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P51448

- RORA_MOUSE

UniProt

P51448 - RORA_MOUSE

Protein

Nuclear receptor ROR-alpha

Gene

Rora

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development, regulates SHH gene expression, among others, to induce granule cells proliferation as well as expression of genes involved in calcium-mediated signal transduction. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG. In liver, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1. Induces a rhythmic expression of some of these genes. In addition, interplays functionally with NR1H2 and NR1H3 for the regulation of genes involved in cholesterol metabolism. Also involved in the regulation of hepatic glucose metabolism through the modulation of G6PC and PCK1. In adipose tissue, plays a role as negative regulator of adipocyte differentiation, probably acting through dual mechanisms. May suppress CEBPB-dependent adipogenesis through direct interaction and PPARG-dependent adipogenesis through competition for DNA-binding. Downstream of IL6 and TGFB and synergistically with RORC isoform 2, is implicated in the lineage specification of uncommitted CD4+ T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. Involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A. May inhibit cell growth in response to cellular stress. May exert an anti-inflammatory role by inducing CHUK expression and inhibiting NF-kappa-B signaling.13 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi73 – 13866Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri73 – 9321NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri109 – 13325NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. beta-catenin binding Source: UniProtKB
    2. direct ligand regulated sequence-specific DNA binding transcription factor activity Source: UniProtKB
    3. DNA binding Source: UniProtKB
    4. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
    5. oxysterol binding Source: UniProtKB
    6. protein binding Source: UniProtKB
    7. sequence-specific DNA binding Source: UniProtKB
    8. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    9. steroid hormone receptor activity Source: InterPro
    10. transcription coactivator binding Source: UniProtKB
    11. zinc ion binding Source: InterPro

    GO - Biological processi

    1. angiogenesis Source: UniProtKB
    2. cellular response to hypoxia Source: UniProtKB
    3. cellular response to sterol Source: UniProtKB
    4. cerebellar granule cell precursor proliferation Source: UniProtKB
    5. cerebellar Purkinje cell differentiation Source: MGI
    6. cGMP metabolic process Source: MGI
    7. circadian regulation of gene expression Source: UniProtKB
    8. intracellular receptor signaling pathway Source: UniProtKB
    9. muscle cell differentiation Source: UniProtKB
    10. negative regulation of fat cell differentiation Source: UniProtKB
    11. negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    12. negative regulation of inflammatory response Source: UniProtKB
    13. nitric oxide biosynthetic process Source: MGI
    14. positive regulation of circadian rhythm Source: UniProtKB
    15. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    16. positive regulation vascular endothelial growth factor production Source: UniProtKB
    17. regulation of cholesterol homeostasis Source: UniProtKB
    18. regulation of circadian rhythm Source: UniProtKB
    19. regulation of glucose metabolic process Source: UniProtKB
    20. regulation of macrophage activation Source: MGI
    21. regulation of smoothened signaling pathway Source: UniProtKB
    22. regulation of steroid metabolic process Source: UniProtKB
    23. regulation of transcription, DNA-templated Source: UniProtKB
    24. regulation of transcription involved in cell fate commitment Source: UniProtKB
    25. T-helper 17 cell differentiation Source: UniProtKB
    26. triglyceride homeostasis Source: UniProtKB
    27. xenobiotic metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Activator, Receptor

    Keywords - Biological processi

    Biological rhythms, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_118837. Rora activates circadian gene expression.
    REACT_198351. RORA activates circadian gene expression.
    REACT_198352. REV-ERBA represses gene expression.
    REACT_198602. PPARA activates gene expression.
    REACT_24972. Circadian Clock.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear receptor ROR-alpha
    Alternative name(s):
    Nuclear receptor RZR-alpha
    Nuclear receptor subfamily 1 group F member 1
    RAR-related orphan receptor A
    Retinoid-related orphan receptor-alpha
    Gene namesi
    Name:Rora
    Synonyms:Nr1f1, Rzra
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:104661. Rora.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Rora are the cause of the staggerer (SG) mutant phenotype which is characterized by disturbance of Purkinje cell development and immune system functioning. This phenotype exhibits lower body weight, reduced adiposity, decreased plasma cholesterol, triglyceride and apolipoprotein CIII levels, and is resistant to diet-induced obesity. Also has abnormal circadian rhythms.

    Keywords - Diseasei

    Disease mutation

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 523523Nuclear receptor ROR-alphaPRO_0000053513Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei38 – 381N6-methyllysineBy similarity
    Modified residuei183 – 1831Phosphothreonine; by MAPK1By similarity
    Cross-linki240 – 240Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

    Post-translational modificationi

    Phosphorylation by conventional PKCs in neurons inhibits transcriptional activity. Phosphorylated on Thr-183 by MAPK1/ERK1 in vitro By similarity.By similarity
    Sumoylated by SENP1 and SENP2. Sumoylation, promoted by PIAS2, PIAS3, PIAS4 but not PIAS1, enhances the transcriptional activity. Desumoylated by SENP1 By similarity.By similarity
    Ubiquitinated, leading to its degradation by the proteasome. Proteasomal degradation is required for efficient transcriptional activity and is prevented by HR By similarity.By similarity
    Isoform 1: monomethylated at Lys-38 by EZH2, this creates a degron recognized by a DCX (DDB1-DCAF1/VPRBP-CUL4A-RBX1) E3 ubiquitin ligase complex.By similarity

    Keywords - PTMi

    Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiP51448.

    PTM databases

    PhosphoSiteiP51448.

    Expressioni

    Tissue specificityi

    Expressed in cerebellum, heart, liver, lung, kidney, retina and brown and white adipose tissues. Expressed in the subset of mature Th17 cells.4 Publications

    Developmental stagei

    In cerebellum, expression begins at E12.5. In the developing retina, first expressed at E17 in the ganglion cell layer. At P3, expressed in the inner border of the neuroblasitic border (presumptive amacrine cells). By P6, levels increase in developing cones. Expression found in the presumptive bipolar cells by P9. During adipocyte differentiation, expression gradually increases.3 Publications

    Inductioni

    In T(H) cells, induced upon antigen receptor ligation in the presence of IL6 and TGB1 (via STAT3). Oscillates diurnally in central nervous system. In liver, Isoform 1 oscillates diurnally but not isoform 4.4 Publications

    Gene expression databases

    ArrayExpressiP51448.
    BgeeiP51448.
    CleanExiMM_RORA.
    GenevestigatoriP51448.

    Interactioni

    Subunit structurei

    Monomer. Interacts (via the DNA-binding domain) with HIF1A; the interaction enhances HIF1A transcription under hypoxia through increasing protein stability. Interacts with CEBPB; the interaction disrupts the interaction CEBPB:EP300. Interacts with the coactivators NCOA2, PPARGC1A (via LXXLL motif), EP300 and MED1. Interacts with the corepressor NCOR1. Interacts with MAGED1 and CTNNB1. Interacts with CRY1 and PER2.8 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Atxn1P542543EBI-1169722,EBI-1169713
    Maged1Q9QYH65EBI-1169722,EBI-1801274

    Protein-protein interaction databases

    BioGridi202956. 1 interaction.
    DIPiDIP-35351N.
    IntActiP51448. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP51448.
    SMRiP51448. Positions 70-513.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni139 – 271133HingeAdd
    BLAST
    Regioni272 – 523252Ligand-bindingAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi506 – 5116AF-2

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi101 – 17575Gln-richAdd
    BLAST

    Domaini

    The AF-2 (activation function-2) motif is required for recruiting coregulators containing LXXLL motifs.By similarity

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri73 – 9321NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri109 – 13325NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG324222.
    GeneTreeiENSGT00740000114909.
    HOGENOMiHOG000010200.
    HOVERGENiHBG106848.
    InParanoidiP51448.
    KOiK08532.
    OMAiGHCLTGQ.
    OrthoDBiEOG79PJNW.
    PhylomeDBiP51448.
    TreeFamiTF319910.

    Family and domain databases

    Gene3Di1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR003079. ROR_rcpt.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR01293. RORNUCRECPTR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative promoter usage. Align

    Isoform 1 (identifier: P51448-1) [UniParc]FASTAAdd to Basket

    Also known as: Alpha-1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESAPAAPDP AASEPGSSGS EAAAGSRETP LTQDTGRKSE APGAGRRQSY    50
    ASSSRGISVT KKTHTSQIEI IPCKICGDKS SGIHYGVITC EGCKGFFRRS 100
    QQSNATYSCP RQKNCLIDRT SRNRCQHCRL QKCLAVGMSR DAVKFGRMSK 150
    KQRDSLYAEV QKHRMQQQQR DHQQQPGEAE PLTPTYNISA NGLTELHDDL 200
    STYMDGHTPE GSKADSAVSS FYLDIQPSPD QSGLDINGIK PEPICDYTPA 250
    SGFFPYCSFT NGETSPTVSM AELEHLAQNI SKSHLETCQY LREELQQITW 300
    QTFLQEEIEN YQNKQREVMW QLCAIKITEA IQYVVEFAKR IDGFMELCQN 350
    DQIVLLKAGS LEVVFIRMCR AFDSQNNTVY FDGKYASPDV FKSLGCEDFI 400
    SFVFEFGKSL CSMHLTEDEI ALFSAFVLMS ADRSWLQEKV KIEKLQQKIQ 450
    LALQHVLQKN HREDGILTKL ICKVSTLRAL CGRHTEKLMA FKAIYPDIVR 500
    LHFPPLYKEL FTSEFEPAMQ IDG 523
    Length:523
    Mass (Da):58,845
    Last modified:October 1, 1996 - v1
    Checksum:iA194E02E4D9D177E
    GO
    Isoform 2 (identifier: P51448-3)

    Also known as: Alpha-2

    Sequence is not available
    Length:
    Mass (Da):
    Isoform 3 (identifier: P51448-4)

    Also known as: Alpha-3

    Sequence is not available
    Length:
    Mass (Da):
    Isoform 4 (identifier: P51448-2) [UniParc]FASTAAdd to Basket

    Also known as: Alpha-4

    The sequence of this isoform differs from the canonical sequence as follows:
         1-66: MESAPAAPDP...ISVTKKTHTS → MYFVIAAMKA

    Show »
    Length:467
    Mass (Da):53,414
    Checksum:i5621E275EC282A54
    GO

    Sequence cautioni

    The sequence AAH03757.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAA69930.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti163 – 1631H → R in CAA69930. (PubMed:7935491)Curated
    Sequence conflicti180 – 1812EP → T in CAA69930. (PubMed:7935491)Curated
    Sequence conflicti182 – 1821L → I in AAB46801. (PubMed:8750880)Curated
    Sequence conflicti182 – 1821L → I in BAA22970. (PubMed:8750880)Curated
    Sequence conflicti193 – 1942LT → SA in CAA69930. (PubMed:7935491)Curated
    Sequence conflicti304 – 3041L → W in CAA69930. (PubMed:7935491)Curated
    Sequence conflicti315 – 3151Missing in AAB46801. (PubMed:8750880)Curated
    Sequence conflicti315 – 3151Missing in BAA22970. (PubMed:8750880)Curated
    Sequence conflicti362 – 3621E → G in CAA69930. (PubMed:7935491)Curated
    Sequence conflicti433 – 4331R → P in CAA69930. (PubMed:7935491)Curated
    Sequence conflicti450 – 4512QL → HM in CAA69930. (PubMed:7935491)Curated
    Sequence conflicti487 – 4871K → N in AAB46801. (PubMed:8750880)Curated
    Sequence conflicti487 – 4871K → N in BAA22970. (PubMed:8750880)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti275 – 31440Missing in SG; disturbance of Purkinje cell and muscle development, lipid metabolism, circadian behavior and immune system functioning. 1 Publication
    Add
    BLAST

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6666MESAP…KTHTS → MYFVIAAMKA in isoform 4. 4 PublicationsVSP_003658Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U53228 mRNA. Translation: AAC52513.1.
    Y08640 mRNA. Translation: CAA69930.1. Different initiation.
    Z82994 mRNA. Translation: CAB05396.1.
    S82720 mRNA. Translation: AAB46801.2.
    D45910 mRNA. Translation: BAA22970.1.
    BC003757 mRNA. Translation: AAH03757.2. Different initiation.
    CCDSiCCDS23314.1. [P51448-1]
    CCDS72268.1. [P51448-2]
    PIRiS68517.
    RefSeqiNP_001276845.1. NM_001289916.1. [P51448-2]
    NP_038674.1. NM_013646.2. [P51448-1]
    UniGeneiMm.378450.
    Mm.391890.
    Mm.427266.
    Mm.445802.
    Mm.491288.

    Genome annotation databases

    EnsembliENSMUST00000034766; ENSMUSP00000034766; ENSMUSG00000032238. [P51448-1]
    ENSMUST00000113624; ENSMUSP00000109254; ENSMUSG00000032238. [P51448-2]
    GeneIDi19883.
    KEGGimmu:19883.
    UCSCiuc009qmx.1. mouse. [P51448-1]

    Keywords - Coding sequence diversityi

    Alternative promoter usage

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U53228 mRNA. Translation: AAC52513.1 .
    Y08640 mRNA. Translation: CAA69930.1 . Different initiation.
    Z82994 mRNA. Translation: CAB05396.1 .
    S82720 mRNA. Translation: AAB46801.2 .
    D45910 mRNA. Translation: BAA22970.1 .
    BC003757 mRNA. Translation: AAH03757.2 . Different initiation.
    CCDSi CCDS23314.1. [P51448-1 ]
    CCDS72268.1. [P51448-2 ]
    PIRi S68517.
    RefSeqi NP_001276845.1. NM_001289916.1. [P51448-2 ]
    NP_038674.1. NM_013646.2. [P51448-1 ]
    UniGenei Mm.378450.
    Mm.391890.
    Mm.427266.
    Mm.445802.
    Mm.491288.

    3D structure databases

    ProteinModelPortali P51448.
    SMRi P51448. Positions 70-513.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202956. 1 interaction.
    DIPi DIP-35351N.
    IntActi P51448. 2 interactions.

    PTM databases

    PhosphoSitei P51448.

    Proteomic databases

    PRIDEi P51448.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034766 ; ENSMUSP00000034766 ; ENSMUSG00000032238 . [P51448-1 ]
    ENSMUST00000113624 ; ENSMUSP00000109254 ; ENSMUSG00000032238 . [P51448-2 ]
    GeneIDi 19883.
    KEGGi mmu:19883.
    UCSCi uc009qmx.1. mouse. [P51448-1 ]

    Organism-specific databases

    CTDi 6095.
    MGIi MGI:104661. Rora.

    Phylogenomic databases

    eggNOGi NOG324222.
    GeneTreei ENSGT00740000114909.
    HOGENOMi HOG000010200.
    HOVERGENi HBG106848.
    InParanoidi P51448.
    KOi K08532.
    OMAi GHCLTGQ.
    OrthoDBi EOG79PJNW.
    PhylomeDBi P51448.
    TreeFami TF319910.

    Enzyme and pathway databases

    Reactomei REACT_118837. Rora activates circadian gene expression.
    REACT_198351. RORA activates circadian gene expression.
    REACT_198352. REV-ERBA represses gene expression.
    REACT_198602. PPARA activates gene expression.
    REACT_24972. Circadian Clock.

