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P51523

- ZNF84_HUMAN

UniProt

P51523 - ZNF84_HUMAN

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Protein

Zinc finger protein 84

Gene

ZNF84

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri207 – 22923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri235 – 25723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri263 – 28523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri291 – 31323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri319 – 34123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri347 – 36923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri375 – 39723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri403 – 42523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri487 – 50923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri515 – 53723C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri543 – 56523C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri571 – 59323C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri599 – 62123C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri627 – 64923C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri655 – 67723C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri683 – 70523C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri711 – 73323C2H2-type 19PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 84
Alternative name(s):
Zinc finger protein HPF2
Gene namesi
Name:ZNF84
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:13159. ZNF84.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37732.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 738738Zinc finger protein 84PRO_0000047397Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei128 – 1281Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP51523.
PaxDbiP51523.
PRIDEiP51523.

PTM databases

PhosphoSiteiP51523.

Expressioni

Gene expression databases

BgeeiP51523.
CleanExiHS_ZNF84.
ExpressionAtlasiP51523. baseline and differential.
GenevestigatoriP51523.

Organism-specific databases

HPAiHPA028860.

Interactioni

Protein-protein interaction databases

BioGridi113453. 2 interactions.
IntActiP51523. 1 interaction.
STRINGi9606.ENSP00000331465.

Structurei

3D structure databases

ProteinModelPortaliP51523.
SMRiP51523. Positions 9-49, 178-738.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 19 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri207 – 22923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri235 – 25723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri263 – 28523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri291 – 31323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri319 – 34123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri347 – 36923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri375 – 39723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri403 – 42523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri487 – 50923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri515 – 53723C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri543 – 56523C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri571 – 59323C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri599 – 62123C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri627 – 64923C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri655 – 67723C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri683 – 70523C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri711 – 73323C2H2-type 19PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00770000120458.
HOVERGENiHBG018163.
InParanoidiP51523.
KOiK09228.
OMAiHIREIAY.
PhylomeDBiP51523.
TreeFamiTF337898.

Family and domain databases

Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51523-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTMLQESFSF DDLSVDFTQK EWQLLDPSQK NLYKDVMLEN YSSLVSLGYE
60 70 80 90 100
VMKPDVIFKL EQGEEPWVGD GEIPSSDSPE VWKVDGNMMW HQDNQDKLKI
110 120 130 140 150
IKRGHECDAF GKNFNLNMNF VPLRKSNSEG DLDGLILKHH LDLLIPKGDY
160 170 180 190 200
GKAESDDFNV FDNFFLHSKP EDTDTWLKYY DCDKYKESYK KSQIIIYHRN
210 220 230 240 250
RLGEKLYECS ECRKRFSKKP SLIKHQSRHI RDIAFGCGNC GKTFPQKSQF
260 270 280 290 300
ITHHRTHTGE KPYNCSQCGK AFSQKSQLTS HQRTHTGEKP YECGECGKAF
310 320 330 340 350
SRKSHLISHW RTHTGEKPYG CNECGRAFSE KSNLINHQRI HTGEKPFECR
360 370 380 390 400
ECGKAFSRKS QLVTHHRTHT GTKPFGCSDC RKAFFEKSEL IRHQTIHTGE
410 420 430 440 450
KPYECSECRK AFRERSSLIN HQRTHTGEKP HGCIQCGKAF SQKSHLISHQ
460 470 480 490 500
MTHTGEKPFI CSKCGKAFSR KSQLVRHQRT HTGEKPYECS ECGKAFSEKL
510 520 530 540 550
SLTNHQRIHT GEKPYVCSEC GKAFCQKSHL ISHQRTHTGE KPYECSECGK
560 570 580 590 600
AFGEKSSLAT HQRTHTGEKP YECRDCEKAF SQKSQLNTHQ RIHTGEKPYE
610 620 630 640 650
CSLCRKAFFE KSELIRHLRT HTGEKPYECN ECRKAFREKS SLINHQRIHT
660 670 680 690 700
GEKPFECSEC GKAFSRKSHL IPHQRTHTGE KPYGCSECRK AFSQKSQLVN
710 720 730
HQRIHTGEKP YRCIECGKAF SQKSQLINHQ RTHTVKKS
Length:738
Mass (Da):85,457
Last modified:May 2, 2006 - v2
Checksum:iE682053680438D5F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621Q → E in AAA79359. (PubMed:2505992)Curated
Sequence conflicti594 – 5941T → A in AAH36656. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27878 mRNA. Translation: AAA79359.1.
X60156 mRNA. Translation: CAB94232.2.
AK314232 mRNA. Translation: BAG36902.1.
CH471218 Genomic DNA. Translation: EAW54799.1.
CH471218 Genomic DNA. Translation: EAW54801.1.
CH471218 Genomic DNA. Translation: EAW54802.1.
BC036656 mRNA. Translation: AAH36656.1.
BC048350 mRNA. Translation: AAH48350.2.
BC062552 mRNA. Translation: AAH62552.1.
CCDSiCCDS31940.1.
PIRiB32891.
RefSeqiNP_001120844.1. NM_001127372.2.
NP_001276900.1. NM_001289971.1.
NP_001276901.1. NM_001289972.1.
NP_003419.3. NM_003428.5.
XP_005266242.1. XM_005266185.1.
XP_005266243.1. XM_005266186.1.
XP_006719810.1. XM_006719747.1.
UniGeneiHs.445019.

Genome annotation databases

EnsembliENST00000327668; ENSP00000331465; ENSG00000198040.
ENST00000392319; ENSP00000376133; ENSG00000198040.
ENST00000539354; ENSP00000445549; ENSG00000198040.
GeneIDi7637.
KEGGihsa:7637.
UCSCiuc001ulm.4. human.

Polymorphism databases

DMDMi94730445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27878 mRNA. Translation: AAA79359.1 .
X60156 mRNA. Translation: CAB94232.2 .
AK314232 mRNA. Translation: BAG36902.1 .
CH471218 Genomic DNA. Translation: EAW54799.1 .
CH471218 Genomic DNA. Translation: EAW54801.1 .
CH471218 Genomic DNA. Translation: EAW54802.1 .
BC036656 mRNA. Translation: AAH36656.1 .
BC048350 mRNA. Translation: AAH48350.2 .
BC062552 mRNA. Translation: AAH62552.1 .
CCDSi CCDS31940.1.
PIRi B32891.
RefSeqi NP_001120844.1. NM_001127372.2.
NP_001276900.1. NM_001289971.1.
NP_001276901.1. NM_001289972.1.
NP_003419.3. NM_003428.5.
XP_005266242.1. XM_005266185.1.
XP_005266243.1. XM_005266186.1.
XP_006719810.1. XM_006719747.1.
UniGenei Hs.445019.

3D structure databases

ProteinModelPortali P51523.
SMRi P51523. Positions 9-49, 178-738.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113453. 2 interactions.
IntActi P51523. 1 interaction.
STRINGi 9606.ENSP00000331465.

PTM databases

PhosphoSitei P51523.

Polymorphism databases

DMDMi 94730445.

Proteomic databases

MaxQBi P51523.
PaxDbi P51523.
PRIDEi P51523.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000327668 ; ENSP00000331465 ; ENSG00000198040 .
ENST00000392319 ; ENSP00000376133 ; ENSG00000198040 .
ENST00000539354 ; ENSP00000445549 ; ENSG00000198040 .
GeneIDi 7637.
KEGGi hsa:7637.
UCSCi uc001ulm.4. human.

Organism-specific databases

CTDi 7637.
GeneCardsi GC12P133613.
HGNCi HGNC:13159. ZNF84.
HPAi HPA028860.
neXtProti NX_P51523.
PharmGKBi PA37732.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00770000120458.
HOVERGENi HBG018163.
InParanoidi P51523.
KOi K09228.
OMAi HIREIAY.
PhylomeDBi P51523.
TreeFami TF337898.

Miscellaneous databases

GenomeRNAii 7637.
NextBioi 29744.
PROi P51523.

Gene expression databases

Bgeei P51523.
CleanExi HS_ZNF84.
ExpressionAtlasi P51523. baseline and differential.
Genevestigatori P51523.

Family and domain databases

Gene3Di 3.30.160.60. 19 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human genome contains hundreds of genes coding for finger proteins of the Kruppel type."
    Bellefroid E.J., Lecocq P.J., Benhida A., Poncelet D.A., Belayew A., Martial J.A.
    DNA 8:377-387(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. Grimaldi G.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung, Testis and Uterus.
  6. "Members of the zinc finger protein gene family sharing a conserved N-terminal module."
    Rosati M., Marino M., Franze A., Tramontano A., Grimaldi G.
    Nucleic Acids Res. 19:5661-5667(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-257.
    Tissue: Teratocarcinoma.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZNF84_HUMAN
AccessioniPrimary (citable) accession number: P51523
Secondary accession number(s): B2RAK5
, D3DXJ1, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 2, 2006
Last modified: November 26, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3