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Protein

RNA-binding protein Nova-1

Gene

NOVA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May regulate RNA splicing or metabolism in a specific subset of developing neurons.

GO - Molecular functioni

  • mRNA binding Source: Ensembl
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: ProtInc

GO - Biological processi

  • chemical synaptic transmission Source: ProtInc
  • locomotory behavior Source: ProtInc
  • mRNA splicing, via spliceosome Source: Ensembl
  • regulation of RNA metabolic process Source: Ensembl
  • RNA processing Source: ProtInc
  • RNA splicing Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein Nova-1
Alternative name(s):
Neuro-oncological ventral antigen 1
Onconeural ventral antigen 1
Paraneoplastic Ri antigen
Ventral neuron-specific protein 1
Gene namesi
Name:NOVA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:7886. NOVA1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4857.
OpenTargetsiENSG00000139910.
PharmGKBiPA31688.

Polymorphism and mutation databases

BioMutaiNOVA1.
DMDMi1709303.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501161 – 510RNA-binding protein Nova-1Add BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei157PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP51513.
MaxQBiP51513.
PaxDbiP51513.
PeptideAtlasiP51513.
PRIDEiP51513.
TopDownProteomicsiP51513-2. [P51513-2]

PTM databases

iPTMnetiP51513.
PhosphoSitePlusiP51513.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSG00000139910.
CleanExiHS_NOVA1.
ExpressionAtlasiP51513. baseline and differential.
GenevisibleiP51513. HS.

Organism-specific databases

HPAiHPA004155.

Interactioni

Subunit structurei

Interacts with PTBP2; the interaction is direct.By similarity

Protein-protein interaction databases

BioGridi110919. 10 interactors.
IntActiP51513. 8 interactors.
MINTiMINT-1381951.
STRINGi9606.ENSP00000438875.

Structurei

Secondary structure

1510
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi50 – 57Combined sources8
Helixi58 – 65Combined sources8
Helixi67 – 69Combined sources3
Helixi70 – 79Combined sources10
Beta strandi82 – 85Combined sources4
Beta strandi98 – 107Combined sources10
Helixi109 – 123Combined sources15
Helixi173 – 175Combined sources3
Beta strandi176 – 182Combined sources7
Helixi183 – 190Combined sources8
Helixi192 – 194Combined sources3
Helixi195 – 203Combined sources9
Beta strandi207 – 210Combined sources4
Beta strandi221 – 229Combined sources9
Helixi230 – 245Combined sources16
Beta strandi425 – 432Combined sources8
Turni433 – 436Combined sources4
Helixi437 – 440Combined sources4
Helixi442 – 444Combined sources3
Helixi445 – 454Combined sources10
Beta strandi457 – 460Combined sources4
Beta strandi472 – 479Combined sources8
Helixi481 – 494Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DT4X-ray2.60A424-495[»]
2ANNX-ray2.30A49-249[»]
2ANRX-ray1.94A49-249[»]
ProteinModelPortaliP51513.
SMRiP51513.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP51513.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 119KH 1PROSITE-ProRule annotationAdd BLAST71
Domaini174 – 240KH 2PROSITE-ProRule annotationAdd BLAST67
Domaini424 – 491KH 3PROSITE-ProRule annotationAdd BLAST68

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi27 – 43Bipartite nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi276 – 412Ala-richAdd BLAST137

Sequence similaritiesi

Contains 3 KH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2191. Eukaryota.
ENOG410XRZD. LUCA.
GeneTreeiENSGT00760000119144.
HOGENOMiHOG000007833.
HOVERGENiHBG082048.
InParanoidiP51513.
KOiK14944.
OMAiISKKGMF.
OrthoDBiEOG091G185U.
PhylomeDBiP51513.
TreeFamiTF316981.

