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P51267

- ODPA_PORPU

UniProt

P51267 - ODPA_PORPU

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Protein
Pyruvate dehydrogenase E1 component subunit alpha
Gene
pdhA, odpA
Organism
Porphyra purpurea (Red seaweed)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate.

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Gene namesi
Name:pdhA
Synonyms:odpA
Encoded oniPlastid; Chloroplast
OrganismiPorphyra purpurea (Red seaweed)
Taxonomic identifieri2787 [NCBI]
Taxonomic lineageiEukaryotaRhodophytaBangiophyceaeBangialesBangiaceaePorphyra

Subcellular locationi

GO - Cellular componenti

  1. chloroplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Pyruvate dehydrogenase E1 component subunit alpha
PRO_0000162215Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain By similarity.

Structurei

3D structure databases

ProteinModelPortaliP51267.

Family & Domainsi

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
TIGRFAMsiTIGR03182. PDH_E1_alph_y. 1 hit.

Sequencei

Sequence statusi: Complete.

P51267-1 [UniParc]FASTAAdd to Basket

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MSYPKKVELP LTNCNQINLT KHKLLVLYED MLLGRNFEDM CAQMYYKGKM    50
FGFVHLYNGQ EAVSTGVIKL LDSKDYVCST YRDHVHALSK GVPSQNVMAE 100
LFGKETGCSR GRGGSMHIFS APHNFLGGFA FIAEGIPVAT GAAFQSIYRQ 150
QVLKEPGELR VTACFFGDGT TNNGQFFECL NMAVLWKLPI IFVVENNQWA 200
IGMAHHRSSS IPEIHKKAEA FGLPGIEVDG MDVLAVRQVA EKAVERARQG 250
QGPTLIEALT YRFRGHSLAD PDELRSRQEK EAWVARDPIK KLKKHILDNQ 300
IASSDELNDI QSSVKIDLEQ SVEFAMSSPE PNISELKRYL FADN 344
Length:344
Mass (Da):38,507
Last modified:October 1, 1996 - v1
Checksum:i799BD9AFA06FF455
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U38804 Genomic DNA. Translation: AAC08153.1.
PIRiS73188.
RefSeqiNP_053877.1. NC_000925.1.

Genome annotation databases

GeneIDi809896.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U38804 Genomic DNA. Translation: AAC08153.1 .
PIRi S73188.
RefSeqi NP_053877.1. NC_000925.1.

3D structure databases

ProteinModelPortali P51267.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 809896.

Family and domain databases

Gene3Di 3.40.50.970. 1 hit.
InterProi IPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
[Graphical view ]
Pfami PF00676. E1_dh. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 1 hit.
TIGRFAMsi TIGR03182. PDH_E1_alph_y. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete nucleotide sequence of the Porphyra purpurea chloroplast genome."
    Reith M.E., Munholland J.
    Plant Mol. Biol. Rep. 13:333-335(1995)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Avonport.

Entry informationi

Entry nameiODPA_PORPU
AccessioniPrimary (citable) accession number: P51267
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

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