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P51450

- RORG_MOUSE

UniProt

P51450 - RORG_MOUSE

Protein

Nuclear receptor ROR-gamma

Gene

Rorc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A. Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays also a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC and PCK1.
    Isoform 2: Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes and Peyer's patches (PubMed:10602018, PubMed:14691482, PubMed:16148126). Required for the generation of LTi (lymphoid tissue inducer) cells. Regulates thymocyte survival through DNA-binding on ROREs of target gene promoter regions and recruitment of coactivaros via the AF-2. Also plays a key role, downstream of IL6 and TGFB and synergistically with RORA, for lineage specification of uncommitted CD4+ T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. May also play a role in the pre-TCR activation cascade leading to the maturation of alpha/beta T-cells and may participate in the regulation of DNA accessibility in the TCR-J(alpha) locus.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi31 – 9666Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri31 – 5121NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri67 – 9125NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
    3. protein binding Source: IntAct
    4. sequence-specific DNA binding Source: UniProtKB
    5. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    6. steroid hormone receptor activity Source: InterPro
    7. transcription coactivator binding Source: UniProtKB
    8. zinc ion binding Source: InterPro

    GO - Biological processi

    1. adipose tissue development Source: UniProtKB
    2. alpha-beta T cell differentiation Source: MGI
    3. cell differentiation Source: MGI
    4. circadian regulation of gene expression Source: UniProtKB
    5. lymph node development Source: MGI
    6. mucosal-associated lymphoid tissue development Source: MGI
    7. negative regulation of thymocyte apoptotic process Source: UniProtKB
    8. Peyer's patch development Source: UniProtKB
    9. positive regulation of circadian rhythm Source: UniProtKB
    10. protein phosphorylation Source: MGI
    11. regulation of fat cell differentiation Source: UniProtKB
    12. regulation of gamma-delta T cell differentiation Source: MGI
    13. regulation of glucose metabolic process Source: UniProtKB
    14. regulation of steroid metabolic process Source: UniProtKB
    15. regulation of transcription involved in cell fate commitment Source: UniProtKB
    16. T cell differentiation in thymus Source: MGI
    17. T-helper 17 cell differentiation Source: MGI
    18. T-helper cell differentiation Source: UniProtKB
    19. xenobiotic metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Receptor

    Keywords - Biological processi

    Biological rhythms, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear receptor ROR-gamma
    Alternative name(s):
    Nuclear receptor RZR-gamma
    Nuclear receptor subfamily 1 group F member 3
    RAR-related orphan receptor C
    Retinoid-related orphan receptor-gamma
    Thymus orphan receptor
    Short name:
    TOR
    Gene namesi
    Name:Rorc
    Synonyms:Nr1f3, Rorg, Thor
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:104856. Rorc.

    Subcellular locationi

    Nucleus 2 PublicationsPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Mice show decreased adipocytes size and highly insulin sensitivity, leading to an improved control of circulating fatty acids. Mutants are protected from hyperglycemia and insulin resistance in the state of obesity. Loss of circadian pattern of some clock genes expression in the peripheral tissues and massive apoptosis of thymocytes. Knockout mice for isoform 2 lack all lymph nodes and Peyer's patches, as well as LTi cells. They also show a reduction of T(H)17 cells in the lamina propria by at least 10-fold to less than 1% of the T(H) cells. Mice are less susceptible to autoimmune inflammatory diseases.4 Publications

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi31 – 311C → A: Loss of adipogenesis inhibition, when associated with A-48. 1 Publication
    Mutagenesisi48 – 481C → A: Loss of adipogenesis inhibition, when associated with A-31. 1 Publication
    Mutagenesisi56 – 572RR → AG: Abolishes DNA-binding. No effect neither on interaction with NCOA1 and NCOA2 nor on inhibition of NFATC1 expression.
    Mutagenesisi500 – 5001Y → F: Abolishes interaction with NCOA1 and NCOA2. 1 Publication
    Mutagenesisi502 – 5021E → Q: Loss of transactivation function. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 516516Nuclear receptor ROR-gammaPRO_0000053518Add
    BLAST

    Proteomic databases

    PRIDEiP51450.

    PTM databases

    PhosphoSiteiP51450.

    Expressioni

    Tissue specificityi

    Isoform 1 is widely expressed with highest levels in muscle, kidney and liver. Isoform 2 is expressed primarily in immature thymocytes and the subset of mature T(H)17 cells. Neither isoform is expressed in spleen or bone marrow.4 Publications

    Developmental stagei

    In 3T3-L1 cells, sharp decline at mRNA and protein levels upon induction of adipocyte differentiation. Isoform 2 is detected in the immediate vicinity of vessels among small clusters of CD45+ cells as early as E12.5. At E16.5, isoform 2 is expressed exclusively in tight clusters of cells found in lymph node anlagen, in the submucosal region of the intestine and around central vessels in the spleen.2 Publications

    Inductioni

    Isoform 1 expression oscillates diurnally in peripheral tissues such as liver, brown adipose tissue (BAT), kidney and small intestines. Isoform 2 is induced upon antigen receptor ligation in the presence of IL6 and TGB1 (via STAT3).1 Publication

    Gene expression databases

    BgeeiP51450.
    CleanExiMM_RORC.
    GenevestigatoriP51450.

    Interactioni

    Subunit structurei

    Interacts (via AF-2 motif) with the coactivators NCOA1, NCOA2 and PPARGC1A (via LXXLL motif). Interacts with the corepressor NCOR1. Interacts with CRY1.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HIF1AQ166652EBI-4422078,EBI-447269From a different organism.
    Hif1aQ612212EBI-4422078,EBI-298954

    Protein-protein interaction databases

    BioGridi202957. 3 interactions.
    DIPiDIP-59439N.
    IntActiP51450. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP51450.
    SMRiP51450. Positions 29-506.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 3030ModulatingSequence AnalysisAdd
    BLAST
    Regioni97 – 266170HingeSequence AnalysisAdd
    BLAST
    Regioni267 – 516250Ligand-bindingSequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi499 – 5046AF-2

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi119 – 13012Poly-GlnAdd
    BLAST

    Domaini

    The AF-2 (activation function-2) motif is required for recruiting coregulators containing LXXLL motifs such as NCOA1 and NCOA2.1 Publication

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri31 – 5121NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri67 – 9125NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG317095.
    GeneTreeiENSGT00740000114909.
    HOGENOMiHOG000010200.
    HOVERGENiHBG106848.
    InParanoidiP51450.
    KOiK08534.
    OrthoDBiEOG79PJNW.
    PhylomeDBiP51450.
    TreeFamiTF319910.

    Family and domain databases

    Gene3Di1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR003079. ROR_rcpt.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR01293. RORNUCRECPTR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative promoter usage. Align

    Isoform 1 (identifier: P51450-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDRAPQRHHR TSRELLAAKK THTSQIEVIP CKICGDKSSG IHYGVITCEG    50
    CKGFFRRSQQ CNVAYSCTRQ QNCPIDRTSR NRCQHCRLQK CLALGMSRDA 100
    VKFGRMSKKQ RDSLHAEVQK QLQQQQQQEQ VAKTPPAGSR GADTLTYTLG 150
    LSDGQLPLGA SPDLPEASAC PPGLLRASGS GPPYSNTLAK TEVQGASCHL 200
    EYSPERGKAE GRDSIYSTDG QLTLGRCGLR FEETRHPELG EPEQGPDSHC 250
    IPSFCSAPEV PYASLTDIEY LVQNVCKSFR ETCQLRLEDL LRQRTNLFSR 300
    EEVTSYQRKS MWEMWERCAH HLTEAIQYVV EFAKRLSGFM ELCQNDQIIL 350
    LTAGAMEVVL VRMCRAYNAN NHTVFFEGKY GGVELFRALG CSELISSIFD 400
    FSHFLSALCF SEDEIALYTA LVLINANRPG LQEKRRVEHL QYNLELAFHH 450
    HLCKTHRQGL LAKLPPKGKL RSLCSQHVEK LQIFQHLHPI VVQAAFPPLY 500
    KELFSTDVES PEGLSK 516
    Length:516
    Mass (Da):58,117
    Last modified:October 1, 1996 - v1
    Checksum:i218068AF4598A93B
    GO
    Isoform 2 (identifier: P51450-2) [UniParc]FASTAAdd to Basket

    Also known as: RORgT

    The sequence of this isoform differs from the canonical sequence as follows:
         1-21: Missing.
         22-24: HTS → MRT

    Show »
    Length:495
    Mass (Da):55,696
    Checksum:iA8A1C1A08921CFB6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti181 – 1811G → D in AAB02582. (PubMed:8614404)Curated
    Sequence conflicti352 – 3521T → K in AAB02582. (PubMed:8614404)Curated
    Sequence conflicti352 – 3521T → K in AAD46913. (PubMed:9881970)Curated
    Sequence conflicti352 – 3521T → K in AAH14804. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2121Missing in isoform 2. 2 PublicationsVSP_003659Add
    BLAST
    Alternative sequencei22 – 243HTS → MRT in isoform 2. 2 PublicationsVSP_003660

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43508 mRNA. Translation: AAB40709.1.
    AF019660
    , AF019655, AF019656, AF019657, AF019658, AF019659 Genomic DNA. Translation: AAC53501.1.
    U39071 mRNA. Translation: AAB02582.1.
    AF163668 mRNA. Translation: AAD46913.1.
    AJ132394 mRNA. Translation: CAA10661.1.
    BC014804 mRNA. Translation: AAH14804.1.
    CCDSiCCDS17591.1. [P51450-1]
    PIRiJC5375.
    RefSeqiNP_035411.2. NM_011281.3.
    UniGeneiMm.4372.

    Genome annotation databases

    EnsembliENSMUST00000029795; ENSMUSP00000029795; ENSMUSG00000028150.
    ENSMUST00000107292; ENSMUSP00000102913; ENSMUSG00000028150.
    GeneIDi19885.
    KEGGimmu:19885.
    UCSCiuc008qfy.2. mouse. [P51450-1]

    Keywords - Coding sequence diversityi

    Alternative promoter usage

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43508 mRNA. Translation: AAB40709.1 .
    AF019660
    , AF019655 , AF019656 , AF019657 , AF019658 , AF019659 Genomic DNA. Translation: AAC53501.1 .
    U39071 mRNA. Translation: AAB02582.1 .
    AF163668 mRNA. Translation: AAD46913.1 .
    AJ132394 mRNA. Translation: CAA10661.1 .
    BC014804 mRNA. Translation: AAH14804.1 .
    CCDSi CCDS17591.1. [P51450-1 ]
    PIRi JC5375.
    RefSeqi NP_035411.2. NM_011281.3.
    UniGenei Mm.4372.

    3D structure databases

    ProteinModelPortali P51450.
    SMRi P51450. Positions 29-506.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202957. 3 interactions.
    DIPi DIP-59439N.
    IntActi P51450. 2 interactions.

    Chemistry

    ChEMBLi CHEMBL1293231.

    PTM databases

    PhosphoSitei P51450.

    Proteomic databases

    PRIDEi P51450.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029795 ; ENSMUSP00000029795 ; ENSMUSG00000028150 .
    ENSMUST00000107292 ; ENSMUSP00000102913 ; ENSMUSG00000028150 .
    GeneIDi 19885.
    KEGGi mmu:19885.
    UCSCi uc008qfy.2. mouse. [P51450-1 ]

    Organism-specific databases

    CTDi 6097.
    MGIi MGI:104856. Rorc.

    Phylogenomic databases

    eggNOGi NOG317095.
    GeneTreei ENSGT00740000114909.
    HOGENOMi HOG000010200.
    HOVERGENi HBG106848.
    InParanoidi P51450.
    KOi K08534.
    OrthoDBi EOG79PJNW.
    PhylomeDBi P51450.
    TreeFami TF319910.

    Miscellaneous databases

    NextBioi 297392.
    PROi P51450.
    SOURCEi Search...

    Gene expression databases

    Bgeei P51450.
    CleanExi MM_RORC.
    Genevestigatori P51450.

    Family and domain databases

    Gene3Di 1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR003079. ROR_rcpt.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR01293. RORNUCRECPTR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a cDNA encoding the murine orphan receptor RZR/ROR gamma and characterization of its response element."
      Medvedev A., Yan Z.H., Hirose T., Giguere V., Jetten A.M.
      Gene 181:199-206(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    2. "Genomic structure and chromosomal mapping of the nuclear orphan receptor ROR gamma (RORC) gene."
      Medvedev A., Chistokhina A., Hirose A., Jetten A.M.
      Genomics 46:93-102(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
      Strain: 129.
    3. "TOR: a new orphan receptor expressed in the thymus that can modulate retinoid and thyroid hormone signals."
      Ortiz M.A., Piedrafita F.J., Pfahl M., Maki R.
      Mol. Endocrinol. 9:1679-1691(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: CD-1.
      Tissue: Thymus.
    4. "RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells."
      He Y.-W., Deftos M.L., Ojala E.W., Bevan M.J.
      Immunity 9:797-806(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION IN T CELLS, TISSUE SPECIFICITY.
      Tissue: Thymus.
    5. "RORgammaT, a thymus-specific isoform of the orphan nuclear receptor RORg/TOR, is up-regulated by signaling through the pre-T cell receptor (TCR) and binds to the TEA promoter."
      Villey I., De Chasseval R., De Villartay J.-P.
      Eur. J. Immunol. 29:4072-4080(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION IN PRE-TCR ACTIVATION (ISOFORM 2), TISSUE SPECIFICITY.
      Tissue: Thymus.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. "An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells."
      Eberl G., Marmon S., Sunshine M.J., Rennert P.D., Choi Y., Littman D.R.
      Nat. Immunol. 5:64-73(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN THYMOPOIESIS (ISOFORM 2), DISRUPTION PHENOTYPE (ISOFORM 2), DEVELOPMENTAL STAGE (ISOFORM 2), TISSUE SPECIFICITY (ISOFORM 2).
    8. "RORgammat recruits steroid receptor coactivators to ensure thymocyte survival."
      Xie H., Sadim M.S., Sun Z.
      J. Immunol. 175:3800-3809(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN THYMOCYTE SURVIVAL (ISOFORM 2), INTERACTION WITH NCOA1 AND NCOA2, DISRUPTION PHENOTYPE, DNA-BINDING, MUTAGENESIS OF 56-ARG-ARG-57 AND TYR-500, DOMAIN.
    9. "The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells."
      Ivanov I.I., McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., Cua D.J., Littman D.R.
      Cell 126:1121-1133(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN T(H)17 CELLS DIFFERENTIATION (ISOFORM 2), DISRUPTION PHENOTYPE (ISOFORM 2), INDUCTION BY IL6 AND TGFB1 (ISOFORM 2), TISSUE SPECIFICITY (ISOFORM 2).
    10. "Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism."
      Liu C., Li S., Liu T., Borjigin J., Lin J.D.
      Nature 447:477-481(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PPARGC1A.
    11. "Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism."
      Kang H.S., Angers M., Beak J.Y., Wu X., Gimble J.M., Wada T., Xie W., Collins J.B., Grissom S.F., Jetten A.M.
      Physiol. Genomics 31:281-294(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN METABOLISM REGULATION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
    12. "T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma."
      Yang X.O., Pappu B.P., Nurieva R., Akimzhanov A., Kang H.S., Chung Y., Ma L., Shah B., Panopoulos A.D., Schluns K.S., Watowich S.S., Tian Q., Jetten A.M., Dong C.
      Immunity 28:29-39(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN T(H)17 CELLS DIFFERENTIATION (ISOFORM 2), INDUCTION BY IL6 AND TGB1 (ISOFORM 2), TISSUE SPECIFICITY (ISOFORM 2).
    13. "Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism."
      Jetten A.M.
      Nucl. Recept. Signal. 7:3-35(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON FUNCTION.
    14. "Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands."
      Wang Y., Kumar N., Solt L.A., Richardson T.I., Helvering L.M., Crumbley C., Garcia-Ordonez R.D., Stayrook K.R., Zhang X., Novick S., Chalmers M.J., Griffin P.R., Burris T.P.
      J. Biol. Chem. 285:5013-5025(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN GLUCOSE METABOLISM REGULATION, IDENTIFICATION OF LIGANDS.
    15. "Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma."
      Meissburger B., Ukropec J., Roeder E., Beaton N., Geiger M., Teupser D., Civan B., Langhans W., Nawroth P.P., Gasperikova D., Rudofsky G., Wolfrum C.
      EMBO Mol. Med. 3:637-651(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN ADIPOGENESIS, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, MUTAGENESIS OF CYS-31 AND CYS-48.
    16. Cited for: INTERACTION WITH NCOR1 AND NCOA2, IDENTIFICATION OF LIGANDS.
    17. "Cryptochromes mediate rhythmic repression of the glucocorticoid receptor."
      Lamia K.A., Papp S.J., Yu R.T., Barish G.D., Uhlenhaut N.H., Jonker J.W., Downes M., Evans R.M.
      Nature 480:552-556(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CRY1.
    18. "RORgamma directly regulates the circadian expression of clock genes and downstream targets in vivo."
      Takeda Y., Jothi R., Birault V., Jetten A.M.
      Nucleic Acids Res. 40:8519-8535(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CIRCADIAN RHYTHMS, TISSUE SPECIFICITY, INDUCTION, SUBCELLULAR LOCATION, DNA-BINDING, DISRUPTION PHENOTYPE, MUTAGENESIS OF GLU-502.
    19. "Action of RORs and their ligands in (patho)physiology."
      Solt L.A., Burris T.P.
      Trends Endocrinol. Metab. 23:619-627(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON FUNCTION AND LIGANDS.

    Entry informationi

    Entry nameiRORG_MOUSE
    AccessioniPrimary (citable) accession number: P51450
    Secondary accession number(s): Q61027
    , Q91YT5, Q9QXD9, Q9R177
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 136 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3