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P51538

- CP3A9_RAT

UniProt

P51538 - CP3A9_RAT

Protein

Cytochrome P450 3A9

Gene

Cyp3a9

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    This isozyme seems to be implicated in olfaction. Active in the demethylation of erythromycin as well as benzphetamine.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. monooxygenase activity Source: UniProtKB
    5. steroid hydroxylase activity Source: RGD

    GO - Biological processi

    1. response to stimulus Source: UniProtKB-KW
    2. sensory perception of smell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A9 (EC:1.14.14.1)
    Alternative name(s):
    3AH15
    CYPIIIA9
    Cytochrome P450 olfactive 3
    Cytochrome P450-OLF3
    Gene namesi
    Name:Cyp3a9
    Synonyms:Cyp3a13
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi708392. Cyp3a9.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Cytochrome P450 3A9PRO_0000051792Add
    BLAST

    Proteomic databases

    PaxDbiP51538.
    PRIDEiP51538.

    Expressioni

    Tissue specificityi

    Mainly expressed in olfactory epithelium.

    Gene expression databases

    GenevestigatoriP51538.

    Structurei

    3D structure databases

    ProteinModelPortaliP51538.
    SMRiP51538. Positions 28-499.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000039127.
    HOVERGENiHBG108567.
    InParanoidiP51538.
    PhylomeDBiP51538.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51538-1 [UniParc]FASTAAdd to Basket

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    MDLIPNFSME TWLLLVISLV LLYLYGTHSH GIFKKLGIPG PKPLPFLGTI    50
    LAYRKGFWEF DKYCHKKYGK LWGLYDGRQP VLAITDPDII KTVLVKECYS 100
    TFTNRRNFGP VGILKKAISI SEDEEWKRIR ALLSPTFTSG KLKEMFPIIN 150
    QYTDMLVRNM RQGSEEGKPT SMKDIFGAYS MDVITATSFG VNVDSLNNPQ 200
    DPFVEKVKKL LKFDIFDPLF LSVTLFPFLT PLFEALNVSM FPRDVIDFFK 250
    TSVERMKENR MKEKEKQRMD FLQLMINSQN SKVKDSHKAL SDVEIVAQSV 300
    IFIFAGYETT SSALSFVLYL LAIHPDIQKK LQDEIDAALP NKAHATYDTL 350
    LQMEYLDMVV NETLRLYPIA GRLERVCKTD VEINGVFIPK GTVVMIPTFA 400
    LHKDPHYWPE PEEFRPERFS KKNQDNINPY MYLPFGNGPR NCIGMRFALM 450
    NMKVALFRVL QNFSFQPCKE TQIPLKLSKQ GLLQPEKPLL LKVVSRDETV 500
    NGA 503
    Length:503
    Mass (Da):57,812
    Last modified:November 1, 1997 - v2
    Checksum:i9BBB13E690675EB4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti457 – 4571F → V in AAC52582. (PubMed:8660328)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U60085 mRNA. Translation: AAB03662.1.
    U46118 mRNA. Translation: AAC52582.1.
    PIRiJC4702.
    UniGeneiRn.10489.

    Genome annotation databases

    UCSCiRGD:708392. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U60085 mRNA. Translation: AAB03662.1 .
    U46118 mRNA. Translation: AAC52582.1 .
    PIRi JC4702.
    UniGenei Rn.10489.

    3D structure databases

    ProteinModelPortali P51538.
    SMRi P51538. Positions 28-499.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P51538.
    PRIDEi P51538.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:708392. rat.

    Organism-specific databases

    RGDi 708392. Cyp3a9.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000039127.
    HOVERGENi HBG108567.
    InParanoidi P51538.
    PhylomeDBi P51538.

    Gene expression databases

    Genevestigatori P51538.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression and inducibility of cytochrome P450 3A9 (CYP3A9) and other members of the CYP3A subfamily in rat liver."
      Mahnke A., Strotkamp D., Roos P.H., Hanstein W.G., Chabot G.G., Nef P.
      Arch. Biochem. Biophys. 337:62-68(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCP3A9_RAT
    AccessioniPrimary (citable) accession number: P51538
    Secondary accession number(s): Q64557, Q64631
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3