ID   SCNND_HUMAN             Reviewed;         802 AA.
AC   P51172; A6NNF7; A9Z1X6; B1PS44; B3KSD7; Q08AQ3; Q09HT0; Q5T7L3; Q8NA24;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2019, sequence version 3.
DT   27-MAR-2024, entry version 188.
DE   RecName: Full=Amiloride-sensitive sodium channel subunit delta;
DE   AltName: Full=Delta-NaCH;
DE   AltName: Full=Epithelial Na(+) channel subunit delta;
DE            Short=Delta-ENaC;
DE            Short=ENaCD;
DE   AltName: Full=Nonvoltage-gated sodium channel 1 subunit delta;
DE   AltName: Full=SCNED;
GN   Name=SCNN1D; Synonyms=DNACH;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT TYR-696, FUNCTION, AND
RP   SUBUNIT.
RX   PubMed=7499195; DOI=10.1074/jbc.270.46.27411;
RA   Waldmann R., Champigny G., Bassilana F., Voilley N., Lazdunski M.;
RT   "Molecular cloning and functional expression of a novel amiloride-sensitive
RT   Na+ channel.";
RL   J. Biol. Chem. 270:27411-27414(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, AND SUBUNIT.
RC   TISSUE=Lung;
RX   PubMed=16423824; DOI=10.1074/jbc.m512293200;
RA   Ji H.L., Su X.F., Kedar S., Li J., Barbry P., Smith P.R., Matalon S.,
RA   Benos D.J.;
RT   "Delta-subunit confers novel biophysical features to alpha beta gamma-human
RT   epithelial sodium channel (ENaC) via a physical interaction.";
RL   J. Biol. Chem. 281:8233-8241(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, AND TOPOLOGY.
RC   TISSUE=Nasal epithelium;
RX   PubMed=19520916; DOI=10.1165/rcmb.2009-0053oc;
RA   Bangel-Ruland N., Sobczak K., Christmann T., Kentrup D., Langhorst H.,
RA   Kusche-Vihrog K., Weber W.M.;
RT   "Characterization of the epithelial sodium channel delta-subunit in human
RT   nasal epithelium.";
RL   Am. J. Respir. Cell Mol. Biol. 42:498-505(2010).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
RP   SER-726 AND ARG-770.
RC   TISSUE=Hippocampus, and Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS PRO-344
RP   AND GLN-544.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   ALTERNATIVE SPLICING (ISOFORM 2).
RX   PubMed=22505667; DOI=10.1152/ajplung.00331.2011;
RA   Zhao R.Z., Nie H.G., Su X.F., Han D.Y., Lee A., Huang Y., Chang Y.,
RA   Matalon S., Ji H.L.;
RT   "Characterization of a novel splice variant of delta ENaC subunit in human
RT   lungs.";
RL   Am. J. Physiol. 302:L1262-L1272(2012).
RN   [8]
RP   PHYLOGENETIC ANALYSIS, AND NOMENCLATURE.
RX   PubMed=26772908; DOI=10.1016/j.gene.2015.12.061;
RA   Hanukoglu I., Hanukoglu A.;
RT   "Epithelial sodium channel (ENaC) family: Phylogeny, structure-function,
RT   tissue distribution, and associated inherited diseases.";
RL   Gene 579:95-132(2016).
CC   -!- FUNCTION: Sodium permeable non-voltage-sensitive ion channel inhibited
CC       by the diuretic amiloride. Mediates the electrodiffusion of the luminal
CC       sodium (and water, which follows osmotically) through the apical
CC       membrane of epithelial cells. Controls the reabsorption of sodium in
CC       kidney, colon, lung and sweat glands. Also plays a role in taste
CC       perception. {ECO:0000269|PubMed:16423824, ECO:0000269|PubMed:7499195}.
CC   -!- SUBUNIT: Heterotrimer containing a delta/SCNN1D, a beta/SCNN1B and a
CC       gamma/SCNN1G subunit. The additional delta/SCNN1D subunit exists only
CC       in some organisms and can replace the alpha/SCNN1A subunit to form an
CC       alternative channel with specific properties.
CC       {ECO:0000269|PubMed:16423824, ECO:0000269|PubMed:7499195}.
CC   -!- INTERACTION:
CC       P51172; Q8N668: COMMD1; NbExp=3; IntAct=EBI-2547114, EBI-1550112;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19520916};
CC       Multi-pass membrane protein {ECO:0000269|PubMed:19520916}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=3;
CC         IsoId=P51172-3; Sequence=Displayed;
CC       Name=1; Synonyms=delta1;
CC         IsoId=P51172-1; Sequence=VSP_060000, VSP_060002;
CC       Name=2; Synonyms=delta2;
CC         IsoId=P51172-2; Sequence=VSP_060001;
CC   -!- MISCELLANEOUS: [Isoform 2]: Channels including isoform 2 exhibit
CC       greater conductance than those containing isoform 1. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel
CC       (TC 1.A.6) family. SCNN1D subfamily. {ECO:0000305}.
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DR   EMBL; U38254; AAC50283.1; -; mRNA.
DR   EMBL; DQ898176; ABI64069.1; -; mRNA.
DR   EMBL; EU489064; ACA51868.1; -; mRNA.
DR   EMBL; AK093239; BAC04105.1; -; mRNA.
DR   EMBL; AK127357; BAG54495.1; -; mRNA.
DR   EMBL; AL162741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC036752; AAH36752.1; -; mRNA.
DR   EMBL; BC125074; AAI25075.1; -; mRNA.
DR   CCDS; CCDS44037.2; -. [P51172-3]
DR   PIR; I39196; I39196.
DR   RefSeq; NP_001123885.2; NM_001130413.3. [P51172-3]
DR   RefSeq; XP_011540227.1; XM_011541925.2.
DR   RefSeq; XP_011540234.1; XM_011541932.2.
DR   RefSeq; XP_011540235.1; XM_011541933.2.
DR   AlphaFoldDB; P51172; -.
DR   SMR; P51172; -.
DR   BioGRID; 112243; 73.
DR   ComplexPortal; CPX-312; Amiloride-sensitive sodium channel complex, delta-alpha-beta-gamma.
DR   ComplexPortal; CPX-313; Amiloride-sensitive sodium channel complex, delta-beta-gamma.
DR   CORUM; P51172; -.
DR   IntAct; P51172; 21.
DR   STRING; 9606.ENSP00000368411; -.
DR   DrugBank; DB00594; Amiloride.
DR   DrugBank; DB00384; Triamterene.
DR   TCDB; 1.A.6.1.1; the epithelial na(+) channel (enac) family.
DR   GlyCosmos; P51172; 2 sites, No reported glycans.
DR   GlyGen; P51172; 2 sites.
DR   iPTMnet; P51172; -.
DR   PhosphoSitePlus; P51172; -.
DR   BioMuta; SCNN1D; -.
DR   DMDM; 116242784; -.
DR   MassIVE; P51172; -.
DR   PaxDb; 9606-ENSP00000368411; -.
DR   PeptideAtlas; P51172; -.
DR   ProteomicsDB; 1607; -.
DR   ProteomicsDB; 56298; -. [P51172-1]
DR   ProteomicsDB; 56299; -. [P51172-2]
DR   Antibodypedia; 4029; 292 antibodies from 31 providers.
DR   DNASU; 6339; -.
DR   Ensembl; ENST00000325425.12; ENSP00000321594.8; ENSG00000162572.21. [P51172-2]
DR   Ensembl; ENST00000338555.6; ENSP00000339504.2; ENSG00000162572.21. [P51172-1]
DR   Ensembl; ENST00000379116.10; ENSP00000368411.5; ENSG00000162572.21. [P51172-3]
DR   Ensembl; ENST00000400928.7; ENSP00000383717.3; ENSG00000162572.21. [P51172-1]
DR   GeneID; 6339; -.
DR   KEGG; hsa:6339; -.
DR   MANE-Select; ENST00000379116.10; ENSP00000368411.5; NM_001130413.4; NP_001123885.2.
DR   UCSC; uc001adw.3; human. [P51172-3]
DR   AGR; HGNC:10601; -.
DR   CTD; 6339; -.
DR   DisGeNET; 6339; -.
DR   GeneCards; SCNN1D; -.
DR   HGNC; HGNC:10601; SCNN1D.
DR   HPA; ENSG00000162572; Tissue enhanced (brain, testis).
DR   MIM; 601328; gene.
DR   neXtProt; NX_P51172; -.
DR   OpenTargets; ENSG00000162572; -.
DR   PharmGKB; PA35011; -.
DR   VEuPathDB; HostDB:ENSG00000162572; -.
DR   eggNOG; KOG4294; Eukaryota.
DR   GeneTree; ENSGT00940000162685; -.
DR   InParanoid; P51172; -.
DR   OMA; RFHYVDI; -.
DR   OrthoDB; 5344287at2759; -.
DR   PhylomeDB; P51172; -.
DR   TreeFam; TF330663; -.
DR   PathwayCommons; P51172; -.
DR   Reactome; R-HSA-2672351; Stimuli-sensing channels.
DR   Reactome; R-HSA-9730628; Sensory perception of salty taste.
DR   SignaLink; P51172; -.
DR   BioGRID-ORCS; 6339; 18 hits in 1160 CRISPR screens.
DR   GeneWiki; SCNN1D; -.
DR   GenomeRNAi; 6339; -.
DR   Pharos; P51172; Tbio.
DR   PRO; PR:P51172; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; P51172; Protein.
DR   Bgee; ENSG00000162572; Expressed in right hemisphere of cerebellum and 89 other cell types or tissues.
DR   ExpressionAtlas; P51172; baseline and differential.
DR   GO; GO:0015629; C:actin cytoskeleton; IDA:HPA.
DR   GO; GO:0016020; C:membrane; IDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   GO; GO:0034706; C:sodium channel complex; IDA:ComplexPortal.
DR   GO; GO:0015280; F:ligand-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0071468; P:cellular response to acidic pH; IDA:ComplexPortal.
DR   GO; GO:1904045; P:cellular response to aldosterone; NAS:ComplexPortal.
DR   GO; GO:1904117; P:cellular response to vasopressin; NAS:ComplexPortal.
DR   GO; GO:0006883; P:intracellular sodium ion homeostasis; IDA:ComplexPortal.
DR   GO; GO:0008217; P:regulation of blood pressure; NAS:ComplexPortal.
DR   GO; GO:0050914; P:sensory perception of salty taste; NAS:ComplexPortal.
DR   GO; GO:0050915; P:sensory perception of sour taste; NAS:ComplexPortal.
DR   GO; GO:0098719; P:sodium ion import across plasma membrane; IDA:ComplexPortal.
DR   GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006814; P:sodium ion transport; TAS:ProtInc.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR004724; ENaC_chordates.
DR   InterPro; IPR020903; ENaC_CS.
DR   NCBIfam; TIGR00859; ENaC; 1.
