Reviewed, UniProtKB/Swiss-Prot P51397 (DAP1_HUMAN)

Names and origin

Protein names

Recommended name:
    Death-associated protein 1
      Short name=DAP-1

Gene names

Name:	DAP
Synonyms:	DAP1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	102 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function

Involved in mediating interferon-gamma-induced cell death.

Ontologies

Keywords
Biological process	Apoptosis
PTM	Acetylation Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	induction of apoptosis by extracellular signals Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 102	101	Death-associated protein 1		PRO_0000079782
Amino acid modifications
	Modified residue	2	1	N-acetylserine
	Modified residue	3	1	Phosphoserine
	Modified residue	49	1	Phosphoserine
	Modified residue	51	1	Phosphoserine
	Modified residue	91	1	Phosphoserine

Sequences

	Sequence		Length	Mass (Da)
	P51397-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 52FBEFD23ABD182F	FASTA	102	11,165
	10 20 30 40 50 60 MSSPPEGKLE TKAGHPPAVK AGGMRIVQKH PHTGDTKEEK DKDDQEWESP SPPKPTVFIS 70 80 90 100 GVIARGDKDF PPAAAQVAHQ KPHASMDKHP SPRTQHIQQP RK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death." Deiss L.P., Feinstein E., Berissi H., Cohen O., Kimchi A. Genes Dev. 9:15-30(1995) [PubMed: 7828849] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)." Rieder M.J., Livingston R.J., Daniels M.R., Montoya M.A., Chung M.-W., Miyamoto K.E., Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S., Sherwood J.K., Witrak L.A., Nickerson D.A. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[4]	"Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins." Zougman A., Wisniewski J.R. J. Proteome Res. 5:925-934(2006) [PubMed: 16602700] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-8 AND 41-65, ACETYLATION AT SER-2, PHOSPHORYLATION AT SER-3; SER-49 AND SER-51, MASS SPECTROMETRY.
[5]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51, MASS SPECTROMETRY. Tissue: Epithelium.
[6]	"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-91, MASS SPECTROMETRY.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-51 AND SER-91, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X76105 mRNA. Translation: CAA53713.1. AY266680 Genomic DNA. Translation: AAO89078.1. BC002726 mRNA. Translation: AAH02726.2.
PIR	I37274.
RefSeq	NP_004385.1.
UniGene	Hs.75189
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P51397.
PTM databases
PhosphoSite	P51397.
Polymorphism databases
NIEHS-SNPs	Search...
Proteomic databases
PeptideAtlas	P51397.
Genome annotation databases
Ensembl	ENSG00000112977. Homo sapiens. [Contig view]
GeneID	1611.
KEGG	hsa:1611.
Organism-specific databases
H-InvDB	HIX0004749.
HGNC	HGNC:2672. DAP.
MIM	600954. gene.
PharmGKB	PA27140.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	P51397.
Gene expression databases
ArrayExpress	P51397.
CleanEx	HS_DAP.
GermOnline	ENSG00000112977. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	6622.
SOURCE	Search...

Entry information

Entry name

DAP1_HUMAN

Accession

Primary (citable) accession number: P51397
Secondary accession number(s): Q9BUC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 23, 2007
Last modified:	November 25, 2008
This is version 50 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)