P51523 (ZNF84_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 84

Alternative name(s):
Zinc finger protein HPF2

Gene names

Name:

ZNF84

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	738 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 19 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Non-traceable author statement. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular_function	DNA binding Non-traceable author statement Ref.1. Source: UniProtKB zinc ion binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 738	738	Zinc finger protein 84		PRO_0000047397
Regions
	Domain	8 – 79	72	KRAB
	Zinc finger	207 – 229	23	C2H2-type 1
	Zinc finger	235 – 257	23	C2H2-type 2
	Zinc finger	263 – 285	23	C2H2-type 3
	Zinc finger	291 – 313	23	C2H2-type 4
	Zinc finger	319 – 341	23	C2H2-type 5
	Zinc finger	347 – 369	23	C2H2-type 6
	Zinc finger	375 – 397	23	C2H2-type 7
	Zinc finger	403 – 425	23	C2H2-type 8
	Zinc finger	431 – 453	23	C2H2-type 9
	Zinc finger	459 – 481	23	C2H2-type 10
	Zinc finger	487 – 509	23	C2H2-type 11
	Zinc finger	515 – 537	23	C2H2-type 12
	Zinc finger	543 – 565	23	C2H2-type 13
	Zinc finger	571 – 593	23	C2H2-type 14
	Zinc finger	599 – 621	23	C2H2-type 15
	Zinc finger	627 – 649	23	C2H2-type 16
	Zinc finger	655 – 677	23	C2H2-type 17
	Zinc finger	683 – 705	23	C2H2-type 18
	Zinc finger	711 – 733	23	C2H2-type 19
Amino acid modifications
	Modified residue	128	1	Phosphoserine Ref.7
Experimental info
	Sequence conflict	62	1	Q → E in AAA79359. Ref.1
	Sequence conflict	594	1	T → A in AAH36656. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P51523 [UniParc]. Last modified May 2, 2006. Version 2. Checksum: E682053680438D5F	FASTA	738	85,457
	10 20 30 40 50 60 MTMLQESFSF DDLSVDFTQK EWQLLDPSQK NLYKDVMLEN YSSLVSLGYE VMKPDVIFKL 70 80 90 100 110 120 EQGEEPWVGD GEIPSSDSPE VWKVDGNMMW HQDNQDKLKI IKRGHECDAF GKNFNLNMNF 130 140 150 160 170 180 VPLRKSNSEG DLDGLILKHH LDLLIPKGDY GKAESDDFNV FDNFFLHSKP EDTDTWLKYY 190 200 210 220 230 240 DCDKYKESYK KSQIIIYHRN RLGEKLYECS ECRKRFSKKP SLIKHQSRHI RDIAFGCGNC 250 260 270 280 290 300 GKTFPQKSQF ITHHRTHTGE KPYNCSQCGK AFSQKSQLTS HQRTHTGEKP YECGECGKAF 310 320 330 340 350 360 SRKSHLISHW RTHTGEKPYG CNECGRAFSE KSNLINHQRI HTGEKPFECR ECGKAFSRKS 370 380 390 400 410 420 QLVTHHRTHT GTKPFGCSDC RKAFFEKSEL IRHQTIHTGE KPYECSECRK AFRERSSLIN 430 440 450 460 470 480 HQRTHTGEKP HGCIQCGKAF SQKSHLISHQ MTHTGEKPFI CSKCGKAFSR KSQLVRHQRT 490 500 510 520 530 540 HTGEKPYECS ECGKAFSEKL SLTNHQRIHT GEKPYVCSEC GKAFCQKSHL ISHQRTHTGE 550 560 570 580 590 600 KPYECSECGK AFGEKSSLAT HQRTHTGEKP YECRDCEKAF SQKSQLNTHQ RIHTGEKPYE 610 620 630 640 650 660 CSLCRKAFFE KSELIRHLRT HTGEKPYECN ECRKAFREKS SLINHQRIHT GEKPFECSEC 670 680 690 700 710 720 GKAFSRKSHL IPHQRTHTGE KPYGCSECRK AFSQKSQLVN HQRIHTGEKP YRCIECGKAF 730 SQKSQLINHQ RTHTVKKS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human genome contains hundreds of genes coding for finger proteins of the Kruppel type." Bellefroid E.J., Lecocq P.J., Benhida A., Poncelet D.A., Belayew A., Martial J.A. DNA 8:377-387(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	Grimaldi G. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung, Testis and Uterus.
[6]	"Members of the zinc finger protein gene family sharing a conserved N-terminal module." Rosati M., Marino M., Franze A., Tramontano A., Grimaldi G. Nucleic Acids Res. 19:5661-5667(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-257. Tissue: Teratocarcinoma.
[7]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M27878 mRNA. Translation: AAA79359.1. X60156 mRNA. Translation: CAB94232.2. AK314232 mRNA. Translation: BAG36902.1. CH471218 Genomic DNA. Translation: EAW54799.1. CH471218 Genomic DNA. Translation: EAW54801.1. CH471218 Genomic DNA. Translation: EAW54802.1. BC036656 mRNA. Translation: AAH36656.1. BC048350 mRNA. Translation: AAH48350.2. BC062552 mRNA. Translation: AAH62552.1.
IPI	IPI00333480.
PIR	B32891.
RefSeq	NP_001120844.1. NM_001127372.1. NP_003419.3. NM_003428.4. XP_003846493.1. XM_003846445.2. XP_003846494.1. XM_003846446.2. XP_003846495.1. XM_003846447.2. XP_003846496.1. XM_003846448.2. XP_003846497.1. XM_003846449.2. XP_003846498.1. XM_003846450.2. XP_003846499.1. XM_003846451.2.
UniGene	Hs.445019. Hs.722182.
3D structure databases
ProteinModelPortal	P51523.
ModBase	Search...
Protein-protein interaction databases
IntAct	P51523. 1 interaction.
STRING	9606.ENSP00000331465.
PTM databases
PhosphoSite	P51523.
Proteomic databases
PaxDb	P51523.
PRIDE	P51523.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000327668; ENSP00000331465; ENSG00000198040. ENST00000392319; ENSP00000376133; ENSG00000198040. ENST00000539354; ENSP00000445549; ENSG00000198040.
GeneID	100996464. 7637.
KEGG	hsa:100996464. hsa:7637.
UCSC	uc001ulm.4. human.
Organism-specific databases
CTD	7637.
GeneCards	GC00M8D0043. GC12P133613.
HGNC	HGNC:13159. ZNF84.
HPA	HPA028860.
neXtProt	NX_P51523.
PharmGKB	PA37732.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOVERGEN	HBG018163.
InParanoid	P51523.
KO	K09228.
OMA	HIREIAY.
OrthoDB	EOG4FR0R0.
PhylomeDB	P51523.
Gene expression databases
ArrayExpress	P51523.
Bgee	P51523.
CleanEx	HS_ZNF84.
Genevestigator	P51523.
GermOnline	ENSG00000198040. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 19 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 19 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 19 hits. PS50157. ZINC_FINGER_C2H2_2. 19 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	29744.

Entry information

Entry name

ZNF84_HUMAN

Accession

Primary (citable) accession number: P51523
Secondary accession number(s): B2RAK5 , D3DXJ1, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	May 2, 2006
Last modified:	May 1, 2013
This is version 115 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.