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Protein

Zinc finger protein 84

Gene

ZNF84

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri207 – 229C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri235 – 257C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri263 – 285C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri543 – 565C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 593C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri599 – 621C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri627 – 649C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri655 – 677C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri683 – 705C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri711 – 733C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 84
Alternative name(s):
Zinc finger protein HPF2
Gene namesi
Name:ZNF84
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000198040.10
HGNCiHGNC:13159 ZNF84
neXtProtiNX_P51523

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198040
PharmGKBiPA37732

Polymorphism and mutation databases

BioMutaiZNF84
DMDMi94730445

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473971 – 738Zinc finger protein 84Add BLAST738

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki112Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki125Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei128PhosphoserineCombined sources1
Cross-linki191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki457Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP51523
MaxQBiP51523
PaxDbiP51523
PeptideAtlasiP51523
PRIDEiP51523

PTM databases

iPTMnetiP51523
PhosphoSitePlusiP51523

Expressioni

Gene expression databases

BgeeiENSG00000198040
CleanExiHS_ZNF84
ExpressionAtlasiP51523 baseline and differential
GenevisibleiP51523 HS

Organism-specific databases

HPAiHPA028860

Interactioni

Protein-protein interaction databases

BioGridi1134532 interactors.
IntActiP51523 5 interactors.
MINTiP51523
STRINGi9606.ENSP00000394086

Structurei

3D structure databases

ProteinModelPortaliP51523
SMRiP51523
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri207 – 229C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri235 – 257C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri263 – 285C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri543 – 565C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 593C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri599 – 621C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri627 – 649C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri655 – 677C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri683 – 705C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri711 – 733C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140787
HOVERGENiHBG018163
InParanoidiP51523
KOiK09228
OMAiPLRKSNN
OrthoDBiEOG091G02KC
PhylomeDBiP51523
TreeFamiTF337898

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 19 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

Sequencei

Sequence statusi: Complete.

P51523-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMLQESFSF DDLSVDFTQK EWQLLDPSQK NLYKDVMLEN YSSLVSLGYE
60 70 80 90 100
VMKPDVIFKL EQGEEPWVGD GEIPSSDSPE VWKVDGNMMW HQDNQDKLKI
110 120 130 140 150
IKRGHECDAF GKNFNLNMNF VPLRKSNSEG DLDGLILKHH LDLLIPKGDY
160 170 180 190 200
GKAESDDFNV FDNFFLHSKP EDTDTWLKYY DCDKYKESYK KSQIIIYHRN
210 220 230 240 250
RLGEKLYECS ECRKRFSKKP SLIKHQSRHI RDIAFGCGNC GKTFPQKSQF
260 270 280 290 300
ITHHRTHTGE KPYNCSQCGK AFSQKSQLTS HQRTHTGEKP YECGECGKAF
310 320 330 340 350
SRKSHLISHW RTHTGEKPYG CNECGRAFSE KSNLINHQRI HTGEKPFECR
360 370 380 390 400
ECGKAFSRKS QLVTHHRTHT GTKPFGCSDC RKAFFEKSEL IRHQTIHTGE
410 420 430 440 450
KPYECSECRK AFRERSSLIN HQRTHTGEKP HGCIQCGKAF SQKSHLISHQ
460 470 480 490 500
MTHTGEKPFI CSKCGKAFSR KSQLVRHQRT HTGEKPYECS ECGKAFSEKL
510 520 530 540 550
SLTNHQRIHT GEKPYVCSEC GKAFCQKSHL ISHQRTHTGE KPYECSECGK
560 570 580 590 600
AFGEKSSLAT HQRTHTGEKP YECRDCEKAF SQKSQLNTHQ RIHTGEKPYE
610 620 630 640 650
CSLCRKAFFE KSELIRHLRT HTGEKPYECN ECRKAFREKS SLINHQRIHT
660 670 680 690 700
GEKPFECSEC GKAFSRKSHL IPHQRTHTGE KPYGCSECRK AFSQKSQLVN
710 720 730
HQRIHTGEKP YRCIECGKAF SQKSQLINHQ RTHTVKKS
Length:738
Mass (Da):85,457
Last modified:May 2, 2006 - v2
Checksum:iE682053680438D5F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62Q → E in AAA79359 (PubMed:2505992).Curated1
Sequence conflicti594T → A in AAH36656 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27878 mRNA Translation: AAA79359.1
X60156 mRNA Translation: CAB94232.2
AK314232 mRNA Translation: BAG36902.1
CH471218 Genomic DNA Translation: EAW54799.1
CH471218 Genomic DNA Translation: EAW54801.1
CH471218 Genomic DNA Translation: EAW54802.1
BC036656 mRNA Translation: AAH36656.1
BC048350 mRNA Translation: AAH48350.2
BC062552 mRNA Translation: AAH62552.1
CCDSiCCDS31940.1
PIRiB32891
RefSeqiNP_001120844.1, NM_001127372.2
NP_001276900.1, NM_001289971.1
NP_001276901.1, NM_001289972.1
NP_003419.3, NM_003428.5
XP_005266242.1, XM_005266185.1
XP_005266243.1, XM_005266186.1
XP_011533134.1, XM_011534832.1
UniGeneiHs.445019

Genome annotation databases

EnsembliENST00000327668; ENSP00000331465; ENSG00000198040
ENST00000392319; ENSP00000376133; ENSG00000198040
ENST00000539354; ENSP00000445549; ENSG00000198040
GeneIDi7637
KEGGihsa:7637
UCSCiuc001ulm.5 human

Similar proteinsi

Entry informationi

Entry nameiZNF84_HUMAN
AccessioniPrimary (citable) accession number: P51523
Secondary accession number(s): B2RAK5
, D3DXJ1, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 2, 2006
Last modified: February 28, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome