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P51538 (CP3A9_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 3A9

EC=1.14.14.1
Alternative name(s):
3AH15
CYPIIIA9
Cytochrome P450 olfactive 3
Cytochrome P450-OLF3
Gene names
Name:Cyp3a9
Synonyms:Cyp3a13
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This isozyme seems to be implicated in olfaction. Active in the demethylation of erythromycin as well as benzphetamine.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Mainly expressed in olfactory epithelium.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Cytochrome P450 3A9
PRO_0000051792

Sites

Metal binding4421Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict4571F → V in AAC52582. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P51538 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 9BBB13E690675EB4

FASTA50357,812
        10         20         30         40         50         60 
MDLIPNFSME TWLLLVISLV LLYLYGTHSH GIFKKLGIPG PKPLPFLGTI LAYRKGFWEF 

        70         80         90        100        110        120 
DKYCHKKYGK LWGLYDGRQP VLAITDPDII KTVLVKECYS TFTNRRNFGP VGILKKAISI 

       130        140        150        160        170        180 
SEDEEWKRIR ALLSPTFTSG KLKEMFPIIN QYTDMLVRNM RQGSEEGKPT SMKDIFGAYS 

       190        200        210        220        230        240 
MDVITATSFG VNVDSLNNPQ DPFVEKVKKL LKFDIFDPLF LSVTLFPFLT PLFEALNVSM 

       250        260        270        280        290        300 
FPRDVIDFFK TSVERMKENR MKEKEKQRMD FLQLMINSQN SKVKDSHKAL SDVEIVAQSV 

       310        320        330        340        350        360 
IFIFAGYETT SSALSFVLYL LAIHPDIQKK LQDEIDAALP NKAHATYDTL LQMEYLDMVV 

       370        380        390        400        410        420 
NETLRLYPIA GRLERVCKTD VEINGVFIPK GTVVMIPTFA LHKDPHYWPE PEEFRPERFS 

       430        440        450        460        470        480 
KKNQDNINPY MYLPFGNGPR NCIGMRFALM NMKVALFRVL QNFSFQPCKE TQIPLKLSKQ 

       490        500 
GLLQPEKPLL LKVVSRDETV NGA 

« Hide

References

[1]"Expression and inducibility of cytochrome P450 3A9 (CYP3A9) and other members of the CYP3A subfamily in rat liver."
Mahnke A., Strotkamp D., Roos P.H., Hanstein W.G., Chabot G.G., Nef P.
Arch. Biochem. Biophys. 337:62-68(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
[2]"cDNA cloning of a novel CYP3A from rat brain."
Wang H., Kawashima H., Strobel H.W.
Biochem. Biophys. Res. Commun. 221:157-162(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U60085 mRNA. Translation: AAB03662.1.
U46118 mRNA. Translation: AAC52582.1.
PIRJC4702.
UniGeneRn.10489.

3D structure databases

ProteinModelPortalP51538.
SMRP51538. Positions 28-499.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP51538.
PRIDEP51538.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:708392. rat.

Organism-specific databases

RGD708392. Cyp3a9.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000039127.
HOVERGENHBG108567.
InParanoidP51538.
PhylomeDBP51538.

Gene expression databases

GenevestigatorP51538.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP3A9_RAT
AccessionPrimary (citable) accession number: P51538
Secondary accession number(s): Q64557, Q64631
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families