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Protein

Short-wave-sensitive opsin 1

Gene

Opn1sw

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

Chromophore

Enzyme and pathway databases

ReactomeiREACT_280434. The retinoid cycle in cones (daylight vision).
REACT_331048. G alpha (i) signalling events.
REACT_332325. Opsins.

Names & Taxonomyi

Protein namesi
Recommended name:
Short-wave-sensitive opsin 1
Short name:
S opsin
Alternative name(s):
Blue cone photoreceptor pigment
Blue-sensitive opsin
Short name:
BOP
Short wavelength-sensitive cone opsin
Gene namesi
Name:Opn1sw
Synonyms:Bcp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:99438. Opn1sw.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularAdd
BLAST
Transmembranei32 – 5625Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini57 – 6812CytoplasmicAdd
BLAST
Transmembranei69 – 9426Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini95 – 10814ExtracellularAdd
BLAST
Transmembranei109 – 12820Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini129 – 14719CytoplasmicAdd
BLAST
Transmembranei148 – 17124Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini172 – 19726ExtracellularAdd
BLAST
Transmembranei198 – 22528Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini226 – 24722CytoplasmicAdd
BLAST
Transmembranei248 – 27124Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini272 – 2798Extracellular
Transmembranei280 – 30425Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini305 – 34642CytoplasmicAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Short-wave-sensitive opsin 1PRO_0000197766Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi12 – 121N-linked (GlcNAc...)Curated
Disulfide bondi105 ↔ 182PROSITE-ProRule annotation
Modified residuei291 – 2911N6-(retinylidene)lysine

Post-translational modificationi

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP51491.

Expressioni

Tissue specificityi

Expressed in cone photoreceptor cells.1 Publication

Gene expression databases

BgeeiP51491.
ExpressionAtlasiP51491. baseline and differential.
GenevisibleiP51491. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079289.

Structurei

3D structure databases

ProteinModelPortaliP51491.
SMRiP51491. Positions 6-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237118.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000253932.
HOVERGENiHBG107442.
InParanoidiP51491.
KOiK04252.
OMAiCIMEMVC.
OrthoDBiEOG72NRQJ.
PhylomeDBiP51491.
TreeFamiTF324998.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR001521. Opsin_blue.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PR00574. OPSINBLUE.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51491-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGEDDFYLF QNISSVGPWD GPQYHLAPVW AFRLQAAFMG FVFFVGTPLN
60 70 80 90 100
AIVLVATLHY KKLRQPLNYI LVNVSLGGFL FCIFSVFTVF IASCHGYFLF
110 120 130 140 150
GRHVCALEAF LGSVAGLVTG WSLAFLAFER YVVICKPFGS IRFNSKHALM
160 170 180 190 200
VVLATWIIGI GVSIPPFFGW SRFIPEGLQC SCGPDWYTVG TKYRSEYYTW
210 220 230 240 250
FLFIFCFIIP LSLICFSYSQ LLRTLRAVAA QQQESATTQK AEREVSHMVV
260 270 280 290 300
VMVGSFCLCY VPYAALAMYM VNNRNHGLDL RLVTIPAFFS KSSCVYNPII
310 320 330 340
YCFMNKQFRA CILEMVCRKP MADESDVSGS QKTEVSTVSS SKVGPH
Length:346
Mass (Da):38,922
Last modified:October 1, 1996 - v1
Checksum:i8BEEAB0198EE6863
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49720 mRNA. Translation: AAA92458.1.
U92562
, U92558, U92559, U92560, U92561 Genomic DNA. Translation: AAB53320.1.
AF190670 mRNA. Translation: AAG17989.1.
AF190671 Genomic DNA. Translation: AAG17990.1.
BC026021 mRNA. Translation: AAH26021.1.
BC058267 mRNA. Translation: AAH58267.1.
CCDSiCCDS19959.1.
PIRiB54679.
RefSeqiNP_031564.1. NM_007538.3.
UniGeneiMm.56987.

Genome annotation databases

EnsembliENSMUST00000080428; ENSMUSP00000079289; ENSMUSG00000058831.
GeneIDi12057.
KEGGimmu:12057.
UCSCiuc009bdi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49720 mRNA. Translation: AAA92458.1.
U92562
, U92558, U92559, U92560, U92561 Genomic DNA. Translation: AAB53320.1.
AF190670 mRNA. Translation: AAG17989.1.
AF190671 Genomic DNA. Translation: AAG17990.1.
BC026021 mRNA. Translation: AAH26021.1.
BC058267 mRNA. Translation: AAH58267.1.
CCDSiCCDS19959.1.
PIRiB54679.
RefSeqiNP_031564.1. NM_007538.3.
UniGeneiMm.56987.

3D structure databases

ProteinModelPortaliP51491.
SMRiP51491. Positions 6-341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079289.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiP51491.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080428; ENSMUSP00000079289; ENSMUSG00000058831.
GeneIDi12057.
KEGGimmu:12057.
UCSCiuc009bdi.2. mouse.

Organism-specific databases

CTDi611.
MGIiMGI:99438. Opn1sw.

Phylogenomic databases

eggNOGiNOG237118.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000253932.
HOVERGENiHBG107442.
InParanoidiP51491.
KOiK04252.
OMAiCIMEMVC.
OrthoDBiEOG72NRQJ.
PhylomeDBiP51491.
TreeFamiTF324998.

Enzyme and pathway databases

ReactomeiREACT_280434. The retinoid cycle in cones (daylight vision).
REACT_331048. G alpha (i) signalling events.
REACT_332325. Opsins.

Miscellaneous databases

ChiTaRSiOpn1sw. mouse.
NextBioi280363.
PROiP51491.
SOURCEiSearch...

Gene expression databases

BgeeiP51491.
ExpressionAtlasiP51491. baseline and differential.
GenevisibleiP51491. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR001521. Opsin_blue.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PR00574. OPSINBLUE.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Murine and bovine blue cone pigment genes: cloning and characterization of two new members of the S family of visual pigments."
    Chiu M.I., Zack D.J., Wang Y., Nathans J.
    Genomics 21:440-443(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Retina.
  2. "The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning."
    Applebury M.L., Antoch M.P., Baxter L.C., Chun L.Y., Falk J.D., Farhangfar F., Kage K., Krzystolik M.G., Lyass L.A., Robbins J.T.
    Neuron 27:513-523(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: BALB/c and C57BL/10.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Retina.

Entry informationi

Entry nameiOPSB_MOUSE
AccessioniPrimary (citable) accession number: P51491
Secondary accession number(s): Q548Z8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 24, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.