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Protein

Alcohol dehydrogenase

Gene

Adh

Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138SubstrateBy similarity1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 33NADBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:Adh
ORF Names:GH13025
OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Taxonomic identifieri7222 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
Proteomesi
  • UP000001070 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0012316. Dgri\Adh.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000544622 – 254Alcohol dehydrogenaseAdd BLAST253

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi7222.FBpp0146931.

Structurei

3D structure databases

ProteinModelPortaliP51551.
SMRiP51551.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4169. Eukaryota.
COG1028. LUCA.
InParanoidiP51551.
KOiK00001.
OMAiWSKHWDS.
OrthoDBiEOG091G0OC9.
PhylomeDBiP51551.

Family and domain databases

InterProiView protein in InterPro
IPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIANSNIIF VAGLGGIGLD TSREIVKSGP KNLVVLDRVD NPAAIAELKA
60 70 80 90 100
LNPKVTITFY PYDVTVPLAE TKKLLKTIFD KLKTVDLLIN GAGILDDNQI
110 120 130 140 150
ERTIAVNFTG TVNTTTAILD FWDKRKGGPG GVVANICSVT GFNSIYQVPV
160 170 180 190 200
YSASKAAALS FTTSIAKLAH ITGVTAYSIN PGITKTVLVH KFNSWLGVEP
210 220 230 240 250
RVAELLLEHP TQTTLQCAQN FVKAIEANQN GAIWKLDLGR LDAIEWTKHW

DSGI
Length:254
Mass (Da):27,417
Last modified:January 23, 2007 - v2
Checksum:i2449DD6304777EC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48714 Genomic DNA. Translation: AAB40357.1.
CH916372 Genomic DNA. Translation: EDV99435.1.
RefSeqiXP_001993510.1. XM_001993474.1.

Genome annotation databases

EnsemblMetazoaiFBtr0148439; FBpp0146931; FBgn0012316.
GeneIDi6567072.
KEGGidgr:Dgri_GH13025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48714 Genomic DNA. Translation: AAB40357.1.
CH916372 Genomic DNA. Translation: EDV99435.1.
RefSeqiXP_001993510.1. XM_001993474.1.

3D structure databases

ProteinModelPortaliP51551.
SMRiP51551.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7222.FBpp0146931.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0148439; FBpp0146931; FBgn0012316.
GeneIDi6567072.
KEGGidgr:Dgri_GH13025.

Organism-specific databases

FlyBaseiFBgn0012316. Dgri\Adh.

Phylogenomic databases

eggNOGiKOG4169. Eukaryota.
COG1028. LUCA.
InParanoidiP51551.
KOiK00001.
OMAiWSKHWDS.
OrthoDBiEOG091G0OC9.
PhylomeDBiP51551.

Family and domain databases

InterProiView protein in InterPro
IPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH_DROGR
AccessioniPrimary (citable) accession number: P51551
Secondary accession number(s): B4JRA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.