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P51459

- IGF2_HORSE

UniProt

P51459 - IGF2_HORSE

Protein

Insulin-like growth factor II

Gene

IGF2

Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
    Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3 By similarity.By similarity

    GO - Biological processi

    1. glucose metabolic process Source: UniProtKB-KW
    2. ossification Source: UniProtKB-KW
    3. positive regulation of cell division Source: UniProtKB-KW

    Keywords - Molecular functioni

    Growth factor, Hormone, Mitogen

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism, Osteogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor II
    Short name:
    IGF-II
    Alternative name(s):
    Somatomedin-A
    Cleaved into the following 2 chains:
    Gene namesi
    Name:IGF2
    OrganismiEquus caballus (Horse)
    Taxonomic identifieri9796 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
    ProteomesiUP000002281: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424By similarityAdd
    BLAST
    Chaini25 – 9167Insulin-like growth factor IIPRO_0000015715Add
    BLAST
    Propeptidei92 – 18190E peptidePRO_0000015716Add
    BLAST
    Peptidei93 – 12634PreptinPRO_0000370375Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 71By similarity
    Disulfide bondi45 ↔ 84By similarity
    Disulfide bondi70 ↔ 75By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiP51459.

    Interactioni

    Protein-protein interaction databases

    STRINGi9796.ENSECAP00000022093.

    Structurei

    3D structure databases

    ProteinModelPortaliP51459.
    SMRiP51459. Positions 25-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni25 – 5228BAdd
    BLAST
    Regioni53 – 6412CAdd
    BLAST
    Regioni65 – 8521AAdd
    BLAST
    Regioni86 – 916D

    Sequence similaritiesi

    Belongs to the insulin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44017.
    HOGENOMiHOG000233362.
    HOVERGENiHBG006137.
    InParanoidiP51459.
    KOiK13769.

    Family and domain databases

    Gene3Di1.10.100.10. 1 hit.
    InterProiIPR022334. IGF2.
    IPR013576. IGF2_C.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view]
    PfamiPF08365. IGF2_C. 1 hit.
    PF00049. Insulin. 2 hits.
    [Graphical view]
    PRINTSiPR02002. INSLNLIKEGF.
    PR02006. INSLNLIKEGF2.
    PR00276. INSULINFAMLY.
    ProDomiPD005188. IGF2_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 1 hit.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P51459-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGIPVGKSLL MLFTFLAFAS CCIAAYRPSE TLCGGELVDT LQFVCGDRGF    50
    YFSRPASRIN RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSTPPTV 100
    LPDDSPRYPV VKLFQYNAWK QSTQRLRRGL PALLRTRRGR MLVKELEAFR 150
    EAQRHRPLIA LPTEDPTPHG AAFVEVSSDL Q 181
    Length:181
    Mass (Da):20,361
    Last modified:July 15, 1998 - v2
    Checksum:iB88F96951C87AA12
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti111 – 1111V → G(PubMed:7851727)Curated
    Sequence conflicti113 – 1131L → R(PubMed:7851727)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF020599 Genomic DNA. Translation: AAC48807.1.
    U11241 mRNA. Translation: AAA73915.1.
    PIRiI53642.
    RefSeqiNP_001108011.1. NM_001114539.1.
    UniGeneiEca.13091.

    Genome annotation databases

    GeneIDi100034182.
    KEGGiecb:100034182.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF020599 Genomic DNA. Translation: AAC48807.1 .
    U11241 mRNA. Translation: AAA73915.1 .
    PIRi I53642.
    RefSeqi NP_001108011.1. NM_001114539.1.
    UniGenei Eca.13091.

    3D structure databases

    ProteinModelPortali P51459.
    SMRi P51459. Positions 25-91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9796.ENSECAP00000022093.

    Proteomic databases

    PRIDEi P51459.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100034182.
    KEGGi ecb:100034182.

    Organism-specific databases

    CTDi 3481.

    Phylogenomic databases

    eggNOGi NOG44017.
    HOGENOMi HOG000233362.
    HOVERGENi HBG006137.
    InParanoidi P51459.
    KOi K13769.

    Family and domain databases

    Gene3Di 1.10.100.10. 1 hit.
    InterProi IPR022334. IGF2.
    IPR013576. IGF2_C.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view ]
    Pfami PF08365. IGF2_C. 1 hit.
    PF00049. Insulin. 2 hits.
    [Graphical view ]
    PRINTSi PR02002. INSLNLIKEGF.
    PR02006. INSLNLIKEGF2.
    PR00276. INSULINFAMLY.
    ProDomi PD005188. IGF2_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 1 hit.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "FISH mapping of the IGF2 gene in horse and donkey-detection of homoeology with HSA11."
      Raudsepp T., Otte K., Rozell B., Chowdhary B.P.
      Mamm. Genome 8:569-572(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Insulin-like growth factor II in the horse: determination of a cDNA nucleotide sequence and expression in fetal and adult tissue."
      Otte K., Engstrom W.
      Gen. Comp. Endocrinol. 96:270-275(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-117.
      Tissue: Liver.

    Entry informationi

    Entry nameiIGF2_HORSE
    AccessioniPrimary (citable) accession number: P51459
    Secondary accession number(s): O18837
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3