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Protein

Cyclin-dependent kinase inhibitor 2A, isoforms 1/2

Gene

Cdkn2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase inhibitor activity Source: MGI
  2. MDM2/MDM4 family protein binding Source: MGI
  3. NF-kappaB binding Source: MGI
  4. p53 binding Source: MGI
  5. poly(A) RNA binding Source: MGI
  6. protein kinase binding Source: MGI
  7. sequence-specific DNA binding transcription factor activity Source: MGI
  8. transcription factor binding Source: MGI

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  2. aging Source: MGI
  3. apoptotic mitochondrial changes Source: MGI
  4. cell aging Source: MGI
  5. cell cycle arrest Source: MGI
  6. cellular response to hydrogen peroxide Source: MGI
  7. cellular senescence Source: MGI
  8. epidermis development Source: MGI
  9. G1/S transition of mitotic cell cycle Source: MGI
  10. glucose homeostasis Source: MGI
  11. negative regulation of cell cycle Source: MGI
  12. negative regulation of cell growth Source: MGI
  13. negative regulation of cell-matrix adhesion Source: MGI
  14. negative regulation of cell proliferation Source: MGI
  15. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
  16. negative regulation of mammary gland epithelial cell proliferation Source: MGI
  17. negative regulation of NF-kappaB transcription factor activity Source: MGI
  18. negative regulation of phosphorylation Source: MGI
  19. negative regulation of protein binding Source: MGI
  20. negative regulation of protein kinase activity Source: MGI
  21. negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: MGI
  22. negative regulation of proteolysis involved in cellular protein catabolic process Source: MGI
  23. negative regulation of transcription, DNA-templated Source: MGI
  24. positive regulation of apoptotic process involved in mammary gland involution Source: MGI
  25. positive regulation of cell cycle arrest Source: MGI
  26. positive regulation of cellular senescence Source: MGI
  27. positive regulation of DNA damage response, signal transduction by p53 class mediator Source: MGI
  28. positive regulation of macrophage apoptotic process Source: BHF-UCL
  29. positive regulation of protein sumoylation Source: MGI
  30. positive regulation of smooth muscle cell apoptotic process Source: BHF-UCL
  31. positive regulation of transcription, DNA-templated Source: MGI
  32. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  33. protein destabilization Source: MGI
  34. protein K63-linked ubiquitination Source: MGI
  35. protein polyubiquitination Source: MGI
  36. protein stabilization Source: MGI
  37. regulation of apoptotic DNA fragmentation Source: MGI
  38. regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
  39. regulation of G2/M transition of mitotic cell cycle Source: MGI
  40. regulation of gene expression Source: MGI
  41. regulation of nucleocytoplasmic transport Source: MGI
  42. regulation of protein export from nucleus Source: MGI
  43. regulation of transcription, DNA-templated Source: MGI
  44. replicative senescence Source: MGI
  45. rRNA transcription Source: MGI
  46. senescence-associated heterochromatin focus assembly Source: MGI
  47. somatic stem cell maintenance Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase inhibitor 2A, isoforms 1/2
Alternative name(s):
Cyclin-dependent kinase 4 inhibitor A
Short name:
CDK4I
p16-INK4a
Short name:
p16-INK4
Gene namesi
Name:Cdkn2a
Synonyms:P16ink4a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:104738. Cdkn2a.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleolus Source: MGI
  3. nucleoplasm Source: MGI
  4. nucleus Source: MGI
  5. protein complex Source: MGI
  6. senescence-associated heterochromatin focus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi64 – 641C → G or R: No effect on activity. 1 Publication
Mutagenesisi76 – 761D → N: Loss of activity. 1 Publication
Mutagenesisi84 – 852Missing: Loss of activity. 1 Publication

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 168168Cyclin-dependent kinase inhibitor 2A, isoforms 1/2PRO_0000144178Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei152 – 1521PhosphoserineBy similarity
Modified residuei164 – 1641PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation seems to increase interaction with CDK4.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP51480.

PTM databases

PhosphoSiteiP51480.

Expressioni

Gene expression databases

BgeeiP51480.
CleanExiMM_CDKN2A.
ExpressionAtlasiP51480. baseline and differential.
GenevestigatoriP51480.

Interactioni

Subunit structurei

Heterodimer with CDK4 or CDK6. Predominamt P16 complexes contained CDK6. Interacts with CDK4 (both 'T-172'-phosphorylated and non-phosphorylated forms); the interaction inhibits cyclin D-CDK4 kinase activity. Interacts with ISCO2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi198654. 35 interactions.
DIPiDIP-60251N.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LNNmodel-A12-159[»]
ProteinModelPortaliP51480.
SMRiP51480. Positions 2-126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati3 – 3230ANK 1Add
BLAST
Repeati36 – 6429ANK 2Add
BLAST
Repeati69 – 9830ANK 3Add
BLAST
Repeati102 – 13130ANK 4Add
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiNOG42176.
GeneTreeiENSGT00390000008249.
HOVERGENiHBG050870.
KOiK06621.
OMAiADSNCED.
OrthoDBiEOG7TTQ94.
TreeFamiTF352389.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Note: Isoform 1 and isoform 3 arise due to the use of two alternative first exons joined to a common exon 2 at the same acceptor site but in different reading frames, resulting in two completely different isoforms.