Family and domain databases

Gene3Di3.30.1370.10. 3 hits.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR033086. NOVA1.
[Graphical view]
PANTHERiPTHR10288:SF150. PTHR10288:SF150. 3 hits.
PfamiPF00013. KH_1. 3 hits.
[Graphical view]
SMARTiSM00322. KH. 3 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 3 hits.
PROSITEiPS50084. KH_TYPE_1. 3 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P51513-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAAAPIQQN GTHTGVPIDL DPPDSRKRPL EAPPEAGSTK RTNTGEDGQY
60 70 80 90 100
FLKVLIPSYA AGSIIGKGGQ TIVQLQKETG ATIKLSKLSK SKDFYPGTTE
110 120 130 140 150
RVCLIQGTVE ALNAVHGFIA EKIREMPQNV AKTEPVSILQ PQTTVNPDRI
160 170 180 190 200
KQTLPSSPTT TKSSPSDPMT TSRANQVKII VPNSTAGLII GKGGATVKAV
210 220 230 240 250
MEQSGAWVQL SQKPDGINLQ ERVVTVSGEP EQNRKAVELI IQKIQEDPQS
260 270 280 290 300
GSCLNISYAN VTGPVANSNP TGSPYANTAE VLPTAAAAAG LLGHANLAGV
310 320 330 340 350
AAFPAVLSGF TGNDLVAITS ALNTLASYGY NLNTLGLGLS QAAATGALAA
360 370 380 390 400
AAASANPAAA AANLLATYAS EASASGSTAG GTAGTFALGS LAAATAATNG
410 420 430 440 450
YFGAASPLAA SAILGTEKST DGSKDVVEIA VPENLVGAIL GKGGKTLVEY
460 470 480 490 500
QELTGARIQI SKKGEFVPGT RNRKVTITGT PAATQAAQYL ITQRITYEQG
510
VRAANPQKVG
Length:510
Mass (Da):52,056
Last modified:October 1, 1996 - v1
Checksum:i7B9BA8B67CAB6984
GO
Isoform 2 (identifier: P51513-2) [UniParc]FASTAAdd to basket
Also known as: Tumor

The sequence of this isoform differs from the canonical sequence as follows:
     88-90: Missing.
     177-184: VKIIVPNS → KHNISWIS
     185-510: Missing.

Show »
Length:181
Mass (Da):19,491
Checksum:i23EF1C6F5541D52D
GO
Isoform 3 (identifier: P51513-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-176: Missing.

Show »
Length:486
Mass (Da):49,581
Checksum:i7F9A8331C469877E
GO
Isoform 4 (identifier: P51513-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-90: Missing.

Show »
Length:507
Mass (Da):51,727
Checksum:iDBF455477988CDCA
GO
Isoform 5 (identifier: P51513-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-90: Missing.
     153-176: Missing.

Note: Gene prediction based on EST data.
Show »
Length:483
Mass (Da):49,253
Checksum:iBE44FBED4E9664E2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00284188 – 90Missing in isoform 2, isoform 4 and isoform 5. 3 Publications3
Alternative sequenceiVSP_002842153 – 176Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_002843177 – 184VKIIVPNS → KHNISWIS in isoform 2. 2 Publications8
Alternative sequenceiVSP_002844185 – 510Missing in isoform 2. 2 PublicationsAdd BLAST326

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04840 mRNA. Translation: AAA16022.1.
AK289639 mRNA. Translation: BAF82328.1.
AK291022 mRNA. Translation: BAF83711.1.
AL079343 Genomic DNA. No translation available.
AL132716 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65990.1.
CH471078 Genomic DNA. Translation: EAW65991.1.
CH471078 Genomic DNA. Translation: EAW65992.1.
CH471078 Genomic DNA. Translation: EAW65993.1.
CH471078 Genomic DNA. Translation: EAW65995.1.
BC075038 mRNA. Translation: AAH75038.1.
BC075039 mRNA. Translation: AAH75039.1.
Z70771 mRNA. Translation: CAA94810.1.
CCDSiCCDS32060.1. [P51513-5]
CCDS32061.1. [P51513-4]
CCDS9635.1. [P51513-2]
PIRiI38489.
RefSeqiNP_002506.2. NM_002515.2. [P51513-4]
NP_006480.2. NM_006489.2. [P51513-5]
NP_006482.1. NM_006491.2. [P51513-2]
UniGeneiHs.31588.

