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Protein

Parvalbumin alpha

Gene

PVALB

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi47 – 581PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi86 – ›952PROSITE-ProRule annotation›10

GO - Molecular functioni

Keywordsi

Molecular functionMuscle protein
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin alpha
Gene namesi
Name:PVALB
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000073585‹1 – ›95Parvalbumin alphaAdd BLAST›95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000019473.

Structurei

3D structure databases

ProteinModelPortaliP51434.
SMRiP51434.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 69EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini73 – ›95EF-hand 2PROSITE-ProRule annotationAdd BLAST›23

Sequence similaritiesi

Belongs to the parvalbumin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
HOGENOMiHOG000037438.
InParanoidiP51434.

Family and domain databases

InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiView protein in Pfam
PF13499. EF-hand_7. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.

Sequencei

Sequence statusi: Fragment.

P51434-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LLNAEDIKKA VGACAAAESF DHKKFFQMVG LKKKNREEVK MVFQILDKDK
60 70 80 90
SGFIEEEELK FILKGFSADA RDLSDTETKR MMAAGDKDGD GKIGA
Length:95
Mass (Da):10,545
Last modified:October 1, 1996 - v1
Checksum:i98C4740F9E76FE03
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei951

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26677 mRNA. Translation: AAC52499.1.

Similar proteinsi

Entry informationi

Entry nameiPRVA_CAVPO
AccessioniPrimary (citable) accession number: P51434
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: August 30, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families