P51491 (OPSB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Short-wave-sensitive opsin 1
Short name=S opsin

Alternative name(s):
Blue cone photoreceptor pigment
Blue-sensitive opsin
Short name=BOP
Short wavelength-sensitive cone opsin

Gene names

Name:	Opn1sw
Synonyms:	Bcp

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light. Ref.2
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expresssed in cone photoreceptor cells. Ref.2
Post-translational modification	Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

Ontologies

Keywords
Biological process	Sensory transduction Vision
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Chromophore
Molecular function	G-protein coupled receptor Photoreceptor protein Receptor Retinal protein Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phototransduction Inferred from electronic annotation. Source: UniProtKB-KW protein-chromophore linkage Inferred from electronic annotation. Source: UniProtKB-KW visual perception Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW photoreceptor outer segment Inferred from direct assay. Source: MGI
Molecular function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW photoreceptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Short-wave-sensitive opsin 1		PRO_0000197766
Regions
	Topological domain	1 – 31	31	Extracellular
	Transmembrane	32 – 56	25	Helical; Name=1; Potential
	Topological domain	57 – 68	12	Cytoplasmic
	Transmembrane	69 – 94	26	Helical; Name=2; Potential
	Topological domain	95 – 108	14	Extracellular
	Transmembrane	109 – 128	20	Helical; Name=3; Potential
	Topological domain	129 – 147	19	Cytoplasmic
	Transmembrane	148 – 171	24	Helical; Name=4; Potential
	Topological domain	172 – 197	26	Extracellular
	Transmembrane	198 – 225	28	Helical; Name=5; Potential
	Topological domain	226 – 247	22	Cytoplasmic
	Transmembrane	248 – 271	24	Helical; Name=6; Potential
	Topological domain	272 – 279	8	Extracellular
	Transmembrane	280 – 304	25	Helical; Name=7; Potential
	Topological domain	305 – 346	42	Cytoplasmic
Amino acid modifications
	Modified residue	291	1	N6-(retinylidene)lysine
	Glycosylation	12	1	N-linked (GlcNAc...) Probable
	Disulfide bond	105 ↔ 182		Potential

Sequences

	Sequence		Length	Mass (Da)
	P51491 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 8BEEAB0198EE6863	FASTA	346	38,922
	10 20 30 40 50 60 MSGEDDFYLF QNISSVGPWD GPQYHLAPVW AFRLQAAFMG FVFFVGTPLN AIVLVATLHY 70 80 90 100 110 120 KKLRQPLNYI LVNVSLGGFL FCIFSVFTVF IASCHGYFLF GRHVCALEAF LGSVAGLVTG 130 140 150 160 170 180 WSLAFLAFER YVVICKPFGS IRFNSKHALM VVLATWIIGI GVSIPPFFGW SRFIPEGLQC 190 200 210 220 230 240 SCGPDWYTVG TKYRSEYYTW FLFIFCFIIP LSLICFSYSQ LLRTLRAVAA QQQESATTQK 250 260 270 280 290 300 AEREVSHMVV VMVGSFCLCY VPYAALAMYM VNNRNHGLDL RLVTIPAFFS KSSCVYNPII 310 320 330 340 YCFMNKQFRA CILEMVCRKP MADESDVSGS QKTEVSTVSS SKVGPH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Murine and bovine blue cone pigment genes: cloning and characterization of two new members of the S family of visual pigments." Chiu M.I., Zack D.J., Wang Y., Nathans J. Genomics 21:440-443(1994) [PubMed: 8088841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Retina.
[2]	"The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning." Applebury M.L., Antoch M.P., Baxter L.C., Chun L.Y., Falk J.D., Farhangfar F., Kage K., Krzystolik M.G., Lyass L.A., Robbins J.T. Neuron 27:513-523(2000) [PubMed: 11055434] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY. Strain: BALB/c and C57BL/10.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Retina.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U49720 mRNA. Translation: AAA92458.1. U92562 , U92558, U92559, U92560, U92561 Genomic DNA. Translation: AAB53320.1. AF190670 mRNA. Translation: AAG17989.1. AF190671 Genomic DNA. Translation: AAG17990.1. BC026021 mRNA. Translation: AAH26021.1. BC058267 mRNA. Translation: AAH58267.1.
IPI	IPI00122676.
PIR	B54679.
RefSeq	NP_031564.1. NM_007538.3.
UniGene	Mm.56987.
3D structure databases
ProteinModelPortal	P51491.
SMR	P51491. Positions 1-345.
ModBase	Search...
Protein-protein interaction databases
STRING	P51491.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	P51491.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000080428; ENSMUSP00000079289; ENSMUSG00000058831.
GeneID	12057.
KEGG	mmu:12057.
UCSC	uc009bdi.2. mouse.
Organism-specific databases
CTD	611.
MGI	MGI:99438. Opn1sw.
Phylogenomic databases
eggNOG	roNOG13407.
GeneTree	ENSGT00550000074069.
HOGENOM	HBG716226.
HOVERGEN	HBG107442.
InParanoid	P51491.
OMA	YAALAMY.
OrthoDB	EOG4HQDK2.
PhylomeDB	P51491.
Gene expression databases
ArrayExpress	P51491.
Bgee	P51491.
Genevestigator	P51491.
GermOnline	ENSMUSG00000058831. Mus musculus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR001760. Opsin. IPR001521. Opsin_blue. [Graphical view]
KO	K04252.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00238. OPSIN. PR00574. OPSINBLUE.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. PS00238. OPSIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	280363.
SOURCE	Search...

Entry information

Entry name

OPSB_MOUSE

Accession

Primary (citable) accession number: P51491
Secondary accession number(s): Q548Z8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 16, 2011
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program