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P51491

- OPSB_MOUSE

UniProt

P51491 - OPSB_MOUSE

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Protein

Short-wave-sensitive opsin 1

Gene

Opn1sw

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light.1 Publication

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. photoreceptor activity Source: UniProtKB-KW

GO - Biological processi

  1. phototransduction Source: UniProtKB-KW
  2. protein-chromophore linkage Source: UniProtKB-KW
  3. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

Chromophore

Enzyme and pathway databases

ReactomeiREACT_196615. Retinoid cycle disease events.
REACT_196617. The retinoid cycle in cones (daylight vision).
REACT_245980. Opsins.
REACT_250376. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Short-wave-sensitive opsin 1
Short name:
S opsin
Alternative name(s):
Blue cone photoreceptor pigment
Blue-sensitive opsin
Short name:
BOP
Short wavelength-sensitive cone opsin
Gene namesi
Name:Opn1sw
Synonyms:Bcp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:99438. Opn1sw.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularAdd
BLAST
Transmembranei32 – 5625Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini57 – 6812CytoplasmicAdd
BLAST
Transmembranei69 – 9426Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini95 – 10814ExtracellularAdd
BLAST
Transmembranei109 – 12820Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini129 – 14719CytoplasmicAdd
BLAST
Transmembranei148 – 17124Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini172 – 19726ExtracellularAdd
BLAST
Transmembranei198 – 22528Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini226 – 24722CytoplasmicAdd
BLAST
Transmembranei248 – 27124Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini272 – 2798Extracellular
Transmembranei280 – 30425Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini305 – 34642CytoplasmicAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. photoreceptor outer segment Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Short-wave-sensitive opsin 1PRO_0000197766Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi12 – 121N-linked (GlcNAc...)Curated
Disulfide bondi105 ↔ 182PROSITE-ProRule annotation
Modified residuei291 – 2911N6-(retinylidene)lysine

Post-translational modificationi

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP51491.

Expressioni

Tissue specificityi

Expressed in cone photoreceptor cells.1 Publication

Gene expression databases

BgeeiP51491.
ExpressionAtlasiP51491. differential.
GenevestigatoriP51491.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079289.

Structurei

3D structure databases

ProteinModelPortaliP51491.
SMRiP51491. Positions 6-317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237118.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000253932.
HOVERGENiHBG107442.
InParanoidiP51491.
KOiK04252.
OMAiYAALAMY.
OrthoDBiEOG72NRQJ.
PhylomeDBiP51491.
TreeFamiTF324998.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR001521. Opsin_blue.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PR00574. OPSINBLUE.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51491-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGEDDFYLF QNISSVGPWD GPQYHLAPVW AFRLQAAFMG FVFFVGTPLN
60 70 80 90 100
AIVLVATLHY KKLRQPLNYI LVNVSLGGFL FCIFSVFTVF IASCHGYFLF
110 120 130 140 150
GRHVCALEAF LGSVAGLVTG WSLAFLAFER YVVICKPFGS IRFNSKHALM
160 170 180 190 200
VVLATWIIGI GVSIPPFFGW SRFIPEGLQC SCGPDWYTVG TKYRSEYYTW
210 220 230 240 250
FLFIFCFIIP LSLICFSYSQ LLRTLRAVAA QQQESATTQK AEREVSHMVV
260 270 280 290 300
VMVGSFCLCY VPYAALAMYM VNNRNHGLDL RLVTIPAFFS KSSCVYNPII
310 320 330 340
YCFMNKQFRA CILEMVCRKP MADESDVSGS QKTEVSTVSS SKVGPH
Length:346
Mass (Da):38,922
Last modified:October 1, 1996 - v1
Checksum:i8BEEAB0198EE6863
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49720 mRNA. Translation: AAA92458.1.
U92562
, U92558, U92559, U92560, U92561 Genomic DNA. Translation: AAB53320.1.
AF190670 mRNA. Translation: AAG17989.1.
AF190671 Genomic DNA. Translation: AAG17990.1.
BC026021 mRNA. Translation: AAH26021.1.
BC058267 mRNA. Translation: AAH58267.1.
CCDSiCCDS19959.1.
PIRiB54679.
RefSeqiNP_031564.1. NM_007538.3.
UniGeneiMm.56987.

Genome annotation databases

EnsembliENSMUST00000080428; ENSMUSP00000079289; ENSMUSG00000058831.
GeneIDi12057.
KEGGimmu:12057.
UCSCiuc009bdi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49720 mRNA. Translation: AAA92458.1 .
U92562
, U92558 , U92559 , U92560 , U92561 Genomic DNA. Translation: AAB53320.1 .
AF190670 mRNA. Translation: AAG17989.1 .
AF190671 Genomic DNA. Translation: AAG17990.1 .
BC026021 mRNA. Translation: AAH26021.1 .
BC058267 mRNA. Translation: AAH58267.1 .
CCDSi CCDS19959.1.
PIRi B54679.
RefSeqi NP_031564.1. NM_007538.3.
UniGenei Mm.56987.

3D structure databases

ProteinModelPortali P51491.
SMRi P51491. Positions 6-317.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000079289.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi P51491.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000080428 ; ENSMUSP00000079289 ; ENSMUSG00000058831 .
GeneIDi 12057.
KEGGi mmu:12057.
UCSCi uc009bdi.2. mouse.

Organism-specific databases

CTDi 611.
MGIi MGI:99438. Opn1sw.

Phylogenomic databases

eggNOGi NOG237118.
GeneTreei ENSGT00760000118977.
HOGENOMi HOG000253932.
HOVERGENi HBG107442.
InParanoidi P51491.
KOi K04252.
OMAi YAALAMY.
OrthoDBi EOG72NRQJ.
PhylomeDBi P51491.
TreeFami TF324998.

Enzyme and pathway databases

Reactomei REACT_196615. Retinoid cycle disease events.
REACT_196617. The retinoid cycle in cones (daylight vision).
REACT_245980. Opsins.
REACT_250376. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSi Opn1sw. mouse.
NextBioi 280363.
PROi P51491.
SOURCEi Search...

Gene expression databases

Bgeei P51491.
ExpressionAtlasi P51491. differential.
Genevestigatori P51491.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR001521. Opsin_blue.
IPR027430. Retinal_BS.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PR00574. OPSINBLUE.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine and bovine blue cone pigment genes: cloning and characterization of two new members of the S family of visual pigments."
    Chiu M.I., Zack D.J., Wang Y., Nathans J.
    Genomics 21:440-443(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Retina.
  2. "The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning."
    Applebury M.L., Antoch M.P., Baxter L.C., Chun L.Y., Falk J.D., Farhangfar F., Kage K., Krzystolik M.G., Lyass L.A., Robbins J.T.
    Neuron 27:513-523(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: BALB/c and C57BL/10.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Retina.

Entry informationi

Entry nameiOPSB_MOUSE
AccessioniPrimary (citable) accession number: P51491
Secondary accession number(s): Q548Z8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3