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P51588 (TRYP_SARBU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in digestion of a protein meal.

Catalytic activity

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Subcellular location

Secretedextracellular space.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   Biological processDigestion
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Zymogen
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processdigestion

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Propeptide17 – 2610Activation peptide
PRO_0000028297
Chain27 – 254228Trypsin
PRO_0000028298

Regions

Domain27 – 252226Peptidase S1

Sites

Active site681Charge relay system By similarity
Active site1131Charge relay system By similarity
Active site2081Charge relay system By similarity
Site2021Required for specificity By similarity

Amino acid modifications

Disulfide bond53 ↔ 69 By similarity
Disulfide bond154 ↔ 158 By similarity
Disulfide bond178 ↔ 195 By similarity
Disulfide bond204 ↔ 228 By similarity

Sequences

Sequence LengthMass (Da)Tools
P51588 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: F07542C0EC1452AE

FASTA25427,309
        10         20         30         40         50         60 
MLRFIAVFAL VNCALAGTLP NDLDGRIVNG VDTTIEAHPY QVPLQNAALS HFCGGSIISE 

        70         80         90        100        110        120 
DLVVTAAHCM QSYTASQIKV RLGSTIYNEG GELVSVKAFK FHEGYNPKTM VNDVALIKLA 

       130        140        150        160        170        180 
TPVRESSKIR YIRLADRTPP TGTPAVVTGW GTKCFLTCVS LPKTLQEVEV DIVDQKACAS 

       190        200        210        220        230        240 
NEFKYGSQIQ DTMVCAYALK KDACQGDSGG PLVANNQLVG IVSWGSGCAR VGYPGVFCDV 

       250 
PSVRSWIEKT AKEL 

« Hide

References

[1]"Molecular sequencing and modeling of Neobellieria bullata trypsin. Evidence for translational control by Neobellieria trypsin-modulating oostatic factor."
Borovsky D., Janssen I., Vanden Broeck J., Huybrechts R., Verhaert P., de Bondt H.L., Bylemans D., de Loof A.
Eur. J. Biochem. 237:279-287(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 27-36, 3D-STRUCTURE MODELING.
Tissue: Gut.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X94691 mRNA. Translation: CAA64354.1.
PIRS65465.

3D structure databases

ProteinModelPortalP51588.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS01.A85.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRYP_SARBU
AccessionPrimary (citable) accession number: P51588
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 16, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries