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Protein

RNA-binding protein Nova-1

Gene

NOVA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May regulate RNA splicing or metabolism in a specific subset of developing neurons.

GO - Molecular functioni

  • mRNA binding Source: Ensembl
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: ProtInc

GO - Biological processi

  • locomotory behavior Source: ProtInc
  • mRNA splicing, via spliceosome Source: Ensembl
  • regulation of mRNA processing Source: Ensembl
  • RNA processing Source: ProtInc
  • RNA splicing Source: ProtInc
  • spinal cord development Source: Ensembl
  • synaptic transmission Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein Nova-1
Alternative name(s):
Neuro-oncological ventral antigen 1
Onconeural ventral antigen 1
Paraneoplastic Ri antigen
Ventral neuron-specific protein 1
Gene namesi
Name:NOVA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:7886. NOVA1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31688.

Polymorphism and mutation databases

BioMutaiNOVA1.
DMDMi1709303.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510RNA-binding protein Nova-1PRO_0000050116Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei157 – 1571PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP51513.
MaxQBiP51513.
PaxDbiP51513.
PeptideAtlasiP51513.
PRIDEiP51513.
TopDownProteomicsiP51513-2. [P51513-2]

PTM databases

iPTMnetiP51513.
PhosphoSiteiP51513.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiP51513.
CleanExiHS_NOVA1.
ExpressionAtlasiP51513. baseline and differential.
GenevisibleiP51513. HS.

Organism-specific databases

HPAiHPA004155.

Interactioni

Subunit structurei

Interacts with PTBP2; the interaction is direct.By similarity

Protein-protein interaction databases

BioGridi110919. 10 interactions.
IntActiP51513. 8 interactions.
MINTiMINT-1381951.
STRINGi9606.ENSP00000438875.

Structurei

Secondary structure

1
510
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi50 – 578Combined sources
Helixi58 – 658Combined sources
Helixi67 – 693Combined sources
Helixi70 – 7910Combined sources
Beta strandi82 – 854Combined sources
Beta strandi98 – 10710Combined sources
Helixi109 – 12315Combined sources
Helixi173 – 1753Combined sources
Beta strandi176 – 1827Combined sources
Helixi183 – 1908Combined sources
Helixi192 – 1943Combined sources
Helixi195 – 2039Combined sources
Beta strandi207 – 2104Combined sources
Beta strandi221 – 2299Combined sources
Helixi230 – 24516Combined sources
Beta strandi425 – 4328Combined sources
Turni433 – 4364Combined sources
Helixi437 – 4404Combined sources
Helixi442 – 4443Combined sources
Helixi445 – 45410Combined sources
Beta strandi457 – 4604Combined sources
Beta strandi472 – 4798Combined sources
Helixi481 – 49414Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DT4X-ray2.60A424-495[»]
2ANNX-ray2.30A49-249[»]
2ANRX-ray1.94A49-249[»]
ProteinModelPortaliP51513.
SMRiP51513. Positions 49-249, 424-495.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP51513.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 11971KH 1PROSITE-ProRule annotationAdd
BLAST
Domaini174 – 24067KH 2PROSITE-ProRule annotationAdd
BLAST
Domaini424 – 49168KH 3PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi27 – 4317Bipartite nuclear localization signalSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi276 – 412137Ala-richAdd
BLAST

Sequence similaritiesi

Contains 3 KH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2191. Eukaryota.
ENOG410XRZD. LUCA.
GeneTreeiENSGT00760000119144.
HOGENOMiHOG000007833.
HOVERGENiHBG082048.
InParanoidiP51513.
KOiK14944.
OMAiISKKGMF.
PhylomeDBiP51513.
TreeFamiTF316981.

Family and domain databases

Gene3Di3.30.1370.10. 3 hits.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR033086. NOVA1.
[Graphical view]
PANTHERiPTHR10288:SF150. PTHR10288:SF150. 3 hits.
PfamiPF00013. KH_1. 3 hits.
[Graphical view]
SMARTiSM00322. KH. 3 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 3 hits.
PROSITEiPS50084. KH_TYPE_1. 3 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P51513-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAAAPIQQN GTHTGVPIDL DPPDSRKRPL EAPPEAGSTK RTNTGEDGQY
60 70 80 90 100
FLKVLIPSYA AGSIIGKGGQ TIVQLQKETG ATIKLSKLSK SKDFYPGTTE
110 120 130 140 150
RVCLIQGTVE ALNAVHGFIA EKIREMPQNV AKTEPVSILQ PQTTVNPDRI
160 170 180 190 200
KQTLPSSPTT TKSSPSDPMT TSRANQVKII VPNSTAGLII GKGGATVKAV
210 220 230 240 250
MEQSGAWVQL SQKPDGINLQ ERVVTVSGEP EQNRKAVELI IQKIQEDPQS
260 270 280 290 300
GSCLNISYAN VTGPVANSNP TGSPYANTAE VLPTAAAAAG LLGHANLAGV
310 320 330 340 350
AAFPAVLSGF TGNDLVAITS ALNTLASYGY NLNTLGLGLS QAAATGALAA
360 370 380 390 400
AAASANPAAA AANLLATYAS EASASGSTAG GTAGTFALGS LAAATAATNG
410 420 430 440 450
YFGAASPLAA SAILGTEKST DGSKDVVEIA VPENLVGAIL GKGGKTLVEY
460 470 480 490 500
QELTGARIQI SKKGEFVPGT RNRKVTITGT PAATQAAQYL ITQRITYEQG
510
VRAANPQKVG
Length:510
Mass (Da):52,056
Last modified:October 1, 1996 - v1
Checksum:i7B9BA8B67CAB6984
GO
Isoform 2 (identifier: P51513-2) [UniParc]FASTAAdd to basket

Also known as: Tumor

The sequence of this isoform differs from the canonical sequence as follows:
     88-90: Missing.
     177-184: VKIIVPNS → KHNISWIS
     185-510: Missing.

Show »
Length:181
Mass (Da):19,491
Checksum:i23EF1C6F5541D52D
GO
Isoform 3 (identifier: P51513-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-176: Missing.

Show »
Length:486
Mass (Da):49,581
Checksum:i7F9A8331C469877E
GO
Isoform 4 (identifier: P51513-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-90: Missing.

Show »
Length:507
Mass (Da):51,727
Checksum:iDBF455477988CDCA
GO
Isoform 5 (identifier: P51513-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-90: Missing.
     153-176: Missing.

Note: Gene prediction based on EST data.
Show »
Length:483
Mass (Da):49,253
Checksum:iBE44FBED4E9664E2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei88 – 903Missing in isoform 2, isoform 4 and isoform 5. 3 PublicationsVSP_002841
Alternative sequencei153 – 17624Missing in isoform 3 and isoform 5. 1 PublicationVSP_002842Add
BLAST
Alternative sequencei177 – 1848VKIIVPNS → KHNISWIS in isoform 2. 2 PublicationsVSP_002843
Alternative sequencei185 – 510326Missing in isoform 2. 2 PublicationsVSP_002844Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04840 mRNA. Translation: AAA16022.1.
AK289639 mRNA. Translation: BAF82328.1.
AK291022 mRNA. Translation: BAF83711.1.
AL079343 Genomic DNA. No translation available.
AL132716 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65990.1.
CH471078 Genomic DNA. Translation: EAW65991.1.
CH471078 Genomic DNA. Translation: EAW65992.1.
CH471078 Genomic DNA. Translation: EAW65993.1.
CH471078 Genomic DNA. Translation: EAW65995.1.
BC075038 mRNA. Translation: AAH75038.1.
BC075039 mRNA. Translation: AAH75039.1.
Z70771 mRNA. Translation: CAA94810.1.
CCDSiCCDS32060.1. [P51513-5]
CCDS32061.1. [P51513-4]
CCDS9635.1. [P51513-2]
PIRiI38489.
RefSeqiNP_002506.2. NM_002515.2. [P51513-4]
NP_006480.2. NM_006489.2. [P51513-5]
NP_006482.1. NM_006491.2. [P51513-2]
UniGeneiHs.31588.

