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P51164

- ATP4B_HUMAN

UniProt

P51164 - ATP4B_HUMAN

Protein

Potassium-transporting ATPase subunit beta

Gene

ATP4B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.1 Publication

    GO - Molecular functioni

    1. hydrogen:potassium-exchanging ATPase activity Source: ProtInc

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. hydrogen ion transmembrane transport Source: GOC
    3. ion transmembrane transport Source: Reactome
    4. response to lipopolysaccharide Source: Ensembl
    5. response to organonitrogen compound Source: Ensembl
    6. sodium ion transport Source: InterPro
    7. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Cell adhesion, Hydrogen ion transport, Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    BioCyciMetaCyc:G66-33511-MONOMER.
    ReactomeiREACT_25149. Ion transport by P-type ATPases.

    Protein family/group databases

    TCDBi3.A.3.1.2. the p-type atpase (p-atpase) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium-transporting ATPase subunit beta
    Alternative name(s):
    Gastric H(+)/K(+) ATPase subunit beta
    Proton pump beta chain
    Gene namesi
    Name:ATP4B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:820. ATP4B.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: Reactome
    2. sodium:potassium-exchanging ATPase complex Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25114.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 291291Potassium-transporting ATPase subunit betaPRO_0000219091Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi131 ↔ 152By similarity
    Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi162 ↔ 178By similarity
    Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi201 ↔ 263By similarity
    Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP51164.
    PRIDEiP51164.

    PTM databases

    PhosphoSiteiP51164.

    Expressioni

    Gene expression databases

    BgeeiP51164.
    CleanExiHS_ATP4B.
    GenevestigatoriP51164.

    Organism-specific databases

    HPAiCAB005598.
    HPA045400.

    Interactioni

    Subunit structurei

    Composed of two subunits: alpha (catalytic) and beta.

    Protein-protein interaction databases

    BioGridi106986. 4 interactions.
    IntActiP51164. 2 interactions.
    STRINGi9606.ENSP00000334216.

    Structurei

    3D structure databases

    ProteinModelPortaliP51164.
    SMRiP51164. Positions 32-291.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3636CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini58 – 291234ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 5721Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni194 – 29198immunoglobulin-likeAdd
    BLAST

    Domaini

    The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.1 Publication

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG289316.
    HOGENOMiHOG000039248.
    HOVERGENiHBG050603.
    InParanoidiP51164.
    KOiK01543.
    OMAiKAQPHYS.
    OrthoDBiEOG7M6D85.
    PhylomeDBiP51164.
    TreeFamiTF314618.

    Family and domain databases

    InterProiIPR000402. Na/K_ATPase_sub_beta.
    [Graphical view]
    PANTHERiPTHR11523. PTHR11523. 1 hit.
    PfamiPF00287. Na_K-ATPase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
    PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
    PS00391. ATPASE_NA_K_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51164-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAALQEKKTC GQRMEEFQRY CWNPDTGQML GRTLSRWVWI SLYYVAFYVV    50
    MTGLFALCLY VLMQTVDPYT PDYQDQLRSP GVTLRPDVYG EKGLEIVYNV 100
    SDNRTWADLT QTLHAFLAGY SPAAQEDSIN CTSEQYFFQE SFRAPNHTKF 150
    SCKFTADMLQ NCSGLADPNF GFEEGKPCFI IKMNRIVKFL PSNGSAPRVD 200
    CAFLDQPREL GQPLQVKYYP PNGTFSLHYF PYYGKKAQPH YSNPLVAAKL 250
    LNIPRNAEVA IVCKVMAEHV TFNNPHDPYE GKVEFKLKIE K 291
    Length:291
    Mass (Da):33,367
    Last modified:October 1, 1996 - v1
    Checksum:i573F6D729CED1C3D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M75110 mRNA. Translation: AAA35987.1.
    BX537316 Genomic DNA. Translation: CAM28358.1.
    CH471085 Genomic DNA. Translation: EAX09221.1.
    BC029059 mRNA. Translation: AAH29059.1.
    AB008783 Genomic DNA. Translation: BAA23425.1.
    CCDSiCCDS9539.1.
    PIRiJH0480.
    RefSeqiNP_000696.1. NM_000705.3.
    UniGeneiHs.434202.

    Genome annotation databases

    EnsembliENST00000335288; ENSP00000334216; ENSG00000186009.
    GeneIDi496.
    KEGGihsa:496.
    UCSCiuc001vtz.3. human.

    Polymorphism databases

    DMDMi1703461.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M75110 mRNA. Translation: AAA35987.1 .
    BX537316 Genomic DNA. Translation: CAM28358.1 .
    CH471085 Genomic DNA. Translation: EAX09221.1 .
    BC029059 mRNA. Translation: AAH29059.1 .
    AB008783 Genomic DNA. Translation: BAA23425.1 .
    CCDSi CCDS9539.1.
    PIRi JH0480.
    RefSeqi NP_000696.1. NM_000705.3.
    UniGenei Hs.434202.

    3D structure databases

    ProteinModelPortali P51164.
    SMRi P51164. Positions 32-291.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106986. 4 interactions.
    IntActi P51164. 2 interactions.
    STRINGi 9606.ENSP00000334216.

    Chemistry

    BindingDBi P51164.
    ChEMBLi CHEMBL2095173.

    Protein family/group databases

    TCDBi 3.A.3.1.2. the p-type atpase (p-atpase) superfamily.

    PTM databases

    PhosphoSitei P51164.

    Polymorphism databases

    DMDMi 1703461.

    Proteomic databases

    PaxDbi P51164.
    PRIDEi P51164.

    Protocols and materials databases

    DNASUi 496.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335288 ; ENSP00000334216 ; ENSG00000186009 .
    GeneIDi 496.
    KEGGi hsa:496.
    UCSCi uc001vtz.3. human.

    Organism-specific databases

    CTDi 496.
    GeneCardsi GC13M114303.
    HGNCi HGNC:820. ATP4B.
    HPAi CAB005598.
    HPA045400.
    MIMi 137217. gene.
    neXtProti NX_P51164.
    PharmGKBi PA25114.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG289316.
    HOGENOMi HOG000039248.
    HOVERGENi HBG050603.
    InParanoidi P51164.
    KOi K01543.
    OMAi KAQPHYS.
    OrthoDBi EOG7M6D85.
    PhylomeDBi P51164.
    TreeFami TF314618.

    Enzyme and pathway databases

    BioCyci MetaCyc:G66-33511-MONOMER.
    Reactomei REACT_25149. Ion transport by P-type ATPases.

    Miscellaneous databases

    GenomeRNAii 496.
    NextBioi 2083.
    PROi P51164.
    SOURCEi Search...

    Gene expression databases

    Bgeei P51164.
    CleanExi HS_ATP4B.
    Genevestigatori P51164.

    Family and domain databases

    InterProi IPR000402. Na/K_ATPase_sub_beta.
    [Graphical view ]
    PANTHERi PTHR11523. PTHR11523. 1 hit.
    Pfami PF00287. Na_K-ATPase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01107. Na_K_ATPase_bet. 1 hit.
    PROSITEi PS00390. ATPASE_NA_K_BETA_1. 1 hit.
    PS00391. ATPASE_NA_K_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of the beta-subunit of the human gastric H,K-ATPase."
      Ma J.-Y., Song Y.-H., Sjoestrand S.E., Rask L., Maardh S.
      Biochem. Biophys. Res. Commun. 180:39-45(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    5. "GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells."
      Yoshida T., Sato R., Mahmood S., Kawasaki S., Futai M., Maeda M.
      FEBS Lett. 414:333-337(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-14.
      Tissue: Liver.
    6. "A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules."
      Bab-Dinitz E., Albeck S., Peleg Y., Brumfeld V., Gottschalk K.E., Karlish S.J.
      Biochemistry 48:8684-8691(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DOMAIN IMMUNOGLOBULIN-LIKE.

    Entry informationi

    Entry nameiATP4B_HUMAN
    AccessioniPrimary (citable) accession number: P51164
    Secondary accession number(s): B1B0N8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3