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Protein

Glycocyamine kinase

Gene
N/A
Organism
Hediste diversicolor (Sandworm) (Nereis diversicolor)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + guanidinoacetate = ADP + phosphoguanidinoacetate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei186ATPPROSITE-ProRule annotation1
Binding sitei231ATPPROSITE-ProRule annotation1
Binding sitei330ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi123 – 127ATPPROSITE-ProRule annotation5
Nucleotide bindingi287 – 291ATPPROSITE-ProRule annotation5
Nucleotide bindingi315 – 320ATPPROSITE-ProRule annotation6

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glycocyamine kinase (EC:2.7.3.1)
Short name:
GK
Alternative name(s):
Guanidinoacetate kinase
OrganismiHediste diversicolor (Sandworm) (Nereis diversicolor)
Taxonomic identifieri126592 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaPolychaetaPalpataAciculataPhyllodocidaNereididaeHedisteHediste diversicolor species group

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002120081 – 393Glycocyamine kinaseAdd BLAST393

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP51546.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 94Phosphagen kinase N-terminalPROSITE-ProRule annotationAdd BLAST88
Domaini120 – 362Phosphagen kinase C-terminalPROSITE-ProRule annotationAdd BLAST243

Sequence similaritiesi

Belongs to the ATP:guanido phosphotransferase family.PROSITE-ProRule annotation
Contains 1 phosphagen kinase C-terminal domain.PROSITE-ProRule annotation
Contains 1 phosphagen kinase N-terminal domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.135.10. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PANTHERiPTHR11547. PTHR11547. 1 hit.
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
PF02807. ATP-gua_PtransN. 1 hit.
[Graphical view]
SUPFAMiSSF48034. SSF48034. 1 hit.
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51546-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKDYSREKF AKENFPDLSK HNNVMASHLT YELYEKYWDK VTPNGVTLDK
60 70 80 90 100
CIQTGVDNPG NKFYGKKTGC VFGDEHSYET FKDFFDRVIE EIHHFKPEDV
110 120 130 140 150
HPATDLDETK LVGGVFDEKY VKSCRIRCGR SVRGVCLPPA MSRAERRLVE
160 170 180 190 200
KVVSNALGGL KEDLAGKYFP LTTMNDKDME ALIEDHFLFE KPTGALLTTS
210 220 230 240 250
GCARDWPDGR GIWHNNGKNF LVWINEEDHI RIISMQKGGD MRAVFSRFGR
260 270 280 290 300
GLTEVERLMK EKGYELMRNE RLGYICTCPT NLGTVVRASV HLRLANLEKD
310 320 330 340 350
KRFDDFLAKL RLGKRGTGGE SSLAEDSTYD ISNLARLGKS ERELVQVLVD
360 370 380 390
GVNVLIEADK RLEAGKPIDD LTPRLNSSTG TSISATASRH MTL
Length:393
Mass (Da):44,462
Last modified:October 1, 1996 - v1
Checksum:iCB529ADC9B3CCFC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26103 mRNA. Translation: BAA05099.1.
PIRiS77896.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26103 mRNA. Translation: BAA05099.1.
PIRiS77896.

3D structure databases

ProteinModelPortaliP51546.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.135.10. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PANTHERiPTHR11547. PTHR11547. 1 hit.
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
PF02807. ATP-gua_PtransN. 1 hit.
[Graphical view]
SUPFAMiSSF48034. SSF48034. 1 hit.
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKGCY_HEDDI
AccessioniPrimary (citable) accession number: P51546
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 5, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.