Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-10

Gene

IL10

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10
Short name:
IL-10
Alternative name(s):
Cytokine synthesis inhibitory factor
Short name:
CSIF
Gene namesi
Name:IL10
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 178160Interleukin-10PRO_0000015363Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 126By similarity
Disulfide bondi80 ↔ 132By similarity
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Gene expression databases

BgeeiENSMMUG00000023569.
ExpressionAtlasiP51496. baseline.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000031022.

Structurei

3D structure databases

ProteinModelPortaliP51496.
SMRiP51496. Positions 24-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYFW. Eukaryota.
ENOG4111PXC. LUCA.
HOGENOMiHOG000072692.
HOVERGENiHBG004110.
InParanoidiP51496.
KOiK05443.
OMAiPHMLREL.
OrthoDBiEOG091G0Y3M.
TreeFamiTF333253.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000098. IL-10.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01294. INTRLEUKIN10.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51496-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSSALLCCL VLLTGVRASP GQGTQSENSC TRFPGNLPHM LRDLRDAFSR
60 70 80 90 100
VKTFFQMKDQ LDNILLKESL LEDFKGYLGC QALSEMIQFY LEEVMPQAEN
110 120 130 140 150
HDPDIKEHVN SLGENLKTLR LRLRRCHRFL PCENKSKAVE QVKNAFSKLQ
160 170
EKGVYKAMSE FDIFINYIEA YMTMKIQN
Length:178
Mass (Da):20,557
Last modified:October 1, 1996 - v1
Checksum:i35CC0D98B3B8A718
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26029 mRNA. Translation: AAA99975.1.
RefSeqiNP_001038192.1. NM_001044727.1.
UniGeneiMmu.3374.

Genome annotation databases

EnsembliENSMMUT00000033151; ENSMMUP00000031022; ENSMMUG00000023569.
GeneIDi694931.
KEGGimcc:694931.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26029 mRNA. Translation: AAA99975.1.
RefSeqiNP_001038192.1. NM_001044727.1.
UniGeneiMmu.3374.

3D structure databases

ProteinModelPortaliP51496.
SMRiP51496. Positions 24-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000031022.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000033151; ENSMMUP00000031022; ENSMMUG00000023569.
GeneIDi694931.
KEGGimcc:694931.

Organism-specific databases

CTDi3586.

Phylogenomic databases

eggNOGiENOG410IYFW. Eukaryota.
ENOG4111PXC. LUCA.
HOGENOMiHOG000072692.
HOVERGENiHBG004110.
InParanoidiP51496.
KOiK05443.
OMAiPHMLREL.
OrthoDBiEOG091G0Y3M.
TreeFamiTF333253.

Gene expression databases

BgeeiENSMMUG00000023569.
ExpressionAtlasiP51496. baseline.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000098. IL-10.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01294. INTRLEUKIN10.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL10_MACMU
AccessioniPrimary (citable) accession number: P51496
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.