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Protein

P2X purinoceptor 6

Gene

P2rx6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel.

GO - Molecular functioni

GO - Biological processi

  • protein heterooligomerization Source: RGD
  • response to ATP Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 6
Short name:
P2X6
Alternative name(s):
ATP receptor
P2XM
Purinergic receptor
Purinergic receptor P2X-like 1
Gene namesi
Name:P2rx6
Synonyms:P2rxl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3243. P2rx6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131CytoplasmicSequence analysisAdd
BLAST
Transmembranei32 – 5221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini53 – 325273ExtracellularSequence analysisAdd
BLAST
Transmembranei326 – 34621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini347 – 37933CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • dendritic spine Source: RGD
  • integral component of nuclear inner membrane Source: GO_Central
  • integral component of plasma membrane Source: InterPro
  • membrane Source: RGD
  • neuronal cell body Source: RGD
  • postsynaptic density Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2122.
GuidetoPHARMACOLOGYi483.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379P2X purinoceptor 6PRO_0000161559Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei56 – 561PhosphotyrosineBy similarity
Disulfide bondi119 ↔ 169By similarity
Disulfide bondi130 ↔ 153By similarity
Disulfide bondi136 ↔ 163By similarity
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence analysis
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence analysis
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence analysis
Disulfide bondi220 ↔ 230By similarity
Disulfide bondi264 ↔ 273By similarity

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP51579.
PRIDEiP51579.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001873.

Interactioni

Subunit structurei

Unlike most P2XRs, P2RX6 does not seem to form homotrimers or heterotrimers.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
P2rx2P496534EBI-9511515,EBI-9511543

Protein-protein interaction databases

IntActiP51579. 2 interactions.
STRINGi10116.ENSRNOP00000002558.

Chemistry

BindingDBiP51579.

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJF. Eukaryota.
ENOG410XR0C. LUCA.
HOGENOMiHOG000232042.
HOVERGENiHBG053086.
InParanoidiP51579.
KOiK05221.
PhylomeDBiP51579.
TreeFamiTF328633.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003049. P2X6_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PIRSFiPIRSF005713. P2X_purinoceptor. 1 hit.
PRINTSiPR01313. P2X6RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAVAAALV SWGFLDYKTE KYVMTRNCWV GISQRLLQLG VVVYVIGWAL
60 70 80 90 100
LAKKGYQEWD MDPQISVITK LKGVSVTQVK ELEKRLWDVA DFVRPSQGEN
110 120 130 140 150
VFFLVTNFLV TPAQVQGRCP EHPSVPLANC WADEDCPEGE MGTYSHGIKT
160 170 180 190 200
GQCVAFNGTH RTCEIWSWCP VESSAVPRKP LLAQAKNFTL FIKNTVTFNK
210 220 230 240 250
FNFSRTNALD TWDNTYFKYC LYDSLSSPYC PVFRIGDLVA MTGGDFEDLA
260 270 280 290 300
LLGGAVGINI HWDCNLDTKG SDCSPQYSFQ LQERGYNFRT ANYWWAASGV
310 320 330 340 350
ESRSLLKLYG IRFDILVTGQ AGKFALIPTA ITVGTGAAWL GMVTFLCDLL
360 370
LLYVDREAGF YWRTKYEEAR APKATTNSA
Length:379
Mass (Da):42,451
Last modified:October 1, 1996 - v1
Checksum:i6960A99D65C7191D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92070 mRNA. Translation: CAA63053.1.
X97376 mRNA. Translation: CAA66044.1.
PIRiJC4843.
RefSeqiNP_036853.2. NM_012721.2.
UniGeneiRn.10258.

Genome annotation databases

GeneIDi25041.
KEGGirno:25041.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92070 mRNA. Translation: CAA63053.1.
X97376 mRNA. Translation: CAA66044.1.
PIRiJC4843.
RefSeqiNP_036853.2. NM_012721.2.
UniGeneiRn.10258.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP51579. 2 interactions.
STRINGi10116.ENSRNOP00000002558.

Chemistry

BindingDBiP51579.
ChEMBLiCHEMBL2122.
GuidetoPHARMACOLOGYi483.

Proteomic databases

PaxDbiP51579.
PRIDEiP51579.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25041.
KEGGirno:25041.

Organism-specific databases

CTDi9127.
RGDi3243. P2rx6.

Phylogenomic databases

eggNOGiENOG410IFJF. Eukaryota.
ENOG410XR0C. LUCA.
HOGENOMiHOG000232042.
HOVERGENiHBG053086.
InParanoidiP51579.
KOiK05221.
PhylomeDBiP51579.
TreeFamiTF328633.

Miscellaneous databases

PROiP51579.

Gene expression databases

BgeeiENSRNOG00000001873.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003049. P2X6_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PIRSFiPIRSF005713. P2X_purinoceptor. 1 hit.
PRINTSiPR01313. P2X6RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2RX6_RAT
AccessioniPrimary (citable) accession number: P51579
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.