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Protein

Zinc finger protein 83

Gene

ZNF83

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri93 – 115C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri121 – 143C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri149 – 171C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri177 – 199C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri205 – 227C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 83
Alternative name(s):
Zinc finger protein 816B
Zinc finger protein HPF1
Gene namesi
Name:ZNF83
Synonyms:ZNF816B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167766.18
HGNCiHGNC:13158 ZNF83
MIMi194558 gene
neXtProtiNX_P51522

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167766
PharmGKBiPA37731

Polymorphism and mutation databases

BioMutaiZNF83
DMDMi300669707

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473961 – 516Zinc finger protein 83Add BLAST516

Proteomic databases

PaxDbiP51522
PeptideAtlasiP51522
PRIDEiP51522

PTM databases

iPTMnetiP51522
PhosphoSitePlusiP51522

Expressioni

Gene expression databases

BgeeiENSG00000167766
CleanExiHS_ZNF83
ExpressionAtlasiP51522 baseline and differential
GenevisibleiP51522 HS

Organism-specific databases

HPAiHPA025970

Interactioni

Protein-protein interaction databases

BioGridi1208863 interactors.
IntActiP51522 4 interactors.
MINTiP51522
STRINGi9606.ENSP00000301096

Structurei

3D structure databases

ProteinModelPortaliP51522
SMRiP51522
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri93 – 115C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri121 – 143C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri149 – 171C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri177 – 199C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri205 – 227C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00690000102079
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP51522
KOiK09228
OMAiNSYLAYH
OrthoDBiEOG091G02KC
PhylomeDBiP51522
TreeFamiTF341892

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P51522-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHGRKDDAQK QPVKNQLGLN PQSHLPELQL FQAEGKIYKY DHMEKSVNSS
60 70 80 90 100
SLVSPPQRIS STVKTHISHT YECNFVDSLF TQKEKANIGT EHYKCSERGK
110 120 130 140 150
AFHQGLHFTI HQIIHTKETQ FKCDICGKIF NKKSNLASHQ RIHTGEKPYK
160 170 180 190 200
CNECGKVFHN MSHLAQHRRI HTGEKPYKCN ECGKVFNQIS HLAQHQRIHT
210 220 230 240 250
GEKPYKCNEC GKVFHQISHL AQHRTIHTGE KPYECNKCGK VFSRNSYLVQ
260 270 280 290 300
HLIIHTGEKP YRCNVCGKVF HHISHLAQHQ RIHTGEKPYK CNECGKVFSH
310 320 330 340 350
KSSLVNHWRI HTGEKPYKCN ECGKVFSHKS SLVNHWRIHT GEKPYKCNEC
360 370 380 390 400
GKVFSRNSYL AQHLIIHAGE KPYKCDECDK AFSQNSHLVQ HHRIHTGEKP
410 420 430 440 450
YKCDECGKVF SQNSYLAYHW RIHTGEKAYK CNECGKVFGL NSSLAHHRKI
460 470 480 490 500
HTGEKPFKCN ECGKAFSMRS SLTNHHAIHT GEKHFKCNEC GKLFRDNSYL
510
VRHQRFHAGK KSNTCN
Length:516
Mass (Da):59,710
Last modified:July 13, 2010 - v3
Checksum:iA6CA428CFAEA5D69
GO
Isoform 2 (identifier: P51522-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-298: Missing.

Show »
Length:488
Mass (Da):56,429
Checksum:i02D19C75A1677C48
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89 – 91GTE → MDR in AAG41760 (PubMed:2505992).Curated3
Sequence conflicti108 – 109FT → LP in AAG41760 (PubMed:2505992).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05820670T → I. Corresponds to variant dbSNP:rs3786490Ensembl.1
Natural variantiVAR_05820796S → N3 PublicationsCorresponds to variant dbSNP:rs1056185Ensembl.1
Natural variantiVAR_058208119T → M. Corresponds to variant dbSNP:rs329940Ensembl.1
Natural variantiVAR_058209392H → R1 PublicationCorresponds to variant dbSNP:rs11545619Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_037663271 – 298Missing in isoform 2. 2 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289399 mRNA Translation: BAF82088.1
AC022150 Genomic DNA No translation available.
BC050407 mRNA Translation: AAH50407.1
BC032867 mRNA Translation: AAH32867.1
M27877 mRNA Translation: AAG41760.1
CCDSiCCDS12854.1 [P51522-1]
PIRiA32891
RefSeqiNP_001099019.1, NM_001105549.1 [P51522-1]
NP_001099020.1, NM_001105550.1 [P51522-1]
NP_001099021.1, NM_001105551.1 [P51522-1]
NP_001099022.1, NM_001105552.1 [P51522-1]
NP_001264874.1, NM_001277945.1 [P51522-1]
NP_001264875.1, NM_001277946.1 [P51522-1]
NP_001264876.1, NM_001277947.1 [P51522-1]
NP_001264877.1, NM_001277948.1 [P51522-1]
NP_001264878.1, NM_001277949.1 [P51522-1]
NP_001264880.1, NM_001277951.1 [P51522-1]
NP_001264881.1, NM_001277952.1 [P51522-1]
NP_001334944.1, NM_001348015.1 [P51522-1]
NP_001334945.1, NM_001348016.1 [P51522-1]
NP_001334946.1, NM_001348017.1 [P51522-1]
NP_001334947.1, NM_001348018.1 [P51522-1]
NP_001334948.1, NM_001348019.1 [P51522-1]
NP_060770.3, NM_018300.3 [P51522-1]
UniGeneiHs.467210
Hs.659798
Hs.665751
Hs.710125
Hs.744177

Genome annotation databases

EnsembliENST00000301096; ENSP00000301096; ENSG00000167766 [P51522-1]
ENST00000536937; ENSP00000445993; ENSG00000167766 [P51522-1]
ENST00000541777; ENSP00000439681; ENSG00000167766 [P51522-1]
ENST00000545872; ENSP00000440713; ENSG00000167766 [P51522-1]
ENST00000597597; ENSP00000472619; ENSG00000167766 [P51522-1]
GeneIDi55769
KEGGihsa:55769
UCSCiuc002pzu.5 human [P51522-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZNF83_HUMAN
AccessioniPrimary (citable) accession number: P51522
Secondary accession number(s): A8MT75, Q3ZCX0, Q6PI08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 13, 2010
Last modified: February 28, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome