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P51437

- CRAMP_MOUSE

UniProt

P51437 - CRAMP_MOUSE

Protein

Cathelin-related antimicrobial peptide

Gene

Camp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Acts as a potent antimicrobial peptide.

    GO - Biological processi

    1. cellular response to interleukin-1 Source: Ensembl
    2. cellular response to interleukin-6 Source: Ensembl
    3. cellular response to lipopolysaccharide Source: Ensembl
    4. cellular response to peptidoglycan Source: Ensembl
    5. cellular response to tumor necrosis factor Source: Ensembl
    6. defense response to Gram-negative bacterium Source: MGI
    7. defense response to Gram-positive bacterium Source: MGI
    8. killing by host of symbiont cells Source: MGI
    9. negative regulation of growth of symbiont in host Source: MGI
    10. negative regulation of growth of symbiont on or near host surface Source: MGI
    11. positive regulation of angiogenesis Source: Ensembl
    12. positive regulation of cell proliferation Source: Ensembl
    13. positive regulation of protein phosphorylation Source: Ensembl

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cathelin-related antimicrobial peptide
    Short name:
    Cramp
    Alternative name(s):
    Cathelin-like protein
    Short name:
    CLP
    Gene namesi
    Name:Camp
    Synonyms:Cnlp, Cramp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:108443. Camp.

    Subcellular locationi

    GO - Cellular componenti

    1. cell projection Source: Ensembl
    2. extracellular space Source: Ensembl
    3. specific granule Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Propeptidei28 – 139112Sequence AnalysisPRO_0000004728Add
    BLAST
    Peptidei140 – 17334Cathelin-related antimicrobial peptidePRO_0000004729Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi83 ↔ 94By similarity
    Disulfide bondi105 ↔ 122By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP51437.
    PRIDEiP51437.

    Expressioni

    Tissue specificityi

    Expressed in testis, spleen, stomach, and intestine. Very low expression found in heart, lung and skeletal muscle. No expression in brain, kidney or liver.

    Gene expression databases

    ArrayExpressiP51437.
    BgeeiP51437.
    CleanExiMM_CAMP.
    GenevestigatoriP51437.

    Structurei

    3D structure databases

    ProteinModelPortaliP51437.
    SMRiP51437. Positions 31-124.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cathelicidin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40811.
    GeneTreeiENSGT00390000000410.
    HOGENOMiHOG000093184.
    HOVERGENiHBG006116.
    KOiK13916.
    OrthoDBiEOG793B9Q.
    TreeFamiTF338457.

    Family and domain databases

    InterProiIPR001894. Cathelicidin.
    IPR018216. Cathelicidin_CS.
    IPR022746. Cathlecidin_C.
    [Graphical view]
    PANTHERiPTHR10206. PTHR10206. 1 hit.
    PfamiPF12153. CAP18_C. 1 hit.
    PF00666. Cathelicidins. 1 hit.
    [Graphical view]
    ProDomiPD001838. Cathelicidin. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
    PS00947. CATHELICIDINS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P51437-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQFQRDVPSL WLWRSLSLLL LLGLGFSQTP SYRDAVLRAV DDFNQQSLDT    50
    NLYRLLDLDP EPQGDEDPDT PKSVRFRVKE TVCGKAERQL PEQCAFKEQG 100
    VVKQCMGAVT LNPAADSFDI SCNEPGAQPF RFKKISRLAG LLRKGGEKIG 150
    EKLKKIGQKI KNFFQKLVPQ PEQ 173
    Length:173
    Mass (Da):19,582
    Last modified:October 1, 1996 - v1
    Checksum:i143F0E784762F77E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti24 – 241L → M in CAA64078. (PubMed:8706928)Curated
    Sequence conflicti173 – 1731Missing in AAA85898. (PubMed:9148921)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43409 mRNA. Translation: AAA85898.1.
    X94353 mRNA. Translation: CAA64078.1.
    AF035680 Genomic DNA. Translation: AAB88303.1.
    BC120752 mRNA. Translation: AAI20753.1.
    BC120754 mRNA. Translation: AAI20755.1.
    PIRiS70521.
    RefSeqiNP_034051.2. NM_009921.2.
    UniGeneiMm.3834.

    Genome annotation databases

    EnsembliENSMUST00000112022; ENSMUSP00000107653; ENSMUSG00000038357.
    GeneIDi12796.
    KEGGimmu:12796.
    UCSCiuc009rsv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43409 mRNA. Translation: AAA85898.1 .
    X94353 mRNA. Translation: CAA64078.1 .
    AF035680 Genomic DNA. Translation: AAB88303.1 .
    BC120752 mRNA. Translation: AAI20753.1 .
    BC120754 mRNA. Translation: AAI20755.1 .
    PIRi S70521.
    RefSeqi NP_034051.2. NM_009921.2.
    UniGenei Mm.3834.

    3D structure databases

    ProteinModelPortali P51437.
    SMRi P51437. Positions 31-124.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P51437.
    PRIDEi P51437.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000112022 ; ENSMUSP00000107653 ; ENSMUSG00000038357 .
    GeneIDi 12796.
    KEGGi mmu:12796.
    UCSCi uc009rsv.2. mouse.

    Organism-specific databases

    CTDi 820.
    MGIi MGI:108443. Camp.

    Phylogenomic databases

    eggNOGi NOG40811.
    GeneTreei ENSGT00390000000410.
    HOGENOMi HOG000093184.
    HOVERGENi HBG006116.
    KOi K13916.
    OrthoDBi EOG793B9Q.
    TreeFami TF338457.

    Miscellaneous databases

    ChiTaRSi CAMP. mouse.
    NextBioi 282210.
    PROi P51437.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51437.
    Bgeei P51437.
    CleanExi MM_CAMP.
    Genevestigatori P51437.

    Family and domain databases

    InterProi IPR001894. Cathelicidin.
    IPR018216. Cathelicidin_CS.
    IPR022746. Cathlecidin_C.
    [Graphical view ]
    PANTHERi PTHR10206. PTHR10206. 1 hit.
    Pfami PF12153. CAP18_C. 1 hit.
    PF00666. Cathelicidins. 1 hit.
    [Graphical view ]
    ProDomi PD001838. Cathelicidin. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    PROSITEi PS00946. CATHELICIDINS_1. 1 hit.
    PS00947. CATHELICIDINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse."
      Gallo R.L., Kim K.J., Bernfield M., Kozak C.A., Zanetti M., Merluzzi L., Gennaro R.
      J. Biol. Chem. 272:13088-13093(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Bone marrow.
    2. "A novel murine cathelin-like protein expressed in bone marrow."
      Popsueva A.E., Zinovjeva M.V., Visser Y.W.M., Fibbe W.E., Belyavsky A.V.
      FEBS Lett. 391:5-8(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Bone marrow.
    3. Huttner K.M., Piraino J., Gallo R.L.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/SvJ.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCRAMP_MOUSE
    AccessioniPrimary (citable) accession number: P51437
    Secondary accession number(s): Q0VB78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3