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Protein

Protein-glutamine gamma-glutamyltransferase 2

Gene

TGM2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei277 – 2771PROSITE-ProRule annotation
Active sitei335 – 3351PROSITE-ProRule annotation
Active sitei358 – 3581PROSITE-ProRule annotation
Metal bindingi398 – 3981CalciumBy similarity
Metal bindingi400 – 4001CalciumBy similarity
Metal bindingi447 – 4471CalciumBy similarity
Metal bindingi452 – 4521CalciumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. apoptotic cell clearance Source: Ensembl
  2. branching involved in salivary gland morphogenesis Source: Ensembl
  3. negative regulation of endoplasmic reticulum calcium ion concentration Source: Ensembl
  4. peptide cross-linking Source: InterPro
  5. positive regulation of apoptotic process Source: Ensembl
  6. positive regulation of cell adhesion Source: Ensembl
  7. positive regulation of mitochondrial calcium ion concentration Source: Ensembl
  8. salivary gland cavitation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase 2 (EC:2.3.2.13)
Alternative name(s):
Tissue transglutaminase
Transglutaminase C
Short name:
TG(C)
Short name:
TGC
Short name:
TGase C
Transglutaminase-2
Short name:
TGase-2
Gene namesi
Name:TGM2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 13

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. focal adhesion Source: Ensembl
  4. mitochondrion Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 687686Protein-glutamine gamma-glutamyltransferase 2PRO_0000213705Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei468 – 4681N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP51176.
PRIDEiP51176.

Expressioni

Tissue specificityi

Highest levels are detected in the lung. Lower levels are found in the liver, spleen and heart, but not in the brain.

Inductioni

By retinoic acid.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021569.

Structurei

3D structure databases

ProteinModelPortaliP51176.
SMRiP51176. Positions 15-687.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG80379.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiP51176.
KOiK05625.
OrthoDBiEOG7WT40M.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51176-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEELVLERC DLELEANGRD HHTADLCRER LVVRRGQPFW LTLHFEGRNY
60 70 80 90 100
EASVDSLTFC AVTGPDPSEE AGTKALFRLS DATEEGAWAA VAADQRDSTL
110 120 130 140 150
SLHLSTPANA PVGHYRLSLE ASTGYQGSSF MLGQFTLLFN SWCPADAVYL
160 170 180 190 200
DSDEERQEYV LTQQGFIYQG SAKFIKNIPW NFGQFEEGIL DICLMLLDVN
210 220 230 240 250
PKFLRNAGRD CSRRSSPVYV GRVVSGMVNC NDDQGVLLGR WDNNYADGIS
260 270 280 290 300
PMSWIGSVDI LRRWKRDGCQ RVKYGQCWVF AAVACTVLRC LGIPTRVVTN
310 320 330 340 350
YNSAHDQNSN LLIEYFRNEF GEIQSDKSEM IWNFHCWVES WMTRPDLQPG
360 370 380 390 400
YEGWQALDPT PQEKSEGTYC CGPVPVRAIK EGDLSTKYDA PFVFAEVNAD
410 420 430 440 450
VVDWIRQDDG SLHKSINHSL VVGLKISTKC VGRDDREDIT HSYKYPEGSP
460 470 480 490 500
EEREAFTRAN HLNKLVNKEE TGVAMRIRVG EGMNRGCDFD VFAHITNSTP
510 520 530 540 550
EEHTGRLLLC ARTVSYNGIL GPECGTKDLL SLSLEPYSEK SIPLRILYEK
560 570 580 590 600
YCDCLTESNL IKVRGLLIEP AANSYLLAER DIYLENPEIK IRILGEPKQN
610 620 630 640 650
RKLVAEISLQ NPLTVALSGC TFTVEGAGLI EEQKTVDVPD PVEAGEEVKV
660 670 680
RVDLLPLYVG RHKLVVNFES DRLKAVKGFR NVIVGPS
Length:687
Mass (Da):77,112
Last modified:October 1, 1996 - v1
Checksum:i7BBA00F15E779944
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti638 – 6381V → I in AAI03291 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60686 mRNA. Translation: CAA43097.1.
BC103290 mRNA. Translation: AAI03291.1.
PIRiS19680.
RefSeqiNP_803473.1. NM_177507.2.
UniGeneiBt.5401.

Genome annotation databases

GeneIDi281528.
KEGGibta:281528.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60686 mRNA. Translation: CAA43097.1.
BC103290 mRNA. Translation: AAI03291.1.
PIRiS19680.
RefSeqiNP_803473.1. NM_177507.2.
UniGeneiBt.5401.

3D structure databases

ProteinModelPortaliP51176.
SMRiP51176. Positions 15-687.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021569.

Proteomic databases

PaxDbiP51176.
PRIDEiP51176.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281528.
KEGGibta:281528.

Organism-specific databases

CTDi7052.

Phylogenomic databases

eggNOGiNOG80379.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiP51176.
KOiK05625.
OrthoDBiEOG7WT40M.
TreeFamiTF324278.

Miscellaneous databases

NextBioi20805485.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence analysis of cDNA clones for bovine aortic-endothelial-cell transglutaminase."
    Nakanishi K., Nara K., Hagiwara H., Aoyama Y., Ueno H., Hirose S.
    Eur. J. Biochem. 202:15-21(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 79-95; 157-166; 242-251 AND 581-587.
    Tissue: Artery.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Uterus.
  3. "Retinol-induced morphological changes of cultured bovine endothelial cells are accompanied by a marked increase in transglutaminase."
    Nara K., Nakanishi K., Hagiwara H., Wakita K., Kojima S., Hirose S.
    J. Biol. Chem. 264:19308-19312(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 79-95; 157-166 AND 242-251.

Entry informationi

Entry nameiTGM2_BOVIN
AccessioniPrimary (citable) accession number: P51176
Secondary accession number(s): Q3ZBH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 4, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.