Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P51166

- CDK5_XENLA

UniProt

P51166 - CDK5_XENLA

Protein

Cyclin-dependent-like kinase 5

Gene

cdk5

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. The complex p35/CDK5 may participate in the regulation of the circadian clock.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPPROSITE-ProRule annotation
    Active sitei126 – 1261Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. acetylcholine receptor activator activity Source: UniProtKB
    2. ATP binding Source: UniProtKB-KW
    3. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    4. ErbB-2 class receptor binding Source: UniProtKB
    5. ErbB-3 class receptor binding Source: UniProtKB
    6. kinase activity Source: UniProtKB
    7. protein serine/threonine kinase activity Source: UniProtKB
    8. tau-protein kinase activity Source: UniProtKB

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. embryo development Source: UniProtKB
    4. neuron differentiation Source: UniProtKB
    5. neuron projection development Source: UniProtKB
    6. positive regulation of neuron apoptotic process Source: UniProtKB
    7. positive regulation of receptor activity Source: GOC
    8. regulation of dendritic spine morphogenesis Source: UniProtKB
    9. rhythmic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Biological rhythms, Cell cycle, Cell division, Neurogenesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.22. 6726.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent-like kinase 5 (EC:2.7.11.1)
    Alternative name(s):
    Cell division protein kinase 5
    Neuronal cyclin-dependent kinase 5
    Gene namesi
    Name:cdk5
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6254177. cdk5.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity. Perikaryon By similarity. Cell projectiongrowth cone By similarity. Cell projectionlamellipodium By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity

    GO - Cellular componenti

    1. axon Source: UniProtKB
    2. cell junction Source: UniProtKB-KW
    3. cytoplasm Source: UniProtKB
    4. dendrite Source: UniProtKB
    5. growth cone Source: UniProtKB
    6. lamellipodium Source: UniProtKB-SubCell
    7. membrane Source: UniProtKB
    8. neuromuscular junction Source: UniProtKB
    9. neuronal cell body Source: UniProtKB
    10. nucleus Source: UniProtKB
    11. perikaryon Source: UniProtKB-SubCell
    12. postsynaptic density Source: UniProtKB
    13. postsynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Cyclin-dependent-like kinase 5PRO_0000085787Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei14 – 141PhosphothreonineBy similarity
    Modified residuei15 – 151PhosphotyrosineBy similarity
    Modified residuei17 – 171PhosphothreonineBy similarity
    Modified residuei46 – 461PhosphoserineBy similarity
    Modified residuei56 – 561N6-acetyllysineBy similarity
    Modified residuei72 – 721PhosphoserineBy similarity
    Modified residuei159 – 1591PhosphoserineBy similarity
    Modified residuei239 – 2391PhosphotyrosineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP51166.
    SMRiP51166. Positions 1-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 286283Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG014652.
    KOiK02090.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51166-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKYEKLEKI GEGTYGTVFK AKNRDTHEIV ALKRVRLDDD DEGVPSSALR    50
    EICLLKELKH KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP 100
    EIVKSFMYQL LKGLAFCHSR NVLHRDLKPQ NLLINRNGEL KLADFGLARA 150
    FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS TSIDMWSAGC IFAELANAGR 200
    PLFPGNDVDD QLKRIFRLLG TPTEEQWPAM TKLPDYKPYP MYPATMSLVN 250
    VVPKLNATGR DLLQNLLKCN PVQRICADEA LQHPYFADFC PP 292
    Length:292
    Mass (Da):33,339
    Last modified:October 1, 1996 - v1
    Checksum:i7692C6B610DC7284
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U24397 mRNA. Translation: AAB37091.1.
    BC072894 mRNA. Translation: AAH72894.1.
    RefSeqiNP_001084086.1. NM_001090617.1.
    UniGeneiXl.67.

    Genome annotation databases

    GeneIDi399296.
    KEGGixla:399296.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U24397 mRNA. Translation: AAB37091.1 .
    BC072894 mRNA. Translation: AAH72894.1 .
    RefSeqi NP_001084086.1. NM_001090617.1.
    UniGenei Xl.67.

    3D structure databases

    ProteinModelPortali P51166.
    SMRi P51166. Positions 1-292.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 399296.
    KEGGi xla:399296.

    Organism-specific databases

    CTDi 1020.
    Xenbasei XB-GENE-6254177. cdk5.

    Phylogenomic databases

    HOVERGENi HBG014652.
    KOi K02090.

    Enzyme and pathway databases

    BRENDAi 2.7.11.22. 6726.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Xenopus laevis homologue to the neuronal cyclin-dependent kinase (cdk5) is expressed in embryos by gastrulation."
      Gervasi C., Szaro B.G.
      Brain Res. Mol. Brain Res. 33:192-200(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Periodic albino.
      Tissue: Brain.
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiCDK5_XENLA
    AccessioniPrimary (citable) accession number: P51166
    Secondary accession number(s): Q6GQ54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3