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Protein

P2X purinoceptor 5

Gene

P2rx5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel.

GO - Molecular functioni

  • ATP binding Source: RGD
  • drug binding Source: RGD
  • extracellular ATP-gated cation channel activity Source: RGD
  • GTP binding Source: RGD
  • purinergic nucleotide receptor activity Source: GO_Central
  • zinc ion binding Source: RGD

GO - Biological processi

  • cation transport Source: RGD
  • neuronal action potential Source: RGD
  • protein homooligomerization Source: RGD
  • regulation of skeletal muscle tissue regeneration Source: RGD
  • response to ATP Source: InterPro
  • skeletal muscle tissue growth Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 5
Short name:
P2X5
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2rx5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620256. P2rx5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30CytoplasmicSequence analysisAdd BLAST30
Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini52 – 341ExtracellularSequence analysisAdd BLAST290
Transmembranei342 – 362Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini363 – 455CytoplasmicSequence analysisAdd BLAST93

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2495.
GuidetoPHARMACOLOGYi482.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001615561 – 455P2X purinoceptor 5Add BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi77N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi118 ↔ 169By similarity
Disulfide bondi129 ↔ 152By similarity
Disulfide bondi135 ↔ 163By similarity
Glycosylationi157N-linked (GlcNAc...)Sequence analysis1
Glycosylationi202N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi220 ↔ 229By similarity
Disulfide bondi263 ↔ 272By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP51578.
PRIDEiP51578.

Expressioni

Tissue specificityi

Predominantly expressed in heart but are also present in brain, spinal cord and adrenal gland.

Interactioni

Subunit structurei

Functional P2XRs are organized as homomeric and heteromeric trimers.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026156.

Chemistry databases

BindingDBiP51578.

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJF. Eukaryota.
ENOG410XR0C. LUCA.
HOGENOMiHOG000232042.
HOVERGENiHBG053086.
InParanoidiP51578.
KOiK05219.
PhylomeDBiP51578.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003048. P2X5_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF12. PTHR10125:SF12. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PIRSFiPIRSF005713. P2X_purinoceptor. 1 hit.
PRINTSiPR01312. P2X5RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51578-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQAAWKGFV LSLFDYKTAK FVVAKSKKVG LLYRVLQLII LLYLLIWVFL
60 70 80 90 100
IKKSYQDIDT SLQSAVVTKV KGVAYTNTTM LGERLWDVAD FVIPSQGENV
110 120 130 140 150
FFVVTNLIVT PNQRQGICAE REGIPDGECS EDDDCHAGES VVAGHGLKTG
160 170 180 190 200
RCLRVGNSTR GTCEIFAWCP VETKSMPTDP LLKDAESFTI SIKNFIRFPK
210 220 230 240 250
FNFSKANVLE TDNKHFLKTC HFSSTNLYCP IFRLGSIVRW AGADFQDIAL
260 270 280 290 300
KGGVIGIYIE WDCDLDKAAS KCNPHYYFNR LDNKHTHSIS SGYNFRFARY
310 320 330 340 350
YRDPNGVEFR DLMKAYGIRF DVIVNGKAGK FSIIPTVINI GSGLALMGAG
360 370 380 390 400
AFFCDLVLIY LIRKSEFYRD KKFEKVRGQK EDANVEVEAN EMEQERPEDE
410 420 430 440 450
PLERVRQDEQ SQELAQSGRK QNSNCQVLLE PARFGLRENA IVNVKQSQIL

HPVKT
Length:455
Mass (Da):51,479
Last modified:October 1, 1996 - v1
Checksum:iD4405BE440490F70
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191S → F in CAA65993 (PubMed:8690069).Curated1
Sequence conflicti396R → Q in CAA65993 (PubMed:8690069).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92069 mRNA. Translation: CAA63052.1.
X97328 mRNA. Translation: CAA65993.1.
PIRiS71344.
RefSeqiNP_542958.2. NM_080780.2.
UniGeneiRn.10257.

Genome annotation databases

GeneIDi113995.
KEGGirno:113995.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92069 mRNA. Translation: CAA63052.1.
X97328 mRNA. Translation: CAA65993.1.
PIRiS71344.
RefSeqiNP_542958.2. NM_080780.2.
UniGeneiRn.10257.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026156.

Chemistry databases

BindingDBiP51578.
ChEMBLiCHEMBL2495.
GuidetoPHARMACOLOGYi482.

Proteomic databases

PaxDbiP51578.
PRIDEiP51578.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi113995.
KEGGirno:113995.

Organism-specific databases

CTDi5026.
RGDi620256. P2rx5.

Phylogenomic databases

eggNOGiENOG410IFJF. Eukaryota.
ENOG410XR0C. LUCA.
HOGENOMiHOG000232042.
HOVERGENiHBG053086.
InParanoidiP51578.
KOiK05219.
PhylomeDBiP51578.

Miscellaneous databases

PROiP51578.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003048. P2X5_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF12. PTHR10125:SF12. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PIRSFiPIRSF005713. P2X_purinoceptor. 1 hit.
PRINTSiPR01312. P2X5RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2RX5_RAT
AccessioniPrimary (citable) accession number: P51578
Secondary accession number(s): Q64613
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 6, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.