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P51528

- PA1_VESMC

UniProt

P51528 - PA1_VESMC

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Protein
Phospholipase A1
Gene
N/A
Organism
Vespula maculifrons (Eastern yellow jacket) (Wasp)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities By similarity.

Catalytic activityi

Phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.
Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei137 – 1371Nucleophile By similarity
Active sitei165 – 1651Charge relay system By similarity
Active sitei229 – 2291Charge relay system By similarity

GO - Molecular functioni

  1. 1-acyl-2-lysophosphatidylserine acylhydrolase activity Source: UniProtKB-EC
  2. phosphatidylcholine 1-acylhydrolase activity Source: UniProtKB-EC
  3. phosphatidylserine 1-acylhydrolase activity Source: UniProtKB-EC
  4. phospholipase A2 activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase A1 (EC:3.1.1.32, EC:3.1.1.4)
Alternative name(s):
Allergen Ves m I
Allergen: Ves m 1
OrganismiVespula maculifrons (Eastern yellow jacket) (Wasp)
Taxonomic identifieri7453 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespula

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3514. Ves m 1.0101.
661. Ves m 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Phospholipase A1
PRO_0000090378Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi4 ↔ 244 By similarity
Disulfide bondi87 ↔ 227 By similarity
Disulfide bondi176 ↔ 219 By similarity
Disulfide bondi181 ↔ 261 By similarity
Disulfide bondi239 ↔ 245 By similarity
Disulfide bondi268 ↔ 293 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP51528.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002334. Dol/Ves_allerg.
IPR000734. Lipase.
IPR013818. Lipase_N.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
[Graphical view]
PRINTSiPR00825. DOLALLERGEN.
PR00821. TAGLIPASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51528-1 [UniParc]FASTAAdd to Basket

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GPKCPFNSDT VSIIIETREN RNRDLYTLQT LQNHPEFKKK TITRPVVFIT    50
HGFTSSASEK NFINLAKALV DKDNYMVISI DWQTAACTNE YPGLKYAYYP 100
TAASNTRLVG QYIATITQKL VKDYKISMAN IRLIGHSLGA HVSGFAGKRV 150
QELKLGKYSE IIGLDPARPS FDSNHCSERL CETDAEYVQI IHTSNYLGTE 200
KILGTVDFYM NNGKNNPGCG RFFSEVCSHT RAVIYMAECI KHECCLIGIP 250
RSKSSQPISR CTKQECVCVG LNAKKYPSRG SFYVPVESTA PFCNNKGKII 300
Length:300
Mass (Da):33,540
Last modified:October 1, 1996 - v1
Checksum:i8EE2DE20BD69CCF6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti97 – 971A → M.
Natural varianti191 – 1911I → P.
Natural varianti202 – 2021I → L.

Sequence databases

PIRiA44564.

Cross-referencesi

Sequence databases

PIRi A44564.

3D structure databases

ProteinModelPortali P51528.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 3514. Ves m 1.0101.
661. Ves m 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002334. Dol/Ves_allerg.
IPR000734. Lipase.
IPR013818. Lipase_N.
[Graphical view ]
PANTHERi PTHR11610. PTHR11610. 1 hit.
Pfami PF00151. Lipase. 1 hit.
[Graphical view ]
PRINTSi PR00825. DOLALLERGEN.
PR00821. TAGLIPASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00120. LIPASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Allergens in hymenoptera venom. XXVI: the complete amino acid sequences of two vespid venom phospholipases."
    Hoffman D.R.
    Int. Arch. Allergy Immunol. 104:184-190(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Venom.

Entry informationi

Entry nameiPA1_VESMC
AccessioniPrimary (citable) accession number: P51528
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi