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P51523 (ZNF84_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 84
Alternative name(s):
Zinc finger protein HPF2
Gene names
Name:ZNF84
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length738 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 19 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Non-traceable author statement Ref.1. Source: UniProtKB

zinc ion binding

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 738738Zinc finger protein 84
PRO_0000047397

Regions

Domain8 – 7972KRAB
Zinc finger207 – 22923C2H2-type 1
Zinc finger235 – 25723C2H2-type 2
Zinc finger263 – 28523C2H2-type 3
Zinc finger291 – 31323C2H2-type 4
Zinc finger319 – 34123C2H2-type 5
Zinc finger347 – 36923C2H2-type 6
Zinc finger375 – 39723C2H2-type 7
Zinc finger403 – 42523C2H2-type 8
Zinc finger431 – 45323C2H2-type 9
Zinc finger459 – 48123C2H2-type 10
Zinc finger487 – 50923C2H2-type 11
Zinc finger515 – 53723C2H2-type 12
Zinc finger543 – 56523C2H2-type 13
Zinc finger571 – 59323C2H2-type 14
Zinc finger599 – 62123C2H2-type 15
Zinc finger627 – 64923C2H2-type 16
Zinc finger655 – 67723C2H2-type 17
Zinc finger683 – 70523C2H2-type 18
Zinc finger711 – 73323C2H2-type 19

Amino acid modifications

Modified residue1281Phosphoserine Ref.7

Experimental info

Sequence conflict621Q → E in AAA79359. Ref.1
Sequence conflict5941T → A in AAH36656. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P51523 [UniParc].

Last modified May 2, 2006. Version 2.
Checksum: E682053680438D5F

FASTA73885,457
        10         20         30         40         50         60 
MTMLQESFSF DDLSVDFTQK EWQLLDPSQK NLYKDVMLEN YSSLVSLGYE VMKPDVIFKL 

        70         80         90        100        110        120 
EQGEEPWVGD GEIPSSDSPE VWKVDGNMMW HQDNQDKLKI IKRGHECDAF GKNFNLNMNF 

       130        140        150        160        170        180 
VPLRKSNSEG DLDGLILKHH LDLLIPKGDY GKAESDDFNV FDNFFLHSKP EDTDTWLKYY 

       190        200        210        220        230        240 
DCDKYKESYK KSQIIIYHRN RLGEKLYECS ECRKRFSKKP SLIKHQSRHI RDIAFGCGNC 

       250        260        270        280        290        300 
GKTFPQKSQF ITHHRTHTGE KPYNCSQCGK AFSQKSQLTS HQRTHTGEKP YECGECGKAF 

       310        320        330        340        350        360 
SRKSHLISHW RTHTGEKPYG CNECGRAFSE KSNLINHQRI HTGEKPFECR ECGKAFSRKS 

       370        380        390        400        410        420 
QLVTHHRTHT GTKPFGCSDC RKAFFEKSEL IRHQTIHTGE KPYECSECRK AFRERSSLIN 

       430        440        450        460        470        480 
HQRTHTGEKP HGCIQCGKAF SQKSHLISHQ MTHTGEKPFI CSKCGKAFSR KSQLVRHQRT 

       490        500        510        520        530        540 
HTGEKPYECS ECGKAFSEKL SLTNHQRIHT GEKPYVCSEC GKAFCQKSHL ISHQRTHTGE 

       550        560        570        580        590        600 
KPYECSECGK AFGEKSSLAT HQRTHTGEKP YECRDCEKAF SQKSQLNTHQ RIHTGEKPYE 

       610        620        630        640        650        660 
CSLCRKAFFE KSELIRHLRT HTGEKPYECN ECRKAFREKS SLINHQRIHT GEKPFECSEC 

       670        680        690        700        710        720 
GKAFSRKSHL IPHQRTHTGE KPYGCSECRK AFSQKSQLVN HQRIHTGEKP YRCIECGKAF 

       730 
SQKSQLINHQ RTHTVKKS 

« Hide

References

« Hide 'large scale' references
[1]"The human genome contains hundreds of genes coding for finger proteins of the Kruppel type."
Bellefroid E.J., Lecocq P.J., Benhida A., Poncelet D.A., Belayew A., Martial J.A.
DNA 8:377-387(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]Grimaldi G.
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung, Testis and Uterus.
[6]"Members of the zinc finger protein gene family sharing a conserved N-terminal module."
Rosati M., Marino M., Franze A., Tramontano A., Grimaldi G.
Nucleic Acids Res. 19:5661-5667(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-257.
Tissue: Teratocarcinoma.
[7]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M27878 mRNA. Translation: AAA79359.1.
X60156 mRNA. Translation: CAB94232.2.
AK314232 mRNA. Translation: BAG36902.1.
CH471218 Genomic DNA. Translation: EAW54799.1.
CH471218 Genomic DNA. Translation: EAW54801.1.
CH471218 Genomic DNA. Translation: EAW54802.1.
BC036656 mRNA. Translation: AAH36656.1.
BC048350 mRNA. Translation: AAH48350.2.
BC062552 mRNA. Translation: AAH62552.1.
PIRB32891.
RefSeqNP_001120844.1. NM_001127372.2.
NP_003419.3. NM_003428.5.
XP_005266242.1. XM_005266185.1.
XP_005266243.1. XM_005266186.1.
UniGeneHs.445019.

3D structure databases

ProteinModelPortalP51523.
SMRP51523. Positions 9-49, 178-738.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113453. 2 interactions.
IntActP51523. 1 interaction.
STRING9606.ENSP00000331465.

PTM databases

PhosphoSiteP51523.

Polymorphism databases

DMDM94730445.

Proteomic databases

PaxDbP51523.
PRIDEP51523.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000327668; ENSP00000331465; ENSG00000198040.
ENST00000392319; ENSP00000376133; ENSG00000198040.
ENST00000539354; ENSP00000445549; ENSG00000198040.
GeneID7637.
KEGGhsa:7637.
UCSCuc001ulm.4. human.

Organism-specific databases

CTD7637.
GeneCardsGC12P133613.
HGNCHGNC:13159. ZNF84.
HPAHPA028860.
neXtProtNX_P51523.
PharmGKBPA37732.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOVERGENHBG018163.
InParanoidP51523.
KOK09228.
OMAHIREIAY.
PhylomeDBP51523.
TreeFamTF337898.

Gene expression databases

ArrayExpressP51523.
BgeeP51523.
CleanExHS_ZNF84.
GenevestigatorP51523.

Family and domain databases

Gene3D3.30.160.60. 19 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi7637.
NextBio29744.
PROP51523.

Entry information

Entry nameZNF84_HUMAN
AccessionPrimary (citable) accession number: P51523
Secondary accession number(s): B2RAK5 expand/collapse secondary AC list , D3DXJ1, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 2, 2006
Last modified: April 16, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM