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P51523

- ZNF84_HUMAN

UniProt

P51523 - ZNF84_HUMAN

Protein

Zinc finger protein 84

Gene

ZNF84

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (02 May 2006)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri207 – 22923C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri235 – 25723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri263 – 28523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri291 – 31323C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri319 – 34123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri347 – 36923C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri375 – 39723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri403 – 42523C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri431 – 45323C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri459 – 48123C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri487 – 50923C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri515 – 53723C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri543 – 56523C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri571 – 59323C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri599 – 62123C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri627 – 64923C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri655 – 67723C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri683 – 70523C2H2-type 18PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri711 – 73323C2H2-type 19PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 84
    Alternative name(s):
    Zinc finger protein HPF2
    Gene namesi
    Name:ZNF84
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:13159. ZNF84.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37732.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 738738Zinc finger protein 84PRO_0000047397Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei128 – 1281Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP51523.
    PRIDEiP51523.

    PTM databases

    PhosphoSiteiP51523.

    Expressioni

    Gene expression databases

    ArrayExpressiP51523.
    BgeeiP51523.
    CleanExiHS_ZNF84.
    GenevestigatoriP51523.

    Organism-specific databases

    HPAiHPA028860.

    Interactioni

    Protein-protein interaction databases

    BioGridi113453. 2 interactions.
    IntActiP51523. 1 interaction.
    STRINGi9606.ENSP00000331465.

    Structurei

    3D structure databases

    ProteinModelPortaliP51523.
    SMRiP51523. Positions 9-49, 178-738.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 19 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri207 – 22923C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri235 – 25723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri263 – 28523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri291 – 31323C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri319 – 34123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri347 – 36923C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri375 – 39723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri403 – 42523C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri431 – 45323C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri459 – 48123C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri487 – 50923C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri515 – 53723C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri543 – 56523C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri571 – 59323C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri599 – 62123C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri627 – 64923C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri655 – 67723C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri683 – 70523C2H2-type 18PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri711 – 73323C2H2-type 19PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOVERGENiHBG018163.
    InParanoidiP51523.
    KOiK09228.
    OMAiHIREIAY.
    PhylomeDBiP51523.
    TreeFamiTF337898.

    Family and domain databases

    Gene3Di3.30.160.60. 19 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 19 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 19 hits.
    PS50157. ZINC_FINGER_C2H2_2. 19 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51523-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTMLQESFSF DDLSVDFTQK EWQLLDPSQK NLYKDVMLEN YSSLVSLGYE    50
    VMKPDVIFKL EQGEEPWVGD GEIPSSDSPE VWKVDGNMMW HQDNQDKLKI 100
    IKRGHECDAF GKNFNLNMNF VPLRKSNSEG DLDGLILKHH LDLLIPKGDY 150
    GKAESDDFNV FDNFFLHSKP EDTDTWLKYY DCDKYKESYK KSQIIIYHRN 200
    RLGEKLYECS ECRKRFSKKP SLIKHQSRHI RDIAFGCGNC GKTFPQKSQF 250
    ITHHRTHTGE KPYNCSQCGK AFSQKSQLTS HQRTHTGEKP YECGECGKAF 300
    SRKSHLISHW RTHTGEKPYG CNECGRAFSE KSNLINHQRI HTGEKPFECR 350
    ECGKAFSRKS QLVTHHRTHT GTKPFGCSDC RKAFFEKSEL IRHQTIHTGE 400
    KPYECSECRK AFRERSSLIN HQRTHTGEKP HGCIQCGKAF SQKSHLISHQ 450
    MTHTGEKPFI CSKCGKAFSR KSQLVRHQRT HTGEKPYECS ECGKAFSEKL 500
    SLTNHQRIHT GEKPYVCSEC GKAFCQKSHL ISHQRTHTGE KPYECSECGK 550
    AFGEKSSLAT HQRTHTGEKP YECRDCEKAF SQKSQLNTHQ RIHTGEKPYE 600
    CSLCRKAFFE KSELIRHLRT HTGEKPYECN ECRKAFREKS SLINHQRIHT 650
    GEKPFECSEC GKAFSRKSHL IPHQRTHTGE KPYGCSECRK AFSQKSQLVN 700
    HQRIHTGEKP YRCIECGKAF SQKSQLINHQ RTHTVKKS 738
    Length:738
    Mass (Da):85,457
    Last modified:May 2, 2006 - v2
    Checksum:iE682053680438D5F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti62 – 621Q → E in AAA79359. (PubMed:2505992)Curated
    Sequence conflicti594 – 5941T → A in AAH36656. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M27878 mRNA. Translation: AAA79359.1.
    X60156 mRNA. Translation: CAB94232.2.
    AK314232 mRNA. Translation: BAG36902.1.
    CH471218 Genomic DNA. Translation: EAW54799.1.
    CH471218 Genomic DNA. Translation: EAW54801.1.
    CH471218 Genomic DNA. Translation: EAW54802.1.
    BC036656 mRNA. Translation: AAH36656.1.
    BC048350 mRNA. Translation: AAH48350.2.
    BC062552 mRNA. Translation: AAH62552.1.
    CCDSiCCDS31940.1.
    PIRiB32891.
    RefSeqiNP_001120844.1. NM_001127372.2.
    NP_001276900.1. NM_001289971.1.
    NP_001276901.1. NM_001289972.1.
    NP_003419.3. NM_003428.5.
    XP_005266242.1. XM_005266185.1.
    XP_005266243.1. XM_005266186.1.
    XP_006719810.1. XM_006719747.1.
    UniGeneiHs.445019.

