ID   RL9_MOUSE               Reviewed;         192 AA.
AC   P51410; Q9JK58;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2002, sequence version 2.
DT   27-MAR-2024, entry version 180.
DE   RecName: Full=Large ribosomal subunit protein uL6 {ECO:0000305};
DE   AltName: Full=60S ribosomal protein L9;
GN   Name=Rpl9;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Cheong C., Lee H.;
RT   "Retinoblastoma(Rb) regulates 60S ribosomal protein L9.";
RL   Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryo, Eye, and Head;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, Colon, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 14-185.
RC   STRAIN=C3H/HeN;
RX   PubMed=7600302; DOI=10.1016/1074-7613(95)90078-0;
RA   Monach P.A., Meredith S.C., Siegel C.T., Schreiber H.;
RT   "A unique tumor antigen produced by a single amino acid substitution.";
RL   Immunity 2:45-59(1995).
RN   [5] {ECO:0007744|PDB:7CPU, ECO:0007744|PDB:7CPV}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.03 ANGSTROMS) OF RIBOSOME, FUNCTION,
RP   SUBUNIT, AND SUBCELLULAR LOCATION.
RX   PubMed=36517592; DOI=10.1038/s41586-022-05508-0;
RA   Li H., Huo Y., He X., Yao L., Zhang H., Cui Y., Xiao H., Xie W., Zhang D.,
RA   Wang Y., Zhang S., Tu H., Cheng Y., Guo Y., Cao X., Zhu Y., Jiang T.,
RA   Guo X., Qin Y., Sha J.;
RT   "A male germ-cell-specific ribosome controls male fertility.";
RL   Nature 0:0-0(2022).
CC   -!- FUNCTION: Component of the large ribosomal subunit (PubMed:36517592).
CC       The ribosome is a large ribonucleoprotein complex responsible for the
CC       synthesis of proteins in the cell (PubMed:36517592).
CC       {ECO:0000269|PubMed:36517592}.
CC   -!- SUBUNIT: Component of the large ribosomal subunit.
CC       {ECO:0000269|PubMed:36517592}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:36517592}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL6 family.
CC       {ECO:0000305}.
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DR   EMBL; AF260271; AAF70508.1; -; mRNA.
DR   EMBL; AK012331; BAB28167.1; -; mRNA.
DR   EMBL; AK012445; BAB28244.1; -; mRNA.
DR   EMBL; AK017388; BAB30725.1; -; mRNA.
DR   EMBL; AK017427; BAB30739.1; -; mRNA.
DR   EMBL; AK084278; BAC39154.1; -; mRNA.
DR   EMBL; BC013165; AAH13165.1; -; mRNA.
DR   EMBL; BC081435; AAH81435.1; -; mRNA.
DR   EMBL; BC083166; AAH83166.1; -; mRNA.
DR   EMBL; BC083329; AAH83329.1; -; mRNA.
DR   EMBL; U17332; AAA85686.1; -; mRNA.
DR   EMBL; U17331; AAA85685.1; -; mRNA.
DR   CCDS; CCDS39097.1; -.
DR   RefSeq; NP_035422.1; NM_011292.2.
DR   PDB; 6SWA; EM; 3.10 A; H=1-192.
DR   PDB; 7CPU; EM; 2.82 A; LH=1-192.
DR   PDB; 7CPV; EM; 3.03 A; LH=1-192.
DR   PDB; 7LS1; EM; 3.30 A; C1=1-192.
DR   PDB; 7LS2; EM; 3.10 A; C1=1-192.
DR   PDBsum; 6SWA; -.
DR   PDBsum; 7CPU; -.
DR   PDBsum; 7CPV; -.
DR   PDBsum; 7LS1; -.
DR   PDBsum; 7LS2; -.
DR   AlphaFoldDB; P51410; -.
DR   EMDB; EMD-10321; -.
DR   EMDB; EMD-23500; -.
DR   EMDB; EMD-23501; -.
DR   EMDB; EMD-30432; -.
DR   EMDB; EMD-30433; -.
DR   SMR; P51410; -.
DR   BioGRID; 202989; 36.
DR   ComplexPortal; CPX-5262; 60S cytosolic large ribosomal subunit.
DR   ComplexPortal; CPX-7662; 60S cytosolic large ribosomal subunit, testis-specific variant.
DR   ComplexPortal; CPX-7663; 60S cytosolic large ribosomal subunit, striated muscle variant.
DR   STRING; 10090.ENSMUSP00000109399; -.
DR   iPTMnet; P51410; -.
DR   PhosphoSitePlus; P51410; -.
DR   SwissPalm; P51410; -.
DR   EPD; P51410; -.
DR   jPOST; P51410; -.
DR   PaxDb; 10090-ENSMUSP00000109399; -.
DR   PeptideAtlas; P51410; -.
DR   ProteomicsDB; 300394; -.
DR   Pumba; P51410; -.
DR   DNASU; 20005; -.
DR   Ensembl; ENSMUST00000057885.13; ENSMUSP00000109399.3; ENSMUSG00000047215.15.
DR   Ensembl; ENSMUST00000120094.5; ENSMUSP00000113704.2; ENSMUSG00000047215.15.
DR   GeneID; 20005; -.
DR   KEGG; mmu:20005; -.
DR   UCSC; uc008xnp.2; mouse.
DR   AGR; MGI:1298373; -.
DR   CTD; 6133; -.
DR   MGI; MGI:1298373; Rpl9.
DR   VEuPathDB; HostDB:ENSMUSG00000047215; -.
DR   eggNOG; KOG3255; Eukaryota.
DR   GeneTree; ENSGT00390000015224; -.
DR   HOGENOM; CLU_065464_0_2_1; -.
DR   InParanoid; P51410; -.
DR   OMA; YAHFPMK; -.
DR   OrthoDB; 5486004at2759; -.
DR   PhylomeDB; P51410; -.
DR   TreeFam; TF300033; -.
DR   Reactome; R-MMU-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-MMU-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-MMU-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-MMU-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-MMU-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-MMU-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   BioGRID-ORCS; 20005; 14 hits in 39 CRISPR screens.
DR   ChiTaRS; Rpl9; mouse.
DR   PRO; PR:P51410; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; P51410; Protein.
DR   Bgee; ENSMUSG00000047215; Expressed in dentate gyrus of hippocampal formation granule cell and 185 other cell types or tissues.
DR   ExpressionAtlas; P51410; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IDA:ComplexPortal.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:UniProtKB.
DR   GO; GO:0022626; C:cytosolic ribosome; ISO:MGI.
DR   GO; GO:0098794; C:postsynapse; NAS:SynGO.
DR   GO; GO:0098793; C:presynapse; NAS:SynGO.
DR   GO; GO:0005840; C:ribosome; NAS:SynGO.
DR   GO; GO:0045202; C:synapse; IDA:SynGO.
DR   GO; GO:0019843; F:rRNA binding; IEA:InterPro.
DR   GO; GO:0003735; F:structural constituent of ribosome; IDA:UniProtKB.
DR   GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR   GO; GO:0006412; P:translation; IC:MGI.
DR   GO; GO:0140242; P:translation at postsynapse; NAS:SynGO.
DR   GO; GO:0140236; P:translation at presynapse; NAS:SynGO.
DR   Gene3D; 3.90.930.12; Ribosomal protein L6, alpha-beta domain; 2.
DR   InterPro; IPR000702; Ribosomal_uL6-like.
DR   InterPro; IPR036789; Ribosomal_uL6-like_a/b-dom_sf.
DR   InterPro; IPR020040; Ribosomal_uL6_a/b-dom.
DR   InterPro; IPR002359; Ribosomal_uL6_CS2.
DR   PANTHER; PTHR11655:SF16; 60S RIBOSOMAL PROTEIN L9; 1.
DR   PANTHER; PTHR11655; 60S/50S RIBOSOMAL PROTEIN L6/L9; 1.
DR   Pfam; PF00347; Ribosomal_L6; 2.
DR   PIRSF; PIRSF002162; Ribosomal_L6; 1.
DR   SUPFAM; SSF56053; Ribosomal protein L6; 2.
DR   PROSITE; PS00700; RIBOSOMAL_L6_2; 1.
DR   Genevisible; P51410; MM.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Cytoplasm; Reference proteome;
KW   Ribonucleoprotein; Ribosomal protein; Tumor antigen.
FT   CHAIN           1..192
FT                   /note="Large ribosomal subunit protein uL6"
FT                   /id="PRO_0000131099"
FT   MOD_RES         121
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P32969"
FT   VARIANT         47
FT                   /note="L -> H (in UV-induced tumor 6132A antigen)"
SQ   SEQUENCE   192 AA;  21881 MW;  94948BA07E86BBEB CRC64;
     MKTILSNQTV DIPENVEITL KGRTVIVKGP RGTLRRDFNH INVELSLLGK KKKRLRVDKW
     WGNRKELATV RTICSHVQNM IKGVTLGFRY KMRSVYAHFP INVVIQENGS LVEIRNFLGE
     KYIRRVRMRT GVACSVSQAQ KDELILEGND IELVSNSAAL IQQATTVKNK DIRKFLDGIY
     VSEKGTVQQA DE
//