s): Arachidonic acid epoxygenase CYPIIJ2 |
Gene namesi | Name:CYP2J2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000134716.9. |
HGNCi | HGNC:2634. CYP2J2. |
MIMi | 601258. gene. |
neXtProti | NX_P51589. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 1573. |
OpenTargetsi | ENSG00000134716. |
PharmGKBi | PA27112. |
Chemistry databases
ChEMBLi | CHEMBL3491. |
DrugBanki | DB06605. Apixaban. DB00637. Astemizole. DB00169. Cholecalciferol. DB09148. Florbetaben (18F). DB08918. Levomilnacipran. DB04725. Licofelone. DB00179. Masoprocol. DB08931. Riociguat. DB06228. Rivaroxaban. DB00342. Terfenadine. |
GuidetoPHARMACOLOGYi | 1332. |
Polymorphism and mutation databases
BioMutai | CYP2J2. |
DMDMi | 21264413. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051769 | 1 – 502 | Cytochrome P450 2J2Add BLAST | 502 |
Proteomic databases
MaxQBi | P51589. |
PaxDbi | P51589. |
PeptideAtlasi | P51589. |
PRIDEi | P51589. |
PTM databases
iPTMneti | P51589. |
PhosphoSitePlusi | P51589. |
Expressioni
Tissue specificityi
Highly expressed in heart, present at lower levels in liver, ileum, jejunum, colon, and kidney.
Gene expression databases
Bgeei | ENSG00000134716. |
CleanExi | HS_CYP2J2. |
Genevisiblei | P51589. HS. |
Interactioni
Protein-protein interaction databases
BioGridi | 107946. 27 interactors. |
IntActi | P51589. 2 interactors. |
STRINGi | 9606.ENSP00000360247. |
Chemistry databases
BindingDBi | P51589. |
Structurei
3D structure databases
ProteinModelPortali | P51589. |
SMRi | P51589. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0156. Eukaryota. COG2124. LUCA. |
GeneTreei | ENSGT00900000140799. |
HOGENOMi | HOG000036991. |
HOVERGENi | HBG015789. |
InParanoidi | P51589. |
KOi | K07418. |
OMAi | RTIFSCN. |
OrthoDBi | EOG091G0BT8. |
PhylomeDBi | P51589. |
TreeFami | TF352043. |
Family and domain databases
Gene3Di | 1.10.630.10. 1 hit. |
InterProi | View protein in InterPro IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008071. Cyt_P450_E_grp-I_CYP2J-like. IPR036396. Cyt_P450_sf. |
Pfami | View protein in Pfam PF00067. p450. 1 hit. |
PRINTSi | PR00463. EP450I. PR01688. EP450ICYP2J. PR00385. P450. |
SUPFAMi | SSF48264. SSF48264. 1 hit. |
PROSITEi | View protein in PROSITE PS00086. CYTOCHROME_P450. 1 hit. |
i Sequence
Sequence statusi: Complete.
P51589-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLAAMGSLAA ALWAVVHPRT LLLGTVAFLL AADFLKRRRP KNYPPGPWRL
60 70 80 90 100
PFLGNFFLVD FEQSHLEVQL FVKKYGNLFS LELGDISAVL ITGLPLIKEA
110 120 130 140 150
LIHMDQNFGN RPVTPMREHI FKKNGLIMSS GQAWKEQRRF TLTALRNFGL
160 170 180 190 200
GKKSLEERIQ EEAQHLTEAI KEENGQPFDP HFKINNAVSN IICSITFGER
210 220 230 240 250
FEYQDSWFQQ LLKLLDEVTY LEASKTCQLY NVFPWIMKFL PGPHQTLFSN
260 270 280 290 300
WKKLKLFVSH MIDKHRKDWN PAETRDFIDA YLKEMSKHTG NPTSSFHEEN
310 320 330 340 350
LICSTLDLFF AGTETTSTTL RWALLYMALY PEIQEKVQAE IDRVIGQGQQ
360 370 380 390 400
PSTAARESMP YTNAVIHEVQ RMGNIIPLNV PREVTVDTTL AGYHLPKGTM
410 420 430 440 450
ILTNLTALHR DPTEWATPDT FNPDHFLENG QFKKREAFMP FSIGKRACLG
460 470 480 490 500
EQLARTELFI FFTSLMQKFT FRPPNNEKLS LKFRMGITIS PVSHRLCAVP
QV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 264 | K → E in BAG37780 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 318 | T → A in BAG37780 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 339 | A → V in BAB85489 (PubMed:12386130).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029159 | 49 | R → S1 PublicationCorresponds to variant dbSNP:rs11572190Ensembl. | 1 | |
Natural variantiVAR_029160 | 113 | V → M. Corresponds to variant dbSNP:rs11572242Ensembl. | 1 | |
Natural variantiVAR_022084 | 124 | N → S. Corresponds to variant dbSNP:rs2228113Ensembl. | 1 | |
Natural variantiVAR_014317 | 143 | T → A in allele CYP2J2*2; significantly reduced metabolism of both arachidonic acid and linoleic acid. 1 PublicationCorresponds to variant dbSNP:rs55753213Ensembl. | 1 | |
Natural variantiVAR_014318 | 158 | R → C in allele CYP2J2*3; significantly reduced metabolism of both arachidonic acid and linoleic acid. 1 PublicationCorresponds to variant dbSNP:rs56307989Ensembl. | 1 | |
Natural variantiVAR_014319 | 192 | I → N in allele CYP2J2*4; significantly reduced metabolism of arachidonic acid only. 1 PublicationCorresponds to variant dbSNP:rs66515830Ensembl. | 1 | |
Natural variantiVAR_014320 | 342 | D → N in allele CYP2J2*5; no change in activity. 1 PublicationCorresponds to variant dbSNP:rs56053398Ensembl. | 1 | |
Natural variantiVAR_014321 | 404 | N → Y in allele CYP2J2*6; significantly reduced metabolism of both arachidonic acid and linoleic acid. 1 PublicationCorresponds to variant dbSNP:rs72547598Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U37143 mRNA. Translation: AAC50370.2. AB080265 mRNA. Translation: BAB85489.1. AF272142 Genomic DNA. Translation: AAM44456.1. AY426985 Genomic DNA. Translation: AAQ93356.1. AK315387 mRNA. Translation: BAG37780.1. BC032594 mRNA. Translation: AAH32594.1. |
CCDSi | CCDS613.1. |
RefSeqi | NP_000766.2. NM_000775.3. |
UniGenei | Hs.152096. |
Genome annotation databases
Ensembli | ENST00000371204; ENSP00000360247; ENSG00000134716. |
GeneIDi | 1573. |
KEGGi | hsa:1573. |
UCSCi | uc001czq.4. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | CP2J2_HUMAN | |
Accessioni | P51589Primary (citable) accession number: P51589 Secondary accession number(s): B2RD33, Q8TF13 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | May 27, 2002 | |
Last modified: | March 28, 2018 | |
This is version 173 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |