Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P51528

- PA1_VESMC

UniProt

P51528 - PA1_VESMC

Protein

Phospholipase A1

Gene
N/A
Organism
Vespula maculifrons (Eastern yellow jacket) (Wasp)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities.By similarity

    Catalytic activityi

    Phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.
    Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei137 – 1371NucleophileBy similarity
    Active sitei165 – 1651Charge relay systemPROSITE-ProRule annotation
    Active sitei229 – 2291Charge relay systemPROSITE-ProRule annotation

    GO - Molecular functioni

    1. 1-acyl-2-lysophosphatidylserine acylhydrolase activity Source: UniProtKB-EC
    2. phosphatidylcholine 1-acylhydrolase activity Source: UniProtKB-EC
    3. phosphatidylserine 1-acylhydrolase activity Source: UniProtKB-EC
    4. phospholipase A2 activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phospholipase A1 (EC:3.1.1.32, EC:3.1.1.4)
    Alternative name(s):
    Allergen Ves m I
    Allergen: Ves m 1
    OrganismiVespula maculifrons (Eastern yellow jacket) (Wasp)
    Taxonomic identifieri7453 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespula

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei3514. Ves m 1.0101.
    661. Ves m 1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 300300Phospholipase A1PRO_0000090378Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi4 ↔ 244By similarity
    Disulfide bondi87 ↔ 227By similarity
    Disulfide bondi176 ↔ 219By similarity
    Disulfide bondi181 ↔ 261By similarity
    Disulfide bondi239 ↔ 245By similarity
    Disulfide bondi268 ↔ 293By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Interactioni

    Subunit structurei

    Monomer.

    Structurei

    3D structure databases

    ProteinModelPortaliP51528.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily. Lipase family.Curated

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR002334. Dol/Ves_allerg.
    IPR000734. Lipase.
    IPR013818. Lipase_N.
    [Graphical view]
    PANTHERiPTHR11610. PTHR11610. 1 hit.
    PfamiPF00151. Lipase. 1 hit.
    [Graphical view]
    PRINTSiPR00825. DOLALLERGEN.
    PR00821. TAGLIPASE.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00120. LIPASE_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51528-1 [UniParc]FASTAAdd to Basket

    « Hide

    GPKCPFNSDT VSIIIETREN RNRDLYTLQT LQNHPEFKKK TITRPVVFIT    50
    HGFTSSASEK NFINLAKALV DKDNYMVISI DWQTAACTNE YPGLKYAYYP 100
    TAASNTRLVG QYIATITQKL VKDYKISMAN IRLIGHSLGA HVSGFAGKRV 150
    QELKLGKYSE IIGLDPARPS FDSNHCSERL CETDAEYVQI IHTSNYLGTE 200
    KILGTVDFYM NNGKNNPGCG RFFSEVCSHT RAVIYMAECI KHECCLIGIP 250
    RSKSSQPISR CTKQECVCVG LNAKKYPSRG SFYVPVESTA PFCNNKGKII 300
    Length:300
    Mass (Da):33,540
    Last modified:October 1, 1996 - v1
    Checksum:i8EE2DE20BD69CCF6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti97 – 971A → M.
    Natural varianti191 – 1911I → P.
    Natural varianti202 – 2021I → L.

    Sequence databases

    PIRiA44564.

    Cross-referencesi

    Sequence databases

    PIRi A44564.

    3D structure databases

    ProteinModelPortali P51528.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 3514. Ves m 1.0101.
    661. Ves m 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR002334. Dol/Ves_allerg.
    IPR000734. Lipase.
    IPR013818. Lipase_N.
    [Graphical view ]
    PANTHERi PTHR11610. PTHR11610. 1 hit.
    Pfami PF00151. Lipase. 1 hit.
    [Graphical view ]
    PRINTSi PR00825. DOLALLERGEN.
    PR00821. TAGLIPASE.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00120. LIPASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Allergens in hymenoptera venom. XXVI: the complete amino acid sequences of two vespid venom phospholipases."
      Hoffman D.R.
      Int. Arch. Allergy Immunol. 104:184-190(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Venom.

    Entry informationi

    Entry nameiPA1_VESMC
    AccessioniPrimary (citable) accession number: P51528
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3