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P51437

- CRAMP_MOUSE

UniProt

P51437 - CRAMP_MOUSE

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Protein

Cathelin-related antimicrobial peptide

Gene

Camp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Acts as a potent antimicrobial peptide.

GO - Biological processi

  1. antibacterial humoral response Source: Ensembl
  2. cellular response to interleukin-1 Source: Ensembl
  3. cellular response to interleukin-6 Source: Ensembl
  4. cellular response to lipopolysaccharide Source: Ensembl
  5. cellular response to peptidoglycan Source: Ensembl
  6. cellular response to tumor necrosis factor Source: Ensembl
  7. defense response to Gram-negative bacterium Source: MGI
  8. defense response to Gram-positive bacterium Source: MGI
  9. innate immune response in mucosa Source: Ensembl
  10. killing by host of symbiont cells Source: MGI
  11. negative regulation of growth of symbiont in host Source: MGI
  12. negative regulation of growth of symbiont on or near host surface Source: MGI
  13. positive regulation of angiogenesis Source: Ensembl
  14. positive regulation of cell proliferation Source: Ensembl
  15. positive regulation of protein phosphorylation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Enzyme and pathway databases

ReactomeiREACT_198345. Phagosomal maturation (early endosomal stage).

Names & Taxonomyi

Protein namesi
Recommended name:
Cathelin-related antimicrobial peptide
Short name:
Cramp
Alternative name(s):
Cathelin-like protein
Short name:
CLP
Gene namesi
Name:Camp
Synonyms:Cnlp, Cramp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:108443. Camp.

Subcellular locationi

GO - Cellular componenti

  1. cell projection Source: Ensembl
  2. extracellular space Source: Ensembl
  3. extracellular vesicular exosome Source: Ensembl
  4. specific granule Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Propeptidei28 – 139112Sequence AnalysisPRO_0000004728Add
BLAST
Peptidei140 – 17334Cathelin-related antimicrobial peptidePRO_0000004729Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 ↔ 94By similarity
Disulfide bondi105 ↔ 122By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP51437.
PRIDEiP51437.

Expressioni

Tissue specificityi

Expressed in testis, spleen, stomach, and intestine. Very low expression found in heart, lung and skeletal muscle. No expression in brain, kidney or liver.

Gene expression databases

BgeeiP51437.
CleanExiMM_CAMP.
ExpressionAtlasiP51437. baseline and differential.
GenevestigatoriP51437.

Structurei

3D structure databases

ProteinModelPortaliP51437.
SMRiP51437. Positions 31-124.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cathelicidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40811.
GeneTreeiENSGT00390000000410.
HOGENOMiHOG000093184.
HOVERGENiHBG006116.
InParanoidiP51437.
KOiK13916.
OrthoDBiEOG793B9Q.
TreeFamiTF338457.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
IPR022746. Cathlecidin_C.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PfamiPF12153. CAP18_C. 1 hit.
PF00666. Cathelicidins. 1 hit.
[Graphical view]
ProDomiPD001838. Cathelicidin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51437-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQFQRDVPSL WLWRSLSLLL LLGLGFSQTP SYRDAVLRAV DDFNQQSLDT
60 70 80 90 100
NLYRLLDLDP EPQGDEDPDT PKSVRFRVKE TVCGKAERQL PEQCAFKEQG
110 120 130 140 150
VVKQCMGAVT LNPAADSFDI SCNEPGAQPF RFKKISRLAG LLRKGGEKIG
160 170
EKLKKIGQKI KNFFQKLVPQ PEQ
Length:173
Mass (Da):19,582
Last modified:October 1, 1996 - v1
Checksum:i143F0E784762F77E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241L → M in CAA64078. (PubMed:8706928)Curated
Sequence conflicti173 – 1731Missing in AAA85898. (PubMed:9148921)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43409 mRNA. Translation: AAA85898.1.
X94353 mRNA. Translation: CAA64078.1.
AF035680 Genomic DNA. Translation: AAB88303.1.
BC120752 mRNA. Translation: AAI20753.1.
BC120754 mRNA. Translation: AAI20755.1.
PIRiS70521.
RefSeqiNP_034051.2. NM_009921.2.
UniGeneiMm.3834.

Genome annotation databases

EnsembliENSMUST00000112022; ENSMUSP00000107653; ENSMUSG00000038357.
GeneIDi12796.
KEGGimmu:12796.
UCSCiuc009rsv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43409 mRNA. Translation: AAA85898.1 .
X94353 mRNA. Translation: CAA64078.1 .
AF035680 Genomic DNA. Translation: AAB88303.1 .
BC120752 mRNA. Translation: AAI20753.1 .
BC120754 mRNA. Translation: AAI20755.1 .
PIRi S70521.
RefSeqi NP_034051.2. NM_009921.2.
UniGenei Mm.3834.

3D structure databases

ProteinModelPortali P51437.
SMRi P51437. Positions 31-124.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P51437.
PRIDEi P51437.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000112022 ; ENSMUSP00000107653 ; ENSMUSG00000038357 .
GeneIDi 12796.
KEGGi mmu:12796.
UCSCi uc009rsv.2. mouse.

Organism-specific databases

CTDi 820.
MGIi MGI:108443. Camp.

Phylogenomic databases

eggNOGi NOG40811.
GeneTreei ENSGT00390000000410.
HOGENOMi HOG000093184.
HOVERGENi HBG006116.
InParanoidi P51437.
KOi K13916.
OrthoDBi EOG793B9Q.
TreeFami TF338457.

Enzyme and pathway databases

Reactomei REACT_198345. Phagosomal maturation (early endosomal stage).

Miscellaneous databases

NextBioi 282210.
PROi P51437.
SOURCEi Search...

Gene expression databases

Bgeei P51437.
CleanExi MM_CAMP.
ExpressionAtlasi P51437. baseline and differential.
Genevestigatori P51437.

Family and domain databases

InterProi IPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
IPR022746. Cathlecidin_C.
[Graphical view ]
PANTHERi PTHR10206. PTHR10206. 1 hit.
Pfami PF12153. CAP18_C. 1 hit.
PF00666. Cathelicidins. 1 hit.
[Graphical view ]
ProDomi PD001838. Cathelicidin. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse."
    Gallo R.L., Kim K.J., Bernfield M., Kozak C.A., Zanetti M., Merluzzi L., Gennaro R.
    J. Biol. Chem. 272:13088-13093(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Bone marrow.
  2. "A novel murine cathelin-like protein expressed in bone marrow."
    Popsueva A.E., Zinovjeva M.V., Visser Y.W.M., Fibbe W.E., Belyavsky A.V.
    FEBS Lett. 391:5-8(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Bone marrow.
  3. Huttner K.M., Piraino J., Gallo R.L.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvJ.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCRAMP_MOUSE
AccessioniPrimary (citable) accession number: P51437
Secondary accession number(s): Q0VB78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3