Reviewed,
UniProtKB/Swiss-Prot P51397 (DAP1_HUMAN)
Last modified
November 25, 2008.
Version 50.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Death-associated protein 1 Short name=DAP-1 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 102 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Involved in mediating interferon-gamma-induced cell death. |
Ontologies
Keywords | |
|---|---|
| Biological process | Apoptosis |
| PTM | Acetylation Phosphoprotein |
| Technical term | Direct protein sequencing |
Gene Ontology (GO) | |
| Biological process | induction of apoptosis by extracellular signals Ref.1 Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed | ||||||
| Chain | 2 – 102 | 101 | Death-associated protein 1 | PRO_0000079782 | |||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylserine | ||||||
| Modified residue | 3 | 1 | Phosphoserine | ||||||
| Modified residue | 49 | 1 | Phosphoserine | ||||||
| Modified residue | 51 | 1 | Phosphoserine | ||||||
| Modified residue | 91 | 1 | Phosphoserine | ||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death." Deiss L.P., Feinstein E., Berissi H., Cohen O., Kimchi A. Genes Dev. 9:15-30(1995) [PubMed: 7828849] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)." Rieder M.J., Livingston R.J., Daniels M.R., Montoya M.A., Chung M.-W., Miyamoto K.E., Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S., Sherwood J.K., Witrak L.A., Nickerson D.A. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus. |
| [4] | "Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins." Zougman A., Wisniewski J.R. J. Proteome Res. 5:925-934(2006) [PubMed: 16602700] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-8 AND 41-65, ACETYLATION AT SER-2, PHOSPHORYLATION AT SER-3; SER-49 AND SER-51, MASS SPECTROMETRY. |
| [5] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51, MASS SPECTROMETRY. Tissue: Epithelium. |
| [6] | "Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-91, MASS SPECTROMETRY. |
| [7] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-51 AND SER-91, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| X76105 mRNA. Translation: CAA53713.1. AY266680 Genomic DNA. Translation: AAO89078.1. BC002726 mRNA. Translation: AAH02726.2. | |
| PIR | I37274. |
| RefSeq | NP_004385.1. |
| UniGene | Hs.75189 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P51397. |
PTM databases | |
| PhosphoSite | P51397. |
Polymorphism databases | |
| NIEHS-SNPs | Search... |
Proteomic databases | |
| PeptideAtlas | P51397. |
Genome annotation databases | |
| Ensembl | ENSG00000112977. Homo sapiens. [Contig view] |
| GeneID | 1611. |
| KEGG | hsa:1611. |
Organism-specific databases | |
| H-InvDB | HIX0004749. |
| HGNC | HGNC:2672. DAP. |
| MIM | 600954. gene. |
| PharmGKB | PA27140. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOVERGEN | P51397. |
Gene expression databases | |
| ArrayExpress | P51397. |
| CleanEx | HS_DAP. |
| GermOnline | ENSG00000112977. Homo sapiens. |
Family and domain databases | |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 6622. |
| SOURCE | Search... |
Entry information
| Entry name | DAP1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P51397 Secondary accession number(s): Q9BUC9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 5 Human chromosome 5: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |

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