Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P51459 (IGF2_HORSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Insulin-like growth factor II

Short name=IGF-II
Alternative name(s):
Somatomedin-A

Cleaved into the following 2 chains:

  1. Insulin-like growth factor II
  2. Preptin
Gene names
Name:IGF2
OrganismEquus caballus (Horse) [Reference proteome]
Taxonomic identifier9796 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus

Protein attributes

Sequence length181 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.

Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3 By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the insulin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 By similarity
Chain25 – 9167Insulin-like growth factor II
PRO_0000015715
Propeptide92 – 18190E peptide
PRO_0000015716
Peptide93 – 12634Preptin
PRO_0000370375

Regions

Region25 – 5228B
Region53 – 6412C
Region65 – 8521A
Region86 – 916D

Amino acid modifications

Disulfide bond33 ↔ 71 By similarity
Disulfide bond45 ↔ 84 By similarity
Disulfide bond70 ↔ 75 By similarity

Experimental info

Sequence conflict1111V → G Ref.2
Sequence conflict1131L → R Ref.2

Sequences

Sequence LengthMass (Da)Tools
P51459 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: B88F96951C87AA12

FASTA18120,361
        10         20         30         40         50         60 
MGIPVGKSLL MLFTFLAFAS CCIAAYRPSE TLCGGELVDT LQFVCGDRGF YFSRPASRIN 

        70         80         90        100        110        120 
RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSTPPTV LPDDSPRYPV VKLFQYNAWK 

       130        140        150        160        170        180 
QSTQRLRRGL PALLRTRRGR MLVKELEAFR EAQRHRPLIA LPTEDPTPHG AAFVEVSSDL 


Q 

« Hide

References

[1]"FISH mapping of the IGF2 gene in horse and donkey-detection of homoeology with HSA11."
Raudsepp T., Otte K., Rozell B., Chowdhary B.P.
Mamm. Genome 8:569-572(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Insulin-like growth factor II in the horse: determination of a cDNA nucleotide sequence and expression in fetal and adult tissue."
Otte K., Engstrom W.
Gen. Comp. Endocrinol. 96:270-275(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-117.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF020599 Genomic DNA. Translation: AAC48807.1.
U11241 mRNA. Translation: AAA73915.1.
PIRI53642.
RefSeqNP_001108011.1. NM_001114539.1.
UniGeneEca.13091.

3D structure databases

ProteinModelPortalP51459.
SMRP51459. Positions 25-91.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9796.ENSECAP00000022093.

Proteomic databases

PRIDEP51459.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100034182.
KEGGecb:100034182.

Organism-specific databases

CTD3481.

Phylogenomic databases

eggNOGNOG44017.
HOGENOMHOG000233362.
HOVERGENHBG006137.
InParanoidP51459.
KOK13769.

Family and domain databases

Gene3D1.10.100.10. 1 hit.
InterProIPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamPF08365. IGF2_C. 1 hit.
PF00049. Insulin. 2 hits.
[Graphical view]
PRINTSPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomPD005188. IGF2_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMSSF56994. SSF56994. 1 hit.
PROSITEPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIGF2_HORSE
AccessionPrimary (citable) accession number: P51459
Secondary accession number(s): O18837
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: November 13, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families