DR   PANTHER; PTHR11690:SF132; AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT DELTA; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
DR   Genevisible; P51172; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell membrane; Glycoprotein; Ion channel;
KW   Ion transport; Membrane; Reference proteome; Sensory transduction; Sodium;
KW   Sodium channel; Sodium transport; Taste; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..802
FT                   /note="Amiloride-sensitive sodium channel subunit delta"
FT                   /id="PRO_0000181282"
FT   TOPO_DOM        1..250
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000269|PubMed:19520916"
FT   TRANSMEM        251..271
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        272..694
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000269|PubMed:19520916"
FT   TRANSMEM        695..715
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        716..802
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000269|PubMed:19520916"
FT   REGION          145..211
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          738..777
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        191..208
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        330
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        548
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..164
FT                   /note="Missing (in isoform 1)"
FT                   /id="VSP_060000"
FT   VAR_SEQ         1..98
FT                   /note="Missing (in isoform 2)"
FT                   /id="VSP_060001"
FT   VAR_SEQ         165..185
FT                   /note="PCHLKGWQHRPTQHNAACKQG -> MAEHRSMDGRMEAATRGGSHL (in
FT                   isoform 1)"
FT                   /id="VSP_060002"
FT   VARIANT         344
FT                   /note="R -> P (in dbSNP:rs11260579)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_028209"
FT   VARIANT         544
FT                   /note="E -> Q (in dbSNP:rs2228579)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_028210"
FT   VARIANT         636
FT                   /note="A -> T (in dbSNP:rs13306651)"
FT                   /id="VAR_028211"
FT   VARIANT         696
FT                   /note="C -> Y (in dbSNP:rs1053844)"
FT                   /evidence="ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:7499195"
FT                   /id="VAR_028212"
FT   VARIANT         726
FT                   /note="G -> S (in dbSNP:rs6690013)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_028213"
FT   VARIANT         770
FT                   /note="G -> R (in dbSNP:rs609805)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_028214"
FT   CONFLICT        176
FT                   /note="T -> A (in Ref. 2; ABI64069)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        210
FT                   /note="Q -> R (in Ref. 2; ABI64069)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        424
FT                   /note="V -> A (in Ref. 2; ABI64069)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        444
FT                   /note="H -> Y (in Ref. 4; BAC04105)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        597
FT                   /note="F -> L (in Ref. 4; BAC04105)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   802 AA;  87850 MW;  5CC845DA14F2E6B4 CRC64;
     MRAVLSQKTT PLPRYLWPGH LSGPRRLTWS WCSDHRTPTC RELGSPHPTP CTGPARGWPR
     RGGGPCGFTS AGHVLCGYPL CLLSGPIQGC GTGLGDSSMA FLSRTSPVAA ASFQSRQEAR
     GSILLQSCQL PPQWLSTEAW TGEWKQPHGG ALTSRSPGPV APQRPCHLKG WQHRPTQHNA
     ACKQGQAAAQ TPPRPGPPSA PPPPPKEGHQ EGLVELPASF RELLTFFCTN ATIHGAIRLV
     CSRGNRLKTT SWGLLSLGAL VALCWQLGLL FERHWHRPVL MAVSVHSERK LLPLVTLCDG
     NPRRPSPVLR HLELLDEFAR ENIDSLYNVN LSKGRAALSA TVPRHEPPFH LDREIRLQRL
     SHSGSRVRVG FRLCNSTGGD CFYRGYTSGV AAVQDWYHFH YVDILALLPA AWEDSHGSQD
     GHFVLSCSYD GLDCQARQFR TFHHPTYGSC YTVDGVWTAQ RPGITHGVGL VLRVEQQPHL
     PLLSTLAGIR VMVHGRNHTP FLGHHSFSVR PGTEATISIR EDEVHRLGSP YGHCTAGGEG
     VEVELLHNTS YTRQACLVSC FQQLMVETCS CGYYLHPLPA GAEYCSSARH PAWGHCFYRL
     YQDLETHRLP CTSRCPRPCR ESAFKLSTGT SRWPSAKSAG WTLATLGEQG LPHQSHRQRS
     SLAKINIVYQ ELNYRSVEEA PVYSVPQLLS AMGSLCSLWF GASVLSLLEL LELLLDASAL
     TLVLGGRRLR RAWFSWPRAS PASGASSIKP EASQMPPPAG GTSDDPEPSG PHLPRVMLPG
     VLAGVSAEES WAGPQPLETL DT
//