##gff-version 3
P51530	UniProtKB	Chain	1	1060	.	.	.	ID=PRO_0000080712;Note=DNA replication ATP-dependent helicase/nuclease DNA2	
P51530	UniProtKB	Region	81	519	.	.	.	Note=Nuclease activity;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P51530	UniProtKB	Region	520	1060	.	.	.	Note=Helicase activity;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P51530	UniProtKB	Binding site	136	136	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
P51530	UniProtKB	Binding site	393	393	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
P51530	UniProtKB	Binding site	396	396	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
P51530	UniProtKB	Binding site	402	402	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
P51530	UniProtKB	Binding site	648	655	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
P51530	UniProtKB	Alternative sequence	663	900	.	.	.	ID=VSP_021869;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334	
P51530	UniProtKB	Alternative sequence	664	687	.	.	.	ID=VSP_021870;Note=In isoform 2. ILYACGFSVLLTSYTHSAVDNILL->FRRFIQLSSNLQSKKFADQSPLNP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334	
P51530	UniProtKB	Alternative sequence	688	1060	.	.	.	ID=VSP_021871;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334	
P51530	UniProtKB	Alternative sequence	1040	1060	.	.	.	ID=VSP_044185;Note=In isoform 4. IDLPSREHESLCHILGDFQRE->SFFFCIWSHLIAL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334	
P51530	UniProtKB	Natural variant	198	198	.	.	.	ID=VAR_069905;Note=In PEOA6%3B the mutant protein has a complete loss of nuclease activity and severely impaired helicase activity%3B consistent with a loss of function mutation. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23352259;Dbxref=dbSNP:rs1272393477,PMID:23352259	
P51530	UniProtKB	Natural variant	227	227	.	.	.	ID=VAR_069906;Note=In PEOA6%3B the mutant protein has significantly reduced nuclease and helicase activity%3B consistent with a loss of function mutation. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23352259;Dbxref=dbSNP:rs760412883,PMID:23352259	
P51530	UniProtKB	Natural variant	637	637	.	.	.	ID=VAR_069907;Note=In PEOA6%3B the mutant protein has decreased nuclease activity (30%25 of wild-type) and enhanced helicase activity%3B consistent with a loss of function mutation. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23352259;Dbxref=dbSNP:rs746522359,PMID:23352259	
P51530	UniProtKB	Mutagenesis	277	277	.	.	.	Note=Abolishes ability to resect DNA in present of BLM. D->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16595800,ECO:0000269|PubMed:21325134,ECO:0000269|PubMed:22570476;Dbxref=PMID:16595800,PMID:21325134,PMID:22570476	
P51530	UniProtKB	Mutagenesis	654	654	.	.	.	Note=Abolishes ability to unwind DNA%2C while it does not affect ability to resect DNA. K->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16595800,ECO:0000269|PubMed:21325134,ECO:0000269|PubMed:21572043,ECO:0000269|PubMed:22570476;Dbxref=PMID:16595800,PMID:21325134,PMID:21572043,PMID:22570476	
P51530	UniProtKB	Sequence conflict	986	986	.	.	.	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P51530	UniProtKB	Helix	7	10	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EAY