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P51523

- ZNF84_HUMAN

UniProt

P51523 - ZNF84_HUMAN

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Protein
Zinc finger protein 84
Gene
ZNF84
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri207 – 22923C2H2-type 1
Add
BLAST
Zinc fingeri235 – 25723C2H2-type 2
Add
BLAST
Zinc fingeri263 – 28523C2H2-type 3
Add
BLAST
Zinc fingeri291 – 31323C2H2-type 4
Add
BLAST
Zinc fingeri319 – 34123C2H2-type 5
Add
BLAST
Zinc fingeri347 – 36923C2H2-type 6
Add
BLAST
Zinc fingeri375 – 39723C2H2-type 7
Add
BLAST
Zinc fingeri403 – 42523C2H2-type 8
Add
BLAST
Zinc fingeri431 – 45323C2H2-type 9
Add
BLAST
Zinc fingeri459 – 48123C2H2-type 10
Add
BLAST
Zinc fingeri487 – 50923C2H2-type 11
Add
BLAST
Zinc fingeri515 – 53723C2H2-type 12
Add
BLAST
Zinc fingeri543 – 56523C2H2-type 13
Add
BLAST
Zinc fingeri571 – 59323C2H2-type 14
Add
BLAST
Zinc fingeri599 – 62123C2H2-type 15
Add
BLAST
Zinc fingeri627 – 64923C2H2-type 16
Add
BLAST
Zinc fingeri655 – 67723C2H2-type 17
Add
BLAST
Zinc fingeri683 – 70523C2H2-type 18
Add
BLAST
Zinc fingeri711 – 73323C2H2-type 19
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. zinc ion binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 84
Alternative name(s):
Zinc finger protein HPF2
Gene namesi
Name:ZNF84
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:13159. ZNF84.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37732.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 738738Zinc finger protein 84
PRO_0000047397Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei128 – 1281Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP51523.
PRIDEiP51523.

PTM databases

PhosphoSiteiP51523.

Expressioni

Gene expression databases

ArrayExpressiP51523.
BgeeiP51523.
CleanExiHS_ZNF84.
GenevestigatoriP51523.

Organism-specific databases

HPAiHPA028860.

Interactioni

Protein-protein interaction databases

BioGridi113453. 2 interactions.
IntActiP51523. 1 interaction.
STRINGi9606.ENSP00000331465.

Structurei

3D structure databases

ProteinModelPortaliP51523.
SMRiP51523. Positions 9-49, 178-738.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7972KRAB
Add
BLAST

Sequence similaritiesi

Contains 19 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOVERGENiHBG018163.
InParanoidiP51523.
KOiK09228.
OMAiHIREIAY.
PhylomeDBiP51523.
TreeFamiTF337898.

Family and domain databases

Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51523-1 [UniParc]FASTAAdd to Basket

« Hide

MTMLQESFSF DDLSVDFTQK EWQLLDPSQK NLYKDVMLEN YSSLVSLGYE    50
VMKPDVIFKL EQGEEPWVGD GEIPSSDSPE VWKVDGNMMW HQDNQDKLKI 100
IKRGHECDAF GKNFNLNMNF VPLRKSNSEG DLDGLILKHH LDLLIPKGDY 150
GKAESDDFNV FDNFFLHSKP EDTDTWLKYY DCDKYKESYK KSQIIIYHRN 200
RLGEKLYECS ECRKRFSKKP SLIKHQSRHI RDIAFGCGNC GKTFPQKSQF 250
ITHHRTHTGE KPYNCSQCGK AFSQKSQLTS HQRTHTGEKP YECGECGKAF 300
SRKSHLISHW RTHTGEKPYG CNECGRAFSE KSNLINHQRI HTGEKPFECR 350
ECGKAFSRKS QLVTHHRTHT GTKPFGCSDC RKAFFEKSEL IRHQTIHTGE 400
KPYECSECRK AFRERSSLIN HQRTHTGEKP HGCIQCGKAF SQKSHLISHQ 450
MTHTGEKPFI CSKCGKAFSR KSQLVRHQRT HTGEKPYECS ECGKAFSEKL 500
SLTNHQRIHT GEKPYVCSEC GKAFCQKSHL ISHQRTHTGE KPYECSECGK 550
AFGEKSSLAT HQRTHTGEKP YECRDCEKAF SQKSQLNTHQ RIHTGEKPYE 600
CSLCRKAFFE KSELIRHLRT HTGEKPYECN ECRKAFREKS SLINHQRIHT 650
GEKPFECSEC GKAFSRKSHL IPHQRTHTGE KPYGCSECRK AFSQKSQLVN 700
HQRIHTGEKP YRCIECGKAF SQKSQLINHQ RTHTVKKS 738
Length:738
Mass (Da):85,457
Last modified:May 2, 2006 - v2
Checksum:iE682053680438D5F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621Q → E in AAA79359. 1 Publication
Sequence conflicti594 – 5941T → A in AAH36656. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M27878 mRNA. Translation: AAA79359.1.
X60156 mRNA. Translation: CAB94232.2.
AK314232 mRNA. Translation: BAG36902.1.
CH471218 Genomic DNA. Translation: EAW54799.1.
CH471218 Genomic DNA. Translation: EAW54801.1.
CH471218 Genomic DNA. Translation: EAW54802.1.
BC036656 mRNA. Translation: AAH36656.1.
BC048350 mRNA. Translation: AAH48350.2.
BC062552 mRNA. Translation: AAH62552.1.
CCDSiCCDS31940.1.
PIRiB32891.
RefSeqiNP_001120844.1. NM_001127372.2.
NP_001276900.1. NM_001289971.1.
NP_001276901.1. NM_001289972.1.
NP_003419.3. NM_003428.5.
XP_005266242.1. XM_005266185.1.
XP_005266243.1. XM_005266186.1.
XP_006719810.1. XM_006719747.1.
UniGeneiHs.445019.

Genome annotation databases

EnsembliENST00000327668; ENSP00000331465; ENSG00000198040.
ENST00000392319; ENSP00000376133; ENSG00000198040.
ENST00000539354; ENSP00000445549; ENSG00000198040.
GeneIDi7637.
KEGGihsa:7637.
UCSCiuc001ulm.4. human.

Polymorphism databases

DMDMi94730445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M27878 mRNA. Translation: AAA79359.1 .
X60156 mRNA. Translation: CAB94232.2 .
AK314232 mRNA. Translation: BAG36902.1 .
CH471218 Genomic DNA. Translation: EAW54799.1 .
CH471218 Genomic DNA. Translation: EAW54801.1 .
CH471218 Genomic DNA. Translation: EAW54802.1 .
BC036656 mRNA. Translation: AAH36656.1 .
BC048350 mRNA. Translation: AAH48350.2 .
BC062552 mRNA. Translation: AAH62552.1 .
CCDSi CCDS31940.1.
PIRi B32891.
RefSeqi NP_001120844.1. NM_001127372.2.
NP_001276900.1. NM_001289971.1.
NP_001276901.1. NM_001289972.1.
NP_003419.3. NM_003428.5.
XP_005266242.1. XM_005266185.1.
XP_005266243.1. XM_005266186.1.
XP_006719810.1. XM_006719747.1.
UniGenei Hs.445019.

3D structure databases

ProteinModelPortali P51523.
SMRi P51523. Positions 9-49, 178-738.
ModBasei Search...

Protein-protein interaction databases

BioGridi 113453. 2 interactions.
IntActi P51523. 1 interaction.
STRINGi 9606.ENSP00000331465.

PTM databases

PhosphoSitei P51523.

Polymorphism databases

DMDMi 94730445.

Proteomic databases

PaxDbi P51523.
PRIDEi P51523.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000327668 ; ENSP00000331465 ; ENSG00000198040 .
ENST00000392319 ; ENSP00000376133 ; ENSG00000198040 .
ENST00000539354 ; ENSP00000445549 ; ENSG00000198040 .
GeneIDi 7637.
KEGGi hsa:7637.
UCSCi uc001ulm.4. human.

Organism-specific databases

CTDi 7637.
GeneCardsi GC12P133613.
HGNCi HGNC:13159. ZNF84.
HPAi HPA028860.
neXtProti NX_P51523.
PharmGKBi PA37732.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOVERGENi HBG018163.
InParanoidi P51523.
KOi K09228.
OMAi HIREIAY.
PhylomeDBi P51523.
TreeFami TF337898.

Miscellaneous databases

GenomeRNAii 7637.
NextBioi 29744.
PROi P51523.

Gene expression databases

ArrayExpressi P51523.
Bgeei P51523.
CleanExi HS_ZNF84.
Genevestigatori P51523.

Family and domain databases

Gene3Di 3.30.160.60. 19 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human genome contains hundreds of genes coding for finger proteins of the Kruppel type."
    Bellefroid E.J., Lecocq P.J., Benhida A., Poncelet D.A., Belayew A., Martial J.A.
    DNA 8:377-387(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. Grimaldi G.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung, Testis and Uterus.
  6. "Members of the zinc finger protein gene family sharing a conserved N-terminal module."
    Rosati M., Marino M., Franze A., Tramontano A., Grimaldi G.
    Nucleic Acids Res. 19:5661-5667(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-257.
    Tissue: Teratocarcinoma.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZNF84_HUMAN
AccessioniPrimary (citable) accession number: P51523
Secondary accession number(s): B2RAK5
, D3DXJ1, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 2, 2006
Last modified: July 9, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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