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P51436

- DRD4_MOUSE

UniProt

P51436 - DRD4_MOUSE

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Protein

D(4) dopamine receptor

Gene

Drd4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells.1 Publication

GO - Molecular functioni

  1. dopamine binding Source: Ensembl
  2. dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: MGI
  3. drug binding Source: Ensembl

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: MGI
  3. adult locomotory behavior Source: MGI
  4. arachidonic acid secretion Source: Ensembl
  5. behavioral fear response Source: Ensembl
  6. behavioral response to cocaine Source: MGI
  7. circadian rhythm Source: Ensembl
  8. fear response Source: MGI
  9. negative regulation of adenylate cyclase activity Source: Ensembl
  10. negative regulation of protein secretion Source: Ensembl
  11. negative regulation of voltage-gated calcium channel activity Source: Ensembl
  12. olfactory learning Source: Ensembl
  13. photoperiodism Source: Ensembl
  14. positive regulation of excitatory postsynaptic membrane potential Source: Ensembl
  15. positive regulation of penile erection Source: Ensembl
  16. positive regulation of sodium:proton antiporter activity Source: Ensembl
  17. regulation of calcium-mediated signaling Source: Ensembl
  18. regulation of circadian rhythm Source: UniProtKB
  19. regulation of dopamine metabolic process Source: MGI
  20. regulation of inhibitory postsynaptic membrane potential Source: MGI
  21. regulation of neurotransmitter secretion Source: Ensembl
  22. response to amphetamine Source: MGI
  23. response to histamine Source: Ensembl
  24. response to steroid hormone Source: Ensembl
  25. retina development in camera-type eye Source: Ensembl
  26. short-term memory Source: Ensembl
  27. synaptic transmission, dopaminergic Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Biological rhythms

Names & Taxonomyi

Protein namesi
Recommended name:
D(4) dopamine receptor
Alternative name(s):
D(2C) dopamine receptor
Dopamine D4 receptor
Gene namesi
Name:Drd4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:94926. Drd4.

Subcellular locationi

GO - Cellular componenti

  1. cell cortex Source: Ensembl
  2. dendritic spine Source: Ensembl
  3. integral component of plasma membrane Source: Ensembl
  4. neuronal cell body Source: Ensembl
  5. terminal bouton Source: Ensembl
  6. vesicle membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice show a significant reduction in daytime contrast sensitivity.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387D(4) dopamine receptorPRO_0000069402Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi105 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP51436.

PTM databases

PhosphoSiteiP51436.

Expressioni

Gene expression databases

BgeeiP51436.
CleanExiMM_DRD4.
GenevestigatoriP51436.

Interactioni

Subunit structurei

Forms homo- and heterooligomers with DRD2. The interaction with DRD2 may modulate agonist-induced downstream signaling. Interacts with CLIC6 and GPRASP1. May interact with ADORA2A.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026569.

Structurei

3D structure databases

ProteinModelPortaliP51436.
SMRiP51436. Positions 32-383.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularSequence AnalysisAdd
BLAST
Topological domaini58 – 6710CytoplasmicSequence Analysis
Topological domaini91 – 10616ExtracellularSequence AnalysisAdd
BLAST
Topological domaini129 – 14618CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini171 – 18616ExtracellularSequence AnalysisAdd
BLAST
Topological domaini209 – 314106CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini338 – 3469ExtracellularSequence Analysis
Topological domaini370 – 38718CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5723Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei68 – 9023Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei107 – 12822Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei147 – 17024Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei187 – 20822Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei315 – 33723Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei347 – 36923Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256691.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP51436.
KOiK04147.
OMAiDPAVCRL.
OrthoDBiEOG769ZMG.
PhylomeDBiP51436.
TreeFamiTF334382.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR002185. Dopamine_D4_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24249:SF37. PTHR24249:SF37. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00569. DOPAMINED4R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51436-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNSSATEDG GLLAGRGPES LGTGAGLGGA GAAALVGGVL LIGLVLAGNS
60 70 80 90 100
LVCVSVASER TLQTPTNYFI VSLAAADLLL AVLVLPLFVY SEVQGGVWLL
110 120 130 140 150
SPRLCDTLMA MDVMLCTASI FNLCAISVDR FVAVTVPLRY NQQGQCQLLL
160 170 180 190 200
IAATWLLSAA VASPVVCGLN DVPGRDPAVC CLENRDYVVY SSVCSFFLPC
210 220 230 240 250
PLMLLLYWAT FRGLRRWEAA RHTKLHSRAP RRPSGPGPPV SDPTQGPFFP
260 270 280 290 300
DCPPPLPSLR TSPSDSSRPE SELSQRPCSP GCLLADAALP QPPEPSSRRR
310 320 330 340 350
RGAKITGRER KAMRVLPVVV GAFLVCWTPF FVVHITRALC PACFVSPRLV
360 370 380
SAVTWLGYVN SALNPIIYTI FNAEFRSVFR KTLRLRC
Length:387
Mass (Da):41,487
Last modified:October 1, 1996 - v1
Checksum:iBEA306D5E8AA02E9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 11M → L in BAC31893. (PubMed:16141072)Curated
Sequence conflicti19 – 191E → K in BAC31893. (PubMed:16141072)Curated
Sequence conflicti47 – 471A → T in AAB50730. (PubMed:8584230)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19880 Genomic DNA. Translation: AAC52190.1.
S80929
, S80920, S80927, S80928 Genomic DNA. Translation: AAB50730.1.
AK044379 mRNA. Translation: BAC31893.1.
CH466531 Genomic DNA. Translation: EDL18041.1.
BC016086 mRNA. Translation: AAH16086.1.
BC051421 mRNA. Translation: AAH51421.2.
CCDSiCCDS22007.1.
PIRiI49246.
RefSeqiNP_031904.1. NM_007878.2.
UniGeneiMm.41075.

Genome annotation databases

EnsembliENSMUST00000026569; ENSMUSP00000026569; ENSMUSG00000025496.
GeneIDi13491.
KEGGimmu:13491.
UCSCiuc009kkm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19880 Genomic DNA. Translation: AAC52190.1 .
S80929
, S80920 , S80927 , S80928 Genomic DNA. Translation: AAB50730.1 .
AK044379 mRNA. Translation: BAC31893.1 .
CH466531 Genomic DNA. Translation: EDL18041.1 .
BC016086 mRNA. Translation: AAH16086.1 .
BC051421 mRNA. Translation: AAH51421.2 .
CCDSi CCDS22007.1.
PIRi I49246.
RefSeqi NP_031904.1. NM_007878.2.
UniGenei Mm.41075.

3D structure databases

ProteinModelPortali P51436.
SMRi P51436. Positions 32-383.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000026569.

Chemistry

BindingDBi P51436.
ChEMBLi CHEMBL2111359.
GuidetoPHARMACOLOGYi 217.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P51436.

Proteomic databases

PRIDEi P51436.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026569 ; ENSMUSP00000026569 ; ENSMUSG00000025496 .
GeneIDi 13491.
KEGGi mmu:13491.
UCSCi uc009kkm.1. mouse.

Organism-specific databases

CTDi 1815.
MGIi MGI:94926. Drd4.

Phylogenomic databases

eggNOGi NOG256691.
GeneTreei ENSGT00760000118795.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi P51436.
KOi K04147.
OMAi DPAVCRL.
OrthoDBi EOG769ZMG.
PhylomeDBi P51436.
TreeFami TF334382.

Miscellaneous databases

NextBioi 284009.
PROi P51436.
SOURCEi Search...

Gene expression databases

Bgeei P51436.
CleanExi MM_DRD4.
Genevestigatori P51436.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR002185. Dopamine_D4_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24249:SF37. PTHR24249:SF37. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00569. DOPAMINED4R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterisation of the gene encoding the murine D4 dopamine receptor."
    Fishburn C.S., Carmon S., Fuchs S.
    FEBS Lett. 361:215-219(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "Genomic structure and tissue distribution of the mouse dopamine D4 receptor."
    Suzuki T., Kobayashi K., Nagatsu T.
    Neurosci. Lett. 199:69-72(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Retina.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Retina.
  6. "BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase."
    Rondou P., Haegeman G., Vanhoenacker P., Van Craenenbroeck K.
    J. Biol. Chem. 283:11083-11096(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. "Circadian rhythm of contrast sensitivity is regulated by a dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling pathway in retinal ganglion cells."
    Hwang C.K., Chaurasia S.S., Jackson C.R., Chan G.C., Storm D.R., Iuvone P.M.
    J. Neurosci. 33:14989-14997(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiDRD4_MOUSE
AccessioniPrimary (citable) accession number: P51436
Secondary accession number(s): O35838, Q7TT80, Q8BXS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

In contrast to human protein, does not interact with KLHL12 and is not ubiquitinated by the BCR(KLHL12) complex.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3