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P51397

- DAP1_HUMAN

UniProt

P51397 - DAP1_HUMAN

Protein

Death-associated protein 1

Gene

DAP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death.1 Publication

    GO - Molecular functioni

    1. death domain binding Source: UniProtKB

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    2. apoptotic process Source: MGI
    3. apoptotic signaling pathway Source: UniProtKB
    4. autophagy Source: UniProtKB-KW
    5. cellular response to amino acid starvation Source: UniProtKB
    6. negative regulation of autophagy Source: UniProtKB
    7. negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
    8. negative regulation of transcription, DNA-templated Source: UniProtKB

    Keywords - Biological processi

    Apoptosis, Autophagy

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Death-associated protein 1
    Short name:
    DAP-1
    Gene namesi
    Name:DAP
    Synonyms:DAP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:2672. DAP.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27140.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 102101Death-associated protein 1PRO_0000079782Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei3 – 31Phosphoserine; by MTOR2 Publications
    Modified residuei29 – 291N6-acetyllysineBy similarity
    Modified residuei49 – 491Phosphoserine3 Publications
    Modified residuei51 – 511Phosphoserine; by MTOR5 Publications
    Modified residuei91 – 911Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy.5 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP51397.
    PaxDbiP51397.
    PeptideAtlasiP51397.
    PRIDEiP51397.

    PTM databases

    PhosphoSiteiP51397.

    Expressioni

    Gene expression databases

    ArrayExpressiP51397.
    BgeeiP51397.
    CleanExiHS_DAP.
    GenevestigatoriP51397.

    Interactioni

    Protein-protein interaction databases

    BioGridi107981. 3 interactions.
    IntActiP51397. 1 interaction.
    STRINGi9606.ENSP00000230895.

    Structurei

    3D structure databases

    ProteinModelPortaliP51397.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG84666.
    HOGENOMiHOG000039719.
    HOVERGENiHBG005451.
    OMAiWAREEMD.
    OrthoDBiEOG757D0J.
    PhylomeDBiP51397.
    TreeFamiTF329716.

    Family and domain databases

    InterProiIPR024130. DAP1/DAPL1.
    [Graphical view]
    PANTHERiPTHR13177. PTHR13177. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P51397-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSPPEGKLE TKAGHPPAVK AGGMRIVQKH PHTGDTKEEK DKDDQEWESP    50
    SPPKPTVFIS GVIARGDKDF PPAAAQVAHQ KPHASMDKHP SPRTQHIQQP 100
    RK 102
    Length:102
    Mass (Da):11,165
    Last modified:January 23, 2007 - v3
    Checksum:i52FBEFD23ABD182F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76105 mRNA. Translation: CAA53713.1.
    CR542184 mRNA. Translation: CAG46981.1.
    AY266680 Genomic DNA. Translation: AAO89078.1.
    BC002726 mRNA. Translation: AAH02726.2.
    CCDSiCCDS3880.1.
    PIRiI37274.
    RefSeqiNP_004385.1. NM_004394.2.
    UniGeneiHs.75189.

    Genome annotation databases

    EnsembliENST00000230895; ENSP00000230895; ENSG00000112977.
    GeneIDi1611.
    KEGGihsa:1611.
    UCSCiuc003jez.4. human.

    Polymorphism databases

    DMDMi1706298.

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76105 mRNA. Translation: CAA53713.1 .
    CR542184 mRNA. Translation: CAG46981.1 .
    AY266680 Genomic DNA. Translation: AAO89078.1 .
    BC002726 mRNA. Translation: AAH02726.2 .
    CCDSi CCDS3880.1.
    PIRi I37274.
    RefSeqi NP_004385.1. NM_004394.2.
    UniGenei Hs.75189.

    3D structure databases

    ProteinModelPortali P51397.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107981. 3 interactions.
    IntActi P51397. 1 interaction.
    STRINGi 9606.ENSP00000230895.

    PTM databases

    PhosphoSitei P51397.

    Polymorphism databases

    DMDMi 1706298.

    Proteomic databases

    MaxQBi P51397.
    PaxDbi P51397.
    PeptideAtlasi P51397.
    PRIDEi P51397.

    Protocols and materials databases

    DNASUi 1611.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000230895 ; ENSP00000230895 ; ENSG00000112977 .
    GeneIDi 1611.
    KEGGi hsa:1611.
    UCSCi uc003jez.4. human.

    Organism-specific databases

    CTDi 1611.
    GeneCardsi GC05M010679.
    HGNCi HGNC:2672. DAP.
    MIMi 600954. gene.
    neXtProti NX_P51397.
    PharmGKBi PA27140.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG84666.
    HOGENOMi HOG000039719.
    HOVERGENi HBG005451.
    OMAi WAREEMD.
    OrthoDBi EOG757D0J.
    PhylomeDBi P51397.
    TreeFami TF329716.

    Miscellaneous databases

    ChiTaRSi DAP. human.
    GeneWikii DAP_(gene).
    GenomeRNAii 1611.
    NextBioi 6622.
    PROi P51397.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51397.
    Bgeei P51397.
    CleanExi HS_DAP.
    Genevestigatori P51397.

    Family and domain databases

    InterProi IPR024130. DAP1/DAPL1.
    [Graphical view ]
    PANTHERi PTHR13177. PTHR13177. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death."
      Deiss L.P., Feinstein E., Berissi H., Cohen O., Kimchi A.
      Genes Dev. 9:15-30(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. NIEHS SNPs program
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    5. "Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins."
      Zougman A., Wisniewski J.R.
      J. Proteome Res. 5:925-934(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-8 AND 41-65, ACETYLATION AT SER-2, PHOSPHORYLATION AT SER-3; SER-49 AND SER-51, IDENTIFICATION BY MASS SPECTROMETRY.
    6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-51 AND SER-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "DAP1, a novel substrate of mTOR, negatively regulates autophagy."
      Koren I., Reem E., Kimchi A.
      Curr. Biol. 20:1093-1098(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN AUTOPHAGY, PHOSPHORYLATION AT SER-3 AND SER-51 BY MTOR.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-51 AND SER-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDAP1_HUMAN
    AccessioniPrimary (citable) accession number: P51397
    Secondary accession number(s): Q6FGC3, Q9BUC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3