Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 80

Gene

ZNF80

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri49 – 7123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri77 – 9923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri105 – 12723C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri133 – 15523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri161 – 18323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri189 – 21123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri217 – 23923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 80
Alternative name(s):
ZNFpT17
Gene namesi
Name:ZNF80
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:13155. ZNF80.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37729.

Polymorphism and mutation databases

BioMutaiZNF80.
DMDMi206729946.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Zinc finger protein 80PRO_0000047391Add
BLAST

Proteomic databases

PaxDbiP51504.
PRIDEiP51504.

PTM databases

PhosphoSiteiP51504.

Expressioni

Gene expression databases

BgeeiP51504.
CleanExiHS_ZNF80.
GenevisibleiP51504. HS.

Organism-specific databases

HPAiHPA065484.

Interactioni

Protein-protein interaction databases

BioGridi113452. 1 interaction.
STRINGi9606.ENSP00000309812.

Structurei

3D structure databases

ProteinModelPortaliP51504.
SMRiP51504. Positions 47-270.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri49 – 7123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri77 – 9923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri105 – 12723C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri133 – 15523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri161 – 18323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri189 – 21123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri217 – 23923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00750000117699.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP51504.
OMAiSVFFRHS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP51504.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51504-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPKRDGLGT GDGLHSQVLQ EQVSTGDNLH ECDSQGPSKD TLVREGKTYK
60 70 80 90 100
CKECGSVFNK NSLLVRHQQI HTGVKPYECQ ECGKAFPEKV DFVRPMRIHT
110 120 130 140 150
GEKPCKCVEC GKVFNRRSHL LCYRQIHTGE KPYECSECGK TFSYHSVFIQ
160 170 180 190 200
HRVTHTGEKL FGCKECGKTF YYNSSLTRHM KIHTGEKPCK CSECGKTFTY
210 220 230 240 250
RSVFFRHSMT HTAGKPYECK ECGKGFYYSY SLTRHTRSHT GEKPYECLEH
260 270
RKDFGYHSAF AQQSKIHSGG KNL
Length:273
Mass (Da):31,224
Last modified:September 23, 2008 - v2
Checksum:i16A1CA82DCE2F579
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951P → H in CAA46340 (PubMed:8478004).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti201 – 2011R → H.
Corresponds to variant rs6438191 [ dbSNP | Ensembl ].
VAR_046561
Natural varianti253 – 2531D → A.
Corresponds to variant rs3732782 [ dbSNP | Ensembl ].
VAR_019972

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65233 mRNA. Translation: CAA46340.1.
CH471052 Genomic DNA. Translation: EAW79603.1.
BC069606 mRNA. Translation: AAH69606.2.
BC069826 mRNA. Translation: AAH69826.2.
BC129925 mRNA. Translation: AAI29926.1.
CCDSiCCDS2979.1.
RefSeqiNP_009067.2. NM_007136.3.
UniGeneiHs.271079.
Hs.724900.

Genome annotation databases

EnsembliENST00000308095; ENSP00000309812; ENSG00000174255.
ENST00000482457; ENSP00000417192; ENSG00000174255.
ENST00000619534; ENSP00000483565; ENSG00000174255.
GeneIDi7634.
KEGGihsa:7634.
UCSCiuc010hqo.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65233 mRNA. Translation: CAA46340.1.
CH471052 Genomic DNA. Translation: EAW79603.1.
BC069606 mRNA. Translation: AAH69606.2.
BC069826 mRNA. Translation: AAH69826.2.
BC129925 mRNA. Translation: AAI29926.1.
CCDSiCCDS2979.1.
RefSeqiNP_009067.2. NM_007136.3.
UniGeneiHs.271079.
Hs.724900.

3D structure databases

ProteinModelPortaliP51504.
SMRiP51504. Positions 47-270.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113452. 1 interaction.
STRINGi9606.ENSP00000309812.

PTM databases

PhosphoSiteiP51504.

Polymorphism and mutation databases

BioMutaiZNF80.
DMDMi206729946.

Proteomic databases

PaxDbiP51504.
PRIDEiP51504.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308095; ENSP00000309812; ENSG00000174255.
ENST00000482457; ENSP00000417192; ENSG00000174255.
ENST00000619534; ENSP00000483565; ENSG00000174255.
GeneIDi7634.
KEGGihsa:7634.
UCSCiuc010hqo.5. human.

Organism-specific databases

CTDi7634.
GeneCardsiZNF80.
HGNCiHGNC:13155. ZNF80.
HPAiHPA065484.
MIMi194553. gene.
neXtProtiNX_P51504.
PharmGKBiPA37729.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00750000117699.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP51504.
OMAiSVFFRHS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP51504.
TreeFamiTF337055.

Miscellaneous databases

GenomeRNAii7634.
NextBioi29740.
PROiP51504.
SOURCEiSearch...

Gene expression databases

BgeeiP51504.
CleanExiHS_ZNF80.
GenevisibleiP51504. HS.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization and genomic mapping of the ZNF80 locus: expression of this zinc-finger gene is driven by a solitary LTR of ERV9 endogenous retroviral family."
    di Cristofano A., Strazzullo M., Longo L., la Mantia G.
    Nucleic Acids Res. 23:2823-2830(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiZNF80_HUMAN
AccessioniPrimary (citable) accession number: P51504
Secondary accession number(s): Q6NSW4, Q6NT14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 23, 2008
Last modified: March 16, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.