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Protein

Cytochrome P450 3A9

Gene

Cyp3a9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This isozyme seems to be implicated in olfaction. Active in the demethylation of erythromycin as well as benzphetamine.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

GO - Molecular functioni

  • aromatase activity Source: UniProtKB-EC
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro
  • monooxygenase activity Source: UniProtKB
  • steroid hydroxylase activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Olfaction, Sensory transduction

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A9 (EC:1.14.14.1)
Alternative name(s):
3AH15
CYPIIIA9
Cytochrome P450 olfactive 3
Cytochrome P450-OLF3
Gene namesi
Name:Cyp3a9
Synonyms:Cyp3a13
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708392. Cyp3a9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Cytochrome P450 3A9PRO_0000051792Add
BLAST

Proteomic databases

PaxDbiP51538.
PRIDEiP51538.

Expressioni

Tissue specificityi

Mainly expressed in olfactory epithelium.

Gene expression databases

GenevestigatoriP51538.

Structurei

3D structure databases

ProteinModelPortaliP51538.
SMRiP51538. Positions 28-499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiP51538.
PhylomeDBiP51538.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51538-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLIPNFSME TWLLLVISLV LLYLYGTHSH GIFKKLGIPG PKPLPFLGTI
60 70 80 90 100
LAYRKGFWEF DKYCHKKYGK LWGLYDGRQP VLAITDPDII KTVLVKECYS
110 120 130 140 150
TFTNRRNFGP VGILKKAISI SEDEEWKRIR ALLSPTFTSG KLKEMFPIIN
160 170 180 190 200
QYTDMLVRNM RQGSEEGKPT SMKDIFGAYS MDVITATSFG VNVDSLNNPQ
210 220 230 240 250
DPFVEKVKKL LKFDIFDPLF LSVTLFPFLT PLFEALNVSM FPRDVIDFFK
260 270 280 290 300
TSVERMKENR MKEKEKQRMD FLQLMINSQN SKVKDSHKAL SDVEIVAQSV
310 320 330 340 350
IFIFAGYETT SSALSFVLYL LAIHPDIQKK LQDEIDAALP NKAHATYDTL
360 370 380 390 400
LQMEYLDMVV NETLRLYPIA GRLERVCKTD VEINGVFIPK GTVVMIPTFA
410 420 430 440 450
LHKDPHYWPE PEEFRPERFS KKNQDNINPY MYLPFGNGPR NCIGMRFALM
460 470 480 490 500
NMKVALFRVL QNFSFQPCKE TQIPLKLSKQ GLLQPEKPLL LKVVSRDETV

NGA
Length:503
Mass (Da):57,812
Last modified:November 1, 1997 - v2
Checksum:i9BBB13E690675EB4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti457 – 4571F → V in AAC52582 (PubMed:8660328).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60085 mRNA. Translation: AAB03662.1.
U46118 mRNA. Translation: AAC52582.1.
PIRiJC4702.
UniGeneiRn.10489.

Genome annotation databases

UCSCiRGD:708392. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60085 mRNA. Translation: AAB03662.1.
U46118 mRNA. Translation: AAC52582.1.
PIRiJC4702.
UniGeneiRn.10489.

3D structure databases

ProteinModelPortaliP51538.
SMRiP51538. Positions 28-499.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiP51538.
PRIDEiP51538.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:708392. rat.

Organism-specific databases

RGDi708392. Cyp3a9.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiP51538.
PhylomeDBiP51538.

Miscellaneous databases

PROiP51538.

Gene expression databases

GenevestigatoriP51538.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression and inducibility of cytochrome P450 3A9 (CYP3A9) and other members of the CYP3A subfamily in rat liver."
    Mahnke A., Strotkamp D., Roos P.H., Hanstein W.G., Chabot G.G., Nef P.
    Arch. Biochem. Biophys. 337:62-68(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCP3A9_RAT
AccessioniPrimary (citable) accession number: P51538
Secondary accession number(s): Q64557, Q64631
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: April 29, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.