Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P51451

- BLK_HUMAN

UniProt

P51451 - BLK_HUMAN

Protein

Tyrosine-protein kinase Blk

Gene

BLK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 3 (21 Aug 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.2 Publications

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

    Enzyme regulationi

    Antibody-mediated surface engagement of the B-cell antigen receptor (BCR) which results in the phosphorylation of BLK on tyrosine residues, stimulates the enzymatic activity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei269 – 2691ATPPROSITE-ProRule annotation
    Active sitei360 – 3601Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi247 – 2559ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB
    3. protein binding Source: IntAct
    4. protein tyrosine kinase activity Source: ProtInc

    GO - Biological processi

    1. B cell receptor signaling pathway Source: UniProtKB
    2. intracellular signal transduction Source: ProtInc
    3. peptidyl-tyrosine phosphorylation Source: GOC
    4. positive regulation of insulin secretion Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 2681.
    ReactomeiREACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    SignaLinkiP51451.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase Blk (EC:2.7.10.2)
    Alternative name(s):
    B lymphocyte kinase
    p55-Blk
    Gene namesi
    Name:BLK
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:1057. BLK.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchor By similarity
    Note: Present and active in lipid rafts. Membrane location is required for the phosphorylation of CD79A and CD79B By similarity.By similarity

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Maturity-onset diabetes of the young 11 (MODY11) [MIM:613375]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti71 – 711A → T Associated with MODY11; reduces the enhancing effect of BLK on insulin secretion; reduces the inducing effect of BLK on the expression of PDX1 and NKX6-1; found as somatic mutation in a colorectal adenocarcinoma sample. 2 Publications
    Corresponds to variant rs55758736 [ dbSNP | Ensembl ].
    VAR_041673

    Keywords - Diseasei

    Diabetes mellitus

    Organism-specific databases

    MIMi613375. phenotype.
    Orphaneti552. MODY syndrome.
    536. Systemic lupus erythematosus.
    PharmGKBiPA25368.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 505504Tyrosine-protein kinase BlkPRO_0000088061Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity
    Modified residuei389 – 3891Phosphotyrosine; by autocatalysisBy similarity

    Post-translational modificationi

    Phosphorylated on tyrosine residues after antibody-mediated surface engagement of the B-cell antigen receptor (BCR).By similarity
    Ubiquitination of activated BLK by the UBE3A ubiquitin protein ligase leads to its degradation by the ubiquitin-proteasome pathway.By similarity

    Keywords - PTMi

    Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP51451.
    PaxDbiP51451.
    PRIDEiP51451.

    PTM databases

    PhosphoSiteiP51451.

    Expressioni

    Tissue specificityi

    Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles.1 Publication

    Inductioni

    Expression is under the control of NF-kappa-B as well as the B-cell specific transcription factors PAX5 and EBF1.1 Publication

    Gene expression databases

    ArrayExpressiP51451.
    BgeeiP51451.
    CleanExiHS_BLK.
    GenevestigatoriP51451.

    Organism-specific databases

    HPAiCAB005093.

    Interactioni

    Subunit structurei

    Interacts with CBL (via SH2 domain). Interacts with CD79A and CD79B (via SH2 domain) By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ARP102753EBI-2105445,EBI-608057
    GAB1Q134803EBI-2105445,EBI-517684
    KITP107215EBI-2105445,EBI-1379503

    Protein-protein interaction databases

    BioGridi107109. 13 interactions.
    IntActiP51451. 10 interactions.
    MINTiMINT-1494192.
    STRINGi9606.ENSP00000259089.

    Structurei

    3D structure databases

    ProteinModelPortaliP51451.
    SMRiP51451. Positions 33-505.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini58 – 11861SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini124 – 22097SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini241 – 494254Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain, SH3 domain

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233858.
    HOVERGENiHBG008761.
    InParanoidiP51451.
    KOiK08890.
    OMAiKNNMKVA.
    OrthoDBiEOG7GTT2V.
    PhylomeDBiP51451.
    TreeFamiTF351634.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P51451-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLVSSKKPD KEKPIKEKDK GQWSPLKVSA QDKDAPPLPP LVVFNHLTPP    50
    PPDEHLDEDK HFVVALYDYT AMNDRDLQML KGEKLQVLKG TGDWWLARSL 100
    VTGREGYVPS NFVARVESLE MERWFFRSQG RKEAERQLLA PINKAGSFLI 150
    RESETNKGAF SLSVKDVTTQ GELIKHYKIR CLDEGGYYIS PRITFPSLQA 200
    LVQHYSKKGD GLCQRLTLPC VRPAPQNPWA QDEWEIPRQS LRLVRKLGSG 250
    QFGEVWMGYY KNNMKVAIKT LKEGTMSPEA FLGEANVMKA LQHERLVRLY 300
    AVVTKEPIYI VTEYMARGCL LDFLKTDEGS RLSLPRLIDM SAQIAEGMAY 350
    IERMNSIHRD LRAANILVSE ALCCKIADFG LARIIDSEYT AQEGAKFPIK 400
    WTAPEAIHFG VFTIKADVWS FGVLLMEVVT YGRVPYPGMS NPEVIRNLER 450
    GYRMPRPDTC PPELYRGVIA ECWRSRPEER PTFEFLQSVL EDFYTATERQ 500
    YELQP 505
    Length:505
    Mass (Da):57,706
    Last modified:August 21, 2007 - v3
    Checksum:iB5F739BEF8389176
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti287 – 2871V → M in CAA83965. (PubMed:7822795)Curated
    Sequence conflicti407 – 4071I → Y in AAB33265. (PubMed:7845672)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti48 – 481T → I.1 Publication
    Corresponds to variant rs35339715 [ dbSNP | Ensembl ].
    VAR_041672
    Natural varianti71 – 711A → T Associated with MODY11; reduces the enhancing effect of BLK on insulin secretion; reduces the inducing effect of BLK on the expression of PDX1 and NKX6-1; found as somatic mutation in a colorectal adenocarcinoma sample. 2 Publications
    Corresponds to variant rs55758736 [ dbSNP | Ensembl ].
    VAR_041673

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z33998 mRNA. Translation: CAA83965.1.
    S76617 mRNA. Translation: AAB33265.1.
    AK313751 mRNA. Translation: BAG36491.1.
    CH471157 Genomic DNA. Translation: EAW65617.1.
    BC007371 mRNA. Translation: AAH07371.1.
    BC032413 mRNA. Translation: AAH32413.1.
    CCDSiCCDS5982.1.
    PIRiI37206.
    RefSeqiNP_001706.2. NM_001715.2.
    XP_006716313.1. XM_006716250.1.
    XP_006716314.1. XM_006716251.1.
    UniGeneiHs.146591.

    Genome annotation databases

    EnsembliENST00000259089; ENSP00000259089; ENSG00000136573.
    GeneIDi640.
    KEGGihsa:640.
    UCSCiuc003wty.3. human.

    Polymorphism databases

    DMDMi158936749.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z33998 mRNA. Translation: CAA83965.1 .
    S76617 mRNA. Translation: AAB33265.1 .
    AK313751 mRNA. Translation: BAG36491.1 .
    CH471157 Genomic DNA. Translation: EAW65617.1 .
    BC007371 mRNA. Translation: AAH07371.1 .
    BC032413 mRNA. Translation: AAH32413.1 .
    CCDSi CCDS5982.1.
    PIRi I37206.
    RefSeqi NP_001706.2. NM_001715.2.
    XP_006716313.1. XM_006716250.1.
    XP_006716314.1. XM_006716251.1.
    UniGenei Hs.146591.

    3D structure databases

    ProteinModelPortali P51451.
    SMRi P51451. Positions 33-505.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107109. 13 interactions.
    IntActi P51451. 10 interactions.
    MINTi MINT-1494192.
    STRINGi 9606.ENSP00000259089.

    Chemistry

    BindingDBi P51451.
    ChEMBLi CHEMBL2363074.
    GuidetoPHARMACOLOGYi 1940.

    PTM databases

    PhosphoSitei P51451.

    Polymorphism databases

    DMDMi 158936749.

    Proteomic databases

    MaxQBi P51451.
    PaxDbi P51451.
    PRIDEi P51451.

    Protocols and materials databases

    DNASUi 640.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000259089 ; ENSP00000259089 ; ENSG00000136573 .
    GeneIDi 640.
    KEGGi hsa:640.
    UCSCi uc003wty.3. human.

    Organism-specific databases

    CTDi 640.
    GeneCardsi GC08P011388.
    H-InvDB HIX0007315.
    HIX0168887.
    HGNCi HGNC:1057. BLK.
    HPAi CAB005093.
    MIMi 191305. gene.
    613375. phenotype.
    neXtProti NX_P51451.
    Orphaneti 552. MODY syndrome.
    536. Systemic lupus erythematosus.
    PharmGKBi PA25368.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233858.
    HOVERGENi HBG008761.
    InParanoidi P51451.
    KOi K08890.
    OMAi KNNMKVA.
    OrthoDBi EOG7GTT2V.
    PhylomeDBi P51451.
    TreeFami TF351634.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 2681.
    Reactomei REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    SignaLinki P51451.

    Miscellaneous databases

    ChiTaRSi BLK. human.
    GeneWikii Tyrosine-protein_kinase_BLK.
    GenomeRNAii 640.
    NextBioi 2596.
    PROi P51451.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51451.
    Bgeei P51451.
    CleanExi HS_BLK.
    Genevestigatori P51451.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk."
      Islam K.B., Rabbani H., Larsson C., Sanders R., Smith C.I.
      J. Immunol. 154:1265-1272(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk)."
      Drebin J.A., Hartzell S.W., Griffin C., Campbell M.J., Niederhuber J.E.
      Oncogene 10:477-486(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood and Lymph.
    6. "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor."
      Donovan J.A., Wange R.L., Langdon W.Y., Samelson L.E.
      J. Biol. Chem. 269:22921-22924(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CBL.
    7. "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation."
      Bewarder N., Weinrich V., Budde P., Hartmann D., Flaswinkel H., Reth M., Frey J.
      Mol. Cell. Biol. 16:4735-4743(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF FCGR2A; FCGR2B AND FCGR2C.
    8. "Early B cell factor is an activator of the B lymphoid kinase promoter in early B cell development."
      Akerblad P., Sigvardsson M.
      J. Immunol. 163:5453-5461(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    9. "IgA Fc receptor (FcalphaR) cross-linking recruits tyrosine kinases, phosphoinositide kinases and serine/threonine kinases to glycolipid rafts."
      Lang M.L., Chen Y.W., Shen L., Gao H., Lang G.A., Wade T.K., Wade W.F.
      Biochem. J. 364:517-525(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, SUBCELLULAR LOCATION.
    10. Cited for: FUNCTION AS REGULATOR OF INSULIN SECRETION, TISSUE SPECIFICITY, INVOLVEMENT IN MODY11, VARIANT THR-71, CHARACTERIZATION OF VARIANT THR-71.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-48; THR-71 AND THR-71.

    Entry informationi

    Entry nameiBLK_HUMAN
    AccessioniPrimary (citable) accession number: P51451
    Secondary accession number(s): Q16291, Q96IN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 141 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3