    Miscellaneous databases

    ChiTaRSi RORA. mouse.
    NextBioi 297388.
    PROi P51448.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51448.
    Bgeei P51448.
    CleanExi MM_RORA.
    Genevestigatori P51448.

    Family and domain databases

    Gene3Di 1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR003079. ROR_rcpt.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR01293. RORNUCRECPTR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Cerebellum.
    2. "RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers."
      Carlberg C., Hooft van Huijsduijnen R., Staple J.K., Delamarter J.F., Becker-Andre M.
      Mol. Endocrinol. 8:757-770(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
      Strain: C57BL/6.
      Tissue: Skin.
    3. "The structural integrity of ROR alpha isoforms is mutated in staggerer mice: cerebellar coexpression of ROR alpha1 and ROR alpha4."
      Matysiak-Scholze U., Nehls M.C.
      Genomics 43:78-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANT SG 275-HIS--LYS-314 DEL.
      Strain: C57BL/6.
      Tissue: Cerebellum.
    4. "An orphan nuclear receptor, mROR alpha, and its spatial expression in adult mouse brain."
      Matsui T., Sashihara S., Oh Y., Waxman S.G.
      Brain Res. Mol. Brain Res. 33:217-226(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
      Tissue: Brain.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Strain: FVB/N.
      Tissue: Mammary gland.
    6. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 39-61, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    7. "Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha."
      Raspe E., Duez H., Gervois P., Fievet C., Fruchart J.C., Besnard S., Mariani J., Tedgui A., Staels B.
      J. Biol. Chem. 276:2865-2871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN TRIGLYCERIDE METABOLISM, DNA-BINDING, CHARACTERIZATION OF VARIANT SG PHENOTYPE.
    8. "RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways."
      Gold D.A., Baek S.H., Schork N.J., Rose D.W., Larsen D.D., Sachs B.D., Rosenfeld M.G., Hamilton B.A.
      Neuron 40:1119-1131(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CEREBELLAR DEVELOPMENT, DEVELOPMENTAL STAGE, INTERACTION WITH CTNNB1, CHARACTERIZATION OF VARIANT SG PHENOTYPE.
    9. "The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1."
      Akashi M., Takumi T.
      Nat. Struct. Mol. Biol. 12:441-448(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CIRCADIAN RHYTHMS, CHARACTERIZATION OF VARIANT SG PHENOTYPE.
    10. "Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism."
      Liu C., Li S., Liu T., Borjigin J., Lin J.D.
      Nature 447:477-481(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PPARGC1A.
    11. "Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism."
      Kang H.S., Angers M., Beak J.Y., Wu X., Gimble J.M., Wada T., Xie W., Collins J.B., Grissom S.F., Jetten A.M.
      Physiol. Genomics 31:281-294(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN METABOLISM REGULATION, CHARACTERIZATION OF VARIANT SG PHENOTYPE, TISSUE SPECIFICITY.
    12. "Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)."
      Wada T., Kang H.S., Angers M., Gong H., Bhatia S., Khadem S., Ren S., Ellis E., Strom S.C., Jetten A.M., Xie W.
      Mol. Pharmacol. 73:891-899(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN METABOLISM REGULATION, CHARACTERIZATION OF VARIANT SG PHENOTYPE, DNA-BINDING.
    13. "The emerging role of nuclear receptor RORalpha and its crosstalk with LXR in xeno- and endobiotic gene regulation."
      Wada T., Kang H.S., Jetten A.M., Xie W.
      Exp. Biol. Med. 233:1191-1201(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW OF FUNCTION IN METABOLISM REGULATION.
    14. "T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma."
      Yang X.O., Pappu B.P., Nurieva R., Akimzhanov A., Kang H.S., Chung Y., Ma L., Shah B., Panopoulos A.D., Schluns K.S., Watowich S.S., Tian Q., Jetten A.M., Dong C.
      Immunity 28:29-39(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN T(H)17 CELLS DIFFERENTIATION, INDUCTION BY IL6 AND TGFB1, TISSUE SPECIFICITY.
    15. "The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity."
      Lau P., Fitzsimmons R.L., Raichur S., Wang S.C., Lechtken A., Muscat G.E.
      J. Biol. Chem. 283:18411-18421(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN LIPID METABOLISM REGULATION, TISSUE SPECIFICITY, CHARACTERIZATION OF VARIANT SG PHENOTYPE.
    16. "Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease."
      Chopra A.R., Louet J.F., Saha P., An J., Demayo F., Xu J., York B., Karpen S., Finegold M., Moore D., Chan L., Newgard C.B., O'Malley B.W.
      Science 322:1395-1399(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NCOA2.
    17. "Retinoic acid receptor-related orphan receptor alpha regulates a subset of cone genes during mouse retinal development."
      Fujieda H., Bremner R., Mears A.J., Sasaki H.
      J. Neurochem. 108:91-101(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DEVELOPMENTAL STAGE, CHARACTERIZATION OF VARIANT SG.
    18. "The orphan nuclear receptor RORalpha restrains adipocyte differentiation through a reduction of C/EBPbeta activity and perilipin gene expression."
      Ohoka N., Kato S., Takahashi Y., Hayashi H., Sato R.
      Mol. Endocrinol. 23:759-771(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN ADIPOGENESIS, INTERACTION WITH CEBPB, DEVELOPMENTAL STAGE.
    19. "Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism."
      Jetten A.M.
      Nucl. Recept. Signal. 7:3-35(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON FUNCTION.
    20. "Interaction of MAGED1 with nuclear receptors affects circadian clock function."
      Wang X., Tang J., Xing L., Shi G., Ruan H., Gu X., Liu Z., Wu X., Gao X., Xu Y.
      EMBO J. 29:1389-1400(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MAGED1.
    21. "The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors."
      Schmutz I., Ripperger J.A., Baeriswyl-Aebischer S., Albrecht U.
      Genes Dev. 24:345-357(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PER2.
    22. "Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands."
      Wang Y., Kumar N., Solt L.A., Richardson T.I., Helvering L.M., Crumbley C., Garcia-Ordonez R.D., Stayrook K.R., Zhang X., Novick S., Chalmers M.J., Griffin P.R., Burris T.P.
      J. Biol. Chem. 285:5013-5025(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN GLUCOSE METABOLISM REGULATION, IDENTIFICTION OF LIGANDS.
    23. Cited for: FUNCTION IN T(H)17 CELLS DIFFERENTIATION, INDUCTION BY IL6 AND TGFB1, INTERACTION WITH NCOR1 AND NCOA2, IDENTIFICATION OF LIGANDS.
    24. "Cryptochromes mediate rhythmic repression of the glucocorticoid receptor."
      Lamia K.A., Papp S.J., Yu R.T., Barish G.D., Uhlenhaut N.H., Jonker J.W., Downes M., Evans R.M.
      Nature 480:552-556(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CRY1.
    25. "RORgamma directly regulates the circadian expression of clock genes and downstream targets in vivo."
      Takeda Y., Jothi R., Birault V., Jetten A.M.
      Nucleic Acids Res. 40:8519-8535(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CIRCADIAN RHYTHMS, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DNA-BINDING, INDUCTION.
    26. "Action of RORs and their ligands in (patho)physiology."
      Solt L.A., Burris T.P.
      Trends Endocrinol. Metab. 23:619-627(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON FUNCTION AND LIGANDS.
    27. "Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility."
      Saito T., Hirano M., Ide T., Ichiki T., Koibuchi N., Sunagawa K., Hirano K.
      Circulation 127:104-114(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.

    Entry informationi

    Entry nameiRORA_MOUSE
    AccessioniPrimary (citable) accession number: P51448
    Secondary accession number(s): P70283
    , P97741, P97773, Q923G1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 144 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3