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P51450 (RORG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclear receptor ROR-gamma
Alternative name(s):
Nuclear receptor RZR-gamma
Nuclear receptor subfamily 1 group F member 3
Retinoid-related orphan receptor-gamma
Thymus orphan receptor
Short name=TOR
Gene names
Name:Rorc
Synonyms:Nr1f3, Rorg, Thor
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length516 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4+ T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock By similarity. Isoform 2 negatively regulates expression of TNFSF6/FASL and IL2 production in T-cells. It also binds to the TEA promoter and may participate in the regulation of DNA accessibility in the TCR-Jalpha locus. Ref.5

Subcellular location

Nucleus Probable.

Tissue specificity

Isoform 1 is widely expressed with highest levels in muscle, kidney and liver. Isoform 2 is expressed primarily in immature thymocytes. Neither isoform is expressed in spleen or bone marrow. Ref.4 Ref.5

Sequence similarities

Belongs to the nuclear hormone receptor family. NR1 subfamily.

Contains 1 nuclear receptor DNA-binding domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

HIF1AQ166652EBI-4422078,EBI-447269From a different organism.
Hif1aQ612212EBI-4422078,EBI-298954

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P51450-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P51450-2)

Also known as: RORgT;

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.
     22-24: HTS → MRT

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 516516Nuclear receptor ROR-gamma
PRO_0000053518

Regions

DNA binding31 – 9666Nuclear receptor
Zinc finger31 – 5121NR C4-type
Zinc finger67 – 9125NR C4-type
Region1 – 3030Modulating Potential
Region97 – 266170Hinge Potential
Region267 – 516250Ligand-binding Potential
Compositional bias119 – 13012Poly-Gln

Natural variations

Alternative sequence1 – 2121Missing in isoform 2.
VSP_003659
Alternative sequence22 – 243HTS → MRT in isoform 2.
VSP_003660

Experimental info

Sequence conflict1811G → D in AAB02582. Ref.3
Sequence conflict3521T → K Ref.3
Sequence conflict3521T → K Ref.4
Sequence conflict3521T → K Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 218068AF4598A93B

FASTA51658,117
        10         20         30         40         50         60 
MDRAPQRHHR TSRELLAAKK THTSQIEVIP CKICGDKSSG IHYGVITCEG CKGFFRRSQQ 

        70         80         90        100        110        120 
CNVAYSCTRQ QNCPIDRTSR NRCQHCRLQK CLALGMSRDA VKFGRMSKKQ RDSLHAEVQK 

       130        140        150        160        170        180 
QLQQQQQQEQ VAKTPPAGSR GADTLTYTLG LSDGQLPLGA SPDLPEASAC PPGLLRASGS 

       190        200        210        220        230        240 
GPPYSNTLAK TEVQGASCHL EYSPERGKAE GRDSIYSTDG QLTLGRCGLR FEETRHPELG 

       250        260        270        280        290        300 
EPEQGPDSHC IPSFCSAPEV PYASLTDIEY LVQNVCKSFR ETCQLRLEDL LRQRTNLFSR 

       310        320        330        340        350        360 
EEVTSYQRKS MWEMWERCAH HLTEAIQYVV EFAKRLSGFM ELCQNDQIIL LTAGAMEVVL 

       370        380        390        400        410        420 
VRMCRAYNAN NHTVFFEGKY GGVELFRALG CSELISSIFD FSHFLSALCF SEDEIALYTA 

       430        440        450        460        470        480 
LVLINANRPG LQEKRRVEHL QYNLELAFHH HLCKTHRQGL LAKLPPKGKL RSLCSQHVEK 

       490        500        510 
LQIFQHLHPI VVQAAFPPLY KELFSTDVES PEGLSK

« Hide

Isoform 2 (RORgT) [UniParc].

Checksum: A8A1C1A08921CFB6
Show »

FASTA49555,696

References

« Hide 'large scale' references
[1]"Cloning of a cDNA encoding the murine orphan receptor RZR/ROR gamma and characterization of its response element."
Medvedev A., Yan Z.H., Hirose T., Giguere V., Jetten A.M.
Gene 181:199-206(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
[2]"Genomic structure and chromosomal mapping of the nuclear orphan receptor ROR gamma (RORC) gene."
Medvedev A., Chistokhina A., Hirose A., Jetten A.M.
Genomics 46:93-102(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
Strain: 129.
[3]"TOR: a new orphan receptor expressed in the thymus that can modulate retinoid and thyroid hormone signals."
Ortiz M.A., Piedrafita F.J., Pfahl M., Maki R.
Mol. Endocrinol. 9:1679-1691(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: CD-1.
Tissue: Thymus.
[4]"RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells."
He Y.-W., Deftos M.L., Ojala E.W., Bevan M.J.
Immunity 9:797-806(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
Tissue: Thymus.
[5]"RORgammaT, a thymus-specific isoform of the orphan nuclear receptor RORg/TOR, is up-regulated by signaling through the pre-T cell receptor (TCR) and binds to the TEA promoter."
Villey I., De Chasseval R., De Villartay J.-P.
Eur. J. Immunol. 29:4072-4080(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION (ISOFORM 2), TISSUE SPECIFICITY.
Tissue: Thymus.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U43508 mRNA. Translation: AAB40709.1.
AF019660 expand/collapse EMBL AC list , AF019655, AF019656, AF019657, AF019658, AF019659 Genomic DNA. Translation: AAC53501.1.
U39071 mRNA. Translation: AAB02582.1.
AF163668 mRNA. Translation: AAD46913.1.
AJ132394 mRNA. Translation: CAA10661.1.
BC014804 mRNA. Translation: AAH14804.1.
IPIIPI00228543.
IPI00311164.
PIRJC5375.
RefSeqNP_035411.2. NM_011281.2.
UniGeneMm.4372.

3D structure databases

ProteinModelPortalP51450.
SMRP51450. Positions 31-149, 258-505.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-59439N.
IntActP51450. 2 interactions.

PTM databases

PhosphoSiteP51450.

Proteomic databases

PRIDEP51450.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029795; ENSMUSP00000029795; ENSMUSG00000028150.
ENSMUST00000107292; ENSMUSP00000102913; ENSMUSG00000028150.
GeneID19885.
KEGGmmu:19885.

Organism-specific databases

CTD6097.
MGIMGI:104856. Rorc.

Phylogenomic databases

eggNOGNOG317095.
GeneTreeENSGT00700000104109.
HOGENOMHOG000010200.
HOVERGENHBG106848.
InParanoidP51450.
KOK08534.
OrthoDBEOG4229JB.

Gene expression databases

ArrayExpressP51450.
BgeeP51450.
CleanExMM_RORC.
GenevestigatorP51450.
GermOnlineENSMUSG00000028150. Mus musculus.

Family and domain databases

Gene3D1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003079. ROR_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR01293. RORNUCRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. Str_ncl_receptor. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChEMBLCHEMBL1293231.
NextBio297392.
SOURCESearch...

Entry information

Entry nameRORG_MOUSE
AccessionPrimary (citable) accession number: P51450
Secondary accession number(s): Q61027 expand/collapse secondary AC list , Q91YT5, Q9QXD9, Q9R177
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 1, 2013
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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