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P51397 (DAP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Death-associated protein 1

Short name=DAP-1
Gene names
Name:DAP
Synonyms:DAP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length102 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death. Ref.8

Post-translational modification

Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy. Ref.5 Ref.8

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 102101Death-associated protein 1
PRO_0000079782

Amino acid modifications

Modified residue21N-acetylserine Ref.5
Modified residue31Phosphoserine; by MTOR Ref.5 Ref.8
Modified residue291N6-acetyllysine By similarity
Modified residue491Phosphoserine Ref.5 Ref.7 Ref.9
Modified residue511Phosphoserine; by MTOR Ref.5 Ref.7 Ref.8 Ref.9 Ref.10
Modified residue911Phosphoserine Ref.7 Ref.9

Sequences

Sequence LengthMass (Da)Tools
P51397 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 52FBEFD23ABD182F

FASTA10211,165
        10         20         30         40         50         60 
MSSPPEGKLE TKAGHPPAVK AGGMRIVQKH PHTGDTKEEK DKDDQEWESP SPPKPTVFIS 

        70         80         90        100 
GVIARGDKDF PPAAAQVAHQ KPHASMDKHP SPRTQHIQQP RK 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death."
Deiss L.P., Feinstein E., Berissi H., Cohen O., Kimchi A.
Genes Dev. 9:15-30(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]NIEHS SNPs program
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[5]"Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins."
Zougman A., Wisniewski J.R.
J. Proteome Res. 5:925-934(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-8 AND 41-65, ACETYLATION AT SER-2, PHOSPHORYLATION AT SER-3; SER-49 AND SER-51, IDENTIFICATION BY MASS SPECTROMETRY.
[6]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-51 AND SER-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"DAP1, a novel substrate of mTOR, negatively regulates autophagy."
Koren I., Reem E., Kimchi A.
Curr. Biol. 20:1093-1098(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN AUTOPHAGY, PHOSPHORYLATION AT SER-3 AND SER-51 BY MTOR.
[9]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-51 AND SER-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X76105 mRNA. Translation: CAA53713.1.
CR542184 mRNA. Translation: CAG46981.1.
AY266680 Genomic DNA. Translation: AAO89078.1.
BC002726 mRNA. Translation: AAH02726.2.
CCDSCCDS3880.1.
PIRI37274.
RefSeqNP_004385.1. NM_004394.2.
UniGeneHs.75189.

3D structure databases

ProteinModelPortalP51397.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107981. 3 interactions.
IntActP51397. 1 interaction.
STRING9606.ENSP00000230895.

PTM databases

PhosphoSiteP51397.

Polymorphism databases

DMDM1706298.

Proteomic databases

MaxQBP51397.
PaxDbP51397.
PeptideAtlasP51397.
PRIDEP51397.

Protocols and materials databases

DNASU1611.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000230895; ENSP00000230895; ENSG00000112977.
GeneID1611.
KEGGhsa:1611.
UCSCuc003jez.4. human.

Organism-specific databases

CTD1611.
GeneCardsGC05M010679.
HGNCHGNC:2672. DAP.
MIM600954. gene.
neXtProtNX_P51397.
PharmGKBPA27140.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG84666.
HOGENOMHOG000039719.
HOVERGENHBG005451.
OMAWAREEMD.
OrthoDBEOG757D0J.
PhylomeDBP51397.
TreeFamTF329716.

Gene expression databases

ArrayExpressP51397.
BgeeP51397.
CleanExHS_DAP.
GenevestigatorP51397.

Family and domain databases

InterProIPR024130. DAP1/DAPL1.
[Graphical view]
PANTHERPTHR13177. PTHR13177. 1 hit.
ProtoNetSearch...

Other

ChiTaRSDAP. human.
GeneWikiDAP_(gene).
GenomeRNAi1611.
NextBio6622.
PROP51397.
SOURCESearch...

Entry information

Entry nameDAP1_HUMAN
AccessionPrimary (citable) accession number: P51397
Secondary accession number(s): Q6FGC3, Q9BUC9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM