Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P51528 (PA1_VESMC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phospholipase A1

EC=3.1.1.32
EC=3.1.1.4
Alternative name(s):
Allergen Ves m I
Allergen=Ves m 1
OrganismVespula maculifrons (Eastern yellow jacket) (Wasp)
Taxonomic identifier7453 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespula

Protein attributes

Sequence length300 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities By similarity.

Catalytic activity

Phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

Subunit structure

Monomer.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Allergenic properties

Causes an allergic reaction in human.

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 300300Phospholipase A1
PRO_0000090378

Sites

Active site1371Nucleophile By similarity
Active site1651Charge relay system By similarity
Active site2291Charge relay system By similarity

Amino acid modifications

Disulfide bond4 ↔ 244 By similarity
Disulfide bond87 ↔ 227 By similarity
Disulfide bond176 ↔ 219 By similarity
Disulfide bond181 ↔ 261 By similarity
Disulfide bond239 ↔ 245 By similarity
Disulfide bond268 ↔ 293 By similarity

Natural variations

Natural variant971A → M.
Natural variant1911I → P.
Natural variant2021I → L.

Sequences

Sequence LengthMass (Da)Tools
P51528 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 8EE2DE20BD69CCF6

FASTA30033,540
        10         20         30         40         50         60 
GPKCPFNSDT VSIIIETREN RNRDLYTLQT LQNHPEFKKK TITRPVVFIT HGFTSSASEK 

        70         80         90        100        110        120 
NFINLAKALV DKDNYMVISI DWQTAACTNE YPGLKYAYYP TAASNTRLVG QYIATITQKL 

       130        140        150        160        170        180 
VKDYKISMAN IRLIGHSLGA HVSGFAGKRV QELKLGKYSE IIGLDPARPS FDSNHCSERL 

       190        200        210        220        230        240 
CETDAEYVQI IHTSNYLGTE KILGTVDFYM NNGKNNPGCG RFFSEVCSHT RAVIYMAECI 

       250        260        270        280        290        300 
KHECCLIGIP RSKSSQPISR CTKQECVCVG LNAKKYPSRG SFYVPVESTA PFCNNKGKII 

« Hide

References

[1]"Allergens in hymenoptera venom. XXVI: the complete amino acid sequences of two vespid venom phospholipases."
Hoffman D.R.
Int. Arch. Allergy Immunol. 104:184-190(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Venom.

Cross-references

Sequence databases

PIRA44564.

3D structure databases

ProteinModelPortalP51528.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome3514. Ves m 1.0101.
661. Ves m 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002334. Dol/Ves_allerg.
IPR000734. Lipase.
IPR013818. Lipase_N.
[Graphical view]
PANTHERPTHR11610. PTHR11610. 1 hit.
PfamPF00151. Lipase. 1 hit.
[Graphical view]
PRINTSPR00825. DOLALLERGEN.
PR00821. TAGLIPASE.
PROSITEPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePA1_VESMC
AccessionPrimary (citable) accession number: P51528
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 22, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries