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P51166

- CDK5_XENLA

UniProt

P51166 - CDK5_XENLA

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Protein

Cyclin-dependent-like kinase 5

Gene

cdk5

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. The complex p35/CDK5 may participate in the regulation of the circadian clock.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPPROSITE-ProRule annotation
Active sitei126 – 1261Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. acetylcholine receptor activator activity Source: UniProtKB
  2. ATP binding Source: UniProtKB-KW
  3. ErbB-2 class receptor binding Source: UniProtKB
  4. ErbB-3 class receptor binding Source: UniProtKB
  5. kinase activity Source: UniProtKB
  6. protein serine/threonine kinase activity Source: UniProtKB
  7. tau-protein kinase activity Source: UniProtKB

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. embryo development Source: UniProtKB
  4. neuron differentiation Source: UniProtKB
  5. neuron projection development Source: UniProtKB
  6. positive regulation of neuron apoptotic process Source: UniProtKB
  7. positive regulation of receptor activity Source: GOC
  8. regulation of dendritic spine morphogenesis Source: UniProtKB
  9. rhythmic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Biological rhythms, Cell cycle, Cell division, Neurogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 6726.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent-like kinase 5 (EC:2.7.11.1)
Alternative name(s):
Cell division protein kinase 5
Neuronal cyclin-dependent kinase 5
Gene namesi
Name:cdk5
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6254177. cdk5.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity. Perikaryon By similarity. Cell projectiongrowth cone By similarity. Cell projectionlamellipodium By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity

GO - Cellular componenti

  1. axon Source: UniProtKB
  2. cell junction Source: UniProtKB-KW
  3. cytoplasm Source: UniProtKB
  4. dendrite Source: UniProtKB
  5. growth cone Source: UniProtKB
  6. membrane Source: UniProtKB
  7. neuromuscular junction Source: UniProtKB
  8. neuronal cell body Source: UniProtKB
  9. nucleus Source: UniProtKB
  10. postsynaptic density Source: UniProtKB
  11. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Cyclin-dependent-like kinase 5PRO_0000085787Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141PhosphothreonineBy similarity
Modified residuei15 – 151PhosphotyrosineBy similarity
Modified residuei17 – 171PhosphothreonineBy similarity
Modified residuei46 – 461PhosphoserineBy similarity
Modified residuei56 – 561N6-acetyllysineBy similarity
Modified residuei72 – 721PhosphoserineBy similarity
Modified residuei159 – 1591PhosphoserineBy similarity
Modified residuei239 – 2391PhosphotyrosineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP51166.
SMRiP51166. Positions 1-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 286283Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG014652.
KOiK02090.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51166-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQKYEKLEKI GEGTYGTVFK AKNRDTHEIV ALKRVRLDDD DEGVPSSALR
60 70 80 90 100
EICLLKELKH KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP
110 120 130 140 150
EIVKSFMYQL LKGLAFCHSR NVLHRDLKPQ NLLINRNGEL KLADFGLARA
160 170 180 190 200
FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS TSIDMWSAGC IFAELANAGR
210 220 230 240 250
PLFPGNDVDD QLKRIFRLLG TPTEEQWPAM TKLPDYKPYP MYPATMSLVN
260 270 280 290
VVPKLNATGR DLLQNLLKCN PVQRICADEA LQHPYFADFC PP
Length:292
Mass (Da):33,339
Last modified:October 1, 1996 - v1
Checksum:i7692C6B610DC7284
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U24397 mRNA. Translation: AAB37091.1.
BC072894 mRNA. Translation: AAH72894.1.
RefSeqiNP_001084086.1. NM_001090617.1.
UniGeneiXl.67.

Genome annotation databases

GeneIDi399296.
KEGGixla:399296.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U24397 mRNA. Translation: AAB37091.1 .
BC072894 mRNA. Translation: AAH72894.1 .
RefSeqi NP_001084086.1. NM_001090617.1.
UniGenei Xl.67.

3D structure databases

ProteinModelPortali P51166.
SMRi P51166. Positions 1-292.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 399296.
KEGGi xla:399296.

Organism-specific databases

CTDi 1020.
Xenbasei XB-GENE-6254177. cdk5.

Phylogenomic databases

HOVERGENi HBG014652.
KOi K02090.

Enzyme and pathway databases

BRENDAi 2.7.11.22. 6726.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Xenopus laevis homologue to the neuronal cyclin-dependent kinase (cdk5) is expressed in embryos by gastrulation."
    Gervasi C., Szaro B.G.
    Brain Res. Mol. Brain Res. 33:192-200(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Periodic albino.
    Tissue: Brain.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiCDK5_XENLA
AccessioniPrimary (citable) accession number: P51166
Secondary accession number(s): Q6GQ54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3