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Protein

Death-associated protein 1

Gene

DAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death.1 Publication

GO - Molecular functioni

  • death domain binding Source: UniProtKB

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  • apoptotic process Source: MGI
  • apoptotic signaling pathway Source: UniProtKB
  • autophagy Source: UniProtKB-KW
  • cellular response to amino acid starvation Source: UniProtKB
  • negative regulation of autophagy Source: UniProtKB
  • negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Autophagy

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112977-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Death-associated protein 1
Short name:
DAP-1
Gene namesi
Name:DAP
Synonyms:DAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:2672. DAP.

Pathology & Biotechi

Organism-specific databases

DisGeNETi1611.
OpenTargetsiENSG00000112977.
PharmGKBiPA27140.

Polymorphism and mutation databases

BioMutaiDAP.
DMDMi1706298.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000797822 – 102Death-associated protein 1Add BLAST101

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei3Phosphoserine; by MTOR2 Publications1
Modified residuei29N6-acetyllysineBy similarity1
Modified residuei49PhosphoserineCombined sources1 Publication1
Modified residuei51Phosphoserine; by MTORCombined sources2 Publications1
Modified residuei91PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP51397.
MaxQBiP51397.
PaxDbiP51397.
PeptideAtlasiP51397.
PRIDEiP51397.
TopDownProteomicsiP51397.

PTM databases

iPTMnetiP51397.
PhosphoSitePlusiP51397.

Expressioni

Gene expression databases

BgeeiENSG00000112977.
CleanExiHS_DAP.
ExpressionAtlasiP51397. baseline and differential.
GenevisibleiP51397. HS.

Interactioni

GO - Molecular functioni

  • death domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107981. 1 interactor.
IntActiP51397. 1 interactor.
STRINGi9606.ENSP00000230895.

Structurei

3D structure databases

ProteinModelPortaliP51397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IZ5N. Eukaryota.
ENOG41122SE. LUCA.
GeneTreeiENSGT00390000008309.
HOGENOMiHOG000039719.
HOVERGENiHBG005451.
InParanoidiP51397.
OMAiAQHINQH.
PhylomeDBiP51397.
TreeFamiTF329716.

Family and domain databases

InterProiIPR024130. DAP1/DAPL1.
[Graphical view]
PANTHERiPTHR13177. PTHR13177. 1 hit.
PfamiPF15228. DAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51397-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPPEGKLE TKAGHPPAVK AGGMRIVQKH PHTGDTKEEK DKDDQEWESP
60 70 80 90 100
SPPKPTVFIS GVIARGDKDF PPAAAQVAHQ KPHASMDKHP SPRTQHIQQP

RK
Length:102
Mass (Da):11,165
Last modified:January 23, 2007 - v3
Checksum:i52FBEFD23ABD182F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76105 mRNA. Translation: CAA53713.1.
CR542184 mRNA. Translation: CAG46981.1.
AY266680 Genomic DNA. Translation: AAO89078.1.
BC002726 mRNA. Translation: AAH02726.2.
CCDSiCCDS3880.1.
PIRiI37274.
RefSeqiNP_001278892.1. NM_001291963.1.
NP_004385.1. NM_004394.2.
UniGeneiHs.75189.

Genome annotation databases

EnsembliENST00000230895; ENSP00000230895; ENSG00000112977.
GeneIDi1611.
KEGGihsa:1611.
UCSCiuc003jez.5. human.

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76105 mRNA. Translation: CAA53713.1.
CR542184 mRNA. Translation: CAG46981.1.
AY266680 Genomic DNA. Translation: AAO89078.1.
BC002726 mRNA. Translation: AAH02726.2.
CCDSiCCDS3880.1.
PIRiI37274.
RefSeqiNP_001278892.1. NM_001291963.1.
NP_004385.1. NM_004394.2.
UniGeneiHs.75189.

3D structure databases

ProteinModelPortaliP51397.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107981. 1 interactor.
IntActiP51397. 1 interactor.
STRINGi9606.ENSP00000230895.

PTM databases

iPTMnetiP51397.
PhosphoSitePlusiP51397.

Polymorphism and mutation databases

BioMutaiDAP.
DMDMi1706298.

Proteomic databases

EPDiP51397.
MaxQBiP51397.
PaxDbiP51397.
PeptideAtlasiP51397.
PRIDEiP51397.
TopDownProteomicsiP51397.

Protocols and materials databases

DNASUi1611.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000230895; ENSP00000230895; ENSG00000112977.
GeneIDi1611.
KEGGihsa:1611.
UCSCiuc003jez.5. human.

Organism-specific databases

CTDi1611.
DisGeNETi1611.
GeneCardsiDAP.
HGNCiHGNC:2672. DAP.
MIMi600954. gene.
neXtProtiNX_P51397.
OpenTargetsiENSG00000112977.
PharmGKBiPA27140.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ5N. Eukaryota.
ENOG41122SE. LUCA.
GeneTreeiENSGT00390000008309.
HOGENOMiHOG000039719.
HOVERGENiHBG005451.
InParanoidiP51397.
OMAiAQHINQH.
PhylomeDBiP51397.
TreeFamiTF329716.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112977-MONOMER.

Miscellaneous databases

ChiTaRSiDAP. human.
GeneWikiiDAP_(gene).
GenomeRNAii1611.
PROiP51397.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112977.
CleanExiHS_DAP.
ExpressionAtlasiP51397. baseline and differential.
GenevisibleiP51397. HS.

Family and domain databases

InterProiIPR024130. DAP1/DAPL1.
[Graphical view]
PANTHERiPTHR13177. PTHR13177. 1 hit.
PfamiPF15228. DAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDAP1_HUMAN
AccessioniPrimary (citable) accession number: P51397
Secondary accession number(s): Q6FGC3, Q9BUC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.