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P51398 (RT29_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
28S ribosomal protein S29, mitochondrial

Short name=MRP-S29
Short name=S29mt
Alternative name(s):
Death-associated protein 3
Short name=DAP-3
Ionizing radiation resistance conferring protein
Gene names
Name:DAP3
Synonyms:MRPS29
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in mediating interferon-gamma-induced cell death.

Subunit structure

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Interacts with KIAA0141. Interacts with NOA1. Ref.12 Ref.14

Subcellular location

Mitochondrion Ref.10 Ref.14.

Tissue specificity

Ubiquitous.

Sequence caution

The sequence AAA57443.1 differs from that shown. Reason: Frameshift at position 349.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

NOA1Q8NC605EBI-355912,EBI-717871

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P51398-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P51398-2)

The sequence of this isoform differs from the canonical sequence as follows:
     16-56: Missing.
Isoform 3 (identifier: P51398-3)

The sequence of this isoform differs from the canonical sequence as follows:
     57-90: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1818Mitochondrion Probable
Chain19 – 39838028S ribosomal protein S29, mitochondrial
PRO_0000087717

Amino acid modifications

Modified residue1751N6-acetyllysine Ref.13
Modified residue2071N6-acetyllysine Ref.13

Natural variations

Alternative sequence16 – 5641Missing in isoform 2.
VSP_042790
Alternative sequence57 – 9034Missing in isoform 3.
VSP_044639
Natural variant2401V → F.
Corresponds to variant rs57692591 [ dbSNP | Ensembl ].
VAR_061811

Experimental info

Sequence conflict1571D → Y in BAG63624. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 778AF183FA04DEC8

FASTA39845,566
        10         20         30         40         50         60 
MMLKGITRLI SRIHKLDPGR FLHMGTQARQ SIAAHLDNQV PVESPRAISR TNENDPAKHG 

        70         80         90        100        110        120 
DQHEGQHYNI SPQDLETVFP HGLPPRFVMQ VKTFSEACLM VRKPALELLH YLKNTSFAYP 

       130        140        150        160        170        180 
AIRYLLYGEK GTGKTLSLCH VIHFCAKQDW LILHIPDAHL WVKNCRDLLQ SSYNKQRFDQ 

       190        200        210        220        230        240 
PLEASTWLKN FKTTNERFLN QIKVQEKYVW NKRESTEKGS PLGEVVEQGI TRVRNATDAV 

       250        260        270        280        290        300 
GIVLKELKRQ SSLGMFHLLV AVDGINALWG RTTLKREDKS PIAPEELALV HNLRKMMKND 

       310        320        330        340        350        360 
WHGGAIVSAL SQTGSLFKPR KAYLPQELLG KEGFDALDPF IPILVSNYNP KEFESCIQYY 

       370        380        390 
LENNWLQHEK APTEEGKKEL LFLSNANPSL LERHCAYL 

« Hide

Isoform 2 [UniParc].

Checksum: 20E08FFBBF9C2E57
Show »

FASTA35741,044
Isoform 3 [UniParc].

Checksum: A51F7F4E1B0B12B0
Show »

FASTA36441,673

References

« Hide 'large scale' references
[1]"The molecular genetics of human diseases with defective DNA damage processing."
Henning K.A.
Thesis (1993), University of Stanford, United States
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Cervix carcinoma.
[2]"Isolation of DAP3, a novel mediator of interferon-gamma-induced cell death."
Kissil J.L., Deiss L.P., Bayewitch M., Raveh T., Khaspekov G., Kimchi A.
J. Biol. Chem. 270:27932-27936(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Testis.
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Colon endothelium.
[6]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[9]"The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 202-235.
[10]"A conserved N-terminal sequence targets human DAP3 to mitochondria."
Morgan C.J., Jacques C., Savagner F., Tourmen Y., Mirebeau D.P., Malthiery Y., Reynier P.
Biochem. Biophys. Res. Commun. 280:177-181(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TRANSIT PEPTIDE CLEAVAGE SITE.
[11]"The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[12]"hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis."
Tang T., Zheng B., Chen S.H., Murphy A.N., Kudlicka K., Zhou H., Farquhar M.G.
J. Biol. Chem. 284:5414-5424(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH NOA1.
[13]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-175 AND LYS-207, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction."
Harada T., Iwai A., Miyazaki T.
Apoptosis 15:1247-1255(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH KIAA0141.
[15]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18321 mRNA. Translation: AAA57443.1. Frameshift.
X83544 mRNA. Translation: CAA58535.1.
AK293117 mRNA. Translation: BAF85806.1.
AK298201 mRNA. Translation: BAG60471.1.
AK302281 mRNA. Translation: BAG63624.1.
BT019494 mRNA. Translation: AAV38301.1.
CR749790 mRNA. Translation: CAH18651.1.
AL162734 Genomic DNA. Translation: CAH71647.1.
CH471121 Genomic DNA. Translation: EAW53044.1.
CH471121 Genomic DNA. Translation: EAW53045.1.
CH471121 Genomic DNA. Translation: EAW53047.1.
CH471121 Genomic DNA. Translation: EAW53048.1.
CH471121 Genomic DNA. Translation: EAW53049.1.
CH471121 Genomic DNA. Translation: EAW53051.1.
BC107487 mRNA. Translation: AAI07488.1.
BC107488 mRNA. Translation: AAI07489.1.
PIRG01589.
RefSeqNP_001186778.1. NM_001199849.1.
NP_001186779.1. NM_001199850.1.
NP_001186780.1. NM_001199851.1.
NP_004623.1. NM_004632.3.
NP_387506.1. NM_033657.2.
XP_005245537.1. XM_005245480.1.
XP_005245538.1. XM_005245481.1.
UniGeneHs.516746.

3D structure databases

ProteinModelPortalP51398.
SMRP51398. Positions 119-155.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113587. 29 interactions.
IntActP51398. 12 interactions.
MINTMINT-1149113.
STRING9606.ENSP00000341692.

PTM databases

PhosphoSiteP51398.

Polymorphism databases

DMDM1706299.

Proteomic databases

PaxDbP51398.
PeptideAtlasP51398.
PRIDEP51398.

Protocols and materials databases

DNASU7818.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000343043; ENSP00000341692; ENSG00000132676. [P51398-1]
ENST00000368336; ENSP00000357320; ENSG00000132676. [P51398-1]
ENST00000421487; ENSP00000412605; ENSG00000132676. [P51398-3]
ENST00000471642; ENSP00000476592; ENSG00000132676. [P51398-2]
ENST00000535183; ENSP00000445003; ENSG00000132676. [P51398-2]
GeneID7818.
KEGGhsa:7818.
UCSCuc001flq.3. human. [P51398-1]
uc010pgl.2. human. [P51398-2]

Organism-specific databases

CTD7818.
GeneCardsGC01P155657.
HGNCHGNC:2673. DAP3.
HPAHPA006076.
HPA023687.
MIM602074. gene.
neXtProtNX_P51398.
PharmGKBPA27141.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG260931.
HOGENOMHOG000046851.
HOVERGENHBG025946.
InParanoidP51398.
KOK17408.
OMANERFLNQ.
OrthoDBEOG7GQXVS.
PhylomeDBP51398.
TreeFamTF313726.

Gene expression databases

ArrayExpressP51398.
BgeeP51398.
CleanExHS_DAP3.
GenevestigatorP51398.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR019368. Ribosomal_S23/S29_mit.
IPR008092. Ribosomal_S29_mit.
[Graphical view]
PfamPF10236. DAP3. 1 hit.
[Graphical view]
PRINTSPR01716. DEATHASSOCP3.
SUPFAMSSF52540. SSF52540. 2 hits.
ProtoNetSearch...

Other

GeneWikiDAP3.
GenomeRNAi7818.
NextBio30217.
PROP51398.
SOURCESearch...

Entry information

Entry nameRT29_HUMAN
AccessionPrimary (citable) accession number: P51398
Secondary accession number(s): B4DP59 expand/collapse secondary AC list , B4DY62, E7EM60, Q13044, Q68CT7, Q96Q20
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM