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P51491 (OPSB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Short-wave-sensitive opsin 1

Short name=S opsin
Alternative name(s):
Blue cone photoreceptor pigment
Blue-sensitive opsin
Short name=BOP
Short wavelength-sensitive cone opsin
Gene names
Name:Opn1sw
Synonyms:Bcp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light. Ref.2

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in cone photoreceptor cells. Ref.2

Post-translational modification

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Short-wave-sensitive opsin 1
PRO_0000197766

Regions

Topological domain1 – 3131Extracellular
Transmembrane32 – 5625Helical; Name=1; Potential
Topological domain57 – 6812Cytoplasmic
Transmembrane69 – 9426Helical; Name=2; Potential
Topological domain95 – 10814Extracellular
Transmembrane109 – 12820Helical; Name=3; Potential
Topological domain129 – 14719Cytoplasmic
Transmembrane148 – 17124Helical; Name=4; Potential
Topological domain172 – 19726Extracellular
Transmembrane198 – 22528Helical; Name=5; Potential
Topological domain226 – 24722Cytoplasmic
Transmembrane248 – 27124Helical; Name=6; Potential
Topological domain272 – 2798Extracellular
Transmembrane280 – 30425Helical; Name=7; Potential
Topological domain305 – 34642Cytoplasmic

Amino acid modifications

Modified residue2911N6-(retinylidene)lysine
Glycosylation121N-linked (GlcNAc...) Probable
Disulfide bond105 ↔ 182 Potential

Sequences

Sequence LengthMass (Da)Tools
P51491 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 8BEEAB0198EE6863

FASTA34638,922
        10         20         30         40         50         60 
MSGEDDFYLF QNISSVGPWD GPQYHLAPVW AFRLQAAFMG FVFFVGTPLN AIVLVATLHY 

        70         80         90        100        110        120 
KKLRQPLNYI LVNVSLGGFL FCIFSVFTVF IASCHGYFLF GRHVCALEAF LGSVAGLVTG 

       130        140        150        160        170        180 
WSLAFLAFER YVVICKPFGS IRFNSKHALM VVLATWIIGI GVSIPPFFGW SRFIPEGLQC 

       190        200        210        220        230        240 
SCGPDWYTVG TKYRSEYYTW FLFIFCFIIP LSLICFSYSQ LLRTLRAVAA QQQESATTQK 

       250        260        270        280        290        300 
AEREVSHMVV VMVGSFCLCY VPYAALAMYM VNNRNHGLDL RLVTIPAFFS KSSCVYNPII 

       310        320        330        340 
YCFMNKQFRA CILEMVCRKP MADESDVSGS QKTEVSTVSS SKVGPH 

« Hide

References

« Hide 'large scale' references
[1]"Murine and bovine blue cone pigment genes: cloning and characterization of two new members of the S family of visual pigments."
Chiu M.I., Zack D.J., Wang Y., Nathans J.
Genomics 21:440-443(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Retina.
[2]"The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning."
Applebury M.L., Antoch M.P., Baxter L.C., Chun L.Y., Falk J.D., Farhangfar F., Kage K., Krzystolik M.G., Lyass L.A., Robbins J.T.
Neuron 27:513-523(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
Strain: BALB/c and C57BL/10.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Retina.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U49720 mRNA. Translation: AAA92458.1.
U92562 expand/collapse EMBL AC list , U92558, U92559, U92560, U92561 Genomic DNA. Translation: AAB53320.1.
AF190670 mRNA. Translation: AAG17989.1.
AF190671 Genomic DNA. Translation: AAG17990.1.
BC026021 mRNA. Translation: AAH26021.1.
BC058267 mRNA. Translation: AAH58267.1.
CCDSCCDS19959.1.
PIRB54679.
RefSeqNP_031564.1. NM_007538.3.
UniGeneMm.56987.

3D structure databases

ProteinModelPortalP51491.
SMRP51491. Positions 6-317.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000079289.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEP51491.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000080428; ENSMUSP00000079289; ENSMUSG00000058831.
GeneID12057.
KEGGmmu:12057.
UCSCuc009bdi.2. mouse.

Organism-specific databases

CTD611.
MGIMGI:99438. Opn1sw.

Phylogenomic databases

eggNOGNOG237118.
GeneTreeENSGT00710000106574.
HOGENOMHOG000253932.
HOVERGENHBG107442.
InParanoidP51491.
KOK04252.
OMAYAALAMY.
OrthoDBEOG72NRQJ.
PhylomeDBP51491.
TreeFamTF324998.

Gene expression databases

BgeeP51491.
GenevestigatorP51491.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR001521. Opsin_blue.
IPR027430. Retinal_BS.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PR00574. OPSINBLUE.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSOPN1SW. mouse.
NextBio280363.
PROP51491.
SOURCESearch...

Entry information

Entry nameOPSB_MOUSE
AccessionPrimary (citable) accession number: P51491
Secondary accession number(s): Q548Z8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries