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P51480

- CD2A1_MOUSE

UniProt

P51480 - CD2A1_MOUSE

Protein

Cyclin-dependent kinase inhibitor 2A, isoforms 1/2

Gene

Cdkn2a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (25 Oct 2005)
      Previous versions | rss
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    Functioni

    Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase inhibitor activity Source: MGI
    2. protein binding Source: MGI
    3. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. aging Source: MGI
    2. cell aging Source: MGI
    3. cell cycle arrest Source: MGI
    4. cellular response to hydrogen peroxide Source: MGI
    5. epidermis development Source: MGI
    6. negative regulation of cell cycle Source: MGI
    7. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
    8. negative regulation of mammary gland epithelial cell proliferation Source: MGI
    9. positive regulation of apoptotic process involved in mammary gland involution Source: MGI
    10. positive regulation of macrophage apoptotic process Source: BHF-UCL
    11. positive regulation of smooth muscle cell apoptotic process Source: BHF-UCL
    12. regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
    13. regulation of gene expression Source: MGI
    14. regulation of nucleocytoplasmic transport Source: MGI
    15. regulation of transcription, DNA-templated Source: MGI
    16. rRNA transcription Source: MGI
    17. somatic stem cell maintenance Source: MGI

    Keywords - Biological processi

    Cell cycle

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase inhibitor 2A, isoforms 1/2
    Alternative name(s):
    Cyclin-dependent kinase 4 inhibitor A
    Short name:
    CDK4I
    p16-INK4a
    Short name:
    p16-INK4
    Gene namesi
    Name:Cdkn2a
    Synonyms:P16ink4a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:104738. Cdkn2a.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleolus Source: MGI
    3. nucleoplasm Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi64 – 641C → G or R: No effect on activity. 1 Publication
    Mutagenesisi76 – 761D → N: Loss of activity. 1 Publication
    Mutagenesisi84 – 852Missing: Loss of activity.

    Keywords - Diseasei

    Tumor suppressor

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 168168Cyclin-dependent kinase inhibitor 2A, isoforms 1/2PRO_0000144178Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei152 – 1521PhosphoserineBy similarity
    Modified residuei164 – 1641PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylation seems to increase interaction with CDK4.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP51480.

    PTM databases

    PhosphoSiteiP51480.

    Expressioni

    Gene expression databases

    ArrayExpressiP51480.
    BgeeiP51480.
    CleanExiMM_CDKN2A.
    GenevestigatoriP51480.

    Interactioni

    Subunit structurei

    Heterodimer with CDK4 or CDK6. Predominamt P16 complexes contained CDK6. Interacts with CDK4 (both 'T-172'-phosphorylated and non-phosphorylated forms); the interaction inhibits cyclin D-CDK4 kinase activity. Interacts with ISCO2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi198654. 34 interactions.
    DIPiDIP-60251N.

    Structurei

    Secondary structure

    1
    168
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni13 – 153
    Helixi17 – 259
    Helixi40 – 434
    Helixi49 – 5810
    Helixi72 – 809
    Helixi83 – 919
    Helixi106 – 1138
    Helixi116 – 1238
    Turni124 – 1263
    Helixi139 – 1457
    Helixi149 – 1579

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1LNNmodel-A12-159[»]
    ProteinModelPortaliP51480.
    SMRiP51480. Positions 2-126.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati3 – 3230ANK 1Add
    BLAST
    Repeati36 – 6429ANK 2Add
    BLAST
    Repeati69 – 9830ANK 3Add
    BLAST
    Repeati102 – 13130ANK 4Add
    BLAST

    Sequence similaritiesi

    Contains 4 ANK repeats.Curated

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG42176.
    GeneTreeiENSGT00390000008249.
    HOVERGENiHBG050870.
    KOiK06621.
    OMAiPLRRERY.
    OrthoDBiEOG7TTQ94.
    TreeFamiTF352389.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view]
    PfamiPF00023. Ank. 1 hit.
    PF12796. Ank_2. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 4 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Note: Isoform 1 and isoform 3 arise due to the use of two alternative first exons joined to a common exon 2 at the same acceptor site but in different reading frames, resulting in two completely different isoforms.

    Isoform 1 (identifier: P51480-1) [UniParc]FASTAAdd to Basket

    Also known as: p16INK4a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESAADRLAR AAAQGRVHDV RALLEAGVSP NAPNSFGRTP IQVMMMGNVH    50
    VAALLLNYGA DSNCEDPTTF SRPVHDAARE GFLDTLVVLH GSGARLDVRD 100
    AWGRLPLDLA QERGHQDIVR YLRSAGCSLC SAGWSLCTAG NVAQTDGHSF 150
    SSSTPRALEL RGQSQEQS 168
    Length:168
    Mass (Da):17,941
    Last modified:October 25, 2005 - v2
    Checksum:i9A6B0F24F34D5FEC
    GO
    Isoform 2 (identifier: P51480-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-43: Missing.

    Show »
    Length:125
    Mass (Da):13,458
    Checksum:i97BE6143D7C8542D
    GO
    Isoform 3 (identifier: Q64364-1) [UniParc]FASTAAdd to Basket

    Also known as: p19ARF, ARF

    The sequence of this isoform can be found in the external entry Q64364.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:169
    Mass (Da):19,238
    GO
    Isoform 4 (identifier: Q64364-2) [UniParc]FASTAAdd to Basket

    Also known as: smARF

    The sequence of this isoform can be found in the external entry Q64364.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:125
    Mass (Da):14,096
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti11 – 111Missing in AAA85453. (PubMed:7651726)Curated

    Polymorphismi

    Strain BALB/c displays a significantly reduced ability to inhibit phosphorylation of the retinoblastoma protein.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti12 – 121A → V in some liver tumors. 1 Publication
    Natural varianti18 – 181H → P in strain: 020, BALB/c, BALB/cJ, C3H/21BG, C3H/HeJ, CBA/J, MA/M4J and PL/J. 3 Publications
    Natural varianti27 – 271G → E in some liver tumors. 1 Publication
    Natural varianti51 – 511V → I in strain: BALB/c and BALB/cJ. 2 Publications
    Natural varianti73 – 731P → L in some liver tumors. 1 Publication
    Natural varianti74 – 741V → M in plasmacytoma cell lines. 1 Publication
    Natural varianti75 – 751H → Y in plasmacytoma cell lines. 1 Publication
    Natural varianti90 – 901H → Q in strain: BALB/cJ, C57BL/6J and MOLF/Ei. 1 Publication
    Natural varianti90 – 901H → R in plasmacytoma cell lines. 1 Publication
    Natural varianti127 – 1271C → S in strain: BALB/cJ, C57BL/6J and MOLF/Ei. 1 Publication

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4343Missing in isoform 2. CuratedVSP_015867Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L76150 mRNA. Translation: AAA85453.1.
    AF044335 mRNA. Translation: AAC08962.1.
    AF044336 mRNA. Translation: AAC08963.1.
    AF332190 Genomic DNA. Translation: AAK83159.1.
    AK155307 mRNA. Translation: BAE33180.1.
    AL831719 Genomic DNA. Translation: CAM16002.1.
    AL831719 Genomic DNA. Translation: CAM16003.1.
    U66087, U66086 Genomic DNA. Translation: AAB39600.1.
    U79625 Genomic DNA. Translation: AAD00223.1.
    U79626 Genomic DNA. Translation: AAD00224.1.
    U79627 Genomic DNA. Translation: AAD00225.1.
    U79628 Genomic DNA. Translation: AAD00226.1.
    U79630 Genomic DNA. Translation: AAD00227.1.
    U79631 Genomic DNA. Translation: AAD00228.1.
    U79632 Genomic DNA. Translation: AAD00229.1.
    U49279 Genomic DNA. Translation: AAC00051.1.
    U49280 Genomic DNA. Translation: AAC00052.1.
    AF004588 Genomic DNA. Translation: AAB61416.1.
    CCDSiCCDS38812.1. [P51480-1]
    RefSeqiNP_001035744.1. NM_001040654.1. [P51480-1]
    UniGeneiMm.4733.

    Genome annotation databases

    EnsembliENSMUST00000060501; ENSMUSP00000061847; ENSMUSG00000044303. [P51480-1]
    GeneIDi12578.
    KEGGimmu:12578.
    UCSCiuc008toh.1. mouse. [P51480-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L76150 mRNA. Translation: AAA85453.1 .
    AF044335 mRNA. Translation: AAC08962.1 .
    AF044336 mRNA. Translation: AAC08963.1 .
    AF332190 Genomic DNA. Translation: AAK83159.1 .
    AK155307 mRNA. Translation: BAE33180.1 .
    AL831719 Genomic DNA. Translation: CAM16002.1 .
    AL831719 Genomic DNA. Translation: CAM16003.1 .
    U66087 , U66086 Genomic DNA. Translation: AAB39600.1 .
    U79625 Genomic DNA. Translation: AAD00223.1 .
    U79626 Genomic DNA. Translation: AAD00224.1 .
    U79627 Genomic DNA. Translation: AAD00225.1 .
    U79628 Genomic DNA. Translation: AAD00226.1 .
    U79630 Genomic DNA. Translation: AAD00227.1 .
    U79631 Genomic DNA. Translation: AAD00228.1 .
    U79632 Genomic DNA. Translation: AAD00229.1 .
    U49279 Genomic DNA. Translation: AAC00051.1 .
    U49280 Genomic DNA. Translation: AAC00052.1 .
    AF004588 Genomic DNA. Translation: AAB61416.1 .
    CCDSi CCDS38812.1. [P51480-1 ]
    RefSeqi NP_001035744.1. NM_001040654.1. [P51480-1 ]
    UniGenei Mm.4733.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1LNN model - A 12-159 [» ]
    ProteinModelPortali P51480.
    SMRi P51480. Positions 2-126.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198654. 34 interactions.
    DIPi DIP-60251N.

    PTM databases

    PhosphoSitei P51480.

    Proteomic databases

    PRIDEi P51480.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000060501 ; ENSMUSP00000061847 ; ENSMUSG00000044303 . [P51480-1 ]
    GeneIDi 12578.
    KEGGi mmu:12578.
    UCSCi uc008toh.1. mouse. [P51480-1 ]

    Organism-specific databases

    CTDi 1029.
    MGIi MGI:104738. Cdkn2a.

    Phylogenomic databases

    eggNOGi NOG42176.
    GeneTreei ENSGT00390000008249.
    HOVERGENi HBG050870.
    KOi K06621.
    OMAi PLRRERY.
    OrthoDBi EOG7TTQ94.
    TreeFami TF352389.

    Miscellaneous databases

    NextBioi 281698.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51480.
    Bgeei P51480.
    CleanExi MM_CDKN2A.
    Genevestigatori P51480.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view ]
    Pfami PF00023. Ank. 1 hit.
    PF12796. Ank_2. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 4 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of murine p16INK4a and p15INK4b genes."
      Quelle D.E., Ashmun R.A., Hannon G.J., Rehberger P.A., Trono D., Richter K.H., Walker C., Beach D., Sherr C.J., Serrano M.
      Oncogene 11:635-645(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16(INK4a) and p19(ARF), is a candidate for the plasmacytoma susceptibility locus, Pctr1."
      Zhang S., Ramsay E.S., Mock B.A.
      Proc. Natl. Acad. Sci. U.S.A. 95:2429-2434(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS PRO-18; ILE-51; MET-74; TYR-75 AND ARG-90.
      Strain: BALB/c and DBA/2N.
      Tissue: Spleen.
    3. "Cloning and structure analysis of murine p16INK4a."
      Gong Z., Li J., Fu J.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    6. "Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas."
      Malumbres M., de Castro I.P., Santos J., Melendez B., Mangues R., Serrano M., Pellicer A., Fernandez-Piqueras J.
      Oncogene 14:1361-1370(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-155.
      Strain: C57BL/6J X DBA.
    7. "Comparative analysis of the p16(INK4a) and p15(INK4b) DNA sequences in mouse inbred strains."
      Santos J., Melendez B., Perez de Castro I., Malumbres M., Serrano M., Pellicer A., Fernandez-Piqueras J.
      Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-155, VARIANTS PRO-18; ILE-51; GLN-90 AND SER-127.
      Strain: BALB/cJ, C57BL/6J, CAST/Ei, MOLF/Ei and RF/J.
    8. "Sequence variation and chromosomal mapping of the murine Cdkn2a tumor suppressor gene."
      Herzog C.R., You M.
      Mamm. Genome 8:65-66(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-42 (ISOFORM 1), VARIANT PRO-18.
      Strain: 020, 129/J, A/J, A/Wy, AKR/J, B10.A, B10.D2(58N), BALB/c, C3H/21BG, C3H/HeJ, C57BL/10SCN, C57BL/10SN, C57BL/6By, C57BL/6J, C57BR/cdJ, CBA/J, DBA/2J, HS/IBG, LP/J, LS/IBG, MA/M4J, PL/J, RF/J, Sencar, SJL/J, SM/J, ST/J and SWR/J.
      Tissue: Lung.
    9. "Induction of mutations in Ki-ras and INK4a in liver tumors of mice exposed in utero to 3-methylcholanthrene."
      Gressani K.M., Rollins L.A., Leone-Kabler S., Cline J.M., Miller M.S.
      Carcinogenesis 19:1045-1052(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42, VARIANTS VAL-12; GLU-27 AND LEU-73.
    10. "Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF."
      Quelle D.E., Cheng M., Ashmun R.A., Sherr C.J.
      Proc. Natl. Acad. Sci. U.S.A. 94:669-673(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF CYS-64; ASP-76 AND 84-ASP-THR-85.

    Entry informationi

    Entry nameiCD2A1_MOUSE
    AccessioniPrimary (citable) accession number: P51480
    Secondary accession number(s): A2ANM1
    , A2ANM2, O89088, P97510, P97937, Q6PEA2, Q78E39, Q78E57, Q792X7, Q9QWH6, Q9QWH7, Q9QWH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 25, 2005
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3