Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

D(4) dopamine receptor

Gene

Drd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells.1 Publication

GO - Molecular functioni

GO - Biological processi

  • activation of MAPK activity Source: MGI
  • adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: MGI
  • adult locomotory behavior Source: MGI
  • arachidonic acid secretion Source: MGI
  • behavioral response to cocaine Source: MGI
  • dopamine receptor signaling pathway Source: MGI
  • fear response Source: MGI
  • inhibitory postsynaptic potential Source: MGI
  • negative regulation of adenylate cyclase activity Source: MGI
  • negative regulation of cAMP biosynthetic process Source: MGI
  • negative regulation of protein secretion Source: MGI
  • negative regulation of voltage-gated calcium channel activity Source: MGI
  • positive regulation of kinase activity Source: MGI
  • positive regulation of sodium:proton antiporter activity Source: MGI
  • regulation of circadian rhythm Source: UniProtKB
  • regulation of dopamine metabolic process Source: MGI
  • response to amphetamine Source: MGI
  • response to histamine Source: MGI
  • rhythmic process Source: UniProtKB-KW
  • synaptic transmission, dopaminergic Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Biological rhythms

Enzyme and pathway databases

ReactomeiR-MMU-390651. Dopamine receptors.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
D(4) dopamine receptor
Alternative name(s):
D(2C) dopamine receptor
Dopamine D4 receptor
Gene namesi
Name:Drd4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:94926. Drd4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 57Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini58 – 67CytoplasmicSequence analysis10
Transmembranei68 – 90Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini91 – 106ExtracellularSequence analysisAdd BLAST16
Transmembranei107 – 128Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini129 – 146CytoplasmicSequence analysisAdd BLAST18
Transmembranei147 – 170Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini171 – 186ExtracellularSequence analysisAdd BLAST16
Transmembranei187 – 208Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini209 – 314CytoplasmicSequence analysisAdd BLAST106
Transmembranei315 – 337Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini338 – 346ExtracellularSequence analysis9
Transmembranei347 – 369Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini370 – 387CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice show a significant reduction in daytime contrast sensitivity.1 Publication

Chemistry databases

ChEMBLiCHEMBL2574.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694021 – 387D(4) dopamine receptorAdd BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi105 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP51436.
PRIDEiP51436.

PTM databases

iPTMnetiP51436.
PhosphoSitePlusiP51436.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025496.
CleanExiMM_DRD4.
GenevisibleiP51436. MM.

Interactioni

Subunit structurei

Forms homo- and heterooligomers with DRD2. The interaction with DRD2 may modulate agonist-induced downstream signaling. Interacts with CLIC6 and GPRASP1. May interact with ADORA2A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-61454N.
STRINGi10090.ENSMUSP00000026569.

Structurei

3D structure databases

ProteinModelPortaliP51436.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP51436.
KOiK04147.
OMAiGPCGPDC.
OrthoDBiEOG091G06VI.
PhylomeDBiP51436.
TreeFamiTF334382.

Family and domain databases

InterProiIPR002185. Dopamine_D4_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00569. DOPAMINED4R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51436-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNSSATEDG GLLAGRGPES LGTGAGLGGA GAAALVGGVL LIGLVLAGNS
60 70 80 90 100
LVCVSVASER TLQTPTNYFI VSLAAADLLL AVLVLPLFVY SEVQGGVWLL
110 120 130 140 150
SPRLCDTLMA MDVMLCTASI FNLCAISVDR FVAVTVPLRY NQQGQCQLLL
160 170 180 190 200
IAATWLLSAA VASPVVCGLN DVPGRDPAVC CLENRDYVVY SSVCSFFLPC
210 220 230 240 250
PLMLLLYWAT FRGLRRWEAA RHTKLHSRAP RRPSGPGPPV SDPTQGPFFP
260 270 280 290 300
DCPPPLPSLR TSPSDSSRPE SELSQRPCSP GCLLADAALP QPPEPSSRRR
310 320 330 340 350
RGAKITGRER KAMRVLPVVV GAFLVCWTPF FVVHITRALC PACFVSPRLV
360 370 380
SAVTWLGYVN SALNPIIYTI FNAEFRSVFR KTLRLRC
Length:387
Mass (Da):41,487
Last modified:October 1, 1996 - v1
Checksum:iBEA306D5E8AA02E9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → L in BAC31893 (PubMed:16141072).Curated1
Sequence conflicti19E → K in BAC31893 (PubMed:16141072).Curated1
Sequence conflicti47A → T in AAB50730 (PubMed:8584230).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19880 Genomic DNA. Translation: AAC52190.1.
S80929
, S80920, S80927, S80928 Genomic DNA. Translation: AAB50730.1.
AK044379 mRNA. Translation: BAC31893.1.
CH466531 Genomic DNA. Translation: EDL18041.1.
BC016086 mRNA. Translation: AAH16086.1.
BC051421 mRNA. Translation: AAH51421.2.
CCDSiCCDS22007.1.
PIRiI49246.
RefSeqiNP_031904.1. NM_007878.2.
UniGeneiMm.41075.

Genome annotation databases

EnsembliENSMUST00000026569; ENSMUSP00000026569; ENSMUSG00000025496.
GeneIDi13491.
KEGGimmu:13491.
UCSCiuc009kkm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19880 Genomic DNA. Translation: AAC52190.1.
S80929
, S80920, S80927, S80928 Genomic DNA. Translation: AAB50730.1.
AK044379 mRNA. Translation: BAC31893.1.
CH466531 Genomic DNA. Translation: EDL18041.1.
BC016086 mRNA. Translation: AAH16086.1.
BC051421 mRNA. Translation: AAH51421.2.
CCDSiCCDS22007.1.
PIRiI49246.
RefSeqiNP_031904.1. NM_007878.2.
UniGeneiMm.41075.

3D structure databases

ProteinModelPortaliP51436.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61454N.
STRINGi10090.ENSMUSP00000026569.

Chemistry databases

ChEMBLiCHEMBL2574.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP51436.
PhosphoSitePlusiP51436.

Proteomic databases

PaxDbiP51436.
PRIDEiP51436.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026569; ENSMUSP00000026569; ENSMUSG00000025496.
GeneIDi13491.
KEGGimmu:13491.
UCSCiuc009kkm.1. mouse.

Organism-specific databases

CTDi1815.
MGIiMGI:94926. Drd4.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP51436.
KOiK04147.
OMAiGPCGPDC.
OrthoDBiEOG091G06VI.
PhylomeDBiP51436.
TreeFamiTF334382.

Enzyme and pathway databases

ReactomeiR-MMU-390651. Dopamine receptors.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP51436.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025496.
CleanExiMM_DRD4.
GenevisibleiP51436. MM.

Family and domain databases

InterProiIPR002185. Dopamine_D4_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00569. DOPAMINED4R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDRD4_MOUSE
AccessioniPrimary (citable) accession number: P51436
Secondary accession number(s): O35838, Q7TT80, Q8BXS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

In contrast to human protein, does not interact with KLHL12 and is not ubiquitinated by the BCR(KLHL12) complex.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.