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P51176

- TGM2_BOVIN

UniProt

P51176 - TGM2_BOVIN

Protein

Protein-glutamine gamma-glutamyltransferase 2

Gene

TGM2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

    Catalytic activityi

    Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei277 – 2771PROSITE-ProRule annotation
    Active sitei335 – 3351PROSITE-ProRule annotation
    Active sitei358 – 3581PROSITE-ProRule annotation
    Metal bindingi398 – 3981CalciumBy similarity
    Metal bindingi400 – 4001CalciumBy similarity
    Metal bindingi447 – 4471CalciumBy similarity
    Metal bindingi452 – 4521CalciumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. apoptotic cell clearance Source: Ensembl
    2. branching involved in salivary gland morphogenesis Source: Ensembl
    3. peptide cross-linking Source: InterPro
    4. positive regulation of cell adhesion Source: Ensembl
    5. salivary gland cavitation Source: Ensembl

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein-glutamine gamma-glutamyltransferase 2 (EC:2.3.2.13)
    Alternative name(s):
    Tissue transglutaminase
    Transglutaminase C
    Short name:
    TG(C)
    Short name:
    TGC
    Short name:
    TGase C
    Transglutaminase-2
    Short name:
    TGase-2
    Gene namesi
    Name:TGM2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 13

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 687686Protein-glutamine gamma-glutamyltransferase 2PRO_0000213705Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei468 – 4681N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP51176.
    PRIDEiP51176.

    Expressioni

    Tissue specificityi

    Highest levels are detected in the lung. Lower levels are found in the liver, spleen and heart, but not in the brain.

    Inductioni

    By retinoic acid.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000021569.

    Structurei

    3D structure databases

    ProteinModelPortaliP51176.
    SMRiP51176. Positions 15-687.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG80379.
    GeneTreeiENSGT00740000115156.
    HOGENOMiHOG000231695.
    HOVERGENiHBG004342.
    InParanoidiP51176.
    KOiK05625.
    OrthoDBiEOG7WT40M.
    TreeFamiTF324278.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view]
    PANTHERiPTHR11590. PTHR11590. 1 hit.
    PfamiPF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
    SMARTiSM00460. TGc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P51176-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEELVLERC DLELEANGRD HHTADLCRER LVVRRGQPFW LTLHFEGRNY    50
    EASVDSLTFC AVTGPDPSEE AGTKALFRLS DATEEGAWAA VAADQRDSTL 100
    SLHLSTPANA PVGHYRLSLE ASTGYQGSSF MLGQFTLLFN SWCPADAVYL 150
    DSDEERQEYV LTQQGFIYQG SAKFIKNIPW NFGQFEEGIL DICLMLLDVN 200
    PKFLRNAGRD CSRRSSPVYV GRVVSGMVNC NDDQGVLLGR WDNNYADGIS 250
    PMSWIGSVDI LRRWKRDGCQ RVKYGQCWVF AAVACTVLRC LGIPTRVVTN 300
    YNSAHDQNSN LLIEYFRNEF GEIQSDKSEM IWNFHCWVES WMTRPDLQPG 350
    YEGWQALDPT PQEKSEGTYC CGPVPVRAIK EGDLSTKYDA PFVFAEVNAD 400
    VVDWIRQDDG SLHKSINHSL VVGLKISTKC VGRDDREDIT HSYKYPEGSP 450
    EEREAFTRAN HLNKLVNKEE TGVAMRIRVG EGMNRGCDFD VFAHITNSTP 500
    EEHTGRLLLC ARTVSYNGIL GPECGTKDLL SLSLEPYSEK SIPLRILYEK 550
    YCDCLTESNL IKVRGLLIEP AANSYLLAER DIYLENPEIK IRILGEPKQN 600
    RKLVAEISLQ NPLTVALSGC TFTVEGAGLI EEQKTVDVPD PVEAGEEVKV 650
    RVDLLPLYVG RHKLVVNFES DRLKAVKGFR NVIVGPS 687
    Length:687
    Mass (Da):77,112
    Last modified:October 1, 1996 - v1
    Checksum:i7BBA00F15E779944
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti638 – 6381V → I in AAI03291. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60686 mRNA. Translation: CAA43097.1.
    BC103290 mRNA. Translation: AAI03291.1.
    PIRiS19680.
    RefSeqiNP_803473.1. NM_177507.2.
    UniGeneiBt.5401.

    Genome annotation databases

    EnsembliENSBTAT00000021569; ENSBTAP00000021569; ENSBTAG00000016208.
    GeneIDi281528.
    KEGGibta:281528.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60686 mRNA. Translation: CAA43097.1 .
    BC103290 mRNA. Translation: AAI03291.1 .
    PIRi S19680.
    RefSeqi NP_803473.1. NM_177507.2.
    UniGenei Bt.5401.

    3D structure databases

    ProteinModelPortali P51176.
    SMRi P51176. Positions 15-687.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000021569.

    Proteomic databases

    PaxDbi P51176.
    PRIDEi P51176.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000021569 ; ENSBTAP00000021569 ; ENSBTAG00000016208 .
    GeneIDi 281528.
    KEGGi bta:281528.

    Organism-specific databases

    CTDi 7052.

    Phylogenomic databases

    eggNOGi NOG80379.
    GeneTreei ENSGT00740000115156.
    HOGENOMi HOG000231695.
    HOVERGENi HBG004342.
    InParanoidi P51176.
    KOi K05625.
    OrthoDBi EOG7WT40M.
    TreeFami TF324278.

    Miscellaneous databases

    NextBioi 20805485.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view ]
    PANTHERi PTHR11590. PTHR11590. 1 hit.
    Pfami PF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
    SMARTi SM00460. TGc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence analysis of cDNA clones for bovine aortic-endothelial-cell transglutaminase."
      Nakanishi K., Nara K., Hagiwara H., Aoyama Y., Ueno H., Hirose S.
      Eur. J. Biochem. 202:15-21(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 79-95; 157-166; 242-251 AND 581-587.
      Tissue: Artery.
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Uterus.
    3. "Retinol-induced morphological changes of cultured bovine endothelial cells are accompanied by a marked increase in transglutaminase."
      Nara K., Nakanishi K., Hagiwara H., Wakita K., Kojima S., Hirose S.
      J. Biol. Chem. 264:19308-19312(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 79-95; 157-166 AND 242-251.

    Entry informationi

    Entry nameiTGM2_BOVIN
    AccessioniPrimary (citable) accession number: P51176
    Secondary accession number(s): Q3ZBH7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3