UniProtKB - P51522 (ZNF83_HUMAN)
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Protein
Zinc finger protein 83
Gene
ZNF83
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 93 – 115 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 121 – 143 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 149 – 171 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 177 – 199 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 205 – 227 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 233 – 255 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 261 – 283 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 289 – 311 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 317 – 339 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 345 – 367 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 373 – 395 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 401 – 423 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 429 – 451 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 457 – 479 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 485 – 507 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA binding transcription factor activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- regulation of transcription, DNA-templated Source: GO_Central
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 83Alternative name(s): Zinc finger protein 816B Zinc finger protein HPF1 |
Gene namesi | Name:ZNF83 Synonyms:ZNF816B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000167766.18 |
HGNCi | HGNC:13158 ZNF83 |
MIMi | 194558 gene |
neXtProti | NX_P51522 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000167766 |
PharmGKBi | PA37731 |
Polymorphism and mutation databases
BioMutai | ZNF83 |
DMDMi | 300669707 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047396 | 1 – 516 | Zinc finger protein 83Add BLAST | 516 |
Proteomic databases
PaxDbi | P51522 |
PeptideAtlasi | P51522 |
PRIDEi | P51522 |
PTM databases
iPTMneti | P51522 |
PhosphoSitePlusi | P51522 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167766 |
CleanExi | HS_ZNF83 |
ExpressionAtlasi | P51522 baseline and differential |
Genevisiblei | P51522 HS |
Organism-specific databases
HPAi | HPA025970 |
Interactioni
Protein-protein interaction databases
BioGridi | 1208863 interactors. |
IntActi | P51522 4 interactors. |
MINTi | P51522 |
STRINGi | 9606.ENSP00000301096 |
Structurei
3D structure databases
ProteinModelPortali | P51522 |
SMRi | P51522 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 93 – 115 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 121 – 143 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 149 – 171 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 177 – 199 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 205 – 227 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 233 – 255 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 261 – 283 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 289 – 311 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 317 – 339 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 345 – 367 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 373 – 395 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 401 – 423 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 429 – 451 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 457 – 479 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 485 – 507 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721 Eukaryota COG5048 LUCA |
GeneTreei | ENSGT00690000102079 |
HOGENOMi | HOG000234617 |
HOVERGENi | HBG018163 |
InParanoidi | P51522 |
KOi | K09228 |
OMAi | NSYLAYH |
OrthoDBi | EOG091G02KC |
PhylomeDBi | P51522 |
TreeFami | TF341892 |
Family and domain databases
InterProi | View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
SMARTi | View protein in SMART SM00355 ZnF_C2H2, 15 hits |
SUPFAMi | SSF57667 SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 14 hits PS50157 ZINC_FINGER_C2H2_2, 15 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: P51522-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MHGRKDDAQK QPVKNQLGLN PQSHLPELQL FQAEGKIYKY DHMEKSVNSS
60 70 80 90 100
SLVSPPQRIS STVKTHISHT YECNFVDSLF TQKEKANIGT EHYKCSERGK
110 120 130 140 150
AFHQGLHFTI HQIIHTKETQ FKCDICGKIF NKKSNLASHQ RIHTGEKPYK
160 170 180 190 200
CNECGKVFHN MSHLAQHRRI HTGEKPYKCN ECGKVFNQIS HLAQHQRIHT
210 220 230 240 250
GEKPYKCNEC GKVFHQISHL AQHRTIHTGE KPYECNKCGK VFSRNSYLVQ
260 270 280 290 300
HLIIHTGEKP YRCNVCGKVF HHISHLAQHQ RIHTGEKPYK CNECGKVFSH
310 320 330 340 350
KSSLVNHWRI HTGEKPYKCN ECGKVFSHKS SLVNHWRIHT GEKPYKCNEC
360 370 380 390 400
GKVFSRNSYL AQHLIIHAGE KPYKCDECDK AFSQNSHLVQ HHRIHTGEKP
410 420 430 440 450
YKCDECGKVF SQNSYLAYHW RIHTGEKAYK CNECGKVFGL NSSLAHHRKI
460 470 480 490 500
HTGEKPFKCN ECGKAFSMRS SLTNHHAIHT GEKHFKCNEC GKLFRDNSYL
510
VRHQRFHAGK KSNTCN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 89 – 91 | GTE → MDR in AAG41760 (PubMed:2505992).Curated | 3 | |
Sequence conflicti | 108 – 109 | FT → LP in AAG41760 (PubMed:2505992).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_058206 | 70 | T → I. Corresponds to variant dbSNP:rs3786490Ensembl. | 1 | |
Natural variantiVAR_058207 | 96 | S → N3 PublicationsCorresponds to variant dbSNP:rs1056185Ensembl. | 1 | |
Natural variantiVAR_058208 | 119 | T → M. Corresponds to variant dbSNP:rs329940Ensembl. | 1 | |
Natural variantiVAR_058209 | 392 | H → R1 PublicationCorresponds to variant dbSNP:rs11545619Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037663 | 271 – 298 | Missing in isoform 2. 2 PublicationsAdd BLAST | 28 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000301096; ENSP00000301096; ENSG00000167766 [P51522-1] ENST00000536937; ENSP00000445993; ENSG00000167766 [P51522-1] ENST00000541777; ENSP00000439681; ENSG00000167766 [P51522-1] ENST00000545872; ENSP00000440713; ENSG00000167766 [P51522-1] ENST00000597597; ENSP00000472619; ENSG00000167766 [P51522-1] |
GeneIDi | 55769 |
KEGGi | hsa:55769 |
UCSCi | uc002pzu.5 human [P51522-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | ZNF83_HUMAN | |
Accessioni | P51522Primary (citable) accession number: P51522 Secondary accession number(s): A8MT75, Q3ZCX0, Q6PI08 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | July 13, 2010 | |
Last modified: | February 28, 2018 | |
This is version 157 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |