P51522 (ZNF83_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 83

Alternative name(s):
Zinc finger protein 816B
Zinc finger protein HPF1

Gene names

Name:	ZNF83
Synonyms:	ZNF816B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	516 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 15 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Non-traceable author statement. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P51522-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P51522-2)

The sequence of this isoform differs from the canonical sequence as follows:
     271-298: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 516	516	Zinc finger protein 83		PRO_0000047396
Regions
	Zinc finger	93 – 115	23	C2H2-type 1; degenerate
	Zinc finger	121 – 143	23	C2H2-type 2
	Zinc finger	149 – 171	23	C2H2-type 3
	Zinc finger	177 – 199	23	C2H2-type 4
	Zinc finger	205 – 227	23	C2H2-type 5
	Zinc finger	233 – 255	23	C2H2-type 6
	Zinc finger	261 – 283	23	C2H2-type 7
	Zinc finger	289 – 311	23	C2H2-type 8
	Zinc finger	317 – 339	23	C2H2-type 9
	Zinc finger	345 – 367	23	C2H2-type 10
	Zinc finger	373 – 395	23	C2H2-type 11
	Zinc finger	401 – 423	23	C2H2-type 12
	Zinc finger	429 – 451	23	C2H2-type 13
	Zinc finger	457 – 479	23	C2H2-type 14
	Zinc finger	485 – 507	23	C2H2-type 15
Natural variations
	Alternative sequence	271 – 298	28	Missing in isoform 2.		VSP_037663
	Natural variant	70	1	T → I. Corresponds to variant rs3786490 [ dbSNP | Ensembl ].		VAR_058206
	Natural variant	96	1	S → N. Ref.1 Ref.3 Ref.4 Corresponds to variant rs1056185 [ dbSNP | Ensembl ].		VAR_058207
	Natural variant	119	1	T → M. Corresponds to variant rs329940 [ dbSNP | Ensembl ].		VAR_058208
	Natural variant	392	1	H → R. Ref.3 Corresponds to variant rs11545619 [ dbSNP | Ensembl ].		VAR_058209
Experimental info
	Sequence conflict	89 – 91	3	GTE → MDR in AAG41760. Ref.4
	Sequence conflict	108 – 109	2	FT → LP in AAG41760. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 13, 2010. Version 3. Checksum: A6CA428CFAEA5D69	FASTA	516	59,710
	10 20 30 40 50 60 MHGRKDDAQK QPVKNQLGLN PQSHLPELQL FQAEGKIYKY DHMEKSVNSS SLVSPPQRIS 70 80 90 100 110 120 STVKTHISHT YECNFVDSLF TQKEKANIGT EHYKCSERGK AFHQGLHFTI HQIIHTKETQ 130 140 150 160 170 180 FKCDICGKIF NKKSNLASHQ RIHTGEKPYK CNECGKVFHN MSHLAQHRRI HTGEKPYKCN 190 200 210 220 230 240 ECGKVFNQIS HLAQHQRIHT GEKPYKCNEC GKVFHQISHL AQHRTIHTGE KPYECNKCGK 250 260 270 280 290 300 VFSRNSYLVQ HLIIHTGEKP YRCNVCGKVF HHISHLAQHQ RIHTGEKPYK CNECGKVFSH 310 320 330 340 350 360 KSSLVNHWRI HTGEKPYKCN ECGKVFSHKS SLVNHWRIHT GEKPYKCNEC GKVFSRNSYL 370 380 390 400 410 420 AQHLIIHAGE KPYKCDECDK AFSQNSHLVQ HHRIHTGEKP YKCDECGKVF SQNSYLAYHW 430 440 450 460 470 480 RIHTGEKAYK CNECGKVFGL NSSLAHHRKI HTGEKPFKCN ECGKAFSMRS SLTNHHAIHT 490 500 510 GEKHFKCNEC GKLFRDNSYL VRHQRFHAGK KSNTCN
	Isoform 2 [UniParc]. Checksum: 02D19C75A1677C48	FASTA	488	56,429
