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Protein

Potassium-transporting ATPase subunit beta

Gene

ATP4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.1 Publication

GO - Molecular functioni

  • hydrogen:potassium-exchanging ATPase activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Hydrogen ion transport, Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciMetaCyc:G66-33511-MONOMER.
ZFISH:G66-33511-MONOMER.
ReactomeiR-HSA-936837. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi3.A.3.1.2. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase subunit beta
Alternative name(s):
Gastric H(+)/K(+) ATPase subunit beta
Proton pump beta chain
Gene namesi
Name:ATP4B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:820. ATP4B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini58 – 291ExtracellularSequence analysisAdd BLAST234

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi496.
OpenTargetsiENSG00000186009.
PharmGKBiPA25114.

Chemistry databases

ChEMBLiCHEMBL2095173.

Polymorphism and mutation databases

BioMutaiATP4B.
DMDMi1703461.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190911 – 291Potassium-transporting ATPase subunit betaAdd BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...)Sequence analysis1
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Glycosylationi130N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi131 ↔ 152By similarity
Glycosylationi146N-linked (GlcNAc...)Sequence analysis1
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi162 ↔ 178By similarity
Glycosylationi193N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi201 ↔ 263By similarity
Glycosylationi222N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP51164.
PeptideAtlasiP51164.
PRIDEiP51164.

PTM databases

iPTMnetiP51164.
PhosphoSitePlusiP51164.

Expressioni

Gene expression databases

BgeeiENSG00000186009.
CleanExiHS_ATP4B.
GenevisibleiP51164. HS.

Organism-specific databases

HPAiHPA045400.
HPA052649.

Interactioni

Subunit structurei

Composed of two subunits: alpha (catalytic) and beta.

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-3904463,EBI-748961

Protein-protein interaction databases

BioGridi106986. 4 interactors.
IntActiP51164. 3 interactors.
STRINGi9606.ENSP00000334216.

Chemistry databases

BindingDBiP51164.

Structurei

3D structure databases

ProteinModelPortaliP51164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni194 – 291immunoglobulin-likeAdd BLAST98

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.1 Publication

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP51164.
KOiK01543.
OMAiCKFTADM.
OrthoDBiEOG091G0DJ4.
PhylomeDBiP51164.
TreeFamiTF314618.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALQEKKTC GQRMEEFQRY CWNPDTGQML GRTLSRWVWI SLYYVAFYVV
60 70 80 90 100
MTGLFALCLY VLMQTVDPYT PDYQDQLRSP GVTLRPDVYG EKGLEIVYNV
110 120 130 140 150
SDNRTWADLT QTLHAFLAGY SPAAQEDSIN CTSEQYFFQE SFRAPNHTKF
160 170 180 190 200
SCKFTADMLQ NCSGLADPNF GFEEGKPCFI IKMNRIVKFL PSNGSAPRVD
210 220 230 240 250
CAFLDQPREL GQPLQVKYYP PNGTFSLHYF PYYGKKAQPH YSNPLVAAKL
260 270 280 290
LNIPRNAEVA IVCKVMAEHV TFNNPHDPYE GKVEFKLKIE K
Length:291
Mass (Da):33,367
Last modified:October 1, 1996 - v1
Checksum:i573F6D729CED1C3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75110 mRNA. Translation: AAA35987.1.
BX537316 Genomic DNA. Translation: CAM28358.1.
CH471085 Genomic DNA. Translation: EAX09221.1.
BC029059 mRNA. Translation: AAH29059.1.
AB008783 Genomic DNA. Translation: BAA23425.1.
CCDSiCCDS9539.1.
PIRiJH0480.
RefSeqiNP_000696.1. NM_000705.3.
UniGeneiHs.434202.

Genome annotation databases

EnsembliENST00000335288; ENSP00000334216; ENSG00000186009.
GeneIDi496.
KEGGihsa:496.
UCSCiuc001vtz.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75110 mRNA. Translation: AAA35987.1.
BX537316 Genomic DNA. Translation: CAM28358.1.
CH471085 Genomic DNA. Translation: EAX09221.1.
BC029059 mRNA. Translation: AAH29059.1.
AB008783 Genomic DNA. Translation: BAA23425.1.
CCDSiCCDS9539.1.
PIRiJH0480.
RefSeqiNP_000696.1. NM_000705.3.
UniGeneiHs.434202.

3D structure databases

ProteinModelPortaliP51164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106986. 4 interactors.
IntActiP51164. 3 interactors.
STRINGi9606.ENSP00000334216.

Chemistry databases

BindingDBiP51164.
ChEMBLiCHEMBL2095173.

Protein family/group databases

TCDBi3.A.3.1.2. the p-type atpase (p-atpase) superfamily.

PTM databases

iPTMnetiP51164.
PhosphoSitePlusiP51164.

Polymorphism and mutation databases

BioMutaiATP4B.
DMDMi1703461.

Proteomic databases

PaxDbiP51164.
PeptideAtlasiP51164.
PRIDEiP51164.

Protocols and materials databases

DNASUi496.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335288; ENSP00000334216; ENSG00000186009.
GeneIDi496.
KEGGihsa:496.
UCSCiuc001vtz.5. human.

Organism-specific databases

CTDi496.
DisGeNETi496.
GeneCardsiATP4B.
HGNCiHGNC:820. ATP4B.
HPAiHPA045400.
HPA052649.
MIMi137217. gene.
neXtProtiNX_P51164.
OpenTargetsiENSG00000186009.
PharmGKBiPA25114.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP51164.
KOiK01543.
OMAiCKFTADM.
OrthoDBiEOG091G0DJ4.
PhylomeDBiP51164.
TreeFamiTF314618.

Enzyme and pathway databases

BioCyciMetaCyc:G66-33511-MONOMER.
ZFISH:G66-33511-MONOMER.
ReactomeiR-HSA-936837. Ion transport by P-type ATPases.

Miscellaneous databases

GenomeRNAii496.
PROiP51164.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186009.
CleanExiHS_ATP4B.
GenevisibleiP51164. HS.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATP4B_HUMAN
AccessioniPrimary (citable) accession number: P51164
Secondary accession number(s): B1B0N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.