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Protein

P2X purinoceptor 6

Gene

P2rx6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel.

GO - Molecular functioni

GO - Biological processi

  • protein heterooligomerization Source: RGD
  • protein homooligomerization Source: RGD
  • response to ATP Source: InterPro

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 6
Short name:
P2X6
Alternative name(s):
ATP receptor
P2XM
Purinergic receptor
Purinergic receptor P2X-like 1
Gene namesi
Name:P2rx6
Synonyms:P2rxl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3243. P2rx6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31CytoplasmicSequence analysisAdd BLAST31
Transmembranei32 – 52Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini53 – 325ExtracellularSequence analysisAdd BLAST273
Transmembranei326 – 346Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini347 – 379CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2122.
GuidetoPHARMACOLOGYi483.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001615591 – 379P2X purinoceptor 6Add BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56PhosphotyrosineBy similarity1
Disulfide bondi119 ↔ 169By similarity
Disulfide bondi130 ↔ 153By similarity
Disulfide bondi136 ↔ 163By similarity
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi202N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi220 ↔ 230By similarity
Disulfide bondi264 ↔ 273By similarity

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP51579.
PRIDEiP51579.

Interactioni

Subunit structurei

Unlike most P2XRs, P2RX6 does not seem to form homotrimers or heterotrimers.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
P2rx2P496534EBI-9511515,EBI-9511543

GO - Molecular functioni

Protein-protein interaction databases

IntActiP51579. 2 interactors.
STRINGi10116.ENSRNOP00000002558.

Chemistry databases

BindingDBiP51579.

Structurei

3D structure databases

SMRiP51579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJF. Eukaryota.
ENOG410XR0C. LUCA.
HOGENOMiHOG000232042.
HOVERGENiHBG053086.
InParanoidiP51579.
KOiK05221.
PhylomeDBiP51579.
TreeFamiTF328633.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiView protein in InterPro
IPR003049. P2X6_purnocptor.
IPR027309. P2X_extracellular_dom_sf.
IPR001429. P2X_purnocptor.
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF21. PTHR10125:SF21. 1 hit.
PfamiView protein in Pfam
PF00864. P2X_receptor. 1 hit.
PIRSFiPIRSF005713. P2X_purinoceptor. 1 hit.
PRINTSiPR01313. P2X6RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiView protein in PROSITE
PS01212. P2X_RECEPTOR. 1 hit.

Sequencei

Sequence statusi: Complete.

P51579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAVAAALV SWGFLDYKTE KYVMTRNCWV GISQRLLQLG VVVYVIGWAL
60 70 80 90 100
LAKKGYQEWD MDPQISVITK LKGVSVTQVK ELEKRLWDVA DFVRPSQGEN
110 120 130 140 150
VFFLVTNFLV TPAQVQGRCP EHPSVPLANC WADEDCPEGE MGTYSHGIKT
160 170 180 190 200
GQCVAFNGTH RTCEIWSWCP VESSAVPRKP LLAQAKNFTL FIKNTVTFNK
210 220 230 240 250
FNFSRTNALD TWDNTYFKYC LYDSLSSPYC PVFRIGDLVA MTGGDFEDLA
260 270 280 290 300
LLGGAVGINI HWDCNLDTKG SDCSPQYSFQ LQERGYNFRT ANYWWAASGV
310 320 330 340 350
ESRSLLKLYG IRFDILVTGQ AGKFALIPTA ITVGTGAAWL GMVTFLCDLL
360 370
LLYVDREAGF YWRTKYEEAR APKATTNSA
Length:379
Mass (Da):42,451
Last modified:October 1, 1996 - v1
Checksum:i6960A99D65C7191D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92070 mRNA. Translation: CAA63053.1.
X97376 mRNA. Translation: CAA66044.1.
PIRiJC4843.
RefSeqiNP_036853.2. NM_012721.2.
UniGeneiRn.10258.

Genome annotation databases

GeneIDi25041.
KEGGirno:25041.

Similar proteinsi

Entry informationi

Entry nameiP2RX6_RAT
AccessioniPrimary (citable) accession number: P51579
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 22, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families