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Reviewed, UniProtKB/Swiss-Prot P51553 (IDH3G_HUMAN)

Last modified November 25, 2008. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
    EC=1.1.1.41
Alternative name(s):
    Isocitric dehydrogenase
    NAD(+)-specific ICDH
Gene names
Name: IDH3G
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Enzyme regulation

Activated by increasing ADP/ATP ratios and by Ca(2+) By similarity.

Subunit structure

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1 By similarity.

Subcellular location

Mitochondrion.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3939Mitochondrion By similarity
Chain40 – 393354Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
PRO_0000014449

Regions

Nucleotide binding56 – 8429NAD Potential
Nucleotide binding309 – 3168ATP Potential

Sites

Metal binding2541Magnesium or manganese By similarity
Binding site1361Substrate By similarity
Binding site1671Substrate By similarity
Binding site2541Substrate By similarity
Site1741Critical for catalysis By similarity
Site2211Critical for catalysis By similarity

Amino acid modifications

Modified residue3631Phosphothreonine By similarity

Experimental info

Sequence conflict2671F → L in AAH01902. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P51553-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: A0870F2B7D228A37

FASTA39342,794
        10         20         30         40         50         60 
MALKVATVAG SAAKAVLGPA LLCRPWEVLG AHEVPSRNIF SEQTIPPSAK YGGRHTVTMI 

        70         80         90        100        110        120 
PGDGIGPELM LHVKSVFRHA CVPVDFEEVH VSSNADEEDI RNAIMAIRRN RVALKGNIET 

       130        140        150        160        170        180 
NHNLPPSHKS RNNILRTSLD LYANVIHCKS LPGVVTRHKD IDILIVRENT EGEYSSLEHE 

       190        200        210        220        230        240 
SVAGVVESLK IITKAKSLRI AEYAFKLAQE SGRKKVTAVH KANIMKLGDG LFLQCCREVA 

       250        260        270        280        290        300 
ARYPQITFEN MIVDNTTMQL VSRPQQFDVM VMPNLYGNIV NNVCAGLVGG PGLVAGANYG 

       310        320        330        340        350        360 
HVYAVFETAT RNTGKSIANK NIANPTATLL ASCMMLDHLK LHSYATSIRK AVLASMDNEN 

       370        380        390 
MHTPDIGGQG TTSEAIQDVI RHIRVINGRA VEA 

« Hide

References

« Hide 'large scale' references
[1]"Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse."
Brenner V., Nyakatura G., Rosenthal A., Platzer M.
Genomics 44:8-14(1997) [PubMed: 9286695] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Brain.
[2]"Identification and functional characterization of a novel, tissue-specific NAD+-dependent isocitrate dehydrogenase beta subunit isoform."
Kim Y.-O., Koh H.-J., Kim S.-H., Jo S.-H., Huh J.-W., Jeong K.-S., Lee I.J., Song B.J., Huh T.-L.
J. Biol. Chem. 274:36866-36875(1999) [PubMed: 10601238] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta and Skin.
[4]"Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing."
Simpson J.C., Wellenreuther R., Poustka A., Pepperkok R., Wiemann S.
EMBO Rep. 1:287-292(2000) [PubMed: 11256614] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

Z68907 mRNA. Translation: CAA93143.1.
Z68129 Genomic DNA. Translation: CAA92214.1.
U52111 Genomic DNA. No translation available.
U40272 mRNA. Translation: AAD09357.1.
BC000933 mRNA. Translation: AAH00933.1.
BC001902 mRNA. Translation: AAH01902.1.
RefSeqNP_004126.1.
UniGeneHs.410197

3D structure databases

HSSPHSSP built from PDB template 1XAA based on UniProtKB P00351.
ModBaseSearch...

PTM databases

PhosphoSiteP51553.

Genome annotation databases

EnsemblENSG00000067829. Homo sapiens. [Contig view]
GeneID3421.
KEGGhsa:3421.

Organism-specific databases

H-InvDBHIX0017139.
HGNCHGNC:5386. IDH3G.
HPAHPA000425.
HPA002017.
MIM300089. gene.
PharmGKBPA29634.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMP51553.
HOVERGENP51553.

Enzyme and pathway databases

ReactomeREACT_1046. Pyruvate metabolism and TCA cycle.

Gene expression databases

CleanExHS_IDH3G.
GermOnlineENSG00000067829. Homo sapiens.

Family and domain databases

InterProIPR004434. IsoCit_DHase_NAD_mit.
IPR001804. IsoCit_IM_DHase.
[Graphical view]
Gene3DG3DSA:3.40.718.10. IDH_IMDH. 1 hit.
PANTHERPTHR11835. IDH_IMDH_dimeric. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR00175. mito_nad_idh. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB00157. NADH.
LinkHubP51553.
NextBio13490.
SOURCESearch...

Entry information

Entry nameIDH3G_HUMAN
AccessionPrimary (citable) accession number: P51553
Secondary accession number(s): Q9BUU5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 25, 2008
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents