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UniProtKB - P51522 (ZNF83_HUMAN)

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Protein

Zinc finger protein 83

Gene

ZNF83

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri93 – 115C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri121 – 143C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri149 – 171C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri177 – 199C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri205 – 227C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 83
Alternative name(s):
Zinc finger protein 816B
Zinc finger protein HPF1
Gene namesi
Name:ZNF83
Synonyms:ZNF816B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13158. ZNF83.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167766.
PharmGKBiPA37731.

Polymorphism and mutation databases

BioMutaiZNF83.
DMDMi300669707.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473961 – 516Zinc finger protein 83Add BLAST516

Proteomic databases

PaxDbiP51522.
PeptideAtlasiP51522.
PRIDEiP51522.

PTM databases

iPTMnetiP51522.
PhosphoSitePlusiP51522.

Expressioni

Gene expression databases

BgeeiENSG00000167766.
CleanExiHS_ZNF83.
ExpressionAtlasiP51522. baseline and differential.
GenevisibleiP51522. HS.

Organism-specific databases

HPAiHPA025970.

Interactioni

Protein-protein interaction databases

BioGridi120886. 3 interactors.
IntActiP51522. 4 interactors.
MINTiMINT-1182660.
STRINGi9606.ENSP00000301096.

Structurei

3D structure databases

ProteinModelPortaliP51522.
SMRiP51522.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri93 – 115C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri121 – 143C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri149 – 171C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri177 – 199C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri205 – 227C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP51522.
KOiK09228.
OMAiNSYLAYH.
OrthoDBiEOG091G02KC.
PhylomeDBiP51522.
TreeFamiTF341892.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 15 hits.
SUPFAMiSSF57667. SSF57667. 8 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P51522-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHGRKDDAQK QPVKNQLGLN PQSHLPELQL FQAEGKIYKY DHMEKSVNSS 
        60         70         80         90        100
SLVSPPQRIS STVKTHISHT YECNFVDSLF TQKEKANIGT EHYKCSERGK 
       110        120        130        140        150
AFHQGLHFTI HQIIHTKETQ FKCDICGKIF NKKSNLASHQ RIHTGEKPYK 
       160        170        180        190        200
CNECGKVFHN MSHLAQHRRI HTGEKPYKCN ECGKVFNQIS HLAQHQRIHT 
       210        220        230        240        250
GEKPYKCNEC GKVFHQISHL AQHRTIHTGE KPYECNKCGK VFSRNSYLVQ 
       260        270        280        290        300
HLIIHTGEKP YRCNVCGKVF HHISHLAQHQ RIHTGEKPYK CNECGKVFSH 
       310        320        330        340        350
KSSLVNHWRI HTGEKPYKCN ECGKVFSHKS SLVNHWRIHT GEKPYKCNEC 
       360        370        380        390        400
GKVFSRNSYL AQHLIIHAGE KPYKCDECDK AFSQNSHLVQ HHRIHTGEKP 
       410        420        430        440        450
YKCDECGKVF SQNSYLAYHW RIHTGEKAYK CNECGKVFGL NSSLAHHRKI 
       460        470        480        490        500
HTGEKPFKCN ECGKAFSMRS SLTNHHAIHT GEKHFKCNEC GKLFRDNSYL 
       510 
VRHQRFHAGK KSNTCN
Length:516
Mass (Da):59,710
Last modified:July 13, 2010 - v3
Checksum:iA6CA428CFAEA5D69
GO
Isoform 2 (identifier: P51522-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-298: Missing.

Show »
Length:488
Mass (Da):56,429
Checksum:i02D19C75A1677C48
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89 – 91GTE → MDR in AAG41760 (PubMed:2505992).Curated3
Sequence conflicti108 – 109FT → LP in AAG41760 (PubMed:2505992).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05820670T → I. Corresponds to variant dbSNP:rs3786490Ensembl.1
Natural variantiVAR_05820796S → N3 PublicationsCorresponds to variant dbSNP:rs1056185Ensembl.1
Natural variantiVAR_058208119T → M. Corresponds to variant dbSNP:rs329940Ensembl.1
Natural variantiVAR_058209392H → R1 PublicationCorresponds to variant dbSNP:rs11545619Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_037663271 – 298Missing in isoform 2. 2 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289399 mRNA. Translation: BAF82088.1.
AC022150 Genomic DNA. No translation available.
BC050407 mRNA. Translation: AAH50407.1.
BC032867 mRNA. Translation: AAH32867.1.
M27877 mRNA. Translation: AAG41760.1.
CCDSiCCDS12854.1. [P51522-1]
PIRiA32891.
RefSeqiNP_001099019.1. NM_001105549.1. [P51522-1]
NP_001099020.1. NM_001105550.1. [P51522-1]
NP_001099021.1. NM_001105551.1. [P51522-1]
NP_001099022.1. NM_001105552.1. [P51522-1]
NP_001264874.1. NM_001277945.1. [P51522-1]
NP_001264875.1. NM_001277946.1. [P51522-1]
NP_001264876.1. NM_001277947.1. [P51522-1]
NP_001264877.1. NM_001277948.1. [P51522-1]
NP_001264878.1. NM_001277949.1. [P51522-1]
NP_001264880.1. NM_001277951.1. [P51522-1]
NP_001264881.1. NM_001277952.1. [P51522-1]
NP_001334944.1. NM_001348015.1. [P51522-1]
NP_001334945.1. NM_001348016.1. [P51522-1]
NP_001334946.1. NM_001348017.1. [P51522-1]
NP_001334947.1. NM_001348018.1. [P51522-1]
NP_001334948.1. NM_001348019.1. [P51522-1]
NP_060770.3. NM_018300.3. [P51522-1]
UniGeneiHs.467210.
Hs.659798.
Hs.665751.
Hs.710125.
Hs.744177.

Genome annotation databases

EnsembliENST00000301096; ENSP00000301096; ENSG00000167766. [P51522-1]
ENST00000536937; ENSP00000445993; ENSG00000167766. [P51522-1]
ENST00000541777; ENSP00000439681; ENSG00000167766. [P51522-1]
ENST00000545872; ENSP00000440713; ENSG00000167766. [P51522-1]
ENST00000597597; ENSP00000472619; ENSG00000167766. [P51522-1]
GeneIDi55769.
KEGGihsa:55769.
UCSCiuc002pzu.5. human. [P51522-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZNF83_HUMAN
AccessioniPrimary (citable) accession number: P51522
Secondary accession number(s): A8MT75, Q3ZCX0, Q6PI08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 13, 2010
Last modified: June 7, 2017
This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families