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Protein

P2X purinoceptor 1

Gene

P2rx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death (By similarity).By similarity

GO - Molecular functioni

  • ATP binding Source: Ensembl
  • cation channel activity Source: MGI
  • extracellularly ATP-gated cation channel activity Source: GO_Central
  • purinergic nucleotide receptor activity Source: MGI
  • zinc ion binding Source: Ensembl

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • apoptotic process Source: UniProtKB-KW
  • ceramide biosynthetic process Source: MGI
  • insemination Source: MGI
  • ion transport Source: MGI
  • neuronal action potential Source: Ensembl
  • platelet activation Source: MGI
  • positive regulation of ion transport Source: MGI
  • protein heterooligomerization Source: Ensembl
  • protein homooligomerization Source: Ensembl
  • regulation of blood pressure Source: Ensembl
  • regulation of calcium ion transport Source: MGI
  • regulation of smooth muscle contraction Source: MGI
  • regulation of vascular smooth muscle contraction Source: MGI
  • regulation of vasoconstriction Source: MGI
  • response to ATP Source: MGI
  • response to organic substance Source: MGI
  • serotonin secretion by platelet Source: MGI
  • synaptic transmission, glutamatergic Source: Ensembl
  • vasoconstriction Source: Ensembl

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processApoptosis, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-139853 Elevation of cytosolic Ca2+ levels
R-MMU-418346 Platelet homeostasis
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 1
Short name:
P2X1
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2rx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1098235 P2rx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28CytoplasmicSequence analysisAdd BLAST28
Transmembranei29 – 50Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini51 – 338ExtracellularSequence analysisAdd BLAST288
Transmembranei339 – 358Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini359 – 399CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5496

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001615461 – 399P2X purinoceptor 1Add BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi117 ↔ 165By similarity
Disulfide bondi126 ↔ 149By similarity
Disulfide bondi132 ↔ 159By similarity
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi217 ↔ 227By similarity
Disulfide bondi261 ↔ 270By similarity
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei387PhosphoserineBy similarity1
Modified residuei388PhosphoserineBy similarity1
Modified residuei389PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP51576
PaxDbiP51576
PRIDEiP51576

PTM databases

PhosphoSitePlusiP51576

Expressioni

Gene expression databases

BgeeiENSMUSG00000020787
ExpressionAtlasiP51576 baseline and differential
GenevisibleiP51576 MM

Interactioni

Subunit structurei

Homo- or heteropolymers.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021141

Chemistry databases

BindingDBiP51576

Structurei

3D structure databases

ProteinModelPortaliP51576
SMRiP51576
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni331 – 338Pore-forming motifSequence analysis8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi351 – 354Poly-Leu4

Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJF Eukaryota
ENOG410XR0C LUCA
GeneTreeiENSGT00390000016028
HOGENOMiHOG000232042
HOVERGENiHBG053086
InParanoidiP51576
KOiK05215
OMAiFKYAEDM
OrthoDBiEOG091G0A2U
PhylomeDBiP51576
TreeFamiTF328633

Family and domain databases

Gene3Di2.60.490.10, 1 hit
InterProiView protein in InterPro
IPR003044 P2X1_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor
PANTHERiPTHR10125 PTHR10125, 1 hit
PTHR10125:SF9 PTHR10125:SF9, 1 hit
PfamiView protein in Pfam
PF00864 P2X_receptor, 1 hit
PIRSFiPIRSF005713 P2X_purinoceptor, 1 hit
PRINTSiPR01308 P2X1RECEPTOR
PR01307 P2XRECEPTOR
TIGRFAMsiTIGR00863 P2X, 1 hit
PROSITEiView protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit

Sequencei

Sequence statusi: Complete.

P51576-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARRLQDELS AFFFEYDTPR MVLVRNKKVG VIFRLIQLVV LVYVIGWVFV
60 70 80 90 100
YEKGYQTSSG LISSVSVKLK GLAVTQLQGL GPQVWDVADY VFPAHGDSSF
110 120 130 140 150
VVMTNFIMTP QQAQGHCAEN PEGGICQDDS GCTPGKAERK AQGIRTGNCV
160 170 180 190 200
PFNGTVKTCE IFGWCPVEVD DKIPSPALLH EAENFTLFIK NSISFPRFKV
210 220 230 240 250
NRRNLVEEVN GTYMKKCLYH KILHPLCPVF SLGYVVRESG QDFRSLAEKG
260 270 280 290 300
GVVGITIDWE CDLDWHVRHC KPIYQFHGLY GEKNLSPGFN FRFARHFVQN
310 320 330 340 350
GTNRRHLFKV FGIRFDILVD GKAGKFDIIP TMTTIGSGIG IFGVATVLCD
360 370 380 390
LLLLHILPKR HYYKQKKFKY AEDMGPGEGE RDPAATSSTL GLQENMRTS
Length:399
Mass (Da):44,851
Last modified:October 1, 1996 - v1
Checksum:i8CBF6B97F569472E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84896 mRNA Translation: CAA59322.1
AF250123, AF250121, AF250122 Genomic DNA Translation: AAF68968.1
AK035304 mRNA Translation: BAC29024.1
AL670399 Genomic DNA Translation: CAI24783.1
CCDSiCCDS24992.1
RefSeqiNP_032797.3, NM_008771.3
UniGeneiMm.25722

Genome annotation databases

EnsembliENSMUST00000021141; ENSMUSP00000021141; ENSMUSG00000020787
GeneIDi18436
KEGGimmu:18436
UCSCiuc007jzq.2 mouse

Similar proteinsi

Entry informationi

Entry nameiP2RX1_MOUSE
AccessioniPrimary (citable) accession number: P51576
Secondary accession number(s): Q5SRU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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