Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

28S ribosomal protein S29, mitochondrial

Gene

DAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in mediating interferon-gamma-induced cell death.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei100GTP; via carbonyl oxygen1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi128 – 135GTP1 Publication8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
Biological processApoptosis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination
SIGNORiP51398

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S29, mitochondrial
Short name:
MRP-S29
Short name:
S29mt
Alternative name(s):
Death-associated protein 3
Short name:
DAP-3
Ionizing radiation resistance conferring protein
Mitochondrial small ribosomal subunit protein mS291 Publication
Gene namesi
Name:DAP3
Synonyms:MRPS29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000132676.15
HGNCiHGNC:2673 DAP3
MIMi602074 gene
neXtProtiNX_P51398

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi7818
OpenTargetsiENSG00000132676
PharmGKBiPA27141

Polymorphism and mutation databases

BioMutaiDAP3
DMDMi1706299

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 21MitochondrionSequence analysisAdd BLAST21
ChainiPRO_000008771722 – 39828S ribosomal protein S29, mitochondrialAdd BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175N6-acetyllysineCombined sources1
Modified residuei207N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP51398
MaxQBiP51398
PaxDbiP51398
PeptideAtlasiP51398
PRIDEiP51398

PTM databases

iPTMnetiP51398
PhosphoSitePlusiP51398
SwissPalmiP51398

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000132676
CleanExiHS_DAP3
ExpressionAtlasiP51398 baseline and differential
GenevisibleiP51398 HS

Organism-specific databases

HPAiHPA023687

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25838379). Interacts with KIAA0141 (PubMed:20563667). Interacts with NOA1 (PubMed:19103604).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NOA1Q8NC605EBI-355912,EBI-717871

Protein-protein interaction databases

BioGridi113587, 111 interactors
CORUMiP51398
IntActiP51398, 37 interactors
MINTiP51398
STRINGi9606.ENSP00000341692

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AX1-398[»]
ProteinModelPortaliP51398
SMRiP51398
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3928 Eukaryota
ENOG410XSDC LUCA
GeneTreeiENSGT00390000015248
HOGENOMiHOG000046851
HOVERGENiHBG025946
InParanoidiP51398
KOiK17408
OMAiKIAMTEG
OrthoDBiEOG091G08ZG
PhylomeDBiP51398
TreeFamiTF313726

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR019368 Ribosomal_S23/S29_mit
IPR008092 Ribosomal_S29_mit
PANTHERiPTHR12810 PTHR12810, 1 hit
PfamiView protein in Pfam
PF10236 DAP3, 1 hit
PRINTSiPR01716 DEATHASSOCP3
SUPFAMiSSF52540 SSF52540, 2 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P51398-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMLKGITRLI SRIHKLDPGR FLHMGTQARQ SIAAHLDNQV PVESPRAISR
60 70 80 90 100
TNENDPAKHG DQHEGQHYNI SPQDLETVFP HGLPPRFVMQ VKTFSEACLM
110 120 130 140 150
VRKPALELLH YLKNTSFAYP AIRYLLYGEK GTGKTLSLCH VIHFCAKQDW
160 170 180 190 200
LILHIPDAHL WVKNCRDLLQ SSYNKQRFDQ PLEASTWLKN FKTTNERFLN
210 220 230 240 250
QIKVQEKYVW NKRESTEKGS PLGEVVEQGI TRVRNATDAV GIVLKELKRQ
260 270 280 290 300
SSLGMFHLLV AVDGINALWG RTTLKREDKS PIAPEELALV HNLRKMMKND
310 320 330 340 350
WHGGAIVSAL SQTGSLFKPR KAYLPQELLG KEGFDALDPF IPILVSNYNP
360 370 380 390
KEFESCIQYY LENNWLQHEK APTEEGKKEL LFLSNANPSL LERHCAYL
Length:398
Mass (Da):45,566
Last modified:October 1, 1996 - v1
Checksum:i778AF183FA04DEC8
GO
Isoform 2 (identifier: P51398-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-56: Missing.

Show »
Length:357
Mass (Da):41,044
Checksum:i20E08FFBBF9C2E57
GO
Isoform 3 (identifier: P51398-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-90: Missing.

Note: No experimental confirmation available.
Show »
Length:364
Mass (Da):41,673
Checksum:iA51F7F4E1B0B12B0
GO

Sequence cautioni

The sequence AAA57443 differs from that shown. Reason: Frameshift at position 349.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157D → Y in BAG63624 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061811240V → F. Corresponds to variant dbSNP:rs57692591Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04279016 – 56Missing in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_04463957 – 90Missing in isoform 3. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18321 mRNA Translation: AAA57443.1 Frameshift.
X83544 mRNA Translation: CAA58535.1
AK293117 mRNA Translation: BAF85806.1
AK298201 mRNA Translation: BAG60471.1
AK302281 mRNA Translation: BAG63624.1
BT019494 mRNA Translation: AAV38301.1
CR749790 mRNA Translation: CAH18651.1
AL162734 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53044.1
CH471121 Genomic DNA Translation: EAW53045.1
CH471121 Genomic DNA Translation: EAW53047.1
CH471121 Genomic DNA Translation: EAW53048.1
CH471121 Genomic DNA Translation: EAW53049.1
CH471121 Genomic DNA Translation: EAW53051.1
BC107487 mRNA Translation: AAI07488.1
BC107488 mRNA Translation: AAI07489.1
CCDSiCCDS1120.1 [P51398-1]
CCDS55646.1 [P51398-3]
CCDS55647.1 [P51398-2]
PIRiG01589
RefSeqiNP_001186778.1, NM_001199849.1 [P51398-1]
NP_001186779.1, NM_001199850.1 [P51398-3]
NP_001186780.1, NM_001199851.1 [P51398-2]
NP_004623.1, NM_004632.3 [P51398-1]
NP_387506.1, NM_033657.2 [P51398-1]
XP_005245537.1, XM_005245480.2 [P51398-3]
XP_005245538.1, XM_005245481.2 [P51398-2]
XP_016857780.1, XM_017002291.1 [P51398-3]
XP_016857781.1, XM_017002292.1 [P51398-2]
XP_016857782.1, XM_017002293.1 [P51398-2]
UniGeneiHs.516746

Genome annotation databases

EnsembliENST00000343043; ENSP00000341692; ENSG00000132676 [P51398-1]
ENST00000368336; ENSP00000357320; ENSG00000132676 [P51398-1]
ENST00000421487; ENSP00000412605; ENSG00000132676 [P51398-3]
ENST00000471642; ENSP00000476592; ENSG00000132676 [P51398-2]
ENST00000535183; ENSP00000445003; ENSG00000132676 [P51398-2]
GeneIDi7818
KEGGihsa:7818
UCSCiuc001flq.4 human [P51398-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRT29_HUMAN
AccessioniPrimary (citable) accession number: P51398
Secondary accession number(s): B4DP59
, B4DY62, E7EM60, Q13044, Q68CT7, Q96Q20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health