Genome annotation databases

EnsembliENST00000344429; ENSP00000342387; ENSG00000139910. [P51513-2]
ENST00000465357; ENSP00000447391; ENSG00000139910. [P51513-5]
ENST00000539517; ENSP00000438875; ENSG00000139910. [P51513-4]
GeneIDi4857.
KEGGihsa:4857.
UCSCiuc001wpy.4. human. [P51513-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04840 mRNA. Translation: AAA16022.1.
AK289639 mRNA. Translation: BAF82328.1.
AK291022 mRNA. Translation: BAF83711.1.
AL079343 Genomic DNA. No translation available.
AL132716 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65990.1.
CH471078 Genomic DNA. Translation: EAW65991.1.
CH471078 Genomic DNA. Translation: EAW65992.1.
CH471078 Genomic DNA. Translation: EAW65993.1.
CH471078 Genomic DNA. Translation: EAW65995.1.
BC075038 mRNA. Translation: AAH75038.1.
BC075039 mRNA. Translation: AAH75039.1.
Z70771 mRNA. Translation: CAA94810.1.
CCDSiCCDS32060.1. [P51513-5]
CCDS32061.1. [P51513-4]
CCDS9635.1. [P51513-2]
PIRiI38489.
RefSeqiNP_002506.2. NM_002515.2. [P51513-4]
NP_006480.2. NM_006489.2. [P51513-5]
NP_006482.1. NM_006491.2. [P51513-2]
UniGeneiHs.31588.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DT4X-ray2.60A424-495[»]
2ANNX-ray2.30A49-249[»]
2ANRX-ray1.94A49-249[»]
ProteinModelPortaliP51513.
SMRiP51513. Positions 49-249, 424-495.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110919. 10 interactions.
IntActiP51513. 8 interactions.
MINTiMINT-1381951.
STRINGi9606.ENSP00000438875.

PTM databases

iPTMnetiP51513.
PhosphoSiteiP51513.

Polymorphism and mutation databases

BioMutaiNOVA1.
DMDMi1709303.

Proteomic databases

EPDiP51513.
MaxQBiP51513.
PaxDbiP51513.
PeptideAtlasiP51513.
PRIDEiP51513.
TopDownProteomicsiP51513-2. [P51513-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344429; ENSP00000342387; ENSG00000139910. [P51513-2]
ENST00000465357; ENSP00000447391; ENSG00000139910. [P51513-5]
ENST00000539517; ENSP00000438875; ENSG00000139910. [P51513-4]
GeneIDi4857.
KEGGihsa:4857.
UCSCiuc001wpy.4. human. [P51513-1]

Organism-specific databases

CTDi4857.
GeneCardsiNOVA1.
H-InvDBHIX0037755.
HGNCiHGNC:7886. NOVA1.
HPAiHPA004155.
MIMi602157. gene.
neXtProtiNX_P51513.
PharmGKBiPA31688.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2191. Eukaryota.
ENOG410XRZD. LUCA.
GeneTreeiENSGT00760000119144.
HOGENOMiHOG000007833.
HOVERGENiHBG082048.
InParanoidiP51513.
KOiK14944.
OMAiISKKGMF.
PhylomeDBiP51513.
TreeFamiTF316981.

Miscellaneous databases

ChiTaRSiNOVA1. human.
EvolutionaryTraceiP51513.
GeneWikiiNOVA1.
GenomeRNAii4857.
PROiP51513.
SOURCEiSearch...

Gene expression databases

BgeeiP51513.
CleanExiHS_NOVA1.
ExpressionAtlasiP51513. baseline and differential.
GenevisibleiP51513. HS.

Family and domain databases

Gene3Di3.30.1370.10. 3 hits.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR033086. NOVA1.
[Graphical view]
PANTHERiPTHR10288:SF150. PTHR10288:SF150. 3 hits.
PfamiPF00013. KH_1. 3 hits.
[Graphical view]
SMARTiSM00322. KH. 3 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 3 hits.
PROSITEiPS50084. KH_TYPE_1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system."
    Buckanovich R.J., Posner J.B., Darnell R.B.
    Neuron 11:657-672(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Cerebellum and Hippocampus.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
    Tissue: Amygdala.
  3. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Brain.
  6. Dmitrenko V.V., Garifulin O.M., Shostak K.A., Smikodub A.I., Kavsan V.M.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-34.
    Tissue: Fetal brain.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains."
    Lewis H.A., Chen H., Edo C., Buckanovich R.J., Yang Y.Y.-L., Musunuru K., Zhong R., Darnell R.B., Burley S.K.
    Structure 7:191-203(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 423-495.

Entry informationi

Entry nameiNOVA1_HUMAN
AccessioniPrimary (citable) accession number: P51513
Secondary accession number(s): A8K0S4
, A8K4Q7, D3DS81, D3DS82, Q6B004
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 6, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.