	10 20 30 40 50 60 MHGRKDDAQK QPVKNQLGLN PQSHLPELQL FQAEGKIYKY DHMEKSVNSS SLVSPPQRIS 70 80 90 100 110 120 STVKTHISHT YECNFVDSLF TQKEKANIGT EHYKCSERGK AFHQGLHFTI HQIIHTKETQ 130 140 150 160 170 180 FKCDICGKIF NKKSNLASHQ RIHTGEKPYK CNECGKVFHN MSHLAQHRRI HTGEKPYKCN 190 200 210 220 230 240 ECGKVFNQIS HLAQHQRIHT GEKPYKCNEC GKVFHQISHL AQHRTIHTGE KPYECNKCGK 250 260 270 280 290 300 VFSRNSYLVQ HLIIHTGEKP YRCNVCGKVF SHKSSLVNHW RIHTGEKPYK CNECGKVFSH 310 320 330 340 350 360 KSSLVNHWRI HTGEKPYKCN ECGKVFSRNS YLAQHLIIHA GEKPYKCDEC DKAFSQNSHL 370 380 390 400 410 420 VQHHRIHTGE KPYKCDECGK VFSQNSYLAY HWRIHTGEKA YKCNECGKVF GLNSSLAHHR 430 440 450 460 470 480 KIHTGEKPFK CNECGKAFSM RSSLTNHHAI HTGEKHFKCN ECGKLFRDNS YLVRHQRFHA GKKSNTCN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASN-96.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS ASN-96 AND ARG-392. Tissue: PNS.
[4]	"The human genome contains hundreds of genes coding for finger proteins of the Kruppel type." Bellefroid E.J., Lecocq P.J., Benhida A., Poncelet D.A., Belayew A., Martial J.A. DNA 8:377-387(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 89-428 (ISOFORM 1), VARIANT ASN-96. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK289399 mRNA. Translation: BAF82088.1. AC022150 Genomic DNA. No translation available. BC050407 mRNA. Translation: AAH50407.1. BC032867 mRNA. Translation: AAH32867.1. M27877 mRNA. Translation: AAG41760.1.
IPI	IPI00479920. IPI00937015.
PIR	A32891.
RefSeq	NP_001099019.1. NM_001105549.1. NP_001099020.1. NM_001105550.1. NP_001099021.1. NM_001105551.1. NP_001099022.1. NM_001105552.1. NP_001099023.1. NM_001105553.1. NP_001099024.1. NM_001105554.1. NP_001229467.1. NM_001242538.1. NP_060770.3. NM_018300.3.
UniGene	Hs.467210. Hs.659798. Hs.665751. Hs.710125. Hs.742063.
3D structure databases
ProteinModelPortal	P51522.
SMR	P51522. Positions 27-69, 93-515.
ModBase	Search...
Protein-protein interaction databases
IntAct	P51522. 1 interaction.
MINT	MINT-1182660.
STRING	9606.ENSP00000301096.
PTM databases
PhosphoSite	P51522.
Polymorphism databases
DMDM	300669707.
Proteomic databases
PaxDb	P51522.
PRIDE	P51522.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000301096; ENSP00000301096; ENSG00000167766. ENST00000391789; ENSP00000375666; ENSG00000167766. ENST00000434535; ENSP00000412334; ENSG00000167766. ENST00000536937; ENSP00000445993; ENSG00000167766. ENST00000541777; ENSP00000439681; ENSG00000167766. ENST00000544146; ENSP00000445470; ENSG00000167766. ENST00000545872; ENSP00000440713; ENSG00000167766. ENST00000597597; ENSP00000472619; ENSG00000167766.
GeneID	55769.
KEGG	hsa:55769.
UCSC	uc002pzu.4. human. uc010eps.3. human.
Organism-specific databases
CTD	55769.
GeneCards	GC19M053115.
HGNC	HGNC:13158. ZNF83.
HPA	HPA025970.
MIM	194558. gene.
neXtProt	NX_P51522.
PharmGKB	PA37731.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	P51522.
KO	K09228.
OMA	NSYLAYH.
OrthoDB	EOG47WNND.
PhylomeDB	P51522.
Gene expression databases
ArrayExpress	P51522.
Bgee	P51522.
CleanEx	HS_ZNF83.
Genevestigator	P51522.
GermOnline	ENSG00000167766. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 15 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00355. ZnF_C2H2. 15 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 14 hits. PS50157. ZINC_FINGER_C2H2_2. 15 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZNF83. human.
GenomeRNAi	55769.
NextBio	60821.
SOURCE	Search...

Entry information

Entry name

ZNF83_HUMAN

Accession

Primary (citable) accession number: P51522
Secondary accession number(s): A8MT75, Q3ZCX0, Q6PI08

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	July 13, 2010
Last modified:	May 1, 2013
This is version 115 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.