Reviewed,
UniProtKB/Swiss-Prot P51451 (BLK_HUMAN)
Last modified
November 25, 2008.
Version 77.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tyrosine-protein kinase BLK EC=2.7.10.2 Alternative name(s): B lymphocyte kinase p55-BLK | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 505 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May function in a signal transduction pathway that is restricted to B-lymphoid cells. |
| Catalytic activity | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
| Sequence similarities | Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Contains 1 protein kinase domain. Contains 1 SH2 domain. Contains 1 SH3 domain. |
Ontologies
Keywords | |
|---|---|
| Coding sequence diversity | Polymorphism |
| Domain | SH2 domain SH3 domain |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase Tyrosine-protein kinase |
| PTM | Lipoprotein Myristate Phosphoprotein |
Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro protein kinase cascadeTraceable author statement. Source: ProtInc |
| Molecular function | ATP binding Inferred from electronic annotation. Source: InterPro non-membrane spanning protein tyrosine kinase activityInferred from electronic annotation. Source: EC protein bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 505 | 504 | Tyrosine-protein kinase BLK | PRO_0000088061 | |||||
Regions | |||||||||
| Domain | 58 – 118 | 61 | SH3 | ||||||
| Domain | 124 – 220 | 97 | SH2 | ||||||
| Domain | 241 – 494 | 254 | Protein kinase | ||||||
| Nucleotide binding | 247 – 255 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 360 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 269 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 389 | 1 | Phosphotyrosine; by autocatalysis By similarity | ||||||
| Lipidation | 2 | 1 | N-myristoyl glycine By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 48 | 1 | T → I | VAR_041672 | |||||
| Natural variant | 71 | 1 | A → T in a colorectal adenocarcinoma sample; somatic mutation. | VAR_041673 | |||||
Experimental info | |||||||||
| Sequence conflict | 287 | 1 | V → M in CAA83965. Ref.1 | ||||||
| Sequence conflict | 407 | 1 | I → Y in AAB33265. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk." Islam K.B., Rabbani H., Larsson C., Sanders R., Smith C.I. J. Immunol. 154:1265-1272(1995) [PubMed: 7822795] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk)." Drebin J.A., Hartzell S.W., Griffin C., Campbell M.J., Niederhuber J.E. Oncogene 10:477-486(1995) [PubMed: 7845672] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. Stratton M.R.Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-48; THR-71 AND THR-71. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| Z33998 mRNA. Translation: CAA83965.1. S76617 mRNA. Translation: AAB33265.1. | |
| PIR | I37206. |
| RefSeq | NP_001706.2. |
| UniGene | Hs.146591 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1BLK based on UniProtKB P16277. |
| SMR | P51451. Positions 63-505. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P51451. |
Genome annotation databases | |
| Ensembl | ENSG00000136573. Homo sapiens. [Contig view] |
| GeneID | 640. |
| KEGG | hsa:640. |
Organism-specific databases | |
| H-InvDB | HIX0007315. HIX0058582. |
| HGNC | HGNC:1057. BLK. |
| HPA | CAB005093. |
| MIM | 191305. gene. |
| PharmGKB | PA25368. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | P51451. |
| HOVERGEN | P51451. |
Gene expression databases | |
| ArrayExpress | P51451. |
| CleanEx | HS_BLK. |
| GermOnline | ENSG00000136573. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR000980. SH2. IPR001452. SH3. IPR001245. Tyr_pkinase. IPR008266. Tyr_pkinase_AS. [Graphical view] |
| Gene3D | G3DSA:3.30.505.10. SH2. 1 hit. |
| Pfam | PF07714. Pkinase_Tyr. 1 hit. PF00017. SH2. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view] |
| PRINTS | PR00401. SH2DOMAIN. PR00452. SH3DOMAIN. PR00109. TYRKINASE. |
| ProDom | PD000001. Prot_kinase. 1 hit. PD000093. SH2. 1 hit. PD000066. SH3. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00252. SH2. 1 hit. SM00326. SH3. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. False negative. PS50001. SH2. 1 hit. PS50002. SH3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 2596. |
| SOURCE | Search... |
Entry information
| Entry name | BLK_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P51451 Secondary accession number(s): Q16291 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 8 Human chromosome 8: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

Clusters with


