Reviewed, UniProtKB/Swiss-Prot P51397 (DAP1_HUMAN)

Names and origin

Protein names

Recommended name:
    Death-associated protein 1
      Short name=DAP-1

Gene names

Name:	DAP
Synonyms:	DAP1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	102 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function

Involved in mediating interferon-gamma-induced cell death.

Ontologies

Keywords
Biological process	Apoptosis
PTM	Acetylation Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: UniProtKB-KW induction of apoptosis by extracellular signals Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.5
	Chain	2 – 102	101	Death-associated protein 1		PRO_0000079782
Amino acid modifications
	Modified residue	2	1	N-acetylserine Ref.5
	Modified residue	3	1	Phosphoserine Ref.5
	Modified residue	49	1	Phosphoserine Ref.5 Ref.8
	Modified residue	51	1	Phosphoserine Ref.5 Ref.8 Ref.6
	Modified residue	91	1	Phosphoserine Ref.8 Ref.7

Sequences

	Sequence		Length	Mass (Da)
	P51397-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 52FBEFD23ABD182F	FASTA	102	11,165
	10 20 30 40 50 60 MSSPPEGKLE TKAGHPPAVK AGGMRIVQKH PHTGDTKEEK DKDDQEWESP SPPKPTVFIS 70 80 90 100 GVIARGDKDF PPAAAQVAHQ KPHASMDKHP SPRTQHIQQP RK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death." Deiss L.P., Feinstein E., Berissi H., Cohen O., Kimchi A. Genes Dev. 9:15-30(1995) [PubMed: 7828849] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	NIEHS SNPs program Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[5]	"Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins." Zougman A., Wisniewski J.R. J. Proteome Res. 5:925-934(2006) [PubMed: 16602700] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-8 AND 41-65, ACETYLATION AT SER-2, PHOSPHORYLATION AT SER-3; SER-49 AND SER-51, MASS SPECTROMETRY.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51, MASS SPECTROMETRY. Tissue: Epithelium.
[7]	"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-91, MASS SPECTROMETRY.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-51 AND SER-91, MASS SPECTROMETRY.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBLGenBankDDBJ	X76105 mRNA. Translation: CAA53713.1. CR542184 mRNA. Translation: CAG46981.1. AY266680 Genomic DNA. Translation: AAO89078.1. BC002726 mRNA. Translation: AAH02726.2.
IPI	IPI00018117.
PIR	I37274.
RefSeq	NP_004385.1.
UniGene	Hs.75189
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P51397. 1 interaction.
PTM databases
PhosphoSite	P51397.
Proteomic databases
PeptideAtlas	P51397.
PRIDE	P51397.
Genome annotation databases
Ensembl	ENSG00000112977. Homo sapiens. [Contig view]
GeneID	1611.
KEGG	hsa:1611.
Organism-specific databases
GeneCards	GC05M010732.
H-InvDB	HIX0004749.
HGNC	HGNC:2672. DAP.
MIM	600954. gene.
PharmGKB	PA27140.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P51397.
OMA	P51397. QEWESTS.
Gene expression databases
ArrayExpress	P51397.
Bgee	P51397.
CleanEx	HS_DAP.
GermOnline	ENSG00000112977. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	6622.
SOURCE	Search...

Entry information

Entry name

DAP1_HUMAN

Accession

Primary (citable) accession number: P51397
Secondary accession number(s): Q6FGC3, Q9BUC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 54 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)