Isoform 1 (identifier: P51480-1) [UniParc]FASTAAdd to Basket

Also known as: p16INK4a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESAADRLAR AAAQGRVHDV RALLEAGVSP NAPNSFGRTP IQVMMMGNVH
60 70 80 90 100
VAALLLNYGA DSNCEDPTTF SRPVHDAARE GFLDTLVVLH GSGARLDVRD
110 120 130 140 150
AWGRLPLDLA QERGHQDIVR YLRSAGCSLC SAGWSLCTAG NVAQTDGHSF
160
SSSTPRALEL RGQSQEQS
Length:168
Mass (Da):17,941
Last modified:October 25, 2005 - v2
Checksum:i9A6B0F24F34D5FEC
GO
Isoform 2 (identifier: P51480-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Show »
Length:125
Mass (Da):13,458
Checksum:i97BE6143D7C8542D
GO
Isoform 3 (identifier: Q64364-1) [UniParc]FASTAAdd to Basket

Also known as: p19ARF, ARF

The sequence of this isoform can be found in the external entry Q64364.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:169
Mass (Da):19,238
GO
Isoform 4 (identifier: Q64364-2) [UniParc]FASTAAdd to Basket

Also known as: smARF

The sequence of this isoform can be found in the external entry Q64364.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:125
Mass (Da):14,096
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111Missing in AAA85453. (PubMed:7651726)Curated

Polymorphismi

Strain BALB/c displays a significantly reduced ability to inhibit phosphorylation of the retinoblastoma protein.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121A → V in some liver tumors. 1 Publication
Natural varianti18 – 181H → P in strain: 020, BALB/c, BALB/cJ, C3H/21BG, C3H/HeJ, CBA/J, MA/M4J and PL/J. 3 Publications
Natural varianti27 – 271G → E in some liver tumors. 1 Publication
Natural varianti51 – 511V → I in strain: BALB/c and BALB/cJ. 2 Publications
Natural varianti73 – 731P → L in some liver tumors. 1 Publication
Natural varianti74 – 741V → M in plasmacytoma cell lines. 1 Publication
Natural varianti75 – 751H → Y in plasmacytoma cell lines. 1 Publication
Natural varianti90 – 901H → Q in strain: BALB/cJ, C57BL/6J and MOLF/Ei. 1 Publication
Natural varianti90 – 901H → R in plasmacytoma cell lines. 1 Publication
Natural varianti127 – 1271C → S in strain: BALB/cJ, C57BL/6J and MOLF/Ei. 1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4343Missing in isoform 2. CuratedVSP_015867Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76150 mRNA. Translation: AAA85453.1.
AF044335 mRNA. Translation: AAC08962.1.
AF044336 mRNA. Translation: AAC08963.1.
AF332190 Genomic DNA. Translation: AAK83159.1.
AK155307 mRNA. Translation: BAE33180.1.
AL831719 Genomic DNA. Translation: CAM16002.1.
AL831719 Genomic DNA. Translation: CAM16003.1.
U66087, U66086 Genomic DNA. Translation: AAB39600.1.
U79625 Genomic DNA. Translation: AAD00223.1.
U79626 Genomic DNA. Translation: AAD00224.1.
U79627 Genomic DNA. Translation: AAD00225.1.
U79628 Genomic DNA. Translation: AAD00226.1.
U79630 Genomic DNA. Translation: AAD00227.1.
U79631 Genomic DNA. Translation: AAD00228.1.
U79632 Genomic DNA. Translation: AAD00229.1.
U49279 Genomic DNA. Translation: AAC00051.1.
U49280 Genomic DNA. Translation: AAC00052.1.
AF004588 Genomic DNA. Translation: AAB61416.1.
CCDSiCCDS38812.1. [P51480-1]
RefSeqiNP_001035744.1. NM_001040654.1. [P51480-1]
UniGeneiMm.4733.

Genome annotation databases

EnsembliENSMUST00000060501; ENSMUSP00000061847; ENSMUSG00000044303. [P51480-1]
GeneIDi12578.
KEGGimmu:12578.
UCSCiuc008toh.1. mouse. [P51480-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76150 mRNA. Translation: AAA85453.1.
AF044335 mRNA. Translation: AAC08962.1.
AF044336 mRNA. Translation: AAC08963.1.
AF332190 Genomic DNA. Translation: AAK83159.1.
AK155307 mRNA. Translation: BAE33180.1.
AL831719 Genomic DNA. Translation: CAM16002.1.
AL831719 Genomic DNA. Translation: CAM16003.1.
U66087, U66086 Genomic DNA. Translation: AAB39600.1.
U79625 Genomic DNA. Translation: AAD00223.1.
U79626 Genomic DNA. Translation: AAD00224.1.
U79627 Genomic DNA. Translation: AAD00225.1.
U79628 Genomic DNA. Translation: AAD00226.1.
U79630 Genomic DNA. Translation: AAD00227.1.
U79631 Genomic DNA. Translation: AAD00228.1.
U79632 Genomic DNA. Translation: AAD00229.1.
U49279 Genomic DNA. Translation: AAC00051.1.
U49280 Genomic DNA. Translation: AAC00052.1.
AF004588 Genomic DNA. Translation: AAB61416.1.
CCDSiCCDS38812.1. [P51480-1]
RefSeqiNP_001035744.1. NM_001040654.1. [P51480-1]
UniGeneiMm.4733.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LNNmodel-A12-159[»]
ProteinModelPortaliP51480.
SMRiP51480. Positions 2-126.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198654. 35 interactions.
DIPiDIP-60251N.

PTM databases

PhosphoSiteiP51480.

Proteomic databases

PRIDEiP51480.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060501; ENSMUSP00000061847; ENSMUSG00000044303. [P51480-1]
GeneIDi12578.
KEGGimmu:12578.
UCSCiuc008toh.1. mouse. [P51480-1]

Organism-specific databases

CTDi1029.
MGIiMGI:104738. Cdkn2a.

Phylogenomic databases

eggNOGiNOG42176.
GeneTreeiENSGT00390000008249.
HOVERGENiHBG050870.
KOiK06621.
OMAiADSNCED.
OrthoDBiEOG7TTQ94.
TreeFamiTF352389.

Miscellaneous databases

NextBioi281698.
SOURCEiSearch...

Gene expression databases

BgeeiP51480.
CleanExiMM_CDKN2A.
ExpressionAtlasiP51480. baseline and differential.
GenevestigatoriP51480.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of murine p16INK4a and p15INK4b genes."
    Quelle D.E., Ashmun R.A., Hannon G.J., Rehberger P.A., Trono D., Richter K.H., Walker C., Beach D., Sherr C.J., Serrano M.
    Oncogene 11:635-645(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16(INK4a) and p19(ARF), is a candidate for the plasmacytoma susceptibility locus, Pctr1."
    Zhang S., Ramsay E.S., Mock B.A.
    Proc. Natl. Acad. Sci. U.S.A. 95:2429-2434(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS PRO-18; ILE-51; MET-74; TYR-75 AND ARG-90.
    Strain: BALB/c and DBA/2N.
    Tissue: Spleen.
  3. "Cloning and structure analysis of murine p16INK4a."
    Gong Z., Li J., Fu J.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. "Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas."
    Malumbres M., de Castro I.P., Santos J., Melendez B., Mangues R., Serrano M., Pellicer A., Fernandez-Piqueras J.
    Oncogene 14:1361-1370(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-155.
    Strain: C57BL/6J X DBA.
  7. "Comparative analysis of the p16(INK4a) and p15(INK4b) DNA sequences in mouse inbred strains."
    Santos J., Melendez B., Perez de Castro I., Malumbres M., Serrano M., Pellicer A., Fernandez-Piqueras J.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-155, VARIANTS PRO-18; ILE-51; GLN-90 AND SER-127.
    Strain: BALB/cJ, C57BL/6J, CAST/Ei, MOLF/Ei and RF/J.
  8. "Sequence variation and chromosomal mapping of the murine Cdkn2a tumor suppressor gene."
    Herzog C.R., You M.
    Mamm. Genome 8:65-66(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-42 (ISOFORM 1), VARIANT PRO-18.
    Strain: 020, 129/J, A/J, A/Wy, AKR/J, B10.A, B10.D2(58N), BALB/c, C3H/21BG, C3H/HeJ, C57BL/10SCN, C57BL/10SN, C57BL/6By, C57BL/6J, C57BR/cdJ, CBA/J, DBA/2J, HS/IBG, LP/J, LS/IBG, MA/M4J, PL/J, RF/J, Sencar, SJL/J, SM/J, ST/J and SWR/J.
    Tissue: Lung.
  9. "Induction of mutations in Ki-ras and INK4a in liver tumors of mice exposed in utero to 3-methylcholanthrene."
    Gressani K.M., Rollins L.A., Leone-Kabler S., Cline J.M., Miller M.S.
    Carcinogenesis 19:1045-1052(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42, VARIANTS VAL-12; GLU-27 AND LEU-73.
  10. "Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF."
    Quelle D.E., Cheng M., Ashmun R.A., Sherr C.J.
    Proc. Natl. Acad. Sci. U.S.A. 94:669-673(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF CYS-64; ASP-76 AND 84-ASP-THR-85.

Entry informationi

Entry nameiCD2A1_MOUSE
AccessioniPrimary (citable) accession number: P51480
Secondary accession number(s): A2ANM1
, A2ANM2, O89088, P97510, P97937, Q6PEA2, Q78E39, Q78E57, Q792X7, Q9QWH6, Q9QWH7, Q9QWH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 25, 2005
Last modified: February 4, 2015
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.