P51568 (AFC3_ARATH) Reviewed, UniProtKB/Swiss-Prot
Last modified
October 19, 2011.
Version 90.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Serine/threonine-protein kinase AFC3 EC=2.7.12.1 | ||||||||
| Gene names |
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| Organism | Arabidopsis thaliana (Mouse-ear cress) | ||||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Protein attributes
| Sequence length | 400 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Sequence similarities | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. Contains 1 protein kinase domain. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | protein autophosphorylation Inferred from direct assay. Source: TAIR |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activityInferred from direct assay. Source: TAIR protein serine/threonine/tyrosine kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Alternative products
| This entry describes 1 isoform produced by alternative splicing. [Select] Note: A number of isoforms are produced. According to EST sequences. | ||||||
| Isoform 1 (identifier: P51568-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 400 | 400 | Serine/threonine-protein kinase AFC3 | PRO_0000085602 | |||||
Regions | |||||||||
| Domain | 71 – 396 | 326 | Protein kinase | ||||||
| Nucleotide binding | 77 – 85 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 196 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 100 | 1 | ATP By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 8 | 1 | S → N in AAA57119. Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A.thaliana genes encoding protein kinases of a new family." Kuromori T., Yamamoto M. Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana." Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B. McCombie W.R.Nature 402:769-777(1999) [PubMed: 10617198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [3] | The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia. |
| [4] | "AFC1, a LAMMER kinase from Arabidopsis thaliana, activates STE12-dependent processes in yeast." Bender J., Fink G.R. Proc. Natl. Acad. Sci. U.S.A. 91:12105-12109(1994) [PubMed: 7991592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-400. Strain: cv. Landsberg erecta. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | D45355 mRNA. Translation: BAA08216.1. AL022537 Genomic DNA. Translation: CAA18595.1. AL161581 Genomic DNA. Translation: CAB79983.1. CP002687 Genomic DNA. Translation: AEE86100.1. U16178 mRNA. Translation: AAA57119.1. |
| IPI | IPI00548682. |
| PIR | T04460. |
| RefSeq | NP_194992.1. NM_119418.2. |
| UniGene | At.21547. At.71320. |
3D structure databases | |
| ProteinModelPortal | P51568. |
| SMR | P51568. Positions 50-399. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | P51568. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblPlants | AT4G32660.1; AT4G32660.1; AT4G32660. |
| GeneID | 829401. |
| GenomeReviews | Gene locus AT4G32660 in contig CT486007_GR. |
| KEGG | ath:AT4G32660. |
Organism-specific databases | |
| TAIR | At4g32660. |
Phylogenomic databases | |
| HOGENOM | HBG755340. |
| InParanoid | P51568. |
| OMA | GRVLECW. |
| PhylomeDB | P51568. |
| ProtClustDB | CLSN2685428. |
Enzyme and pathway databases | |
| BRENDA | 2.7.12.1. 399. |
Gene expression databases | |
| ArrayExpress | P51568. |
| Genevestigator | P51568. |
Family and domain databases | |
| InterPro | IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. IPR002290. Ser/Thr_kinase_dom. [Graphical view] |
| Pfam | PF00069. Pkinase. 1 hit. [Graphical view] |
| SMART | SM00220. S_TKc. 1 hit. [Graphical view] |
| SUPFAM | SSF56112. Kinase_like. 1 hit. |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AFC3_ARATH | ||||||||
| Accession | Primary (citable) accession number: P51568 Secondary accession number(s): Q39185 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Plant Protein Annotation Program | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with