Reviewed, UniProtKB/Swiss-Prot P51571 (SSRD_HUMAN)

Names and origin

Protein names

Recommended name:
    Translocon-associated protein subunit delta
      Short name=TRAP-delta
Alternative name(s):
    Signal sequence receptor subunit delta
      Short name=SSR-delta

Gene names

Name:	SSR4
Synonyms:	TRAPD

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	173 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
Subunit structure	Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the TRAP-delta family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Signal Transmembrane
PTM	Disulfide bond Isopeptide bond Ubl conjugation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	intracellular protein transport Non-traceable author statement. Source: UniProtKB
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW translocon complex Ref.1 Ref.2 Non-traceable author statement. Source: UniProtKB
Molecular function	calcium ion binding Non-traceable author statement. Source: UniProtKB protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
C20orf24	Q9BUV8	1	EBI-1054539,EBI-1050079
CBWD1	Q9BRT8	1	EBI-1054539,EBI-1054417
PHLDA3	Q9Y5J5	1	EBI-1054539,EBI-1055859
RIOK3	O14730	1	EBI-1054539,EBI-1047061
WDR8	Q9P2S5	1	EBI-1054539,EBI-1054904

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 173	150	Translocon-associated protein subunit delta		PRO_0000033292
Regions
	Topological domain	24 – 144	121	Lumenal Potential
	Transmembrane	145 – 165	21	Potential
	Topological domain	166 – 173	8	Cytoplasmic Potential
Amino acid modifications
	Disulfide bond	26 ↔ 57		By similarity
	Cross-link	73		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.5
Experimental info
	Sequence conflict	109	1	E → K Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P51571-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 063CD2C8F6CE368B	FASTA	173	18,999
	10 20 30 40 50 60 MAAMASLGAL ALLLLSSLSR CSAEACLEPQ ITPSYYTTSD AVISTETVFI VEISLTCKNR 70 80 90 100 110 120 VQNMALYADV GGKQFPVTRG QDVGRYQVSW SLDHKSAHAG TYEVRFFDEE SYSLLRKAQR 130 140 150 160 170 NNEDISIIPP LFTVSVDHRG TWNGPWVSTE VLAAAIGLVI YYLAFSAKSH IQA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Translocon-associated protein TRAP delta and a novel TRAP-like protein are coordinately expressed with pro-opiomelanocortin in Xenopus intermediate pituitary." Holthuis J.C.M., van Riel M.C.H.M., Martens G.J.M. Biochem. J. 312:205-213(1995) [PubMed: 7492314] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse." Brenner V., Nyakatura G., Rosenthal A., Platzer M. Genomics 44:8-14(1997) [PubMed: 9286695] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Liver, Placenta and Spleen.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[5]	"Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry." Meierhofer D., Wang X., Huang L., Kaiser P. J. Proteome Res. 7:4566-4576(2008) [PubMed: 18781797] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-73, MASS SPECTROMETRY.
[6]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U52111 Genomic DNA. No translation available. Z69043 mRNA. Translation: CAA93157.1. X90583 mRNA. Translation: CAA62211.1. Z68129 Genomic DNA. Translation: CAA92215.1. BT007192 mRNA. Translation: AAP35856.1. BC003371 mRNA. Translation: AAH03371.1.
IPI	IPI00019385.
PIR	S59865.
RefSeq	NP_006271.1.
UniGene	Hs.409223
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P51571. 22 interactions.
PTM databases
PhosphoSite	P51571.
Proteomic databases
PRIDE	P51571.
Genome annotation databases
Ensembl	ENSG00000180879. Homo sapiens. [Contig view]
GeneID	6748.
KEGG	hsa:6748.
UCSC	uc004fiw.1. human.
Organism-specific databases
GeneCards	GC0XP152712.
H-InvDB	HIX0017140.
HGNC	HGNC:11326. SSR4.
MIM	300090. gene.
PharmGKB	PA36150.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P51571.
HOVERGEN	P51571.
OMA	P51571. GLSCCSA.
Enzyme and pathway databases
Reactome	REACT_15380. Diabetes pathways.
Gene expression databases
ArrayExpress	P51571.
Bgee	P51571.
CleanEx	HS_SSR4.
GermOnline	ENSG00000180879. Homo sapiens.
Family and domain databases
InterPro	IPR008855. TRAP-delta. [Graphical view]
PANTHER	PTHR12731. TRAP-delta. 1 hit.
Pfam	PF05404. TRAP-delta. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	26324.
SOURCE	Search...

Entry information

Entry name

SSRD_HUMAN

Accession

Primary (citable) accession number: P51571
Secondary accession number(s): Q53XY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	July 7, 2009
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)