Genome annotation databases

EnsembliENST00000344429; ENSP00000342387; ENSG00000139910. [P51513-2]
ENST00000465357; ENSP00000447391; ENSG00000139910. [P51513-5]
ENST00000539517; ENSP00000438875; ENSG00000139910. [P51513-4]
GeneIDi4857.
KEGGihsa:4857.
UCSCiuc001wpy.4. human. [P51513-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04840 mRNA. Translation: AAA16022.1.
AK289639 mRNA. Translation: BAF82328.1.
AK291022 mRNA. Translation: BAF83711.1.
AL079343 Genomic DNA. No translation available.
AL132716 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65990.1.
CH471078 Genomic DNA. Translation: EAW65991.1.
CH471078 Genomic DNA. Translation: EAW65992.1.
CH471078 Genomic DNA. Translation: EAW65993.1.
CH471078 Genomic DNA. Translation: EAW65995.1.
BC075038 mRNA. Translation: AAH75038.1.
BC075039 mRNA. Translation: AAH75039.1.
Z70771 mRNA. Translation: CAA94810.1.
CCDSiCCDS32060.1. [P51513-5]
CCDS32061.1. [P51513-4]
CCDS9635.1. [P51513-2]
PIRiI38489.
RefSeqiNP_002506.2. NM_002515.2. [P51513-4]
NP_006480.2. NM_006489.2. [P51513-5]
NP_006482.1. NM_006491.2. [P51513-2]
UniGeneiHs.31588.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DT4X-ray2.60A424-495[»]
2ANNX-ray2.30A49-249[»]
2ANRX-ray1.94A49-249[»]
ProteinModelPortaliP51513.
SMRiP51513.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110919. 10 interactors.
IntActiP51513. 8 interactors.
MINTiMINT-1381951.
STRINGi9606.ENSP00000438875.

PTM databases

iPTMnetiP51513.
PhosphoSitePlusiP51513.

Polymorphism and mutation databases

BioMutaiNOVA1.
DMDMi1709303.

Proteomic databases

EPDiP51513.
MaxQBiP51513.
PaxDbiP51513.
PeptideAtlasiP51513.
PRIDEiP51513.
TopDownProteomicsiP51513-2. [P51513-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344429; ENSP00000342387; ENSG00000139910. [P51513-2]
ENST00000465357; ENSP00000447391; ENSG00000139910. [P51513-5]
ENST00000539517; ENSP00000438875; ENSG00000139910. [P51513-4]
GeneIDi4857.
KEGGihsa:4857.
UCSCiuc001wpy.4. human. [P51513-1]

Organism-specific databases

CTDi4857.
DisGeNETi4857.
GeneCardsiNOVA1.
H-InvDBHIX0037755.
HGNCiHGNC:7886. NOVA1.
HPAiHPA004155.
MIMi602157. gene.
neXtProtiNX_P51513.
OpenTargetsiENSG00000139910.
PharmGKBiPA31688.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2191. Eukaryota.
ENOG410XRZD. LUCA.
GeneTreeiENSGT00760000119144.
HOGENOMiHOG000007833.
HOVERGENiHBG082048.
InParanoidiP51513.
KOiK14944.
OMAiISKKGMF.
OrthoDBiEOG091G185U.
PhylomeDBiP51513.
TreeFamiTF316981.

Miscellaneous databases

ChiTaRSiNOVA1. human.
EvolutionaryTraceiP51513.
GeneWikiiNOVA1.
GenomeRNAii4857.
PROiP51513.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139910.
CleanExiHS_NOVA1.
ExpressionAtlasiP51513. baseline and differential.
GenevisibleiP51513. HS.

Family and domain databases

Gene3Di3.30.1370.10. 3 hits.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR033086. NOVA1.
[Graphical view]
PANTHERiPTHR10288:SF150. PTHR10288:SF150. 3 hits.
PfamiPF00013. KH_1. 3 hits.
[Graphical view]
SMARTiSM00322. KH. 3 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 3 hits.
PROSITEiPS50084. KH_TYPE_1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNOVA1_HUMAN
AccessioniPrimary (citable) accession number: P51513
Secondary accession number(s): A8K0S4
, A8K4Q7, D3DS81, D3DS82, Q6B004
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.