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P51267

- ODPA_PORPU

UniProt

P51267 - ODPA_PORPU

Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Porphyra purpurea (Red seaweed)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.

    GO - Molecular functioni

    1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Pyruvate, Thiamine pyrophosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
    Gene namesi
    Name:pdhA
    Synonyms:odpA
    Encoded oniPlastid; Chloroplast
    OrganismiPorphyra purpurea (Red seaweed)
    Taxonomic identifieri2787 [NCBI]
    Taxonomic lineageiEukaryotaRhodophytaBangiophyceaeBangialesBangiaceaePorphyra

    Subcellular locationi

    GO - Cellular componenti

    1. chloroplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 344344Pyruvate dehydrogenase E1 component subunit alphaPRO_0000162215Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta chain.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP51267.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    Gene3Di3.40.50.970. 1 hit.
    InterProiIPR001017. DH_E1.
    IPR017597. Pyrv_DH_E1_asu_subgrp-y.
    IPR029061. THDP-binding.
    [Graphical view]
    PfamiPF00676. E1_dh. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 1 hit.
    TIGRFAMsiTIGR03182. PDH_E1_alph_y. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P51267-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYPKKVELP LTNCNQINLT KHKLLVLYED MLLGRNFEDM CAQMYYKGKM    50
    FGFVHLYNGQ EAVSTGVIKL LDSKDYVCST YRDHVHALSK GVPSQNVMAE 100
    LFGKETGCSR GRGGSMHIFS APHNFLGGFA FIAEGIPVAT GAAFQSIYRQ 150
    QVLKEPGELR VTACFFGDGT TNNGQFFECL NMAVLWKLPI IFVVENNQWA 200
    IGMAHHRSSS IPEIHKKAEA FGLPGIEVDG MDVLAVRQVA EKAVERARQG 250
    QGPTLIEALT YRFRGHSLAD PDELRSRQEK EAWVARDPIK KLKKHILDNQ 300
    IASSDELNDI QSSVKIDLEQ SVEFAMSSPE PNISELKRYL FADN 344
    Length:344
    Mass (Da):38,507
    Last modified:October 1, 1996 - v1
    Checksum:i799BD9AFA06FF455
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U38804 Genomic DNA. Translation: AAC08153.1.
    PIRiS73188.
    RefSeqiNP_053877.1. NC_000925.1.

    Genome annotation databases

    GeneIDi809896.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U38804 Genomic DNA. Translation: AAC08153.1 .
    PIRi S73188.
    RefSeqi NP_053877.1. NC_000925.1.

    3D structure databases

    ProteinModelPortali P51267.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 809896.

    Family and domain databases

    Gene3Di 3.40.50.970. 1 hit.
    InterProi IPR001017. DH_E1.
    IPR017597. Pyrv_DH_E1_asu_subgrp-y.
    IPR029061. THDP-binding.
    [Graphical view ]
    Pfami PF00676. E1_dh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 1 hit.
    TIGRFAMsi TIGR03182. PDH_E1_alph_y. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequence of the Porphyra purpurea chloroplast genome."
      Reith M.E., Munholland J.
      Plant Mol. Biol. Rep. 13:333-335(1995)
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Avonport.

    Entry informationi

    Entry nameiODPA_PORPU
    AccessioniPrimary (citable) accession number: P51267
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)