SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P51588

- TRYP_SARBU

UniProt

P51588 - TRYP_SARBU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Trypsin
Gene
N/A
Organism
Sarcophaga bullata (Grey flesh fly) (Neobellieria bullata)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in digestion of a protein meal.

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681Charge relay system By similarity
Active sitei113 – 1131Charge relay system By similarity
Sitei202 – 2021Required for specificity By similarity
Active sitei208 – 2081Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. digestion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Protein family/group databases

MEROPSiS01.A85.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin (EC:3.4.21.4)
OrganismiSarcophaga bullata (Grey flesh fly) (Neobellieria bullata)
Taxonomic identifieri7385 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaOestroideaSarcophagidaeNeobellieria

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed prediction
Add
BLAST
Propeptidei17 – 2610Activation peptide
PRO_0000028297
Chaini27 – 254228Trypsin
PRO_0000028298Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 69 By similarity
Disulfide bondi154 ↔ 158 By similarity
Disulfide bondi178 ↔ 195 By similarity
Disulfide bondi204 ↔ 228 By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliP51588.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 252226Peptidase S1
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51588-1 [UniParc]FASTAAdd to Basket

« Hide

MLRFIAVFAL VNCALAGTLP NDLDGRIVNG VDTTIEAHPY QVPLQNAALS    50
HFCGGSIISE DLVVTAAHCM QSYTASQIKV RLGSTIYNEG GELVSVKAFK 100
FHEGYNPKTM VNDVALIKLA TPVRESSKIR YIRLADRTPP TGTPAVVTGW 150
GTKCFLTCVS LPKTLQEVEV DIVDQKACAS NEFKYGSQIQ DTMVCAYALK 200
KDACQGDSGG PLVANNQLVG IVSWGSGCAR VGYPGVFCDV PSVRSWIEKT 250
AKEL 254
Length:254
Mass (Da):27,309
Last modified:October 1, 1996 - v1
Checksum:iF07542C0EC1452AE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94691 mRNA. Translation: CAA64354.1.
PIRiS65465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94691 mRNA. Translation: CAA64354.1 .
PIRi S65465.

3D structure databases

ProteinModelPortali P51588.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.A85.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular sequencing and modeling of Neobellieria bullata trypsin. Evidence for translational control by Neobellieria trypsin-modulating oostatic factor."
    Borovsky D., Janssen I., Vanden Broeck J., Huybrechts R., Verhaert P., de Bondt H.L., Bylemans D., de Loof A.
    Eur. J. Biochem. 237:279-287(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 27-36, 3D-STRUCTURE MODELING.
    Tissue: Gut.

Entry informationi

Entry nameiTRYP_SARBU
AccessioniPrimary (citable) accession number: P51588
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi