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P51164

- ATP4B_HUMAN

UniProt

P51164 - ATP4B_HUMAN

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Protein

Potassium-transporting ATPase subunit beta

Gene
ATP4B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.1 Publication

GO - Molecular functioni

  1. hydrogen:potassium-exchanging ATPase activity Source: ProtInc

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. hydrogen ion transmembrane transport Source: GOC
  3. ion transmembrane transport Source: Reactome
  4. response to lipopolysaccharide Source: Ensembl
  5. response to organonitrogen compound Source: Ensembl
  6. sodium ion transport Source: InterPro
  7. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Hydrogen ion transport, Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciMetaCyc:G66-33511-MONOMER.
ReactomeiREACT_25149. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi3.A.3.1.2. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase subunit beta
Alternative name(s):
Gastric H(+)/K(+) ATPase subunit beta
Proton pump beta chain
Gene namesi
Name:ATP4B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:820. ATP4B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei37 – 5721Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini58 – 291234Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. plasma membrane Source: Reactome
  2. sodium:potassium-exchanging ATPase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25114.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291Potassium-transporting ATPase subunit betaPRO_0000219091Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi103 – 1031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi131 ↔ 152 By similarity
Glycosylationi146 – 1461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi161 – 1611N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi162 ↔ 178 By similarity
Glycosylationi193 – 1931N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi201 ↔ 263 By similarity
Glycosylationi222 – 2221N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP51164.
PRIDEiP51164.

PTM databases

PhosphoSiteiP51164.

Expressioni

Gene expression databases

BgeeiP51164.
CleanExiHS_ATP4B.
GenevestigatoriP51164.

Organism-specific databases

HPAiCAB005598.
HPA045400.

Interactioni

Subunit structurei

Composed of two subunits: alpha (catalytic) and beta.

Protein-protein interaction databases

BioGridi106986. 4 interactions.
IntActiP51164. 2 interactions.
STRINGi9606.ENSP00000334216.

Structurei

3D structure databases

ProteinModelPortaliP51164.
SMRiP51164. Positions 32-291.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni194 – 29198immunoglobulin-likeAdd
BLAST

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.1 Publication

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG289316.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP51164.
KOiK01543.
OMAiKAQPHYS.
OrthoDBiEOG7M6D85.
PhylomeDBiP51164.
TreeFamiTF314618.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51164-1 [UniParc]FASTAAdd to Basket

« Hide

MAALQEKKTC GQRMEEFQRY CWNPDTGQML GRTLSRWVWI SLYYVAFYVV    50
MTGLFALCLY VLMQTVDPYT PDYQDQLRSP GVTLRPDVYG EKGLEIVYNV 100
SDNRTWADLT QTLHAFLAGY SPAAQEDSIN CTSEQYFFQE SFRAPNHTKF 150
SCKFTADMLQ NCSGLADPNF GFEEGKPCFI IKMNRIVKFL PSNGSAPRVD 200
CAFLDQPREL GQPLQVKYYP PNGTFSLHYF PYYGKKAQPH YSNPLVAAKL 250
LNIPRNAEVA IVCKVMAEHV TFNNPHDPYE GKVEFKLKIE K 291
Length:291
Mass (Da):33,367
Last modified:October 1, 1996 - v1
Checksum:i573F6D729CED1C3D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M75110 mRNA. Translation: AAA35987.1.
BX537316 Genomic DNA. Translation: CAM28358.1.
CH471085 Genomic DNA. Translation: EAX09221.1.
BC029059 mRNA. Translation: AAH29059.1.
AB008783 Genomic DNA. Translation: BAA23425.1.
CCDSiCCDS9539.1.
PIRiJH0480.
RefSeqiNP_000696.1. NM_000705.3.
UniGeneiHs.434202.

Genome annotation databases

EnsembliENST00000335288; ENSP00000334216; ENSG00000186009.
GeneIDi496.
KEGGihsa:496.
UCSCiuc001vtz.3. human.

Polymorphism databases

DMDMi1703461.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M75110 mRNA. Translation: AAA35987.1 .
BX537316 Genomic DNA. Translation: CAM28358.1 .
CH471085 Genomic DNA. Translation: EAX09221.1 .
BC029059 mRNA. Translation: AAH29059.1 .
AB008783 Genomic DNA. Translation: BAA23425.1 .
CCDSi CCDS9539.1.
PIRi JH0480.
RefSeqi NP_000696.1. NM_000705.3.
UniGenei Hs.434202.

3D structure databases

ProteinModelPortali P51164.
SMRi P51164. Positions 32-291.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106986. 4 interactions.
IntActi P51164. 2 interactions.
STRINGi 9606.ENSP00000334216.

Chemistry

BindingDBi P51164.
ChEMBLi CHEMBL2095173.
DrugBanki DB01129. Rabeprazole.

Protein family/group databases

TCDBi 3.A.3.1.2. the p-type atpase (p-atpase) superfamily.

PTM databases

PhosphoSitei P51164.

Polymorphism databases

DMDMi 1703461.

Proteomic databases

PaxDbi P51164.
PRIDEi P51164.

Protocols and materials databases

DNASUi 496.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000335288 ; ENSP00000334216 ; ENSG00000186009 .
GeneIDi 496.
KEGGi hsa:496.
UCSCi uc001vtz.3. human.

Organism-specific databases

CTDi 496.
GeneCardsi GC13M114303.
HGNCi HGNC:820. ATP4B.
HPAi CAB005598.
HPA045400.
MIMi 137217. gene.
neXtProti NX_P51164.
PharmGKBi PA25114.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG289316.
HOGENOMi HOG000039248.
HOVERGENi HBG050603.
InParanoidi P51164.
KOi K01543.
OMAi KAQPHYS.
OrthoDBi EOG7M6D85.
PhylomeDBi P51164.
TreeFami TF314618.

Enzyme and pathway databases

BioCyci MetaCyc:G66-33511-MONOMER.
Reactomei REACT_25149. Ion transport by P-type ATPases.

Miscellaneous databases

GenomeRNAii 496.
NextBioi 2083.
PROi P51164.
SOURCEi Search...

Gene expression databases

Bgeei P51164.
CleanExi HS_ATP4B.
Genevestigatori P51164.

Family and domain databases

InterProi IPR000402. Na/K_ATPase_sub_beta.
[Graphical view ]
PANTHERi PTHR11523. PTHR11523. 1 hit.
Pfami PF00287. Na_K-ATPase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEi PS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of the beta-subunit of the human gastric H,K-ATPase."
    Ma J.-Y., Song Y.-H., Sjoestrand S.E., Rask L., Maardh S.
    Biochem. Biophys. Res. Commun. 180:39-45(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  5. "GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells."
    Yoshida T., Sato R., Mahmood S., Kawasaki S., Futai M., Maeda M.
    FEBS Lett. 414:333-337(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-14.
    Tissue: Liver.
  6. "A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules."
    Bab-Dinitz E., Albeck S., Peleg Y., Brumfeld V., Gottschalk K.E., Karlish S.J.
    Biochemistry 48:8684-8691(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DOMAIN IMMUNOGLOBULIN-LIKE.

Entry informationi

Entry nameiATP4B_HUMAN
AccessioniPrimary (citable) accession number: P51164
Secondary accession number(s): B1B0N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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