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P51450

- RORG_MOUSE

UniProt

P51450 - RORG_MOUSE

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Protein

Nuclear receptor ROR-gamma

Gene
Rorc, Nr1f3, Rorg, Thor
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A. Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays also a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC and PCK1.10 Publications
Isoform 2: Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes and Peyer's patches (1 Publication, 1 Publication, 1 Publication). Required for the generation of LTi (lymphoid tissue inducer) cells. Regulates thymocyte survival through DNA-binding on ROREs of target gene promoter regions and recruitment of coactivaros via the AF-2. Also plays a key role, downstream of IL6 and TGFB and synergistically with RORA, for lineage specification of uncommitted CD4+ T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. May also play a role in the pre-TCR activation cascade leading to the maturation of alpha/beta T-cells and may participate in the regulation of DNA accessibility in the TCR-J(alpha) locus.10 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi31 – 9666Nuclear receptor2 PublicationsAdd
BLAST
Zinc fingeri31 – 5121NR C4-typeAdd
BLAST
Zinc fingeri67 – 9125NR C4-typeAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  3. protein binding Source: IntAct
  4. sequence-specific DNA binding Source: UniProtKB
  5. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  6. steroid hormone receptor activity Source: InterPro
  7. transcription coactivator binding Source: UniProtKB
  8. zinc ion binding Source: InterPro

GO - Biological processi

  1. adipose tissue development Source: UniProtKB
  2. alpha-beta T cell differentiation Source: MGI
  3. cell differentiation Source: MGI
  4. circadian regulation of gene expression Source: UniProtKB
  5. lymph node development Source: MGI
  6. mucosal-associated lymphoid tissue development Source: MGI
  7. negative regulation of thymocyte apoptotic process Source: UniProtKB
  8. Peyer's patch development Source: UniProtKB
  9. positive regulation of circadian rhythm Source: UniProtKB
  10. protein phosphorylation Source: MGI
  11. regulation of fat cell differentiation Source: UniProtKB
  12. regulation of gamma-delta T cell differentiation Source: MGI
  13. regulation of glucose metabolic process Source: UniProtKB
  14. regulation of steroid metabolic process Source: UniProtKB
  15. regulation of transcription involved in cell fate commitment Source: UniProtKB
  16. T cell differentiation in thymus Source: MGI
  17. T-helper 17 cell differentiation Source: MGI
  18. T-helper cell differentiation Source: UniProtKB
  19. xenobiotic metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor ROR-gamma
Alternative name(s):
Nuclear receptor RZR-gamma
Nuclear receptor subfamily 1 group F member 3
RAR-related orphan receptor C
Retinoid-related orphan receptor-gamma
Thymus orphan receptor
Short name:
TOR
Gene namesi
Name:Rorc
Synonyms:Nr1f3, Rorg, Thor
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:104856. Rorc.

Subcellular locationi

Nucleus 2 Publications

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice show decreased adipocytes size and highly insulin sensitivity, leading to an improved control of circulating fatty acids. Mutants are protected from hyperglycemia and insulin resistance in the state of obesity. Loss of circadian pattern of some clock genes expression in the peripheral tissues and massive apoptosis of thymocytes. Knockout mice for isoform 2 lack all lymph nodes and Peyer's patches, as well as LTi cells. They also show a reduction of T(H)17 cells in the lamina propria by at least 10-fold to less than 1% of the T(H) cells. Mice are less susceptible to autoimmune inflammatory diseases.6 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi31 – 311C → A: Loss of adipogenesis inhibition, when associated with A-48. 1 Publication
Mutagenesisi48 – 481C → A: Loss of adipogenesis inhibition, when associated with A-31. 1 Publication
Mutagenesisi56 – 572RR → AG: Abolishes DNA-binding. No effect neither on interaction with NCOA1 and NCOA2 nor on inhibition of NFATC1 expression.
Mutagenesisi500 – 5001Y → F: Abolishes interaction with NCOA1 and NCOA2. 1 Publication
Mutagenesisi502 – 5021E → Q: Loss of transactivation function. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Nuclear receptor ROR-gammaPRO_0000053518Add
BLAST

Proteomic databases

PRIDEiP51450.

PTM databases

PhosphoSiteiP51450.

Expressioni

Tissue specificityi

Isoform 1 is widely expressed with highest levels in muscle, kidney and liver. Isoform 2 is expressed primarily in immature thymocytes and the subset of mature T(H)17 cells. Neither isoform is expressed in spleen or bone marrow.7 Publications

Developmental stagei

In 3T3-L1 cells, sharp decline at mRNA and protein levels upon induction of adipocyte differentiation. Isoform 2 is detected in the immediate vicinity of vessels among small clusters of CD45+ cells as early as E12.5. At E16.5, isoform 2 is expressed exclusively in tight clusters of cells found in lymph node anlagen, in the submucosal region of the intestine and around central vessels in the spleen.3 Publications

Inductioni

Isoform 1 expression oscillates diurnally in peripheral tissues such as liver, brown adipose tissue (BAT), kidney and small intestines. Isoform 2 is induced upon antigen receptor ligation in the presence of IL6 and TGB1 (via STAT3).3 Publications

Gene expression databases

BgeeiP51450.
CleanExiMM_RORC.
GenevestigatoriP51450.

Interactioni

Subunit structurei

Interacts (via AF-2 motif) with the coactivators NCOA1, NCOA2 and PPARGC1A (via LXXLL motif). Interacts with the corepressor NCOR1. Interacts with CRY1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HIF1AQ166652EBI-4422078,EBI-447269From a different organism.
Hif1aQ612212EBI-4422078,EBI-298954

Protein-protein interaction databases

BioGridi202957. 3 interactions.
DIPiDIP-59439N.
IntActiP51450. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP51450.
SMRiP51450. Positions 29-506.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 3030Modulating Reviewed predictionAdd
BLAST
Regioni97 – 266170Hinge Reviewed predictionAdd
BLAST
Regioni267 – 516250Ligand-binding Reviewed predictionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi499 – 5046AF-2

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi119 – 13012Poly-GlnAdd
BLAST

Domaini

The AF-2 (activation function-2) motif is required for recruiting coregulators containing LXXLL motifs such as NCOA1 and NCOA2 (1 Publication).1 Publication

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG317095.
GeneTreeiENSGT00740000114909.
HOGENOMiHOG000010200.
HOVERGENiHBG106848.
InParanoidiP51450.
KOiK08534.
OrthoDBiEOG79PJNW.
PhylomeDBiP51450.
TreeFamiTF319910.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003079. ROR_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01293. RORNUCRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. Align

Isoform 1 (identifier: P51450-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDRAPQRHHR TSRELLAAKK THTSQIEVIP CKICGDKSSG IHYGVITCEG    50
CKGFFRRSQQ CNVAYSCTRQ QNCPIDRTSR NRCQHCRLQK CLALGMSRDA 100
VKFGRMSKKQ RDSLHAEVQK QLQQQQQQEQ VAKTPPAGSR GADTLTYTLG 150
LSDGQLPLGA SPDLPEASAC PPGLLRASGS GPPYSNTLAK TEVQGASCHL 200
EYSPERGKAE GRDSIYSTDG QLTLGRCGLR FEETRHPELG EPEQGPDSHC 250
IPSFCSAPEV PYASLTDIEY LVQNVCKSFR ETCQLRLEDL LRQRTNLFSR 300
EEVTSYQRKS MWEMWERCAH HLTEAIQYVV EFAKRLSGFM ELCQNDQIIL 350
LTAGAMEVVL VRMCRAYNAN NHTVFFEGKY GGVELFRALG CSELISSIFD 400
FSHFLSALCF SEDEIALYTA LVLINANRPG LQEKRRVEHL QYNLELAFHH 450
HLCKTHRQGL LAKLPPKGKL RSLCSQHVEK LQIFQHLHPI VVQAAFPPLY 500
KELFSTDVES PEGLSK 516
Length:516
Mass (Da):58,117
Last modified:October 1, 1996 - v1
Checksum:i218068AF4598A93B
GO
Isoform 2 (identifier: P51450-2) [UniParc]FASTAAdd to Basket

Also known as: RORgT

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.
     22-24: HTS → MRT

Show »
Length:495
Mass (Da):55,696
Checksum:iA8A1C1A08921CFB6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2121Missing in isoform 2. VSP_003659Add
BLAST
Alternative sequencei22 – 243HTS → MRT in isoform 2. VSP_003660

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti181 – 1811G → D in AAB02582. 1 Publication
Sequence conflicti352 – 3521T → K in AAB02582. 1 Publication
Sequence conflicti352 – 3521T → K in AAD46913. 1 Publication
Sequence conflicti352 – 3521T → K in AAH14804. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43508 mRNA. Translation: AAB40709.1.
AF019660
, AF019655, AF019656, AF019657, AF019658, AF019659 Genomic DNA. Translation: AAC53501.1.
U39071 mRNA. Translation: AAB02582.1.
AF163668 mRNA. Translation: AAD46913.1.
AJ132394 mRNA. Translation: CAA10661.1.
BC014804 mRNA. Translation: AAH14804.1.
CCDSiCCDS17591.1. [P51450-1]
PIRiJC5375.
RefSeqiNP_035411.2. NM_011281.3.
UniGeneiMm.4372.

Genome annotation databases

EnsembliENSMUST00000029795; ENSMUSP00000029795; ENSMUSG00000028150.
ENSMUST00000107292; ENSMUSP00000102913; ENSMUSG00000028150.
GeneIDi19885.
KEGGimmu:19885.
UCSCiuc008qfy.2. mouse. [P51450-1]

Keywords - Coding sequence diversityi

Alternative promoter usage

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43508 mRNA. Translation: AAB40709.1 .
AF019660
, AF019655 , AF019656 , AF019657 , AF019658 , AF019659 Genomic DNA. Translation: AAC53501.1 .
U39071 mRNA. Translation: AAB02582.1 .
AF163668 mRNA. Translation: AAD46913.1 .
AJ132394 mRNA. Translation: CAA10661.1 .
BC014804 mRNA. Translation: AAH14804.1 .
CCDSi CCDS17591.1. [P51450-1 ]
PIRi JC5375.
RefSeqi NP_035411.2. NM_011281.3.
UniGenei Mm.4372.

3D structure databases

ProteinModelPortali P51450.
SMRi P51450. Positions 29-506.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202957. 3 interactions.
DIPi DIP-59439N.
IntActi P51450. 2 interactions.

Chemistry

ChEMBLi CHEMBL1293231.

PTM databases

PhosphoSitei P51450.

Proteomic databases

PRIDEi P51450.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029795 ; ENSMUSP00000029795 ; ENSMUSG00000028150 .
ENSMUST00000107292 ; ENSMUSP00000102913 ; ENSMUSG00000028150 .
GeneIDi 19885.
KEGGi mmu:19885.
UCSCi uc008qfy.2. mouse. [P51450-1 ]

Organism-specific databases

CTDi 6097.
MGIi MGI:104856. Rorc.

Phylogenomic databases

eggNOGi NOG317095.
GeneTreei ENSGT00740000114909.
HOGENOMi HOG000010200.
HOVERGENi HBG106848.
InParanoidi P51450.
KOi K08534.
OrthoDBi EOG79PJNW.
PhylomeDBi P51450.
TreeFami TF319910.

Miscellaneous databases

NextBioi 297392.
PROi P51450.
SOURCEi Search...

Gene expression databases

Bgeei P51450.
CleanExi MM_RORC.
Genevestigatori P51450.

Family and domain databases

Gene3Di 1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003079. ROR_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR01293. RORNUCRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a cDNA encoding the murine orphan receptor RZR/ROR gamma and characterization of its response element."
    Medvedev A., Yan Z.H., Hirose T., Giguere V., Jetten A.M.
    Gene 181:199-206(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  2. "Genomic structure and chromosomal mapping of the nuclear orphan receptor ROR gamma (RORC) gene."
    Medvedev A., Chistokhina A., Hirose A., Jetten A.M.
    Genomics 46:93-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    Strain: 129.
  3. "TOR: a new orphan receptor expressed in the thymus that can modulate retinoid and thyroid hormone signals."
    Ortiz M.A., Piedrafita F.J., Pfahl M., Maki R.
    Mol. Endocrinol. 9:1679-1691(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: CD-1.
    Tissue: Thymus.
  4. "RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells."
    He Y.-W., Deftos M.L., Ojala E.W., Bevan M.J.
    Immunity 9:797-806(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION IN T CELLS, TISSUE SPECIFICITY.
    Tissue: Thymus.
  5. "RORgammaT, a thymus-specific isoform of the orphan nuclear receptor RORg/TOR, is up-regulated by signaling through the pre-T cell receptor (TCR) and binds to the TEA promoter."
    Villey I., De Chasseval R., De Villartay J.-P.
    Eur. J. Immunol. 29:4072-4080(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION IN PRE-TCR ACTIVATION (ISOFORM 2), TISSUE SPECIFICITY.
    Tissue: Thymus.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. "An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells."
    Eberl G., Marmon S., Sunshine M.J., Rennert P.D., Choi Y., Littman D.R.
    Nat. Immunol. 5:64-73(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN THYMOPOIESIS (ISOFORM 2), DISRUPTION PHENOTYPE (ISOFORM 2), DEVELOPMENTAL STAGE (ISOFORM 2), TISSUE SPECIFICITY (ISOFORM 2).
  8. "RORgammat recruits steroid receptor coactivators to ensure thymocyte survival."
    Xie H., Sadim M.S., Sun Z.
    J. Immunol. 175:3800-3809(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN THYMOCYTE SURVIVAL (ISOFORM 2), INTERACTION WITH NCOA1 AND NCOA2, DISRUPTION PHENOTYPE, DNA-BINDING, MUTAGENESIS OF 56-ARG-ARG-57 AND TYR-500, DOMAIN.
  9. "The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells."
    Ivanov I.I., McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., Cua D.J., Littman D.R.
    Cell 126:1121-1133(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN T(H)17 CELLS DIFFERENTIATION (ISOFORM 2), DISRUPTION PHENOTYPE (ISOFORM 2), INDUCTION BY IL6 AND TGFB1 (ISOFORM 2), TISSUE SPECIFICITY (ISOFORM 2).
  10. "Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism."
    Liu C., Li S., Liu T., Borjigin J., Lin J.D.
    Nature 447:477-481(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PPARGC1A.
  11. "Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism."
    Kang H.S., Angers M., Beak J.Y., Wu X., Gimble J.M., Wada T., Xie W., Collins J.B., Grissom S.F., Jetten A.M.
    Physiol. Genomics 31:281-294(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN METABOLISM REGULATION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
  12. "T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma."
    Yang X.O., Pappu B.P., Nurieva R., Akimzhanov A., Kang H.S., Chung Y., Ma L., Shah B., Panopoulos A.D., Schluns K.S., Watowich S.S., Tian Q., Jetten A.M., Dong C.
    Immunity 28:29-39(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN T(H)17 CELLS DIFFERENTIATION (ISOFORM 2), INDUCTION BY IL6 AND TGB1 (ISOFORM 2), TISSUE SPECIFICITY (ISOFORM 2).
  13. "Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism."
    Jetten A.M.
    Nucl. Recept. Signal. 7:3-35(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON FUNCTION.
  14. "Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands."
    Wang Y., Kumar N., Solt L.A., Richardson T.I., Helvering L.M., Crumbley C., Garcia-Ordonez R.D., Stayrook K.R., Zhang X., Novick S., Chalmers M.J., Griffin P.R., Burris T.P.
    J. Biol. Chem. 285:5013-5025(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN GLUCOSE METABOLISM REGULATION, IDENTIFICATION OF LIGANDS.
  15. "Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma."
    Meissburger B., Ukropec J., Roeder E., Beaton N., Geiger M., Teupser D., Civan B., Langhans W., Nawroth P.P., Gasperikova D., Rudofsky G., Wolfrum C.
    EMBO Mol. Med. 3:637-651(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN ADIPOGENESIS, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, MUTAGENESIS OF CYS-31 AND CYS-48.
  16. Cited for: INTERACTION WITH NCOR1 AND NCOA2, IDENTIFICATION OF LIGANDS.
  17. "Cryptochromes mediate rhythmic repression of the glucocorticoid receptor."
    Lamia K.A., Papp S.J., Yu R.T., Barish G.D., Uhlenhaut N.H., Jonker J.W., Downes M., Evans R.M.
    Nature 480:552-556(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CRY1.
  18. "RORgamma directly regulates the circadian expression of clock genes and downstream targets in vivo."
    Takeda Y., Jothi R., Birault V., Jetten A.M.
    Nucleic Acids Res. 40:8519-8535(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CIRCADIAN RHYTHMS, TISSUE SPECIFICITY, INDUCTION, SUBCELLULAR LOCATION, DNA-BINDING, DISRUPTION PHENOTYPE, MUTAGENESIS OF GLU-502.
  19. "Action of RORs and their ligands in (patho)physiology."
    Solt L.A., Burris T.P.
    Trends Endocrinol. Metab. 23:619-627(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON FUNCTION AND LIGANDS.

Entry informationi

Entry nameiRORG_MOUSE
AccessioniPrimary (citable) accession number: P51450
Secondary accession number(s): Q61027
, Q91YT5, Q9QXD9, Q9R177
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi