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P51436

- DRD4_MOUSE

UniProt

P51436 - DRD4_MOUSE

Protein

D(4) dopamine receptor

Gene

Drd4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells.1 Publication

    GO - Molecular functioni

    1. dopamine binding Source: Ensembl
    2. dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: MGI
    3. drug binding Source: Ensembl

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: MGI
    3. adult locomotory behavior Source: MGI
    4. arachidonic acid secretion Source: Ensembl
    5. behavioral fear response Source: Ensembl
    6. behavioral response to cocaine Source: MGI
    7. circadian rhythm Source: Ensembl
    8. fear response Source: MGI
    9. negative regulation of adenylate cyclase activity Source: Ensembl
    10. negative regulation of protein secretion Source: Ensembl
    11. negative regulation of voltage-gated calcium channel activity Source: Ensembl
    12. olfactory learning Source: Ensembl
    13. photoperiodism Source: Ensembl
    14. positive regulation of excitatory postsynaptic membrane potential Source: Ensembl
    15. positive regulation of penile erection Source: Ensembl
    16. positive regulation of sodium:proton antiporter activity Source: Ensembl
    17. regulation of calcium-mediated signaling Source: Ensembl
    18. regulation of circadian rhythm Source: UniProtKB
    19. regulation of dopamine metabolic process Source: MGI
    20. regulation of inhibitory postsynaptic membrane potential Source: MGI
    21. regulation of neurotransmitter secretion Source: Ensembl
    22. response to amphetamine Source: MGI
    23. response to histamine Source: Ensembl
    24. response to steroid hormone Source: Ensembl
    25. retina development in camera-type eye Source: Ensembl
    26. short-term memory Source: Ensembl
    27. synaptic transmission, dopaminergic Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Biological rhythms

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D(4) dopamine receptor
    Alternative name(s):
    D(2C) dopamine receptor
    Dopamine D4 receptor
    Gene namesi
    Name:Drd4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:94926. Drd4.

    Subcellular locationi

    GO - Cellular componenti

    1. cell cortex Source: Ensembl
    2. dendritic spine Source: Ensembl
    3. integral component of plasma membrane Source: Ensembl
    4. neuronal cell body Source: Ensembl
    5. terminal bouton Source: Ensembl
    6. vesicle membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mice show a significant reduction in daytime contrast sensitivity.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 387387D(4) dopamine receptorPRO_0000069402Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi105 ↔ 180PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP51436.

    PTM databases

    PhosphoSiteiP51436.

    Expressioni

    Gene expression databases

    BgeeiP51436.
    CleanExiMM_DRD4.
    GenevestigatoriP51436.

    Interactioni

    Subunit structurei

    Forms homo- and heterooligomers with DRD2. The interaction with DRD2 may modulate agonist-induced downstream signaling. Interacts with CLIC6 and GPRASP1. May interact with ADORA2A.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000026569.

    Structurei

    3D structure databases

    ProteinModelPortaliP51436.
    SMRiP51436. Positions 32-383.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini58 – 6710CytoplasmicSequence Analysis
    Topological domaini91 – 10616ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini129 – 14618CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini171 – 18616ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini209 – 314106CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini338 – 3469ExtracellularSequence Analysis
    Topological domaini370 – 38718CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5723Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei68 – 9023Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei107 – 12822Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei147 – 17024Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei187 – 20822Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei315 – 33723Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei347 – 36923Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG256691.
    GeneTreeiENSGT00750000117240.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiQ7TT80.
    KOiK04147.
    OMAiDPAVCRL.
    OrthoDBiEOG769ZMG.
    PhylomeDBiP51436.
    TreeFamiTF334382.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR002185. Dopamine_D4_rcpt.
    IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24249:SF37. PTHR24249:SF37. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00569. DOPAMINED4R.
    PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51436-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNSSATEDG GLLAGRGPES LGTGAGLGGA GAAALVGGVL LIGLVLAGNS    50
    LVCVSVASER TLQTPTNYFI VSLAAADLLL AVLVLPLFVY SEVQGGVWLL 100
    SPRLCDTLMA MDVMLCTASI FNLCAISVDR FVAVTVPLRY NQQGQCQLLL 150
    IAATWLLSAA VASPVVCGLN DVPGRDPAVC CLENRDYVVY SSVCSFFLPC 200
    PLMLLLYWAT FRGLRRWEAA RHTKLHSRAP RRPSGPGPPV SDPTQGPFFP 250
    DCPPPLPSLR TSPSDSSRPE SELSQRPCSP GCLLADAALP QPPEPSSRRR 300
    RGAKITGRER KAMRVLPVVV GAFLVCWTPF FVVHITRALC PACFVSPRLV 350
    SAVTWLGYVN SALNPIIYTI FNAEFRSVFR KTLRLRC 387
    Length:387
    Mass (Da):41,487
    Last modified:October 1, 1996 - v1
    Checksum:iBEA306D5E8AA02E9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 11M → L in BAC31893. (PubMed:16141072)Curated
    Sequence conflicti19 – 191E → K in BAC31893. (PubMed:16141072)Curated
    Sequence conflicti47 – 471A → T in AAB50730. (PubMed:8584230)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19880 Genomic DNA. Translation: AAC52190.1.
    S80929
    , S80920, S80927, S80928 Genomic DNA. Translation: AAB50730.1.
    AK044379 mRNA. Translation: BAC31893.1.
    CH466531 Genomic DNA. Translation: EDL18041.1.
    BC016086 mRNA. Translation: AAH16086.1.
    BC051421 mRNA. Translation: AAH51421.2.
    CCDSiCCDS22007.1.
    PIRiI49246.
    RefSeqiNP_031904.1. NM_007878.2.
    UniGeneiMm.41075.

    Genome annotation databases

    EnsembliENSMUST00000026569; ENSMUSP00000026569; ENSMUSG00000025496.
    GeneIDi13491.
    KEGGimmu:13491.
    UCSCiuc009kkm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19880 Genomic DNA. Translation: AAC52190.1 .
    S80929
    , S80920 , S80927 , S80928 Genomic DNA. Translation: AAB50730.1 .
    AK044379 mRNA. Translation: BAC31893.1 .
    CH466531 Genomic DNA. Translation: EDL18041.1 .
    BC016086 mRNA. Translation: AAH16086.1 .
    BC051421 mRNA. Translation: AAH51421.2 .
    CCDSi CCDS22007.1.
    PIRi I49246.
    RefSeqi NP_031904.1. NM_007878.2.
    UniGenei Mm.41075.

    3D structure databases

    ProteinModelPortali P51436.
    SMRi P51436. Positions 32-383.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000026569.

    Chemistry

    BindingDBi P51436.
    ChEMBLi CHEMBL2111359.
    GuidetoPHARMACOLOGYi 217.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P51436.

    Proteomic databases

    PRIDEi P51436.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026569 ; ENSMUSP00000026569 ; ENSMUSG00000025496 .
    GeneIDi 13491.
    KEGGi mmu:13491.
    UCSCi uc009kkm.1. mouse.

    Organism-specific databases

    CTDi 1815.
    MGIi MGI:94926. Drd4.

    Phylogenomic databases

    eggNOGi NOG256691.
    GeneTreei ENSGT00750000117240.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi Q7TT80.
    KOi K04147.
    OMAi DPAVCRL.
    OrthoDBi EOG769ZMG.
    PhylomeDBi P51436.
    TreeFami TF334382.

    Miscellaneous databases

    NextBioi 284009.
    PROi P51436.
    SOURCEi Search...

    Gene expression databases

    Bgeei P51436.
    CleanExi MM_DRD4.
    Genevestigatori P51436.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR002185. Dopamine_D4_rcpt.
    IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24249:SF37. PTHR24249:SF37. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00569. DOPAMINED4R.
    PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterisation of the gene encoding the murine D4 dopamine receptor."
      Fishburn C.S., Carmon S., Fuchs S.
      FEBS Lett. 361:215-219(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    2. "Genomic structure and tissue distribution of the mouse dopamine D4 receptor."
      Suzuki T., Kobayashi K., Nagatsu T.
      Neurosci. Lett. 199:69-72(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Retina.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Retina.
    6. "BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase."
      Rondou P., Haegeman G., Vanhoenacker P., Van Craenenbroeck K.
      J. Biol. Chem. 283:11083-11096(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    7. "Circadian rhythm of contrast sensitivity is regulated by a dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling pathway in retinal ganglion cells."
      Hwang C.K., Chaurasia S.S., Jackson C.R., Chan G.C., Storm D.R., Iuvone P.M.
      J. Neurosci. 33:14989-14997(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiDRD4_MOUSE
    AccessioniPrimary (citable) accession number: P51436
    Secondary accession number(s): O35838, Q7TT80, Q8BXS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    In contrast to human protein, does not interact with KLHL12 and is not ubiquitinated by the BCR(KLHL12) complex.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3