    Genome annotation databases

    EnsembliENST00000327668; ENSP00000331465; ENSG00000198040.
    ENST00000392319; ENSP00000376133; ENSG00000198040.
    ENST00000539354; ENSP00000445549; ENSG00000198040.
    GeneIDi7637.
    KEGGihsa:7637.
    UCSCiuc001ulm.4. human.

    Polymorphism databases

    DMDMi94730445.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M27878 mRNA. Translation: AAA79359.1 .
    X60156 mRNA. Translation: CAB94232.2 .
    AK314232 mRNA. Translation: BAG36902.1 .
    CH471218 Genomic DNA. Translation: EAW54799.1 .
    CH471218 Genomic DNA. Translation: EAW54801.1 .
    CH471218 Genomic DNA. Translation: EAW54802.1 .
    BC036656 mRNA. Translation: AAH36656.1 .
    BC048350 mRNA. Translation: AAH48350.2 .
    BC062552 mRNA. Translation: AAH62552.1 .
    CCDSi CCDS31940.1.
    PIRi B32891.
    RefSeqi NP_001120844.1. NM_001127372.2.
    NP_001276900.1. NM_001289971.1.
    NP_001276901.1. NM_001289972.1.
    NP_003419.3. NM_003428.5.
    XP_005266242.1. XM_005266185.1.
    XP_005266243.1. XM_005266186.1.
    XP_006719810.1. XM_006719747.1.
    UniGenei Hs.445019.

    3D structure databases

    ProteinModelPortali P51523.
    SMRi P51523. Positions 9-49, 178-738.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113453. 2 interactions.
    IntActi P51523. 1 interaction.
    STRINGi 9606.ENSP00000331465.

    PTM databases

    PhosphoSitei P51523.

    Polymorphism databases

    DMDMi 94730445.

    Proteomic databases

    PaxDbi P51523.
    PRIDEi P51523.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000327668 ; ENSP00000331465 ; ENSG00000198040 .
    ENST00000392319 ; ENSP00000376133 ; ENSG00000198040 .
    ENST00000539354 ; ENSP00000445549 ; ENSG00000198040 .
    GeneIDi 7637.
    KEGGi hsa:7637.
    UCSCi uc001ulm.4. human.

    Organism-specific databases

    CTDi 7637.
    GeneCardsi GC12P133613.
    HGNCi HGNC:13159. ZNF84.
    HPAi HPA028860.
    neXtProti NX_P51523.
    PharmGKBi PA37732.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOVERGENi HBG018163.
    InParanoidi P51523.
    KOi K09228.
    OMAi HIREIAY.
    PhylomeDBi P51523.
    TreeFami TF337898.

    Miscellaneous databases

    GenomeRNAii 7637.
    NextBioi 29744.
    PROi P51523.

    Gene expression databases

    ArrayExpressi P51523.
    Bgeei P51523.
    CleanExi HS_ZNF84.
    Genevestigatori P51523.

    Family and domain databases

    Gene3Di 3.30.160.60. 19 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 19 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 19 hits.
    PS50157. ZINC_FINGER_C2H2_2. 19 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human genome contains hundreds of genes coding for finger proteins of the Kruppel type."
      Bellefroid E.J., Lecocq P.J., Benhida A., Poncelet D.A., Belayew A., Martial J.A.
      DNA 8:377-387(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. Grimaldi G.
      Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung, Testis and Uterus.
    6. "Members of the zinc finger protein gene family sharing a conserved N-terminal module."
      Rosati M., Marino M., Franze A., Tramontano A., Grimaldi G.
      Nucleic Acids Res. 19:5661-5667(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-257.
      Tissue: Teratocarcinoma.
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZNF84_HUMAN
    AccessioniPrimary (citable) accession number: P51523
    Secondary accession number(s): B2RAK5
    , D3DXJ1, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3