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Protein

P2X purinoceptor 6

Gene

P2rx6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel.

GO - Molecular functioni

GO - Biological processi

  • protein heterooligomerization Source: RGD
  • protein homooligomerization Source: RGD
  • response to ATP Source: InterPro

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-139853. Elevation of cytosolic Ca2+ levels.
R-RNO-418346. Platelet homeostasis.

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 6
Short name:
P2X6
Alternative name(s):
ATP receptor
P2XM
Purinergic receptor
Purinergic receptor P2X-like 1
Gene namesi
Name:P2rx6
Synonyms:P2rxl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 11, Unplaced

Organism-specific databases

RGDi3243. P2rx6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
Transmembranei42 – 62Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini63 – 335ExtracellularSequence analysisAdd BLAST273
Transmembranei336 – 356Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini357 – 389CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2122.
GuidetoPHARMACOLOGYi483.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001615591 – 389P2X purinoceptor 6Add BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei66PhosphotyrosineBy similarity1
Disulfide bondi129 ↔ 179By similarity
Disulfide bondi140 ↔ 163By similarity
Disulfide bondi146 ↔ 173By similarity
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi230 ↔ 240By similarity
Disulfide bondi274 ↔ 283By similarity

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP51579.
PRIDEiP51579.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001873.

Interactioni

Subunit structurei

Unlike most P2XRs, P2RX6 does not seem to form homotrimers or heterotrimers.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
P2rx2P496534EBI-9511515,EBI-9511543

GO - Molecular functioni

Protein-protein interaction databases

IntActiP51579. 2 interactors.
STRINGi10116.ENSRNOP00000002558.

Chemistry databases

BindingDBiP51579.

Structurei

3D structure databases

SMRiP51579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJF. Eukaryota.
ENOG410XR0C. LUCA.
GeneTreeiENSGT00390000016028.
HOGENOMiHOG000232042.
HOVERGENiHBG053086.
InParanoidiP51579.
KOiK05221.
OMAiHYSFQLQ.
OrthoDBiEOG091G0A2U.
PhylomeDBiP51579.
TreeFamiTF328633.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiView protein in InterPro
IPR003049. P2X6_purnocptor.
IPR027309. P2X_extracellular_dom_sf.
IPR001429. P2X_purnocptor.
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF21. PTHR10125:SF21. 1 hit.
PfamiView protein in Pfam
PF00864. P2X_receptor. 1 hit.
PIRSFiPIRSF005713. P2X_purinoceptor. 1 hit.
PRINTSiPR01313. P2X6RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiView protein in PROSITE
PS01212. P2X_RECEPTOR. 1 hit.

Sequencei

Sequence statusi: Complete.

P51579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLQPAGTGS MASAVAAALV SWGFLDYKTE KYVMTRNCWV GISQRLLQLG
60 70 80 90 100
VVVYVIGWAL LAKKGYQEWD MDPQISVITK LKGVSVTQVK ELEKRLWDVA
110 120 130 140 150
DFVRPSQGEN VFFLVTNFLV TPAQVQGRCP EHPSVPLANC WADEDCPEGE
160 170 180 190 200
MGTYSHGIKT GQCVAFNGTH RTCEIWSWCP VESSAVPRKP LLAQAKNFTL
210 220 230 240 250
FIKNTVTFNK FNFSRTNALD TWDNTYFKYC LYDSLSSPYC PVFRIGDLVA
260 270 280 290 300
MTGGDFEDLA LLGGAVGINI HWDCNLDTKG SDCSPQYSFQ LQERGYNFRT
310 320 330 340 350
ANYWWAASGV ESRSLLKLYG IRFDILVTGQ AGKFALIPTA ITVGTGAAWL
360 370 380
GMVTFLCDLL LLYVDREAGF YWRTKYEEAR APKATTNSA
Length:389
Mass (Da):43,422
Last modified:January 31, 2018 - v2
Checksum:i1AE683A0191B6A0B
GO

Sequence cautioni

The sequence CAA63053 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA66044 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97376 mRNA. Translation: CAA66044.1. Different initiation.
AABR07034750 Genomic DNA. No translation available.
CH473999 Genomic DNA. Translation: EDL77896.1.
X92070 mRNA. Translation: CAA63053.1. Different initiation.
PIRiJC4843.
RefSeqiNP_036853.2. NM_012721.2.
UniGeneiRn.10258.

Genome annotation databases

EnsembliENSRNOT00000002558; ENSRNOP00000002558; ENSRNOG00000001873.
GeneIDi25041.
KEGGirno:25041.

Similar proteinsi

Entry informationi

Entry nameiP2RX6_RAT
AccessioniPrimary (citable) accession number: P51579
Secondary accession number(s): R9PXR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 31, 2018
Last modified: January 31, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families