Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P51585

- ALGD_AZOVI

UniProt

P51585 - ALGD_AZOVI

Protein

GDP-mannose 6-dehydrogenase

Gene

algD

Organism
Azotobacter vinelandii
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and is essential for cyst formation.

    Catalytic activityi

    GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei10 – 101NAD bindingBy similarity
    Sitei11 – 111NAD bindingBy similarity
    Sitei30 – 301NAD bindingBy similarity
    Sitei35 – 351NAD bindingBy similarity
    Sitei86 – 861NAD bindingBy similarity
    Sitei161 – 1611NAD bindingBy similarity
    Active sitei268 – 2681By similarity
    Sitei271 – 2711NAD bindingBy similarity
    Sitei331 – 3311NAD bindingBy similarity

    GO - Molecular functioni

    1. GDP-mannose 6-dehydrogenase activity Source: UniProtKB-EC
    2. NAD binding Source: InterPro

    GO - Biological processi

    1. alginic acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Alginate biosynthesis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00286.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GDP-mannose 6-dehydrogenase (EC:1.1.1.132)
    Short name:
    GMD
    Gene namesi
    Name:algD
    OrganismiAzotobacter vinelandii
    Taxonomic identifieri354 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 436436GDP-mannose 6-dehydrogenasePRO_0000074066Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP51585.
    SMRiP51585. Positions 1-436.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR028358. GDPman_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR017476. UDP-Glc/GDP-Man.
    IPR014027. UDP-Glc/GDP-Man_DH_C.
    IPR014026. UDP-Glc/GDP-Man_DH_dimer.
    IPR001732. UDP-Glc/GDP-Man_DH_N.
    [Graphical view]
    PANTHERiPTHR11374. PTHR11374. 1 hit.
    PfamiPF00984. UDPG_MGDP_dh. 1 hit.
    PF03720. UDPG_MGDP_dh_C. 1 hit.
    PF03721. UDPG_MGDP_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF500135. GDPman_DH. 1 hit.
    PIRSF000124. UDPglc_GDPman_dh. 1 hit.
    SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    SSF52413. SSF52413. 1 hit.
    TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P51585-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRISIFGLGY VGAVCAGCLS GRGHEVVGVD ISAAKIDMIN QGKSPIVEPG    50
    LGELLAEGVK TGRLRGTTNV TEAVLATELS MLCVGTPSKL NGDLELDYIE 100
    EVCRQMGSAL RDKTERHTVV VRSTVLPGTV HNVVIPILEE FSGKKAGVDF 150
    GVAVNPEFLR ESTAIKDYNF PPMTVIGELD KASGRRLASI YAELDAPIVR 200
    KGIAVAEMIK YTCNVWHATK VTFANEIGNI AKAAGVDGRE VMEVVCMDNK 250
    LNLSQYYMRP GLAFGGSCLP KDVSALSYRA HLWDIEAPLI SSLMRSNAAQ 300
    VQKAYDMIDK HGSRKVALLG LSFKAGTDDL RESPQLELAE MLIGKGFKLS 350
    IFDSNVEYAR DHGANGHYIK NEIPHVSALL QSDLDKVVAE ADVIVLGNAD 400
    PRFEKLAKDV PAGKKVIDLV GFMPQRTAGA AEGICW 436
    Length:436
    Mass (Da):47,003
    Last modified:October 1, 1996 - v1
    Checksum:iFC9E49347F618677
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U11240 Unassigned DNA. Translation: AAB01487.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U11240 Unassigned DNA. Translation: AAB01487.1 .

    3D structure databases

    ProteinModelPortali P51585.
    SMRi P51585. Positions 1-436.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00286 .

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR028358. GDPman_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR017476. UDP-Glc/GDP-Man.
    IPR014027. UDP-Glc/GDP-Man_DH_C.
    IPR014026. UDP-Glc/GDP-Man_DH_dimer.
    IPR001732. UDP-Glc/GDP-Man_DH_N.
    [Graphical view ]
    PANTHERi PTHR11374. PTHR11374. 1 hit.
    Pfami PF00984. UDPG_MGDP_dh. 1 hit.
    PF03720. UDPG_MGDP_dh_C. 1 hit.
    PF03721. UDPG_MGDP_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF500135. GDPman_DH. 1 hit.
    PIRSF000124. UDPglc_GDPman_dh. 1 hit.
    SMARTi SM00984. UDPG_MGDP_dh_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    SSF52413. SSF52413. 1 hit.
    TIGRFAMsi TIGR03026. NDP-sugDHase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the gene coding for GDP-mannose dehydrogenase (algD) from Azotobacter vinelandii."
      Campos M., Martinez-Salazar J.M., Lloret L., Moreno S., Nunez C., Espin G., Soberon-Chavez G.
      J. Bacteriol. 178:1793-1799(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 9046.

    Entry informationi

    Entry nameiALGD_AZOVI
    AccessioniPrimary (citable) accession number: P51585
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3