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Protein

ATP-dependent permease PDR10

Gene

PDR10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi959 – 966ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • cellular response to drug Source: GO_Central
  • drug export Source: InterPro
  • drug transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33805-MONOMER.

Protein family/group databases

TCDBi3.A.1.205.12. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent permease PDR10
Gene namesi
Name:PDR10
Ordered Locus Names:YOR328W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR328W.
SGDiS000005855. PDR10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 587CytoplasmicSequence analysisAdd BLAST587
Transmembranei588 – 608HelicalSequence analysisAdd BLAST21
Transmembranei624 – 644HelicalSequence analysisAdd BLAST21
Transmembranei674 – 694HelicalSequence analysisAdd BLAST21
Transmembranei699 – 719HelicalSequence analysisAdd BLAST21
Transmembranei732 – 752HelicalSequence analysisAdd BLAST21
Transmembranei841 – 861HelicalSequence analysisAdd BLAST21
Topological domaini862 – 1304CytoplasmicSequence analysisAdd BLAST443
Transmembranei1305 – 1325HelicalSequence analysisAdd BLAST21
Transmembranei1340 – 1360HelicalSequence analysisAdd BLAST21
Transmembranei1390 – 1410HelicalSequence analysisAdd BLAST21
Transmembranei1426 – 1446HelicalSequence analysisAdd BLAST21
Transmembranei1459 – 1479HelicalSequence analysisAdd BLAST21
Transmembranei1491 – 1511HelicalSequence analysisAdd BLAST21
Topological domaini1512 – 1564CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000934431 – 1564ATP-dependent permease PDR10Add BLAST1564

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi754N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP51533.

Interactioni

Protein-protein interaction databases

BioGridi34713. 44 interactors.
MINTiMINT-2782339.

Structurei

3D structure databases

ProteinModelPortaliP51533.
SMRiP51533.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini174 – 430ABC transporter 1PROSITE-ProRule annotationAdd BLAST257
Domaini923 – 1166ABC transporter 2PROSITE-ProRule annotationAdd BLAST244

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi73 – 80Poly-Ser8
Compositional biasi568 – 572Poly-Thr5
Compositional biasi845 – 848Poly-Lys4

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000075308.
HOGENOMiHOG000162078.
InParanoidiP51533.
OrthoDBiEOG092C1HKF.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR029481. ABC_trans_N.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR005285. Drug-R_PDR/CDR.
IPR027417. P-loop_NTPase.
IPR010929. PDR_CDR_ABC.
[Graphical view]
PfamiPF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF14510. ABC_trans_N. 1 hit.
PF06422. PDR_CDR. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00956. 3a01205. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51533-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQAPSSSNS GLNQGNAAPD GPPNETQPYE GLDAAAQEEI KELARTLTSQ
60 70 80 90 100
SSLLSQEKRI TGTGDPNTLT AASSSSLSRS IFASDIKGVN PILLDVNDPD
110 120 130 140 150
YDETLDPRSE NFSSVRWVRN MAQICENDSD FYKPFSLGCA WKDLSASGDS
160 170 180 190 200
ADITYQGTFG NMPIKYLKMS WRCISRRLFH RTHGKSEDND SGFQILKPMD
210 220 230 240 250
GCINPGELLV VLGRPGAGCT TLLKSISVNT HGFKISPDTI ITYNGFSNKE
260 270 280 290 300
IKNHYRGEVV YNAESDIHIP HLTVFQTLYT VARLKTPRNR IKGVDRDTFA
310 320 330 340 350
KHMTEVAMAT YGLSHTADTK VGNDFVRGVS GGERKRVSIA EVSICGSKFQ
360 370 380 390 400
CWDNATRGLD SATALEFIKA LKTQATITKS AATVAIYQCS KDAYDLFDKV
410 420 430 440 450
CVLYDGYQIF FGPSKQAKKY FQRMGYVCPE RQTTADYLTS ITSPSERIKD
460 470 480 490 500
KDMVKHGIMI PQTAYEMNQY WIQSEEYKQL QVQVNKHLDT DSSQQREQIK
510 520 530 540 550
NAHIAKQSKR ARPSSPYTVS FFLQVKYILI RDIWRIKNDP SIQLFTVLSH
560 570 580 590 600
AAMALILGSM FYEVMLSTTT TTFYYRGAAI FFAILFNAFS SLLEIFSLYE
610 620 630 640 650
TRPITEKHKT YSLYRPSADA FASTFSDVPT KLATAVTFNI PYYFLINLKR
660 670 680 690 700
DAGAFFFYFL INIITVFAMS HLFRCIGSVS KTLPQAMVPA SVLLLAFAMY
710 720 730 740 750
TGFAIPRVQM LGWSKWISYI NPLSYLFESL MINEFHGRNF PCAQYIPSGP
760 770 780 790 800
NYVNATGDEV TCSALGSIPG NNYVSGDDFI QTNYGYRHKN KWRSVGIGLA
810 820 830 840 850
YIIFFLFLYL FFCEYNEGAK QNGEMLVFPH SVVKKMKKKG IVSEKKKKNQ
860 870 880 890 900
PTLSTSDAEK DVEMNNNSSA TDSRFLRDSD AAIMGNDKTV AKEHYSSPSS
910 920 930 940 950
SASQSNSFSK SDDIELSKSQ AIFHWKNLCY DIPIKNGKRR ILDNVDGWVK
960 970 980 990 1000
PGTLTALIGA SGAGKTTLLD CLAERTTMGL ITGDVFVDGR PRDQSFPRSI
1010 1020 1030 1040 1050
GYCQQQDLHL KTATVRESLR FSAYLRQADD VSIEEKDKYV EEVIEVLEMK
1060 1070 1080 1090 1100
LYADAIVGVP GEGLNVEQRK RLTIGVELAA KPKLLVFLDE PTSGLDSQTA
1110 1120 1130 1140 1150
WSTCQLMKKL ASRGQAILCT IHQPSALLMQ EFDRLLFLQE GGQTVYFGEL
1160 1170 1180 1190 1200
GKGCKTMINY FEAHGAHKCP PDANPAEWML EIVGAAPGTH ASQDYFAIWR
1210 1220 1230 1240 1250
DSEEYREMQK ELDWMERELP KRTEGSSNEE QKEFATSTLY QIKLVSYRLF
1260 1270 1280 1290 1300
HQYWRTPFYL WSKFFSTIVS ELFIGFTFFK ANTSLQGLQN QMLAIFMFTV
1310 1320 1330 1340 1350
VFNPILQQYL PLFVQQRELY EARERPSRTF SWKAFIVSQI LVEIPWNLLA
1360 1370 1380 1390 1400
GTIAFFVYYY PVGFYRNASY ANQLHERGAL FWLFACAFYV YISSMGVLVI
1410 1420 1430 1440 1450
SCIEIAENAA NLASLFFIMS LSFCGVLATP NILPRFWIFM YRVSPLTYLI
1460 1470 1480 1490 1500
DALLSVGLAN ASVVCSSNEL LKIVPPSGMT CSEYMEPYMQ STGTGYLLDG
1510 1520 1530 1540 1550
SSETECHFCQ FSSTNDYLAT VSSSYSRRWM NYGIFSAYIV FDYCAAIFLY
1560
WLVRVPKKSK KLKK
Length:1,564
Mass (Da):176,461
Last modified:October 1, 1996 - v1
Checksum:i7CBE57D9133B8A01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49821 Genomic DNA. Translation: CAA89975.1.
Z75236 Genomic DNA. Translation: CAA99649.1.
Z75237 Genomic DNA. Translation: CAA99651.1.
BK006948 Genomic DNA. Translation: DAA11091.1.
PIRiS55517.
RefSeqiNP_014973.1. NM_001183748.1.

Genome annotation databases

EnsemblFungiiYOR328W; YOR328W; YOR328W.
GeneIDi854506.
KEGGisce:YOR328W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49821 Genomic DNA. Translation: CAA89975.1.
Z75236 Genomic DNA. Translation: CAA99649.1.
Z75237 Genomic DNA. Translation: CAA99651.1.
BK006948 Genomic DNA. Translation: DAA11091.1.
PIRiS55517.
RefSeqiNP_014973.1. NM_001183748.1.

3D structure databases

ProteinModelPortaliP51533.
SMRiP51533.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34713. 44 interactors.
MINTiMINT-2782339.

Protein family/group databases

TCDBi3.A.1.205.12. the atp-binding cassette (abc) superfamily.

Proteomic databases

PRIDEiP51533.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR328W; YOR328W; YOR328W.
GeneIDi854506.
KEGGisce:YOR328W.

Organism-specific databases

EuPathDBiFungiDB:YOR328W.
SGDiS000005855. PDR10.

Phylogenomic databases

GeneTreeiENSGT00550000075308.
HOGENOMiHOG000162078.
InParanoidiP51533.
OrthoDBiEOG092C1HKF.

Enzyme and pathway databases

BioCyciYEAST:G3O-33805-MONOMER.

Miscellaneous databases

PROiP51533.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR029481. ABC_trans_N.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR005285. Drug-R_PDR/CDR.
IPR027417. P-loop_NTPase.
IPR010929. PDR_CDR_ABC.
[Graphical view]
PfamiPF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF14510. ABC_trans_N. 1 hit.
PF06422. PDR_CDR. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00956. 3a01205. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDR10_YEAST
AccessioniPrimary (citable) accession number: P51533
Secondary accession number(s): D6W325
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.