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P51491

- OPSB_MOUSE

UniProt

P51491 - OPSB_MOUSE

Protein

Short-wave-sensitive opsin 1

Gene

Opn1sw

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light.1 Publication

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. photoreceptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. phototransduction Source: UniProtKB-KW
    2. protein-chromophore linkage Source: UniProtKB-KW
    3. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

    Keywords - Biological processi

    Sensory transduction, Vision

    Keywords - Ligandi

    Chromophore

    Enzyme and pathway databases

    ReactomeiREACT_196615. Retinoid cycle disease events.
    REACT_196617. The retinoid cycle in cones (daylight vision).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Short-wave-sensitive opsin 1
    Short name:
    S opsin
    Alternative name(s):
    Blue cone photoreceptor pigment
    Blue-sensitive opsin
    Short name:
    BOP
    Short wavelength-sensitive cone opsin
    Gene namesi
    Name:Opn1sw
    Synonyms:Bcp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:99438. Opn1sw.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. photoreceptor outer segment Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Short-wave-sensitive opsin 1PRO_0000197766Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi12 – 121N-linked (GlcNAc...)Curated
    Disulfide bondi105 ↔ 182PROSITE-ProRule annotation
    Modified residuei291 – 2911N6-(retinylidene)lysine

    Post-translational modificationi

    Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiP51491.

    Expressioni

    Tissue specificityi

    Expressed in cone photoreceptor cells.1 Publication

    Gene expression databases

    BgeeiP51491.
    GenevestigatoriP51491.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000079289.

    Structurei

    3D structure databases

    ProteinModelPortaliP51491.
    SMRiP51491. Positions 6-317.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3131ExtracellularAdd
    BLAST
    Topological domaini57 – 6812CytoplasmicAdd
    BLAST
    Topological domaini95 – 10814ExtracellularAdd
    BLAST
    Topological domaini129 – 14719CytoplasmicAdd
    BLAST
    Topological domaini172 – 19726ExtracellularAdd
    BLAST
    Topological domaini226 – 24722CytoplasmicAdd
    BLAST
    Topological domaini272 – 2798Extracellular
    Topological domaini305 – 34642CytoplasmicAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5625Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei69 – 9426Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei109 – 12820Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei148 – 17124Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 22528Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei248 – 27124Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei280 – 30425Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG237118.
    GeneTreeiENSGT00710000106574.
    HOGENOMiHOG000253932.
    HOVERGENiHBG107442.
    InParanoidiP51491.
    KOiK04252.
    OMAiYAALAMY.
    OrthoDBiEOG72NRQJ.
    PhylomeDBiP51491.
    TreeFamiTF324998.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001760. Opsin.
    IPR001521. Opsin_blue.
    IPR027430. Retinal_BS.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00238. OPSIN.
    PR00574. OPSINBLUE.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS00238. OPSIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51491-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGEDDFYLF QNISSVGPWD GPQYHLAPVW AFRLQAAFMG FVFFVGTPLN    50
    AIVLVATLHY KKLRQPLNYI LVNVSLGGFL FCIFSVFTVF IASCHGYFLF 100
    GRHVCALEAF LGSVAGLVTG WSLAFLAFER YVVICKPFGS IRFNSKHALM 150
    VVLATWIIGI GVSIPPFFGW SRFIPEGLQC SCGPDWYTVG TKYRSEYYTW 200
    FLFIFCFIIP LSLICFSYSQ LLRTLRAVAA QQQESATTQK AEREVSHMVV 250
    VMVGSFCLCY VPYAALAMYM VNNRNHGLDL RLVTIPAFFS KSSCVYNPII 300
    YCFMNKQFRA CILEMVCRKP MADESDVSGS QKTEVSTVSS SKVGPH 346
    Length:346
    Mass (Da):38,922
    Last modified:October 1, 1996 - v1
    Checksum:i8BEEAB0198EE6863
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49720 mRNA. Translation: AAA92458.1.
    U92562
    , U92558, U92559, U92560, U92561 Genomic DNA. Translation: AAB53320.1.
    AF190670 mRNA. Translation: AAG17989.1.
    AF190671 Genomic DNA. Translation: AAG17990.1.
    BC026021 mRNA. Translation: AAH26021.1.
    BC058267 mRNA. Translation: AAH58267.1.
    CCDSiCCDS19959.1.
    PIRiB54679.
    RefSeqiNP_031564.1. NM_007538.3.
    UniGeneiMm.56987.

    Genome annotation databases

    EnsembliENSMUST00000080428; ENSMUSP00000079289; ENSMUSG00000058831.
    GeneIDi12057.
    KEGGimmu:12057.
    UCSCiuc009bdi.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49720 mRNA. Translation: AAA92458.1 .
    U92562
    , U92558 , U92559 , U92560 , U92561 Genomic DNA. Translation: AAB53320.1 .
    AF190670 mRNA. Translation: AAG17989.1 .
    AF190671 Genomic DNA. Translation: AAG17990.1 .
    BC026021 mRNA. Translation: AAH26021.1 .
    BC058267 mRNA. Translation: AAH58267.1 .
    CCDSi CCDS19959.1.
    PIRi B54679.
    RefSeqi NP_031564.1. NM_007538.3.
    UniGenei Mm.56987.

    3D structure databases

    ProteinModelPortali P51491.
    SMRi P51491. Positions 6-317.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000079289.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi P51491.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000080428 ; ENSMUSP00000079289 ; ENSMUSG00000058831 .
    GeneIDi 12057.
    KEGGi mmu:12057.
    UCSCi uc009bdi.2. mouse.

    Organism-specific databases

    CTDi 611.
    MGIi MGI:99438. Opn1sw.

    Phylogenomic databases

    eggNOGi NOG237118.
    GeneTreei ENSGT00710000106574.
    HOGENOMi HOG000253932.
    HOVERGENi HBG107442.
    InParanoidi P51491.
    KOi K04252.
    OMAi YAALAMY.
    OrthoDBi EOG72NRQJ.
    PhylomeDBi P51491.
    TreeFami TF324998.

    Enzyme and pathway databases

    Reactomei REACT_196615. Retinoid cycle disease events.
    REACT_196617. The retinoid cycle in cones (daylight vision).

    Miscellaneous databases

    ChiTaRSi OPN1SW. mouse.
    NextBioi 280363.
    PROi P51491.
    SOURCEi Search...

    Gene expression databases

    Bgeei P51491.
    Genevestigatori P51491.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001760. Opsin.
    IPR001521. Opsin_blue.
    IPR027430. Retinal_BS.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00238. OPSIN.
    PR00574. OPSINBLUE.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS00238. OPSIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine and bovine blue cone pigment genes: cloning and characterization of two new members of the S family of visual pigments."
      Chiu M.I., Zack D.J., Wang Y., Nathans J.
      Genomics 21:440-443(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Retina.
    2. "The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning."
      Applebury M.L., Antoch M.P., Baxter L.C., Chun L.Y., Falk J.D., Farhangfar F., Kage K., Krzystolik M.G., Lyass L.A., Robbins J.T.
      Neuron 27:513-523(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: BALB/c and C57BL/10.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Retina.

    Entry informationi

    Entry nameiOPSB_MOUSE
    AccessioniPrimary (citable) accession number: P51491
    Secondary accession number(s): Q548Z8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3