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Protein

Zinc finger protein 80

Gene

ZNF80

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri49 – 71C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri77 – 99C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri105 – 127C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri133 – 155C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri161 – 183C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri189 – 211C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri217 – 239C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174255-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 80
Alternative name(s):
ZNFpT17
Gene namesi
Name:ZNF80
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:13155. ZNF80.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7634.
OpenTargetsiENSG00000174255.
PharmGKBiPA37729.

Polymorphism and mutation databases

BioMutaiZNF80.
DMDMi206729946.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473911 – 273Zinc finger protein 80Add BLAST273

Proteomic databases

MaxQBiP51504.
PaxDbiP51504.
PeptideAtlasiP51504.
PRIDEiP51504.

PTM databases

iPTMnetiP51504.
PhosphoSitePlusiP51504.

Expressioni

Gene expression databases

BgeeiENSG00000174255.
CleanExiHS_ZNF80.
GenevisibleiP51504. HS.

Organism-specific databases

HPAiHPA065484.

Interactioni

Protein-protein interaction databases

BioGridi113452. 1 interactor.
IntActiP51504. 5 interactors.
STRINGi9606.ENSP00000309812.

Structurei

3D structure databases

ProteinModelPortaliP51504.
SMRiP51504.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri49 – 71C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri77 – 99C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri105 – 127C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri133 – 155C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri161 – 183C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri189 – 211C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri217 – 239C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00750000117699.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP51504.
OMAiSVFFRHS.
OrthoDBiEOG091G02KC.
PhylomeDBiP51504.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51504-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPKRDGLGT GDGLHSQVLQ EQVSTGDNLH ECDSQGPSKD TLVREGKTYK
60 70 80 90 100
CKECGSVFNK NSLLVRHQQI HTGVKPYECQ ECGKAFPEKV DFVRPMRIHT
110 120 130 140 150
GEKPCKCVEC GKVFNRRSHL LCYRQIHTGE KPYECSECGK TFSYHSVFIQ
160 170 180 190 200
HRVTHTGEKL FGCKECGKTF YYNSSLTRHM KIHTGEKPCK CSECGKTFTY
210 220 230 240 250
RSVFFRHSMT HTAGKPYECK ECGKGFYYSY SLTRHTRSHT GEKPYECLEH
260 270
RKDFGYHSAF AQQSKIHSGG KNL
Length:273
Mass (Da):31,224
Last modified:September 23, 2008 - v2
Checksum:i16A1CA82DCE2F579
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95P → H in CAA46340 (PubMed:8478004).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046561201R → H.Corresponds to variant rs6438191dbSNPEnsembl.1
Natural variantiVAR_019972253D → A.Corresponds to variant rs3732782dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65233 mRNA. Translation: CAA46340.1.
CH471052 Genomic DNA. Translation: EAW79603.1.
BC069606 mRNA. Translation: AAH69606.2.
BC069826 mRNA. Translation: AAH69826.2.
BC129925 mRNA. Translation: AAI29926.1.
CCDSiCCDS2979.1.
RefSeqiNP_009067.2. NM_007136.3.
XP_016862621.1. XM_017007132.1.
XP_016862622.1. XM_017007133.1.
XP_016862623.1. XM_017007134.1.
XP_016862624.1. XM_017007135.1.
XP_016862625.1. XM_017007136.1.
UniGeneiHs.271079.
Hs.724900.

Genome annotation databases

EnsembliENST00000308095; ENSP00000309812; ENSG00000174255.
ENST00000482457; ENSP00000417192; ENSG00000174255.
ENST00000619534; ENSP00000483565; ENSG00000174255.
GeneIDi7634.
KEGGihsa:7634.
UCSCiuc010hqo.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65233 mRNA. Translation: CAA46340.1.
CH471052 Genomic DNA. Translation: EAW79603.1.
BC069606 mRNA. Translation: AAH69606.2.
BC069826 mRNA. Translation: AAH69826.2.
BC129925 mRNA. Translation: AAI29926.1.
CCDSiCCDS2979.1.
RefSeqiNP_009067.2. NM_007136.3.
XP_016862621.1. XM_017007132.1.
XP_016862622.1. XM_017007133.1.
XP_016862623.1. XM_017007134.1.
XP_016862624.1. XM_017007135.1.
XP_016862625.1. XM_017007136.1.
UniGeneiHs.271079.
Hs.724900.

3D structure databases

ProteinModelPortaliP51504.
SMRiP51504.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113452. 1 interactor.
IntActiP51504. 5 interactors.
STRINGi9606.ENSP00000309812.

PTM databases

iPTMnetiP51504.
PhosphoSitePlusiP51504.

Polymorphism and mutation databases

BioMutaiZNF80.
DMDMi206729946.

Proteomic databases

MaxQBiP51504.
PaxDbiP51504.
PeptideAtlasiP51504.
PRIDEiP51504.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308095; ENSP00000309812; ENSG00000174255.
ENST00000482457; ENSP00000417192; ENSG00000174255.
ENST00000619534; ENSP00000483565; ENSG00000174255.
GeneIDi7634.
KEGGihsa:7634.
UCSCiuc010hqo.5. human.

Organism-specific databases

CTDi7634.
DisGeNETi7634.
GeneCardsiZNF80.
HGNCiHGNC:13155. ZNF80.
HPAiHPA065484.
MIMi194553. gene.
neXtProtiNX_P51504.
OpenTargetsiENSG00000174255.
PharmGKBiPA37729.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00750000117699.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP51504.
OMAiSVFFRHS.
OrthoDBiEOG091G02KC.
PhylomeDBiP51504.
TreeFamiTF337055.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174255-MONOMER.

Miscellaneous databases

GenomeRNAii7634.
PROiP51504.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174255.
CleanExiHS_ZNF80.
GenevisibleiP51504. HS.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF80_HUMAN
AccessioniPrimary (citable) accession number: P51504
Secondary accession number(s): Q6NSW4, Q6NT14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 23, 2008
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.