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Protein

Cathelicidin antimicrobial peptide

Gene

Camp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a potent antimicrobial peptide.

GO - Biological processi

  • antibacterial humoral response Source: MGI
  • cellular response to interleukin-1 Source: Ensembl
  • cellular response to interleukin-6 Source: Ensembl
  • cellular response to lipopolysaccharide Source: Ensembl
  • cellular response to peptidoglycan Source: Ensembl
  • cellular response to tumor necrosis factor Source: Ensembl
  • defense response to bacterium Source: MGI
  • defense response to Gram-negative bacterium Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • innate immune response Source: UniProtKB
  • innate immune response in mucosa Source: MGI
  • killing by host of symbiont cells Source: MGI
  • negative regulation of growth of symbiont in host Source: MGI
  • negative regulation of growth of symbiont on or near host surface Source: MGI
  • positive regulation of angiogenesis Source: Ensembl
  • positive regulation of cell proliferation Source: Ensembl
  • positive regulation of protein phosphorylation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Cathelicidin antimicrobial peptideImported
Alternative name(s):
Cathelin-like protein1 Publication
Short name:
CLP1 Publication
Cleaved into the following chain:
Cathelin-related antimicrobial peptide1 Publication
Short name:
Cramp1 Publication
Gene namesi
Name:CampImported
Synonyms:Cnlp, Cramp1 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:108443. Camp.

Subcellular locationi

GO - Cellular componenti

  • cell projection Source: Ensembl
  • extracellular exosome Source: MGI
  • extracellular space Source: MGI
  • specific granule Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
PropeptideiPRO_000043527528 – 134By similarityAdd BLAST107
PeptideiPRO_0000435276135 – 172Cathelin-related antimicrobial peptide1 PublicationAdd BLAST38

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83 ↔ 94By similarity
Disulfide bondi105 ↔ 122By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP51437.
PaxDbiP51437.
PeptideAtlasiP51437.
PRIDEiP51437.

PTM databases

PhosphoSitePlusiP51437.

Expressioni

Tissue specificityi

Expressed in testis, spleen, stomach, and intestine. Very low expression found in heart, lung and skeletal muscle. No expression in brain, kidney or liver.

Gene expression databases

BgeeiENSMUSG00000038357.
CleanExiMM_CAMP.
ExpressionAtlasiP51437. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107653.

Structurei

3D structure databases

ProteinModelPortaliP51437.
SMRiP51437.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cathelicidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J18R. Eukaryota.
ENOG41119S0. LUCA.
GeneTreeiENSGT00390000000410.
HOGENOMiHOG000093184.
HOVERGENiHBG006116.
InParanoidiP51437.
KOiK13916.
OMAiCDFKKDG.
TreeFamiTF338457.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
IPR022746. Cathlecidin_C.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PfamiPF12153. CAP18_C. 1 hit.
[Graphical view]
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51437-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFQRDVPSL WLWRSLSLLL LLGLGFSQTP SYRDAVLRAV DDFNQQSLDT
60 70 80 90 100
NLYRLLDLDP EPQGDEDPDT PKSVRFRVKE TVCGKAERQL PEQCAFKEQG
110 120 130 140 150
VVKQCMGAVT LNPAADSFDI SCNEPGAQPF RFKKISRLAG LLRKGGEKIG
160 170
EKLKKIGQKI KNFFQKLVPQ PE
Length:172
Mass (Da):19,453
Last modified:January 20, 2016 - v2
Checksum:i6F0E784762F77E4A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24L → M in CAA64078 (PubMed:8706928).Curated1
Sequence conflicti172E → EQ in CAA64078 (PubMed:8706928).Curated1
Sequence conflicti172E → EQ in AAB88303 (Ref. 3) Curated1
Sequence conflicti172E → EQ in AAI20753 (PubMed:15489334).Curated1
Sequence conflicti172E → EQ in AAI20755 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43409 mRNA. Translation: AAA85898.1.
X94353 mRNA. Translation: CAA64078.1.
AF035680 Genomic DNA. Translation: AAB88303.1.
BC120752 mRNA. Translation: AAI20753.1.
BC120754 mRNA. Translation: AAI20755.1.
CCDSiCCDS52934.1.
PIRiS70521.
RefSeqiNP_034051.2. NM_009921.2.
UniGeneiMm.3834.

Genome annotation databases

EnsembliENSMUST00000112022; ENSMUSP00000107653; ENSMUSG00000038357.
GeneIDi12796.
KEGGimmu:12796.
UCSCiuc009rsv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43409 mRNA. Translation: AAA85898.1.
X94353 mRNA. Translation: CAA64078.1.
AF035680 Genomic DNA. Translation: AAB88303.1.
BC120752 mRNA. Translation: AAI20753.1.
BC120754 mRNA. Translation: AAI20755.1.
CCDSiCCDS52934.1.
PIRiS70521.
RefSeqiNP_034051.2. NM_009921.2.
UniGeneiMm.3834.

3D structure databases

ProteinModelPortaliP51437.
SMRiP51437.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107653.

PTM databases

PhosphoSitePlusiP51437.

Proteomic databases

MaxQBiP51437.
PaxDbiP51437.
PeptideAtlasiP51437.
PRIDEiP51437.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112022; ENSMUSP00000107653; ENSMUSG00000038357.
GeneIDi12796.
KEGGimmu:12796.
UCSCiuc009rsv.2. mouse.

Organism-specific databases

CTDi820.
MGIiMGI:108443. Camp.

Phylogenomic databases

eggNOGiENOG410J18R. Eukaryota.
ENOG41119S0. LUCA.
GeneTreeiENSGT00390000000410.
HOGENOMiHOG000093184.
HOVERGENiHBG006116.
InParanoidiP51437.
KOiK13916.
OMAiCDFKKDG.
TreeFamiTF338457.

Miscellaneous databases

PROiP51437.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038357.
CleanExiMM_CAMP.
ExpressionAtlasiP51437. baseline and differential.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
IPR022746. Cathlecidin_C.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PfamiPF12153. CAP18_C. 1 hit.
[Graphical view]
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAMP_MOUSE
AccessioniPrimary (citable) accession number: P51437
Secondary accession number(s): Q0VB78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 20, 2016
Last modified: November 30, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.