P51551 (ADH_DROGR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alcohol dehydrogenase
EC=1.1.1.1

Gene names

Name:	Adh
ORF Names:	GH13025

Organism

Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) [Complete proteome]

Taxonomic identifier

7222 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Hawaiian Drosophila

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alcohol metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	alcohol dehydrogenase (NAD) activity Inferred from sequence or structural similarity. Source: UniProtKB nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 254	253	Alcohol dehydrogenase		PRO_0000054462
Regions
	Nucleotide binding	10 – 33	24	NAD By similarity
Sites
	Active site	151	1	Proton acceptor By similarity
	Binding site	138	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P51551 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 2449DD6304777EC9	FASTA	254	27,417
	10 20 30 40 50 60 MVIANSNIIF VAGLGGIGLD TSREIVKSGP KNLVVLDRVD NPAAIAELKA LNPKVTITFY 70 80 90 100 110 120 PYDVTVPLAE TKKLLKTIFD KLKTVDLLIN GAGILDDNQI ERTIAVNFTG TVNTTTAILD 130 140 150 160 170 180 FWDKRKGGPG GVVANICSVT GFNSIYQVPV YSASKAAALS FTTSIAKLAH ITGVTAYSIN 190 200 210 220 230 240 PGITKTVLVH KFNSWLGVEP RVAELLLEHP TQTTLQCAQN FVKAIEANQN GAIWKLDLGR 250 LDAIEWTKHW DSGI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular organization of the alcohol dehydrogenase loci of Drosophila grimshawi and Drosophila hawaiiensis." Brennan M.D., Thorpe P.A., Hu J., Dickinson W.J. Gene 181:51-55(1996) [PubMed: 8973307] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: G1.
[2]	"Evolution of genes and genomes on the Drosophila phylogeny." Drosophila 12 genomes consortium Nature 450:203-218(2007) [PubMed: 17994087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tucson 15287-2541.00.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U48714 Genomic DNA. Translation: AAB40357.1. CH916372 Genomic DNA. Translation: EDV99435.1.
RefSeq	XP_001993510.1. XM_001993474.1.
3D structure databases
ProteinModelPortal	P51551.
SMR	P51551. Positions 1-254.
ModBase	Search...
Protein-protein interaction databases
STRING	P51551.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0148439; FBpp0146931; FBgn0012316.
GeneID	6567072.
KEGG	dgr:Dgri_GH13025.
Organism-specific databases
FlyBase	FBgn0012316. Dgri\Adh.
Phylogenomic databases
GeneTree	EMGT00050000006799.
InParanoid	P51551.
OMA	FYPYDVT.
OrthoDB	EOG40K6FN.
PhylomeDB	P51551.
Family and domain databases
InterPro	IPR002425. ADH_Drosophila-type. IPR002424. ADH_insect. IPR002198. DH_sc/Rdtase_SDR. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00001.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01168. ALCDHDRGNASE. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH_DROGR

Accession

Primary (citable) accession number: P51551
Secondary accession number(s): B4JRA5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project