Skip Header

Contribute Send feedback
Read comments (?) or add your own

P51176 (TGM2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein-glutamine gamma-glutamyltransferase 2
EC=2.3.2.13
Alternative name(s):
Tissue transglutaminase
Transglutaminase C
Short name=TG(C)
Short name=TGC
Short name=TGase C
Transglutaminase-2
Short name=TGase-2
Gene names
Name:TGM2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length687 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Catalytic activity

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.

Cofactor

Binds 1 calcium ion per subunit By similarity.

Subunit structure

Monomer By similarity.

Tissue specificity

Highest levels are detected in the lung. Lower levels are found in the liver, spleen and heart, but not in the brain.

Induction

By retinoic acid.

Sequence similarities

Belongs to the transglutaminase superfamily. Transglutaminase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 687686Protein-glutamine gamma-glutamyltransferase 2
PRO_0000213705

Sites

Active site2771 By similarity
Active site3351 By similarity
Active site3581 By similarity
Metal binding3981Calcium By similarity
Metal binding4001Calcium By similarity
Metal binding4471Calcium By similarity
Metal binding4521Calcium By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Experimental info

Sequence conflict6381V → I in AAI03291. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P51176 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 7BBA00F15E779944

FASTA68777,112
        10         20         30         40         50         60 
MAEELVLERC DLELEANGRD HHTADLCRER LVVRRGQPFW LTLHFEGRNY EASVDSLTFC 

        70         80         90        100        110        120 
AVTGPDPSEE AGTKALFRLS DATEEGAWAA VAADQRDSTL SLHLSTPANA PVGHYRLSLE 

       130        140        150        160        170        180 
ASTGYQGSSF MLGQFTLLFN SWCPADAVYL DSDEERQEYV LTQQGFIYQG SAKFIKNIPW 

       190        200        210        220        230        240 
NFGQFEEGIL DICLMLLDVN PKFLRNAGRD CSRRSSPVYV GRVVSGMVNC NDDQGVLLGR 

       250        260        270        280        290        300 
WDNNYADGIS PMSWIGSVDI LRRWKRDGCQ RVKYGQCWVF AAVACTVLRC LGIPTRVVTN 

       310        320        330        340        350        360 
YNSAHDQNSN LLIEYFRNEF GEIQSDKSEM IWNFHCWVES WMTRPDLQPG YEGWQALDPT 

       370        380        390        400        410        420 
PQEKSEGTYC CGPVPVRAIK EGDLSTKYDA PFVFAEVNAD VVDWIRQDDG SLHKSINHSL 

       430        440        450        460        470        480 
VVGLKISTKC VGRDDREDIT HSYKYPEGSP EEREAFTRAN HLNKLVNKEE TGVAMRIRVG 

       490        500        510        520        530        540 
EGMNRGCDFD VFAHITNSTP EEHTGRLLLC ARTVSYNGIL GPECGTKDLL SLSLEPYSEK 

       550        560        570        580        590        600 
SIPLRILYEK YCDCLTESNL IKVRGLLIEP AANSYLLAER DIYLENPEIK IRILGEPKQN 

       610        620        630        640        650        660 
RKLVAEISLQ NPLTVALSGC TFTVEGAGLI EEQKTVDVPD PVEAGEEVKV RVDLLPLYVG 

       670        680 
RHKLVVNFES DRLKAVKGFR NVIVGPS

« Hide

References

« Hide 'large scale' references
[1]"Cloning and sequence analysis of cDNA clones for bovine aortic-endothelial-cell transglutaminase."
Nakanishi K., Nara K., Hagiwara H., Aoyama Y., Ueno H., Hirose S.
Eur. J. Biochem. 202:15-21(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 79-95; 157-166; 242-251 AND 581-587.
Tissue: Artery.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Uterus.
[3]"Retinol-induced morphological changes of cultured bovine endothelial cells are accompanied by a marked increase in transglutaminase."
Nara K., Nakanishi K., Hagiwara H., Wakita K., Kojima S., Hirose S.
J. Biol. Chem. 264:19308-19312(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 79-95; 157-166 AND 242-251.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X60686 mRNA. Translation: CAA43097.1.
BC103290 mRNA. Translation: AAI03291.1.
IPIIPI00703915.
PIRS19680.
RefSeqNP_803473.1. NM_177507.2.
UniGeneBt.5401.

3D structure databases

ProteinModelPortalP51176.
SMRP51176. Positions 15-687.
ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000021569.

Proteomic databases

PaxDbP51176.
PRIDEP51176.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000021569; ENSBTAP00000021569; ENSBTAG00000016208.
GeneID281528.
KEGGbta:281528.

Organism-specific databases

CTD7052.

Phylogenomic databases

eggNOGNOG80379.
GeneTreeENSGT00690000101863.
HOGENOMHOG000231695.
HOVERGENHBG004342.
InParanoidP51176.
KOK05625.
OrthoDBEOG4HMJ8W.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERPTHR11590. PTHR11590. 1 hit.
PfamPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFPIRSF000459. TGM_EBP42. 1 hit.
SMARTSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMSSF81296. Ig_E-set. 1 hit.
SSF49309. Transglut_C. 2 hits.
PROSITEPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805485.

Entry information

Entry nameTGM2_BOVIN
AccessionPrimary (citable) accession number: P51176
Secondary accession number(s): Q3ZBH7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 3, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents