P51437 (CRAMP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cathelin-related antimicrobial peptide
Short name=Cramp

Alternative name(s):
Cathelin-like protein
Short name=CLP

Gene names

Name:	Camp
Synonyms:	Cnlp, Cramp

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	173 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts as a potent antimicrobial peptide.
Subcellular location	Secreted.
Tissue specificity	Expressed in testis, spleen, stomach, and intestine. Very low expression found in heart, lung and skeletal muscle. No expression in brain, kidney or liver.
Sequence similarities	Belongs to the cathelicidin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial
PTM	Disulfide bond Pyrrolidone carboxylic acid
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to Gram-negative bacterium Inferred from direct assay Ref.1. Source: MGI defense response to Gram-positive bacterium Inferred from mutant phenotype PubMed 16177355. Source: MGI killing by host of symbiont cells Inferred from mutant phenotype PubMed 16177355. Source: MGI negative regulation of growth of symbiont in host Inferred from mutant phenotype PubMed 16177355. Source: MGI negative regulation of growth of symbiont on or near host surface Inferred from mutant phenotype PubMed 16177355. Source: MGI
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell specific granule Inferred from direct assay Ref.1. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Propeptide	28 – 139	112	Potential		PRO_0000004728
	Peptide	140 – 173	34	Cathelin-related antimicrobial peptide		PRO_0000004729
Amino acid modifications
	Modified residue	28	1	Pyrrolidone carboxylic acid By similarity
	Disulfide bond	83 ↔ 94		By similarity
	Disulfide bond	105 ↔ 122		By similarity
Experimental info
	Sequence conflict	24	1	L → M in CAA64078. Ref.2
	Sequence conflict	173	1	Missing in AAA85898. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P51437 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 143F0E784762F77E	FASTA	173	19,582
	10 20 30 40 50 60 MQFQRDVPSL WLWRSLSLLL LLGLGFSQTP SYRDAVLRAV DDFNQQSLDT NLYRLLDLDP 70 80 90 100 110 120 EPQGDEDPDT PKSVRFRVKE TVCGKAERQL PEQCAFKEQG VVKQCMGAVT LNPAADSFDI 130 140 150 160 170 SCNEPGAQPF RFKKISRLAG LLRKGGEKIG EKLKKIGQKI KNFFQKLVPQ PEQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse." Gallo R.L., Kim K.J., Bernfield M., Kozak C.A., Zanetti M., Merluzzi L., Gennaro R. J. Biol. Chem. 272:13088-13093(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6. Tissue: Bone marrow.
[2]	"A novel murine cathelin-like protein expressed in bone marrow." Popsueva A.E., Zinovjeva M.V., Visser Y.W.M., Fibbe W.E., Belyavsky A.V. FEBS Lett. 391:5-8(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Bone marrow.
[3]	Huttner K.M., Piraino J., Gallo R.L. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 129/SvJ.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U43409 mRNA. Translation: AAA85898.1. X94353 mRNA. Translation: CAA64078.1. AF035680 Genomic DNA. Translation: AAB88303.1. BC120752 mRNA. Translation: AAI20753.1. BC120754 mRNA. Translation: AAI20755.1.
IPI	IPI00875797.
PIR	S70521.
RefSeq	NP_034051.2. NM_009921.2.
UniGene	Mm.3834.
3D structure databases
ProteinModelPortal	P51437.
SMR	P51437. Positions 28-124.
ModBase	Search...
Proteomic databases
PaxDb	P51437.
PRIDE	P51437.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000112022; ENSMUSP00000107653; ENSMUSG00000038357.
GeneID	12796.
KEGG	mmu:12796.
UCSC	uc009rsv.2. mouse.
Organism-specific databases
CTD	820.
MGI	MGI:108443. Camp.
Phylogenomic databases
eggNOG	NOG40811.
GeneTree	ENSGT00390000000410.
HOGENOM	HOG000093184.
HOVERGEN	HBG006116.
KO	K13916.
OrthoDB	EOG4PK29B.
Gene expression databases
ArrayExpress	P51437.
Bgee	P51437.
CleanEx	MM_CAMP.
Genevestigator	P51437.
GermOnline	ENSMUSG00000038357. Mus musculus.
Family and domain databases
InterPro	IPR001894. Cathelicidin. IPR018216. Cathelicidin_CS. IPR022746. Cathlecidin_C. [Graphical view]
PANTHER	PTHR10206. PTHR10206. 1 hit.
Pfam	PF12153. CAP18_C. 1 hit. PF00666. Cathelicidins. 1 hit. [Graphical view]
ProDom	PD001838. Cathelicidin. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00946. CATHELICIDINS_1. 1 hit. PS00947. CATHELICIDINS_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CAMP. mouse.
NextBio	282210.
SOURCE	Search...

Entry information

Entry name

CRAMP_MOUSE

Accession

Primary (citable) accession number: P51437
Secondary accession number(s): Q0VB78

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program