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P51450 (RORG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 134. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclear receptor ROR-gamma
Alternative name(s):
Nuclear receptor RZR-gamma
Nuclear receptor subfamily 1 group F member 3
RAR-related orphan receptor C
Retinoid-related orphan receptor-gamma
Thymus orphan receptor
Short name=TOR
Gene names
Name:Rorc
Synonyms:Nr1f3, Rorg, Thor
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length516 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A. Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays also a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC and PCK1. Ref.4 Ref.5 Ref.7 Ref.8 Ref.9 Ref.11 Ref.12 Ref.14 Ref.15 Ref.18

Isoform 2:Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes and Peyer's patches (Ref.5, Ref.7, Ref.8). Required for the generation of LTi (lymphoid tissue inducer) cells. Regulates thymocyte survival through DNA-binding on ROREs of target gene promoter regions and recruitment of coactivaros via the AF-2. Also plays a key role, downstream of IL6 and TGFB and synergistically with RORA, for lineage specification of uncommitted CD4+ T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. May also play a role in the pre-TCR activation cascade leading to the maturation of alpha/beta T-cells and may participate in the regulation of DNA accessibility in the TCR-J(alpha) locus. Ref.4 Ref.5 Ref.7 Ref.8 Ref.9 Ref.11 Ref.12 Ref.14 Ref.15 Ref.18

Subunit structure

Interacts (via AF-2 motif) with the coactivators NCOA1, NCOA2 and PPARGC1A (via LXXLL motif). Interacts with the corepressor NCOR1. Interacts with CRY1. Ref.8 Ref.10 Ref.16 Ref.17

Subcellular location

Nucleus Ref.15 Ref.18.

Tissue specificity

Isoform 1 is widely expressed with highest levels in muscle, kidney and liver. Isoform 2 is expressed primarily in immature thymocytes and the subset of mature T(H)17 cells. Neither isoform isexpressed in spleen or bone marrow. Ref.4 Ref.5 Ref.7 Ref.9 Ref.11 Ref.12 Ref.18

Developmental stage

In 3T3-L1 cells, sharp decline at mRNA and protein levels upon induction of adipocyte differentiation. Isoform 2 is detected in the immediate vicinity of vessels among small clusters of CD45+ cells as early as E12.5. At E16.5, isoform 2 is expressed exclusively in tight clusters of cells found in lymph node anlagen, in the submucosal region of the intestine and around central vessels in the spleen. Ref.7 Ref.11 Ref.15

Induction

Isoform 1 expression oscillates diurnally in peripheral tissues such as liver, brown adipose tissue (BAT), kidney and small intestines. Isoform 2 is induced upon antigen receptor ligation in the presence of IL6 and TGB1 (via STAT3). Ref.9 Ref.12 Ref.18

Domain

The AF-2 (activation function-2) motif is required for recruiting coregulators containing LXXLL motifs such as NCOA1 and NCOA2 (Ref.8). Ref.8

Disruption phenotype

Mice show decreased adipocytes size and highly insulin sensitivity, leading to an improved control of circulating fatty acids. Mutants are protected from hyperglycemia and insulin resistance in the state of obesity. Loss of circadian pattern of some clock genes expression in the peripheral tissues and massive apoptosis of thymocytes. Knockout mice for isoform 2 lack all lymph nodes and Peyer's patches, as well as LTi cells. They also show a reduction of T(H)17 cells in the lamina propria by at least 10-fold to less than 1% of the T(H) cells. Mice are less susceptible to autoimmune inflammatory diseases. Ref.7 Ref.8 Ref.9 Ref.11 Ref.15 Ref.18

Sequence similarities

Belongs to the nuclear hormone receptor family. NR1 subfamily.

Contains 1 nuclear receptor DNA-binding domain.

Ontologies

Keywords
   Biological processBiological rhythms
Transcription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative promoter usage
   DomainZinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionDevelopmental protein
Receptor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processPeyer's patch development

Inferred from mutant phenotype Ref.7. Source: UniProtKB

T cell differentiation in thymus

Inferred from mutant phenotype PubMed 15247480. Source: MGI

T-helper 17 cell differentiation

Inferred from direct assay PubMed 18792410. Source: MGI

T-helper cell differentiation

Inferred from mutant phenotype Ref.7. Source: UniProtKB

adipose tissue development

Inferred from mutant phenotype Ref.15. Source: UniProtKB

alpha-beta T cell differentiation

Inferred from mutant phenotype PubMed 15247480. Source: MGI

cell differentiation

Inferred from mutant phenotype Ref.7. Source: MGI

circadian regulation of gene expression

Inferred from mutant phenotype Ref.18. Source: UniProtKB

lymph node development

Inferred from mutant phenotype Ref.7. Source: MGI

mucosal-associated lymphoid tissue development

Inferred from mutant phenotype PubMed 15247480. Source: MGI

negative regulation of thymocyte apoptotic process

Inferred from mutant phenotype Ref.8. Source: UniProtKB

positive regulation of circadian rhythm

Inferred from direct assay Ref.18. Source: UniProtKB

protein phosphorylation

Inferred from mutant phenotype PubMed 15010863. Source: MGI

regulation of fat cell differentiation

Inferred from mutant phenotype Ref.15. Source: UniProtKB

regulation of gamma-delta T cell differentiation

Inferred from direct assay PubMed 21737317. Source: MGI

regulation of glucose metabolic process

Inferred from mutant phenotype Ref.14. Source: UniProtKB

regulation of steroid metabolic process

Inferred from mutant phenotype Ref.11. Source: UniProtKB

regulation of transcription involved in cell fate commitment

Inferred from direct assay Ref.12. Source: UniProtKB

xenobiotic metabolic process

Inferred from mutant phenotype Ref.11. Source: UniProtKB

   Cellular_componentnucleus

Inferred from direct assay Ref.18. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from direct assay Ref.12. Source: UniProtKB

ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity

Inferred from electronic annotation. Source: InterPro

protein binding

Inferred from physical interaction PubMed 21871655. Source: IntAct

sequence-specific DNA binding

Inferred from direct assay Ref.12. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Inferred from direct assay Ref.15Ref.18. Source: UniProtKB

steroid hormone receptor activity

Inferred from electronic annotation. Source: InterPro

transcription coactivator binding

Inferred from physical interaction Ref.10Ref.8. Source: UniProtKB

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

HIF1AQ166652EBI-4422078,EBI-447269From a different organism.
Hif1aQ612212EBI-4422078,EBI-298954

Alternative products

This entry describes 2 isoforms produced by alternative promoter usage. [Align] [Select]
Isoform 1 (identifier: P51450-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P51450-2)

Also known as: RORgT;

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.
     22-24: HTS → MRT

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 516516Nuclear receptor ROR-gamma
PRO_0000053518

Regions

DNA binding31 – 9666Nuclear receptor Ref.8 Ref.18
Zinc finger31 – 5121NR C4-type
Zinc finger67 – 9125NR C4-type
Region1 – 3030Modulating Potential
Region97 – 266170Hinge Potential
Region267 – 516250Ligand-binding Potential
Motif499 – 5046AF-2
Compositional bias119 – 13012Poly-Gln

Natural variations

Alternative sequence1 – 2121Missing in isoform 2.
VSP_003659
Alternative sequence22 – 243HTS → MRT in isoform 2.
VSP_003660

Experimental info

Mutagenesis311C → A: Loss of adipogenesis inhibition, when associated with A-48. Ref.15
Mutagenesis481C → A: Loss of adipogenesis inhibition, when associated with A-31. Ref.15
Mutagenesis56 – 572RR → AG: Abolishes DNA-binding. No effect neither on interaction with NCOA1 and NCOA2 nor on inhibition of NFATC1 expression.
Mutagenesis5001Y → F: Abolishes interaction with NCOA1 and NCOA2. Ref.8
Mutagenesis5021E → Q: Loss of transactivation function. Ref.18
Sequence conflict1811G → D in AAB02582. Ref.3
Sequence conflict3521T → K in AAB02582. Ref.3
Sequence conflict3521T → K in AAD46913. Ref.4
Sequence conflict3521T → K in AAH14804. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 218068AF4598A93B

FASTA51658,117
        10         20         30         40         50         60 
MDRAPQRHHR TSRELLAAKK THTSQIEVIP CKICGDKSSG IHYGVITCEG CKGFFRRSQQ 

        70         80         90        100        110        120 
CNVAYSCTRQ QNCPIDRTSR NRCQHCRLQK CLALGMSRDA VKFGRMSKKQ RDSLHAEVQK 

       130        140        150        160        170        180 
QLQQQQQQEQ VAKTPPAGSR GADTLTYTLG LSDGQLPLGA SPDLPEASAC PPGLLRASGS 

       190        200        210        220        230        240 
GPPYSNTLAK TEVQGASCHL EYSPERGKAE GRDSIYSTDG QLTLGRCGLR FEETRHPELG 

       250        260        270        280        290        300 
EPEQGPDSHC IPSFCSAPEV PYASLTDIEY LVQNVCKSFR ETCQLRLEDL LRQRTNLFSR 

       310        320        330        340        350        360 
EEVTSYQRKS MWEMWERCAH HLTEAIQYVV EFAKRLSGFM ELCQNDQIIL LTAGAMEVVL 

       370        380        390        400        410        420 
VRMCRAYNAN NHTVFFEGKY GGVELFRALG CSELISSIFD FSHFLSALCF SEDEIALYTA 

       430        440        450        460        470        480 
LVLINANRPG LQEKRRVEHL QYNLELAFHH HLCKTHRQGL LAKLPPKGKL RSLCSQHVEK 

       490        500        510 
LQIFQHLHPI VVQAAFPPLY KELFSTDVES PEGLSK 

« Hide

Isoform 2 (RORgT) [UniParc].

Checksum: A8A1C1A08921CFB6
Show »

FASTA49555,696

References

« Hide 'large scale' references
[1]"Cloning of a cDNA encoding the murine orphan receptor RZR/ROR gamma and characterization of its response element."
Medvedev A., Yan Z.H., Hirose T., Giguere V., Jetten A.M.
Gene 181:199-206(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
[2]"Genomic structure and chromosomal mapping of the nuclear orphan receptor ROR gamma (RORC) gene."
Medvedev A., Chistokhina A., Hirose A., Jetten A.M.
Genomics 46:93-102(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
Strain: 129.
[3]"TOR: a new orphan receptor expressed in the thymus that can modulate retinoid and thyroid hormone signals."
Ortiz M.A., Piedrafita F.J., Pfahl M., Maki R.
Mol. Endocrinol. 9:1679-1691(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: CD-1.
Tissue: Thymus.
[4]"RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells."
He Y.-W., Deftos M.L., Ojala E.W., Bevan M.J.
Immunity 9:797-806(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION IN T CELLS, TISSUE SPECIFICITY.
Tissue: Thymus.
[5]"RORgammaT, a thymus-specific isoform of the orphan nuclear receptor RORg/TOR, is up-regulated by signaling through the pre-T cell receptor (TCR) and binds to the TEA promoter."
Villey I., De Chasseval R., De Villartay J.-P.
Eur. J. Immunol. 29:4072-4080(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION IN PRE-TCR ACTIVATION (ISOFORM 2), TISSUE SPECIFICITY.
Tissue: Thymus.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[7]"An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells."
Eberl G., Marmon S., Sunshine M.J., Rennert P.D., Choi Y., Littman D.R.
Nat. Immunol. 5:64-73(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN THYMOPOIESIS (ISOFORM 2), DISRUPTION PHENOTYPE (ISOFORM 2), DEVELOPMENTAL STAGE (ISOFORM 2), TISSUE SPECIFICITY (ISOFORM 2).
[8]"RORgammat recruits steroid receptor coactivators to ensure thymocyte survival."
Xie H., Sadim M.S., Sun Z.
J. Immunol. 175:3800-3809(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN THYMOCYTE SURVIVAL (ISOFORM 2), INTERACTION WITH NCOA1 AND NCOA2, DISRUPTION PHENOTYPE, DNA-BINDING, MUTAGENESIS OF 56-ARG-ARG-57 AND TYR-500, DOMAIN.
[9]"The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells."
Ivanov I.I., McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., Cua D.J., Littman D.R.
Cell 126:1121-1133(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN T(H)17 CELLS DIFFERENTIATION (ISOFORM 2), DISRUPTION PHENOTYPE (ISOFORM 2), INDUCTION BY IL6 AND TGFB1 (ISOFORM 2), TISSUE SPECIFICITY (ISOFORM 2).
[10]"Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism."
Liu C., Li S., Liu T., Borjigin J., Lin J.D.
Nature 447:477-481(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PPARGC1A.
[11]"Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism."
Kang H.S., Angers M., Beak J.Y., Wu X., Gimble J.M., Wada T., Xie W., Collins J.B., Grissom S.F., Jetten A.M.
Physiol. Genomics 31:281-294(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN METABOLISM REGULATION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
[12]"T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma."
Yang X.O., Pappu B.P., Nurieva R., Akimzhanov A., Kang H.S., Chung Y., Ma L., Shah B., Panopoulos A.D., Schluns K.S., Watowich S.S., Tian Q., Jetten A.M., Dong C.
Immunity 28:29-39(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN T(H)17 CELLS DIFFERENTIATION (ISOFORM 2), INDUCTION BY IL6 AND TGB1 (ISOFORM 2), TISSUE SPECIFICITY (ISOFORM 2).
[13]"Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism."
Jetten A.M.
Nucl. Recept. Signal. 7:3-35(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW ON FUNCTION.
[14]"Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands."
Wang Y., Kumar N., Solt L.A., Richardson T.I., Helvering L.M., Crumbley C., Garcia-Ordonez R.D., Stayrook K.R., Zhang X., Novick S., Chalmers M.J., Griffin P.R., Burris T.P.
J. Biol. Chem. 285:5013-5025(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN GLUCOSE METABOLISM REGULATION, IDENTIFICATION OF LIGANDS.
[15]"Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma."
Meissburger B., Ukropec J., Roeder E., Beaton N., Geiger M., Teupser D., Civan B., Langhans W., Nawroth P.P., Gasperikova D., Rudofsky G., Wolfrum C.
EMBO Mol. Med. 3:637-651(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN ADIPOGENESIS, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, MUTAGENESIS OF CYS-31 AND CYS-48.
[16]"Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand."
Solt L.A., Kumar N., Nuhant P., Wang Y., Lauer J.L., Liu J., Istrate M.A., Kamenecka T.M., Roush W.R., Vidovic D., Schuerer S.C., Xu J., Wagoner G., Drew P.D., Griffin P.R., Burris T.P.
Nature 472:491-494(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH NCOR1 AND NCOA2, IDENTIFICATION OF LIGANDS.
[17]"Cryptochromes mediate rhythmic repression of the glucocorticoid receptor."
Lamia K.A., Papp S.J., Yu R.T., Barish G.D., Uhlenhaut N.H., Jonker J.W., Downes M., Evans R.M.
Nature 480:552-556(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CRY1.
[18]"RORgamma directly regulates the circadian expression of clock genes and downstream targets in vivo."
Takeda Y., Jothi R., Birault V., Jetten A.M.
Nucleic Acids Res. 40:8519-8535(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN CIRCADIAN RHYTHMS, TISSUE SPECIFICITY, INDUCTION, SUBCELLULAR LOCATION, DNA-BINDING, DISRUPTION PHENOTYPE, MUTAGENESIS OF GLU-502.
[19]"Action of RORs and their ligands in (patho)physiology."
Solt L.A., Burris T.P.
Trends Endocrinol. Metab. 23:619-627(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW ON FUNCTION AND LIGANDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U43508 mRNA. Translation: AAB40709.1.
AF019660 expand/collapse EMBL AC list , AF019655, AF019656, AF019657, AF019658, AF019659 Genomic DNA. Translation: AAC53501.1.
U39071 mRNA. Translation: AAB02582.1.
AF163668 mRNA. Translation: AAD46913.1.
AJ132394 mRNA. Translation: CAA10661.1.
BC014804 mRNA. Translation: AAH14804.1.
CCDSCCDS17591.1. [P51450-1]
PIRJC5375.
RefSeqNP_035411.2. NM_011281.2.
XP_006501224.1. XM_006501161.1.
UniGeneMm.4372.

