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Protein

Interleukin-1 beta

Gene

IL1B

Organism
Macaca nemestrina (Pig-tailed macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.By similarity

Miscellaneous

IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Mitogen, Pyrogen
Biological processInflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 beta
Short name:
IL-1 beta
Gene namesi
Name:IL1B
OrganismiMacaca nemestrina (Pig-tailed macaque)
Taxonomic identifieri9545 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000153091 – 116By similarityAdd BLAST116
ChainiPRO_0000015310117 – 269Interleukin-1 betaAdd BLAST153

Interactioni

Subunit structurei

Monomer. Interacts with MEFV (By similarity).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP51493.
SMRiP51493.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

HOVERGENiHBG007328.
OrthoDBiEOG091G0GR9.

Family and domain databases

InterProiView protein in InterPro
IPR003296. IL-1_beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
IPR008996. IL1/FGF.
PANTHERiPTHR10078:SF42. PTHR10078:SF42. 1 hit.
PfamiView protein in Pfam
PF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
PRINTSiPR00264. INTERLEUKIN1.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiView protein in PROSITE
PS00253. INTERLEUKIN_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51493-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVPELASE MMAYYSGNED DLFFEVDGPK QMKCSFQDLD LCPLDGGIQL
60 70 80 90 100
QISHEHYNKG FRQAVSVVVA MEKLRKMLVP CPQIFQDNDL STLIPFIFEE
110 120 130 140 150
EPVFLDTRNN DACVHDAPVR SLHCTLRDAQ LKSLVMSGPY ELKALHLQGQ
160 170 180 190 200
DLEQQVVFFM SFVQGEESND KIPVALGLKA KNLYLSCVLK DDKPTLQLES
210 220 230 240 250
VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST SQAENMPVFL
260
GGTRGGQDIT DFTMQFVSS
Length:269
Mass (Da):30,612
Last modified:October 1, 1996 - v1
Checksum:i4E7E9E223EAD3B61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19853 mRNA. Translation: AAA86715.1.
RefSeqiNP_001292822.1. NM_001305893.1.

Genome annotation databases

GeneIDi105471787.

Similar proteinsi

Entry informationi

Entry nameiIL1B_MACNE
AccessioniPrimary (citable) accession number: P51493
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: August 30, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families