Reviewed,
UniProtKB/Swiss-Prot P51174 (ACADL_MOUSE)
Last modified
November 25, 2008.
Version 80.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Long-chain specific acyl-CoA dehydrogenase, mitochondrial Short name=LCAD EC=1.3.99.13 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 430 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. |
| Cofactor | FAD. |
| Pathway | |
| Subunit structure | Homotetramer. |
| Subcellular location | |
| Miscellaneous | A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues. |
| Sequence similarities | Belongs to the acyl-CoA dehydrogenase family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Fatty acid metabolism Lipid metabolism |
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | FAD Flavoprotein |
| Molecular function | Oxidoreductase |
Gene Ontology (GO) | |
| Biological process | fatty acid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | FAD binding Inferred from electronic annotation. Source: InterPro electron carrier activityInferred from electronic annotation. Source: InterPro long-chain-acyl-CoA dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 30 | 30 | Mitochondrion By similarity | ||||||
| Chain | 31 – 430 | 400 | Long-chain specific acyl-CoA dehydrogenase, mitochondrial | PRO_0000000511 | |||||
Experimental info | |||||||||
| Sequence conflict | 14 – 15 | 2 | KA → RP Ref.1 Ref.4 | ||||||
| Sequence conflict | 14 | 1 | K → S in BAB23838. Ref.2 | ||||||
| Sequence conflict | 19 – 20 | 2 | PR → TL Ref.1 | ||||||
| Sequence conflict | 22 | 1 | P → L in BAB23838. Ref.1 Ref.2 | ||||||
| Sequence conflict | 25 | 1 | A → S Ref.1 | ||||||
| Sequence conflict | 32 | 1 | A → P in AAC52329. Ref.1 | ||||||
| Sequence conflict | 35 | 1 | R → G in AAC52329. Ref.1 | ||||||
| Sequence conflict | 47 | 1 | V → I in AAC52329. Ref.1 | ||||||
| Sequence conflict | 47 | 1 | V → I in BAB23838. Ref.2 | ||||||
| Sequence conflict | 58 | 1 | D → E in BAB31161. Ref.2 | ||||||
| Sequence conflict | 131 – 132 | 2 | GP → RA in AAC52329. Ref.1 | ||||||
| Sequence conflict | 135 | 1 | S → T in AAC52329. Ref.1 | ||||||
| Sequence conflict | 225 | 1 | S → W in AAC52329. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "RNA expression and chromosomal location of the mouse long-chain acyl-CoA dehydrogenase gene." Hinsdale M.E., Farmer S.C., Johnson K.R., Davisson M.T., Hamm D.A., Tolwani R.J., Wood P.A. Genomics 28:163-170(1995) [PubMed: 8530022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Liver. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Cerebellum. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney. |
| [4] | "Structural characterization of the mouse long-chain acyl-CoA dehydrogenase gene and 5' regulatory region." Kurtz D.M., Tolwani R.J., Wood P.A. Mamm. Genome 9:361-365(1998) [PubMed: 9545492] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-201. Strain: 129/Sv. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U21489 mRNA. Translation: AAC52329.1. AK005140 mRNA. Translation: BAB23838.1. AK018319 mRNA. Translation: BAB31161.1. BC027412 mRNA. Translation: AAH27412.1. AF018437 AF018436 Genomic DNA. Translation: AAC23587.1. | |
| RefSeq | NP_031407.2. |
| UniGene | Mm.2445 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1BUC based on UniProtKB Q06319. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P51174. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000026003. Mus musculus. [Contig view] |
| GeneID | 11363. |
| KEGG | mmu:11363. |
Organism-specific databases | |
| MGI | MGI:87866. Acadl. |
Phylogenomic databases | |
| HOGENOM | P51174. |
| HOVERGEN | P51174. |
Gene expression databases | |
| ArrayExpress | P51174. |
| CleanEx | MM_ACADL. |
| GermOnline | ENSMUSG00000026003. Mus musculus. |
Family and domain databases | |
| InterPro | IPR006091. Acyl-CoA_DHase/Oxase_M. IPR006089. Acyl-CoA_DHase_CS. IPR006092. Acyl-CoA_DHase_N. IPR006090. Acyl-CoA_Oxase/DHase_1. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view] |
| Gene3D | G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit. |
| Pfam | PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. PF02771. Acyl-CoA_dh_N. 1 hit. [Graphical view] |
| PROSITE | PS00072. ACYL_COA_DH_1. 1 hit. PS00073. ACYL_COA_DH_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 278636. |
| SOURCE | Search... |
Entry information
| Entry name | ACADL_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P51174 Secondary accession number(s): O35302 Q9DB83 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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