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Protein

Cathelin-related antimicrobial peptide

Gene

Camp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a potent antimicrobial peptide.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Cathelin-related antimicrobial peptide
Short name:
Cramp
Alternative name(s):
Cathelin-like protein
Short name:
CLP
Gene namesi
Name:Camp
Synonyms:Cnlp, Cramp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:108443. Camp.

Subcellular locationi

GO - Cellular componenti

  • cell projection Source: Ensembl
  • extracellular exosome Source: MGI
  • extracellular space Source: MGI
  • specific granule Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Propeptidei28 – 139112Sequence AnalysisPRO_0000004728Add
BLAST
Peptidei140 – 17334Cathelin-related antimicrobial peptidePRO_0000004729Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 ↔ 94By similarity
Disulfide bondi105 ↔ 122By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP51437.
PaxDbiP51437.
PRIDEiP51437.

Expressioni

Tissue specificityi

Expressed in testis, spleen, stomach, and intestine. Very low expression found in heart, lung and skeletal muscle. No expression in brain, kidney or liver.

Gene expression databases

BgeeiP51437.
CleanExiMM_CAMP.
ExpressionAtlasiP51437. baseline and differential.
GenevisibleiP51437. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107653.

Structurei

3D structure databases

ProteinModelPortaliP51437.
SMRiP51437. Positions 31-124.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cathelicidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40811.
HOGENOMiHOG000093184.
HOVERGENiHBG006116.
InParanoidiP51437.
KOiK13916.
OrthoDBiEOG793B9Q.
TreeFamiTF338457.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
IPR022746. Cathlecidin_C.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PfamiPF12153. CAP18_C. 1 hit.
PF00666. Cathelicidins. 1 hit.
[Graphical view]
ProDomiPD001838. Cathelicidin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51437-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFQRDVPSL WLWRSLSLLL LLGLGFSQTP SYRDAVLRAV DDFNQQSLDT
60 70 80 90 100
NLYRLLDLDP EPQGDEDPDT PKSVRFRVKE TVCGKAERQL PEQCAFKEQG
110 120 130 140 150
VVKQCMGAVT LNPAADSFDI SCNEPGAQPF RFKKISRLAG LLRKGGEKIG
160 170
EKLKKIGQKI KNFFQKLVPQ PEQ
Length:173
Mass (Da):19,582
Last modified:October 1, 1996 - v1
Checksum:i143F0E784762F77E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241L → M in CAA64078 (PubMed:8706928).Curated
Sequence conflicti173 – 1731Missing in AAA85898 (PubMed:9148921).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43409 mRNA. Translation: AAA85898.1.
X94353 mRNA. Translation: CAA64078.1.
AF035680 Genomic DNA. Translation: AAB88303.1.
BC120752 mRNA. Translation: AAI20753.1.
BC120754 mRNA. Translation: AAI20755.1.
PIRiS70521.
RefSeqiNP_034051.2. NM_009921.2.
UniGeneiMm.3834.

Genome annotation databases

GeneIDi12796.
KEGGimmu:12796.
UCSCiuc009rsv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43409 mRNA. Translation: AAA85898.1.
X94353 mRNA. Translation: CAA64078.1.
AF035680 Genomic DNA. Translation: AAB88303.1.
BC120752 mRNA. Translation: AAI20753.1.
BC120754 mRNA. Translation: AAI20755.1.
PIRiS70521.
RefSeqiNP_034051.2. NM_009921.2.
UniGeneiMm.3834.

3D structure databases

ProteinModelPortaliP51437.
SMRiP51437. Positions 31-124.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107653.

Proteomic databases

MaxQBiP51437.
PaxDbiP51437.
PRIDEiP51437.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi12796.
KEGGimmu:12796.
UCSCiuc009rsv.2. mouse.

Organism-specific databases

CTDi820.
MGIiMGI:108443. Camp.

Phylogenomic databases

eggNOGiNOG40811.
HOGENOMiHOG000093184.
HOVERGENiHBG006116.
InParanoidiP51437.
KOiK13916.
OrthoDBiEOG793B9Q.
TreeFamiTF338457.

Miscellaneous databases

NextBioi282210.
PROiP51437.
SOURCEiSearch...

Gene expression databases

BgeeiP51437.
CleanExiMM_CAMP.
ExpressionAtlasiP51437. baseline and differential.
GenevisibleiP51437. MM.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
IPR022746. Cathlecidin_C.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PfamiPF12153. CAP18_C. 1 hit.
PF00666. Cathelicidins. 1 hit.
[Graphical view]
ProDomiPD001838. Cathelicidin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse."
    Gallo R.L., Kim K.J., Bernfield M., Kozak C.A., Zanetti M., Merluzzi L., Gennaro R.
    J. Biol. Chem. 272:13088-13093(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Bone marrow.
  2. "A novel murine cathelin-like protein expressed in bone marrow."
    Popsueva A.E., Zinovjeva M.V., Visser Y.W.M., Fibbe W.E., Belyavsky A.V.
    FEBS Lett. 391:5-8(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Bone marrow.
  3. Huttner K.M., Piraino J., Gallo R.L.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvJ.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCRAMP_MOUSE
AccessioniPrimary (citable) accession number: P51437
Secondary accession number(s): Q0VB78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 24, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.