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UniProtKB - P51589 (CP2J2_HUMAN)

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Protein

Cytochrome P450 2J2

Gene

CYP2J2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi448Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • arachidonic acid 11,12-epoxygenase activity Source: BHF-UCL
  • arachidonic acid 14,15-epoxygenase activity Source: BHF-UCL
  • arachidonic acid epoxygenase activity Source: BHF-UCL
  • aromatase activity Source: UniProtKB-EC
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro
  • linoleic acid epoxygenase activity Source: BHF-UCL
  • monooxygenase activity Source: Reactome
Complete GO annotation...

GO - Biological processi

  • epoxygenase P450 pathway Source: BHF-UCL
  • icosanoid metabolic process Source: ProtInc
  • linoleic acid metabolic process Source: BHF-UCL
  • regulation of heart contraction Source: ProtInc
  • xenobiotic metabolic process Source: BHF-UCL
Complete GO annotation...

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding, NADP

Enzyme and pathway databases

BRENDAi1.14.13.159. 2681.
ReactomeiR-HSA-211935. Fatty acids.
R-HSA-211981. Xenobiotics.
R-HSA-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).

Chemistry databases

SwissLipidsiSLP:000001594.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2J2 (EC:1.14.14.1)
Alternative name(s):
Arachidonic acid epoxygenase
CYPIIJ2
Gene namesi
Name:CYP2J2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:2634. CYP2J2.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: Reactome
  • extracellular exosome Source: UniProtKB
  • organelle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi1573.
OpenTargetsiENSG00000134716.
PharmGKBiPA27112.

Chemistry databases

ChEMBLiCHEMBL3491.
DrugBankiDB06605. Apixaban.
DB00637. Astemizole.
DB00169. Cholecalciferol.
DB09148. Florbetaben (18F).
DB08918. Levomilnacipran.
DB04725. Licofelone.
DB00179. Masoprocol.
DB08931. Riociguat.
DB06228. Rivaroxaban.
DB00342. Terfenadine.
GuidetoPHARMACOLOGYi1332.

Polymorphism and mutation databases

BioMutaiCYP2J2.
DMDMi21264413.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517691 – 502Cytochrome P450 2J2Add BLAST502

Proteomic databases

EPDiP51589.
MaxQBiP51589.
PaxDbiP51589.
PeptideAtlasiP51589.
PRIDEiP51589.

PTM databases

iPTMnetiP51589.
PhosphoSitePlusiP51589.

Expressioni

Tissue specificityi

Highly expressed in heart, present at lower levels in liver, ileum, jejunum, colon, and kidney.

Gene expression databases

BgeeiENSG00000134716.
CleanExiHS_CYP2J2.
GenevisibleiP51589. HS.

Interactioni

Protein-protein interaction databases

BioGridi107946. 3 interactors.
IntActiP51589. 2 interactors.
STRINGi9606.ENSP00000360247.

Chemistry databases

BindingDBiP51589.

Structurei

3D structure databases

ProteinModelPortaliP51589.
SMRiP51589.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00880000137854.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiP51589.
KOiK07418.
OMAiMSKHTGN.
OrthoDBiEOG091G0BT8.
PhylomeDBiP51589.
TreeFamiTF352043.

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR01688. EP450ICYP2J.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

P51589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAAMGSLAA ALWAVVHPRT LLLGTVAFLL AADFLKRRRP KNYPPGPWRL 
        60         70         80         90        100
PFLGNFFLVD FEQSHLEVQL FVKKYGNLFS LELGDISAVL ITGLPLIKEA 
       110        120        130        140        150
LIHMDQNFGN RPVTPMREHI FKKNGLIMSS GQAWKEQRRF TLTALRNFGL 
       160        170        180        190        200
GKKSLEERIQ EEAQHLTEAI KEENGQPFDP HFKINNAVSN IICSITFGER 
       210        220        230        240        250
FEYQDSWFQQ LLKLLDEVTY LEASKTCQLY NVFPWIMKFL PGPHQTLFSN 
       260        270        280        290        300
WKKLKLFVSH MIDKHRKDWN PAETRDFIDA YLKEMSKHTG NPTSSFHEEN 
       310        320        330        340        350
LICSTLDLFF AGTETTSTTL RWALLYMALY PEIQEKVQAE IDRVIGQGQQ 
       360        370        380        390        400
PSTAARESMP YTNAVIHEVQ RMGNIIPLNV PREVTVDTTL AGYHLPKGTM 
       410        420        430        440        450
ILTNLTALHR DPTEWATPDT FNPDHFLENG QFKKREAFMP FSIGKRACLG 
       460        470        480        490        500
EQLARTELFI FFTSLMQKFT FRPPNNEKLS LKFRMGITIS PVSHRLCAVP 

QV
Length:502
Mass (Da):57,611
Last modified:May 27, 2002 - v2
Checksum:iB5F006581E249EC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti264K → E in BAG37780 (PubMed:14702039).Curated1
Sequence conflicti318T → A in BAG37780 (PubMed:14702039).Curated1
Sequence conflicti339A → V in BAB85489 (PubMed:12386130).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02915949R → S1 PublicationCorresponds to variant dbSNP:rs11572190Ensembl.1
Natural variantiVAR_029160113V → M. Corresponds to variant dbSNP:rs11572242Ensembl.1
Natural variantiVAR_022084124N → S. Corresponds to variant dbSNP:rs2228113Ensembl.1
Natural variantiVAR_014317143T → A in allele CYP2J2*2; significantly reduced metabolism of both arachidonic acid and linoleic acid. 1 PublicationCorresponds to variant dbSNP:rs55753213Ensembl.1
Natural variantiVAR_014318158R → C in allele CYP2J2*3; significantly reduced metabolism of both arachidonic acid and linoleic acid. 1 PublicationCorresponds to variant dbSNP:rs56307989Ensembl.1
Natural variantiVAR_014319192I → N in allele CYP2J2*4; significantly reduced metabolism of arachidonic acid only. 1 PublicationCorresponds to variant dbSNP:rs66515830Ensembl.1
Natural variantiVAR_014320342D → N in allele CYP2J2*5; no change in activity. 1 PublicationCorresponds to variant dbSNP:rs56053398Ensembl.1
Natural variantiVAR_014321404N → Y in allele CYP2J2*6; significantly reduced metabolism of both arachidonic acid and linoleic acid. 1 PublicationCorresponds to variant dbSNP:rs72547598Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37143 mRNA. Translation: AAC50370.2.
AB080265 mRNA. Translation: BAB85489.1.
AF272142 Genomic DNA. Translation: AAM44456.1.
AY426985 Genomic DNA. Translation: AAQ93356.1.
AK315387 mRNA. Translation: BAG37780.1.
BC032594 mRNA. Translation: AAH32594.1.
CCDSiCCDS613.1.
RefSeqiNP_000766.2. NM_000775.3.
UniGeneiHs.152096.

Genome annotation databases

EnsembliENST00000371204; ENSP00000360247; ENSG00000134716.
GeneIDi1573.
KEGGihsa:1573.
UCSCiuc001czq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP2J2 alleles

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37143 mRNA. Translation: AAC50370.2.
AB080265 mRNA. Translation: BAB85489.1.
AF272142 Genomic DNA. Translation: AAM44456.1.
AY426985 Genomic DNA. Translation: AAQ93356.1.
AK315387 mRNA. Translation: BAG37780.1.
BC032594 mRNA. Translation: AAH32594.1.
CCDSiCCDS613.1.
RefSeqiNP_000766.2. NM_000775.3.
UniGeneiHs.152096.

3D structure databases

ProteinModelPortaliP51589.
SMRiP51589.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107946. 3 interactors.
IntActiP51589. 2 interactors.
STRINGi9606.ENSP00000360247.

Chemistry databases

BindingDBiP51589.
ChEMBLiCHEMBL3491.
DrugBankiDB06605. Apixaban.
DB00637. Astemizole.
DB00169. Cholecalciferol.
DB09148. Florbetaben (18F).
DB08918. Levomilnacipran.
DB04725. Licofelone.
DB00179. Masoprocol.
DB08931. Riociguat.
DB06228. Rivaroxaban.
DB00342. Terfenadine.
GuidetoPHARMACOLOGYi1332.
SwissLipidsiSLP:000001594.

PTM databases

iPTMnetiP51589.
PhosphoSitePlusiP51589.

Polymorphism and mutation databases

BioMutaiCYP2J2.
DMDMi21264413.

Proteomic databases

EPDiP51589.
MaxQBiP51589.
PaxDbiP51589.
PeptideAtlasiP51589.
PRIDEiP51589.

Protocols and materials databases

DNASUi1573.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371204; ENSP00000360247; ENSG00000134716.
GeneIDi1573.
KEGGihsa:1573.
UCSCiuc001czq.4. human.

Organism-specific databases

CTDi1573.
DisGeNETi1573.
GeneCardsiCYP2J2.
HGNCiHGNC:2634. CYP2J2.
MIMi601258. gene.
neXtProtiNX_P51589.
OpenTargetsiENSG00000134716.
PharmGKBiPA27112.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00880000137854.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiP51589.
KOiK07418.
OMAiMSKHTGN.
OrthoDBiEOG091G0BT8.
PhylomeDBiP51589.
TreeFamiTF352043.

Enzyme and pathway databases

BRENDAi1.14.13.159. 2681.
ReactomeiR-HSA-211935. Fatty acids.
R-HSA-211981. Xenobiotics.
R-HSA-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).

Miscellaneous databases

GeneWikiiCYP2J2.
GenomeRNAii1573.
PROiPR:P51589.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134716.
CleanExiHS_CYP2J2.
GenevisibleiP51589. HS.

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR01688. EP450ICYP2J.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCP2J2_HUMAN
AccessioniPrimary (citable) accession number: P51589
Secondary accession number(s): B2RD33, Q8TF13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 27, 2002
Last modified: June 7, 2017
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.