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Protein

Zinc finger protein 81

Gene

ZNF81

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri330 – 352C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri526 – 548C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 576C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri582 – 604C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri610 – 632C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri638 – 660C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 81
Alternative name(s):
HFZ20
Gene namesi
Name:ZNF81
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000197779.13.
HGNCiHGNC:13156. ZNF81.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving ZNF81 is found in a severe mental retardation patient. Translocation t(X;9)(p11.23;q34.3).1 Publication

Organism-specific databases

DisGeNETi347344.
MalaCardsiZNF81.
OpenTargetsiENSG00000197779.
Orphaneti777. X-linked non-syndromic intellectual disability.
PharmGKBiPA37730.

Polymorphism and mutation databases

BioMutaiZNF81.
DMDMi55977803.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473951 – 661Zinc finger protein 81Add BLAST661

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP51508.
PaxDbiP51508.
PeptideAtlasiP51508.
PRIDEiP51508.

PTM databases

iPTMnetiP51508.
PhosphoSitePlusiP51508.

Expressioni

Gene expression databases

BgeeiENSG00000197779.
CleanExiHS_ZNF81.
ExpressionAtlasiP51508. baseline and differential.
GenevisibleiP51508. HS.

Organism-specific databases

HPAiHPA001689.

Interactioni

Protein-protein interaction databases

BioGridi131424. 1 interactor.
STRINGi9606.ENSP00000341151.

Structurei

3D structure databases

ProteinModelPortaliP51508.
SMRiP51508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 92KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri330 – 352C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri526 – 548C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 576C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri582 – 604C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri610 – 632C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri638 – 660C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00880000137993.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP51508.
KOiK09228.
OMAiKILNTEW.
OrthoDBiEOG091G02KC.
PhylomeDBiP51508.
TreeFamiTF350810.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 4 hits.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 8 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.

Sequencei

Sequence statusi: Complete.

P51508-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPANEDAPQP GEHGSACEVS VSFEDVTVDF SREEWQQLDS TQRRLYQDVM
60 70 80 90 100
LENYSHLLSV GFEVPKPEVI FKLEQGEGPW TLEGEAPHQS CSDGKFGIKP
110 120 130 140 150
SQRRISGKST FHSEMEGEDT RDDSLYSILE ELWQDAEQIK RCQEKHNKLL
160 170 180 190 200
SRTTFLNKKI LNTEWDYEYK DFGKFVHPSP NLILSQKRPH KRDSFGKSFK
210 220 230 240 250
HNLDLHIHNK SNAAKNLDKT IGHGQVFTQN SSYSHHENTH TGVKFCERNQ
260 270 280 290 300
CGKVLSLKHS LSQNVKFPIG EKANTCTEFG KIFTQRSHFF APQKIHTVEK
310 320 330 340 350
PHELSKCVNV FTQKPLLSIY LRVHRDEKLY ICTKCGKAFI QNSELIMHEK
360 370 380 390 400
THTREKPYKC NECGKSFFQV SSLLRHQTTH TGEKLFECSE CGKGFSLNSA
410 420 430 440 450
LNIHQKIHTG ERHHKCSECG KAFTQKSTLR MHQRIHTGER SYICTQCGQA
460 470 480 490 500
FIQKAHLIAH QRIHTGEKPY ECSDCGKSFP SKSQLQMHKR IHTGEKPYIC
510 520 530 540 550
TECGKAFTNR SNLNTHQKSH TGEKSYICAE CGKAFTDRSN FNKHQTIHTG
560 570 580 590 600
EKPYVCADCG RAFIQKSELI THQRIHTTEK PYKCPDCEKS FSKKPHLKVH
610 620 630 640 650
QRIHTGEKPY ICAECGKAFT DRSNFNKHQT IHTGDKPYKC SDCGKGFTQK
660
SVLSMHRNIH T
Length:661
Mass (Da):75,960
Last modified:November 23, 2004 - v3
Checksum:i6583905D2DB96975
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0199393A → V1 PublicationCorresponds to variant dbSNP:rs183846665Ensembl.1
Natural variantiVAR_038806117G → V. Corresponds to variant dbSNP:rs17147793Ensembl.1
Natural variantiVAR_019940157N → S1 PublicationCorresponds to variant dbSNP:rs41312157Ensembl.1
Natural variantiVAR_019941179S → N Found in a family with mental retardation; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs28933691Ensembl.1
Natural variantiVAR_019942185S → L1 PublicationCorresponds to variant dbSNP:rs186251256Ensembl.1
Natural variantiVAR_052765213A → E. Corresponds to variant dbSNP:rs537825Ensembl.1
Natural variantiVAR_019943499I → V1 PublicationCorresponds to variant dbSNP:rs182239885Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY487248 mRNA. Translation: AAS17752.1.
AL591394 Genomic DNA. No translation available.
AL022578 Genomic DNA. No translation available.
Z98304 Genomic DNA. No translation available.
X68011 Genomic DNA. Translation: CAA48148.1.
CCDSiCCDS43933.1.
PIRiS60520.
RefSeqiNP_009068.2. NM_007137.3.
XP_005272657.1. XM_005272600.3.
XP_011542201.1. XM_011543899.2.
XP_011542202.1. XM_011543900.2.
XP_016884975.1. XM_017029486.1.
XP_016884976.1. XM_017029487.1.
UniGeneiHs.114246.
Hs.710432.

Genome annotation databases

EnsembliENST00000338637; ENSP00000341151; ENSG00000197779.
ENST00000376954; ENSP00000366153; ENSG00000197779.
GeneIDi347344.
KEGGihsa:347344.
UCSCiuc010nhy.3. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZNF81_HUMAN
AccessioniPrimary (citable) accession number: P51508
Secondary accession number(s): Q6RX22, Q96QH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 23, 2004
Last modified: November 22, 2017
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families