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Protein

Steroidogenic acute regulatory protein, mitochondrial

Gene

Star

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Transporter that binds to and transport cholesterol through the intermembrane space of the mitochondrion (Probable).Curated

Pathwayi: cholesterol metabolism

This protein is involved in the pathway cholesterol metabolism, which is part of Steroid metabolism.
View all proteins of this organism that are known to be involved in the pathway cholesterol metabolism and in Steroid metabolism.

GO - Molecular functioni

  • cholesterol binding Source: MGI
  • cholesterol transporter activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Steroidogenesis, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-196108. Pregnenolone biosynthesis.
UniPathwayiUPA00296.

Names & Taxonomyi

Protein namesi
Recommended name:
Steroidogenic acute regulatory protein, mitochondrial
Short name:
StAR
Alternative name(s):
Luteinizing hormone-induced protein
START domain-containing protein 1
Short name:
StARD1
Gene namesi
Name:Star
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:102760. Star.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2029195.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 62Mitochondrion1 PublicationAdd BLAST62
ChainiPRO_000003331863 – 284Steroidogenic acute regulatory protein, mitochondrialAdd BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56Phosphoserine; by PKABy similarity1
Modified residuei194Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP51557.
PaxDbiP51557.
PRIDEiP51557.

PTM databases

iPTMnetiP51557.
PhosphoSitePlusiP51557.

Expressioni

Tissue specificityi

Expressed within glia and neurons in discrete regions of the brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000031574.
CleanExiMM_STAR.
GenevisibleiP51557. MM.

Interactioni

Subunit structurei

May interact with TSPO.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033979.

Structurei

3D structure databases

ProteinModelPortaliP51557.
SMRiP51557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 279STARTPROSITE-ProRule annotationAdd BLAST214

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi170 – 174Poly-Ala5

Sequence similaritiesi

Contains 1 START domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3845. Eukaryota.
ENOG41100B5. LUCA.
GeneTreeiENSGT00530000063139.
HOGENOMiHOG000142452.
HOVERGENiHBG010529.
InParanoidiP51557.
KOiK16931.
OMAiATFKLCA.
OrthoDBiEOG091G06RM.
PhylomeDBiP51557.
TreeFamiTF313869.

Family and domain databases

CDDicd08905. START_STARD1-like. 1 hit.
Gene3Di3.30.530.20. 1 hit.
InterProiIPR029866. StAR.
IPR000799. StAR-like.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PANTHERiPTHR12136:SF9. PTHR12136:SF9. 1 hit.
PfamiPF01852. START. 1 hit.
[Graphical view]
PRINTSiPR00978. STARPROTEIN.
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS50848. START. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51557-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLATFKLCA GSSYRHMRNM KGLRHQAVLA IGQELNWRAL GDSSPGWMGQ
60 70 80 90 100
VRRRSSLLGS QLEATLYSDQ ELSYIQQGEV AMQKALGILN NQEGWKKESQ
110 120 130 140 150
QENGDEVLSK MVPDVGKVFR LEVVVDQPMD RLYEELVDRM EAMGEWNPNV
160 170 180 190 200
KEIKVLQRIG KDTVITHELA AAAAGNLVGP RDFVSVRCTK RRGSTCVLAG
210 220 230 240 250
MATHFGEMPE QSGVIRAEHG PTCMVLHPLA GSPSKTKLTW LLSIDLKGWL
260 270 280
PKTIINQVLS QTQIEFANHL RKRLEASPAS EAQC
Length:284
Mass (Da):31,626
Last modified:October 1, 1996 - v1
Checksum:i9BB13E52D4439B72
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139R → H in BAB31842 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36062 mRNA. Translation: AAB94783.1.
AY032730 Genomic DNA. Translation: AAK50433.2.
AK019725 mRNA. Translation: BAB31842.1.
AK054470 mRNA. Translation: BAC35791.1.
AK136327 mRNA. Translation: BAE22934.1.
BC082283 mRNA. Translation: AAH82283.1.
CCDSiCCDS22203.1.
PIRiA55455.
RefSeqiNP_035615.2. NM_011485.5.
UniGeneiMm.293314.

Genome annotation databases

EnsembliENSMUST00000033979; ENSMUSP00000033979; ENSMUSG00000031574.
GeneIDi20845.
KEGGimmu:20845.
UCSCiuc009lhb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36062 mRNA. Translation: AAB94783.1.
AY032730 Genomic DNA. Translation: AAK50433.2.
AK019725 mRNA. Translation: BAB31842.1.
AK054470 mRNA. Translation: BAC35791.1.
AK136327 mRNA. Translation: BAE22934.1.
BC082283 mRNA. Translation: AAH82283.1.
CCDSiCCDS22203.1.
PIRiA55455.
RefSeqiNP_035615.2. NM_011485.5.
UniGeneiMm.293314.

3D structure databases

ProteinModelPortaliP51557.
SMRiP51557.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033979.

Chemistry databases

ChEMBLiCHEMBL2029195.

PTM databases

iPTMnetiP51557.
PhosphoSitePlusiP51557.

Proteomic databases

MaxQBiP51557.
PaxDbiP51557.
PRIDEiP51557.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033979; ENSMUSP00000033979; ENSMUSG00000031574.
GeneIDi20845.
KEGGimmu:20845.
UCSCiuc009lhb.1. mouse.

Organism-specific databases

CTDi6770.
MGIiMGI:102760. Star.

Phylogenomic databases

eggNOGiKOG3845. Eukaryota.
ENOG41100B5. LUCA.
GeneTreeiENSGT00530000063139.
HOGENOMiHOG000142452.
HOVERGENiHBG010529.
InParanoidiP51557.
KOiK16931.
OMAiATFKLCA.
OrthoDBiEOG091G06RM.
PhylomeDBiP51557.
TreeFamiTF313869.

Enzyme and pathway databases

UniPathwayiUPA00296.
ReactomeiR-MMU-196108. Pregnenolone biosynthesis.

Miscellaneous databases

PROiP51557.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031574.
CleanExiMM_STAR.
GenevisibleiP51557. MM.

Family and domain databases

CDDicd08905. START_STARD1-like. 1 hit.
Gene3Di3.30.530.20. 1 hit.
InterProiIPR029866. StAR.
IPR000799. StAR-like.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PANTHERiPTHR12136:SF9. PTHR12136:SF9. 1 hit.
PfamiPF01852. START. 1 hit.
[Graphical view]
PRINTSiPR00978. STARPROTEIN.
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS50848. START. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTAR_MOUSE
AccessioniPrimary (citable) accession number: P51557
Secondary accession number(s): Q543A5, Q924Y5, Q9D2G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.