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P51437 (CRAMP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cathelin-related antimicrobial peptide

Short name=Cramp
Alternative name(s):
Cathelin-like protein
Short name=CLP
Gene names
Name:Camp
Synonyms:Cnlp, Cramp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length173 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a potent antimicrobial peptide.

Subcellular location

Secreted.

Tissue specificity

Expressed in testis, spleen, stomach, and intestine. Very low expression found in heart, lung and skeletal muscle. No expression in brain, kidney or liver.

Sequence similarities

Belongs to the cathelicidin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAntibiotic
Antimicrobial
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to interleukin-1

Inferred from electronic annotation. Source: Ensembl

cellular response to interleukin-6

Inferred from electronic annotation. Source: Ensembl

cellular response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

cellular response to peptidoglycan

Inferred from electronic annotation. Source: Ensembl

cellular response to tumor necrosis factor

Inferred from electronic annotation. Source: Ensembl

defense response to Gram-negative bacterium

Inferred from direct assay Ref.1. Source: MGI

defense response to Gram-positive bacterium

Inferred from mutant phenotype PubMed 16177355. Source: MGI

killing by host of symbiont cells

Inferred from mutant phenotype PubMed 16177355. Source: MGI

negative regulation of growth of symbiont in host

Inferred from mutant phenotype PubMed 16177355. Source: MGI

negative regulation of growth of symbiont on or near host surface

Inferred from mutant phenotype PubMed 16177355. Source: MGI

positive regulation of angiogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcell projection

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: Ensembl

specific granule

Inferred from direct assay Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Propeptide28 – 139112 Potential
PRO_0000004728
Peptide140 – 17334Cathelin-related antimicrobial peptide
PRO_0000004729

Amino acid modifications

Disulfide bond83 ↔ 94 By similarity
Disulfide bond105 ↔ 122 By similarity

Experimental info

Sequence conflict241L → M in CAA64078. Ref.2
Sequence conflict1731Missing in AAA85898. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P51437 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 143F0E784762F77E

FASTA17319,582
        10         20         30         40         50         60 
MQFQRDVPSL WLWRSLSLLL LLGLGFSQTP SYRDAVLRAV DDFNQQSLDT NLYRLLDLDP 

        70         80         90        100        110        120 
EPQGDEDPDT PKSVRFRVKE TVCGKAERQL PEQCAFKEQG VVKQCMGAVT LNPAADSFDI 

       130        140        150        160        170 
SCNEPGAQPF RFKKISRLAG LLRKGGEKIG EKLKKIGQKI KNFFQKLVPQ PEQ 

« Hide

References

« Hide 'large scale' references
[1]"Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse."
Gallo R.L., Kim K.J., Bernfield M., Kozak C.A., Zanetti M., Merluzzi L., Gennaro R.
J. Biol. Chem. 272:13088-13093(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Bone marrow.
[2]"A novel murine cathelin-like protein expressed in bone marrow."
Popsueva A.E., Zinovjeva M.V., Visser Y.W.M., Fibbe W.E., Belyavsky A.V.
FEBS Lett. 391:5-8(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Bone marrow.
[3]Huttner K.M., Piraino J., Gallo R.L.
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 129/SvJ.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U43409 mRNA. Translation: AAA85898.1.
X94353 mRNA. Translation: CAA64078.1.
AF035680 Genomic DNA. Translation: AAB88303.1.
BC120752 mRNA. Translation: AAI20753.1.
BC120754 mRNA. Translation: AAI20755.1.
PIRS70521.
RefSeqNP_034051.2. NM_009921.2.
UniGeneMm.3834.

3D structure databases

ProteinModelPortalP51437.
SMRP51437. Positions 31-124.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP51437.
PRIDEP51437.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000112022; ENSMUSP00000107653; ENSMUSG00000038357.
GeneID12796.
KEGGmmu:12796.
UCSCuc009rsv.2. mouse.

Organism-specific databases

CTD820.
MGIMGI:108443. Camp.

Phylogenomic databases

eggNOGNOG40811.
GeneTreeENSGT00390000000410.
HOGENOMHOG000093184.
HOVERGENHBG006116.
KOK13916.
OrthoDBEOG793B9Q.
TreeFamTF338457.

Gene expression databases

ArrayExpressP51437.
BgeeP51437.
CleanExMM_CAMP.
GenevestigatorP51437.

Family and domain databases

InterProIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
IPR022746. Cathlecidin_C.
[Graphical view]
PANTHERPTHR10206. PTHR10206. 1 hit.
PfamPF12153. CAP18_C. 1 hit.
PF00666. Cathelicidins. 1 hit.
[Graphical view]
ProDomPD001838. Cathelicidin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCAMP. mouse.
NextBio282210.
PROP51437.
SOURCESearch...

Entry information

Entry nameCRAMP_MOUSE
AccessionPrimary (citable) accession number: P51437
Secondary accession number(s): Q0VB78
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot