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P51585

- ALGD_AZOVI

UniProt

P51585 - ALGD_AZOVI

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Protein
GDP-mannose 6-dehydrogenase
Gene
algD
Organism
Azotobacter vinelandii
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and is essential for cyst formation.

Catalytic activityi

GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei10 – 101NAD binding By similarity
Sitei11 – 111NAD binding By similarity
Sitei30 – 301NAD binding By similarity
Sitei35 – 351NAD binding By similarity
Sitei86 – 861NAD binding By similarity
Sitei161 – 1611NAD binding By similarity
Active sitei268 – 2681 By similarity
Sitei271 – 2711NAD binding By similarity
Sitei331 – 3311NAD binding By similarity

GO - Molecular functioni

  1. GDP-mannose 6-dehydrogenase activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. alginic acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Alginate biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00286.

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-mannose 6-dehydrogenase (EC:1.1.1.132)
Short name:
GMD
Gene namesi
Name:algD
OrganismiAzotobacter vinelandii
Taxonomic identifieri354 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436GDP-mannose 6-dehydrogenase
PRO_0000074066Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP51585.
SMRiP51585. Positions 1-436.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR028358. GDPman_DH.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500135. GDPman_DH. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

P51585-1 [UniParc]FASTAAdd to Basket

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MRISIFGLGY VGAVCAGCLS GRGHEVVGVD ISAAKIDMIN QGKSPIVEPG    50
LGELLAEGVK TGRLRGTTNV TEAVLATELS MLCVGTPSKL NGDLELDYIE 100
EVCRQMGSAL RDKTERHTVV VRSTVLPGTV HNVVIPILEE FSGKKAGVDF 150
GVAVNPEFLR ESTAIKDYNF PPMTVIGELD KASGRRLASI YAELDAPIVR 200
KGIAVAEMIK YTCNVWHATK VTFANEIGNI AKAAGVDGRE VMEVVCMDNK 250
LNLSQYYMRP GLAFGGSCLP KDVSALSYRA HLWDIEAPLI SSLMRSNAAQ 300
VQKAYDMIDK HGSRKVALLG LSFKAGTDDL RESPQLELAE MLIGKGFKLS 350
IFDSNVEYAR DHGANGHYIK NEIPHVSALL QSDLDKVVAE ADVIVLGNAD 400
PRFEKLAKDV PAGKKVIDLV GFMPQRTAGA AEGICW 436
Length:436
Mass (Da):47,003
Last modified:October 1, 1996 - v1
Checksum:iFC9E49347F618677
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11240 Unassigned DNA. Translation: AAB01487.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11240 Unassigned DNA. Translation: AAB01487.1 .

3D structure databases

ProteinModelPortali P51585.
SMRi P51585. Positions 1-436.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00286 .

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR028358. GDPman_DH.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
[Graphical view ]
PANTHERi PTHR11374. PTHR11374. 1 hit.
Pfami PF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF500135. GDPman_DH. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTi SM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsi TIGR03026. NDP-sugDHase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Characterization of the gene coding for GDP-mannose dehydrogenase (algD) from Azotobacter vinelandii."
    Campos M., Martinez-Salazar J.M., Lloret L., Moreno S., Nunez C., Espin G., Soberon-Chavez G.
    J. Bacteriol. 178:1793-1799(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 9046.

Entry informationi

Entry nameiALGD_AZOVI
AccessioniPrimary (citable) accession number: P51585
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 11, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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