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Protein

Insulin-like growth factor I

Gene

IGF1

Organism
Capra hircus (Goat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor I
Short name:
IGF-I
Alternative name(s):
Somatomedin
Gene namesi
Name:IGF1
OrganismiCapra hircus (Goat)
Taxonomic identifieri9925 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeCapra

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei? – 49By similarityPRO_0000015652
Signal peptidei1 – ?Sequence analysis
Chaini50 – 11970Insulin-like growth factor IPRO_0000015653Add
BLAST
Propeptidei120 – 15435E peptidePRO_0000015654Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi55 ↔ 97By similarity
Disulfide bondi67 ↔ 110By similarity
Disulfide bondi96 ↔ 101By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed in all tissues examined: brain, lung, liver, spleen, uterus, ovary, testis, heart and skeletal muscle.1 Publication

Interactioni

Subunit structurei

Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms a ternary complex with IGFR1 and ITGA6:ITGB4.By similarity

Structurei

3D structure databases

ProteinModelPortaliP51457.
SMRiP51457. Positions 51-112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 7829BAdd
BLAST
Regioni79 – 9012CAdd
BLAST
Regioni91 – 11121AAdd
BLAST
Regioni112 – 1198D

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006137.
KOiK05459.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKISSLPTQ LFKCCFCDFL KQVKMPVTSS SHLFYLALCL LAFTSSATAG
60 70 80 90 100
PETLCGAELV DALQFVCGDR GFYFNKPTGY GSSSRRAPQT GIVDECCFRS
110 120 130 140 150
CDLRRLEMYC APLKPTKSAR SVRAQRHTDM PKAQKEVHLK NTSRGSAGNK

NYRM
Length:154
Mass (Da):17,082
Last modified:August 14, 2001 - v2
Checksum:i07238B6AF3068422
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26119 Genomic DNA. Translation: BAB77524.1. Sequence problems.
D11378 mRNA. Translation: BAA01976.1.
PIRiJC2483.
RefSeqiNP_001272626.1. NM_001285697.1.
UniGeneiChi.6376.

Genome annotation databases

GeneIDi100860838.
KEGGichx:100860838.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26119 Genomic DNA. Translation: BAB77524.1. Sequence problems.
D11378 mRNA. Translation: BAA01976.1.
PIRiJC2483.
RefSeqiNP_001272626.1. NM_001285697.1.
UniGeneiChi.6376.

3D structure databases

ProteinModelPortaliP51457.
SMRiP51457. Positions 51-112.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100860838.
KEGGichx:100860838.

Organism-specific databases

CTDi3479.

Phylogenomic databases

HOVERGENiHBG006137.
KOiK05459.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Dynamic aspects in the expression of the goat insulin-like growth factor-I (IGF-I) gene: diversity in transcription and post-transcription."
    Mikawa S., Yoshikawa G., Aoki H., Yamano Y., Sakai H., Komano T.
    Biosci. Biotechnol. Biochem. 59:87-92(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Tissue- and development-specific expression of goat insulin-like growth factor-I (IGF-I) mRNAs."
    Mikawa S., Yoshikawa G., Yamano Y., Sakai H., Komano T., Hosoi Y., Utsumi K.
    Biosci. Biotechnol. Biochem. 59:759-761(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Shiba.
    Tissue: Liver.

Entry informationi

Entry nameiIGF1_CAPHI
AccessioniPrimary (citable) accession number: P51457
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 14, 2001
Last modified: June 8, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.