3D structure databases

ProteinModelPortalP51450.
SMRP51450. Positions 29-506.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202957. 3 interactions.
DIPDIP-59439N.
IntActP51450. 2 interactions.

Chemistry

ChEMBLCHEMBL1293231.

PTM databases

PhosphoSiteP51450.

Proteomic databases

PRIDEP51450.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029795; ENSMUSP00000029795; ENSMUSG00000028150.
ENSMUST00000107292; ENSMUSP00000102913; ENSMUSG00000028150.
GeneID19885.
KEGGmmu:19885.
UCSCuc008qfy.2. mouse. [P51450-1]

Organism-specific databases

CTD6097.
MGIMGI:104856. Rorc.

Phylogenomic databases

eggNOGNOG317095.
GeneTreeENSGT00740000114909.
HOGENOMHOG000010200.
HOVERGENHBG106848.
InParanoidP51450.
KOK08534.
OrthoDBEOG79PJNW.
PhylomeDBP51450.
TreeFamTF319910.

Gene expression databases

BgeeP51450.
CleanExMM_RORC.
GenevestigatorP51450.

Family and domain databases

Gene3D1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003079. ROR_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR01293. RORNUCRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. SSF48508. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio297392.
PROP51450.
SOURCESearch...

Entry information

Entry nameRORG_MOUSE
AccessionPrimary (citable) accession number: P51450
Secondary accession number(s): Q61027 expand/collapse secondary AC list , Q91YT5, Q9QXD9, Q9R177
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot