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P51451

- BLK_HUMAN

UniProt

P51451 - BLK_HUMAN

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Protein

Tyrosine-protein kinase Blk

Gene

BLK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.2 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme regulationi

Antibody-mediated surface engagement of the B-cell antigen receptor (BCR) which results in the phosphorylation of BLK on tyrosine residues, stimulates the enzymatic activity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei269 – 2691ATPPROSITE-ProRule annotation
Active sitei360 – 3601Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi247 – 2559ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB
  3. protein tyrosine kinase activity Source: ProtInc

GO - Biological processi

  1. B cell receptor signaling pathway Source: UniProtKB
  2. intracellular signal transduction Source: ProtInc
  3. peptidyl-tyrosine phosphorylation Source: GOC
  4. positive regulation of insulin secretion Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 2681.
ReactomeiREACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
SignaLinkiP51451.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase Blk (EC:2.7.10.2)
Alternative name(s):
B lymphocyte kinase
p55-Blk
Gene namesi
Name:BLK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:1057. BLK.

Subcellular locationi

Cell membrane By similarity; Lipid-anchor By similarity
Note: Present and active in lipid rafts. Membrane location is required for the phosphorylation of CD79A and CD79B By similarity.By similarity

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Maturity-onset diabetes of the young 11 (MODY11) [MIM:613375]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti71 – 711A → T Associated with MODY11; reduces the enhancing effect of BLK on insulin secretion; reduces the inducing effect of BLK on the expression of PDX1 and NKX6-1; found as somatic mutation in a colorectal adenocarcinoma sample. 2 Publications
Corresponds to variant rs55758736 [ dbSNP | Ensembl ].
VAR_041673

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

MIMi613375. phenotype.
Orphaneti552. MODY syndrome.
536. Systemic lupus erythematosus.
PharmGKBiPA25368.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 505504Tyrosine-protein kinase BlkPRO_0000088061Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Modified residuei389 – 3891Phosphotyrosine; by autocatalysisBy similarity

Post-translational modificationi

Phosphorylated on tyrosine residues after antibody-mediated surface engagement of the B-cell antigen receptor (BCR).By similarity
Ubiquitination of activated BLK by the UBE3A ubiquitin protein ligase leads to its degradation by the ubiquitin-proteasome pathway.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP51451.
PaxDbiP51451.
PRIDEiP51451.

PTM databases

PhosphoSiteiP51451.

Expressioni

Tissue specificityi

Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles.1 Publication

Inductioni

Expression is under the control of NF-kappa-B as well as the B-cell specific transcription factors PAX5 and EBF1.1 Publication

Gene expression databases

BgeeiP51451.
CleanExiHS_BLK.
ExpressionAtlasiP51451. baseline and differential.
GenevestigatoriP51451.

Organism-specific databases

HPAiCAB005093.

Interactioni

Subunit structurei

Interacts with CBL (via SH2 domain). Interacts with CD79A and CD79B (via SH2 domain) By similarity.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ARP102753EBI-2105445,EBI-608057
EGFRP005332EBI-2105445,EBI-297353
GAB1Q134803EBI-2105445,EBI-517684
KITP107215EBI-2105445,EBI-1379503

Protein-protein interaction databases

BioGridi107109. 20 interactions.
IntActiP51451. 10 interactions.
MINTiMINT-1494192.
STRINGi9606.ENSP00000259089.

Structurei

3D structure databases

ProteinModelPortaliP51451.
SMRiP51451. Positions 33-505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 11861SH3PROSITE-ProRule annotationAdd
BLAST
Domaini124 – 22097SH2PROSITE-ProRule annotationAdd
BLAST
Domaini241 – 494254Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118938.
HOGENOMiHOG000233858.
HOVERGENiHBG008761.
InParanoidiP51451.
KOiK08890.
OMAiKNNMKVA.
OrthoDBiEOG7GTT2V.
PhylomeDBiP51451.
TreeFamiTF351634.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51451-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLVSSKKPD KEKPIKEKDK GQWSPLKVSA QDKDAPPLPP LVVFNHLTPP
60 70 80 90 100
PPDEHLDEDK HFVVALYDYT AMNDRDLQML KGEKLQVLKG TGDWWLARSL
110 120 130 140 150
VTGREGYVPS NFVARVESLE MERWFFRSQG RKEAERQLLA PINKAGSFLI
160 170 180 190 200
RESETNKGAF SLSVKDVTTQ GELIKHYKIR CLDEGGYYIS PRITFPSLQA
210 220 230 240 250
LVQHYSKKGD GLCQRLTLPC VRPAPQNPWA QDEWEIPRQS LRLVRKLGSG
260 270 280 290 300
QFGEVWMGYY KNNMKVAIKT LKEGTMSPEA FLGEANVMKA LQHERLVRLY
310 320 330 340 350
AVVTKEPIYI VTEYMARGCL LDFLKTDEGS RLSLPRLIDM SAQIAEGMAY
360 370 380 390 400
IERMNSIHRD LRAANILVSE ALCCKIADFG LARIIDSEYT AQEGAKFPIK
410 420 430 440 450
WTAPEAIHFG VFTIKADVWS FGVLLMEVVT YGRVPYPGMS NPEVIRNLER
460 470 480 490 500
GYRMPRPDTC PPELYRGVIA ECWRSRPEER PTFEFLQSVL EDFYTATERQ

YELQP
Length:505
Mass (Da):57,706
Last modified:August 21, 2007 - v3
Checksum:iB5F739BEF8389176
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti287 – 2871V → M in CAA83965. (PubMed:7822795)Curated
Sequence conflicti407 – 4071I → Y in AAB33265. (PubMed:7845672)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti48 – 481T → I.1 Publication
Corresponds to variant rs35339715 [ dbSNP | Ensembl ].
VAR_041672
Natural varianti71 – 711A → T Associated with MODY11; reduces the enhancing effect of BLK on insulin secretion; reduces the inducing effect of BLK on the expression of PDX1 and NKX6-1; found as somatic mutation in a colorectal adenocarcinoma sample. 2 Publications
Corresponds to variant rs55758736 [ dbSNP | Ensembl ].
VAR_041673

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z33998 mRNA. Translation: CAA83965.1.
S76617 mRNA. Translation: AAB33265.1.
AK313751 mRNA. Translation: BAG36491.1.
CH471157 Genomic DNA. Translation: EAW65617.1.
BC007371 mRNA. Translation: AAH07371.1.
BC032413 mRNA. Translation: AAH32413.1.
CCDSiCCDS5982.1.
PIRiI37206.
RefSeqiNP_001706.2. NM_001715.2.
XP_006716313.1. XM_006716250.1.
XP_006716314.1. XM_006716251.1.
UniGeneiHs.146591.

Genome annotation databases

EnsembliENST00000259089; ENSP00000259089; ENSG00000136573.
GeneIDi640.
KEGGihsa:640.
UCSCiuc003wty.3. human.

Polymorphism databases

DMDMi158936749.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z33998 mRNA. Translation: CAA83965.1 .
S76617 mRNA. Translation: AAB33265.1 .
AK313751 mRNA. Translation: BAG36491.1 .
CH471157 Genomic DNA. Translation: EAW65617.1 .
BC007371 mRNA. Translation: AAH07371.1 .
BC032413 mRNA. Translation: AAH32413.1 .
CCDSi CCDS5982.1.
PIRi I37206.
RefSeqi NP_001706.2. NM_001715.2.
XP_006716313.1. XM_006716250.1.
XP_006716314.1. XM_006716251.1.
UniGenei Hs.146591.

3D structure databases

ProteinModelPortali P51451.
SMRi P51451. Positions 33-505.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107109. 20 interactions.
IntActi P51451. 10 interactions.
MINTi MINT-1494192.
STRINGi 9606.ENSP00000259089.

Chemistry

BindingDBi P51451.
ChEMBLi CHEMBL2363074.
GuidetoPHARMACOLOGYi 1940.

PTM databases

PhosphoSitei P51451.

Polymorphism databases

DMDMi 158936749.

Proteomic databases

MaxQBi P51451.
PaxDbi P51451.
PRIDEi P51451.

Protocols and materials databases

DNASUi 640.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000259089 ; ENSP00000259089 ; ENSG00000136573 .
GeneIDi 640.
KEGGi hsa:640.
UCSCi uc003wty.3. human.

Organism-specific databases

CTDi 640.
GeneCardsi GC08P011388.
H-InvDB HIX0007315.
HIX0168887.
HGNCi HGNC:1057. BLK.
HPAi CAB005093.
MIMi 191305. gene.
613375. phenotype.
neXtProti NX_P51451.
Orphaneti 552. MODY syndrome.
536. Systemic lupus erythematosus.
PharmGKBi PA25368.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118938.
HOGENOMi HOG000233858.
HOVERGENi HBG008761.
InParanoidi P51451.
KOi K08890.
OMAi KNNMKVA.
OrthoDBi EOG7GTT2V.
PhylomeDBi P51451.
TreeFami TF351634.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 2681.
Reactomei REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
SignaLinki P51451.

Miscellaneous databases

ChiTaRSi BLK. human.
GeneWikii Tyrosine-protein_kinase_BLK.
GenomeRNAii 640.
NextBioi 2596.
PROi P51451.
SOURCEi Search...

Gene expression databases

Bgeei P51451.
CleanExi HS_BLK.
ExpressionAtlasi P51451. baseline and differential.
Genevestigatori P51451.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk."
    Islam K.B., Rabbani H., Larsson C., Sanders R., Smith C.I.
    J. Immunol. 154:1265-1272(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk)."
    Drebin J.A., Hartzell S.W., Griffin C., Campbell M.J., Niederhuber J.E.
    Oncogene 10:477-486(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood and Lymph.
  6. "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor."
    Donovan J.A., Wange R.L., Langdon W.Y., Samelson L.E.
    J. Biol. Chem. 269:22921-22924(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CBL.
  7. "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation."
    Bewarder N., Weinrich V., Budde P., Hartmann D., Flaswinkel H., Reth M., Frey J.
    Mol. Cell. Biol. 16:4735-4743(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF FCGR2A; FCGR2B AND FCGR2C.
  8. "Early B cell factor is an activator of the B lymphoid kinase promoter in early B cell development."
    Akerblad P., Sigvardsson M.
    J. Immunol. 163:5453-5461(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  9. "IgA Fc receptor (FcalphaR) cross-linking recruits tyrosine kinases, phosphoinositide kinases and serine/threonine kinases to glycolipid rafts."
    Lang M.L., Chen Y.W., Shen L., Gao H., Lang G.A., Wade T.K., Wade W.F.
    Biochem. J. 364:517-525(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, SUBCELLULAR LOCATION.
  10. Cited for: FUNCTION AS REGULATOR OF INSULIN SECRETION, TISSUE SPECIFICITY, INVOLVEMENT IN MODY11, VARIANT THR-71, CHARACTERIZATION OF VARIANT THR-71.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-48; THR-71 AND THR-71.

Entry informationi

Entry nameiBLK_HUMAN
AccessioniPrimary (citable) accession number: P51451
Secondary accession number(s): Q16291, Q96IN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3