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Protein

Potassium-transporting ATPase subunit beta

Gene

ATP4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.1 Publication

GO - Molecular functioni

  • potassium:proton exchanging ATPase activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processCell adhesion, Hydrogen ion transport, Ion transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

BioCyciMetaCyc:G66-33511-MONOMER
ReactomeiR-HSA-936837 Ion transport by P-type ATPases

Protein family/group databases

TCDBi3.A.3.1.2 the p-type atpase (p-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase subunit beta
Alternative name(s):
Gastric H(+)/K(+) ATPase subunit beta
Proton pump beta chain
Gene namesi
Name:ATP4B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000186009.4
HGNCiHGNC:820 ATP4B
MIMi137217 gene
neXtProtiNX_P51164

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini58 – 291ExtracellularSequence analysisAdd BLAST234

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi496
OpenTargetsiENSG00000186009
PharmGKBiPA25114

Chemistry databases

ChEMBLiCHEMBL2095173

Polymorphism and mutation databases

BioMutaiATP4B
DMDMi1703461

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190911 – 291Potassium-transporting ATPase subunit betaAdd BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi131 ↔ 152By similarity
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi162 ↔ 178By similarity
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi201 ↔ 263By similarity
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP51164
PeptideAtlasiP51164
PRIDEiP51164
ProteomicsDBi56294

PTM databases

iPTMnetiP51164
PhosphoSitePlusiP51164

Expressioni

Gene expression databases

BgeeiENSG00000186009
CleanExiHS_ATP4B
GenevisibleiP51164 HS

Organism-specific databases

HPAiHPA045400
HPA052649

Interactioni

Subunit structurei

Composed of two subunits: alpha (catalytic) and beta.

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-3904463,EBI-748961

Protein-protein interaction databases

BioGridi106986, 4 interactors
ComplexPortaliCPX-2160 Hydrogen:potassium-exchanging ATPase complex
CORUMiP51164
IntActiP51164, 4 interactors
STRINGi9606.ENSP00000334216

Chemistry databases

BindingDBiP51164

Structurei

3D structure databases

ProteinModelPortaliP51164
SMRiP51164
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni194 – 291immunoglobulin-likeAdd BLAST98

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.1 Publication

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927 Eukaryota
ENOG411150A LUCA
GeneTreeiENSGT00550000074530
HOGENOMiHOG000039248
HOVERGENiHBG050603
InParanoidiP51164
KOiK01543
OMAiHYFPYYG
OrthoDBiEOG091G0DJ4
PhylomeDBiP51164
TreeFamiTF314618

Family and domain databases

Gene3Di2.60.40.1660, 1 hit
InterProiView protein in InterPro
IPR000402 Na/K_ATPase_sub_beta
IPR038702 Na/K_ATPase_sub_beta_sf
PANTHERiPTHR11523 PTHR11523, 1 hit
PfamiView protein in Pfam
PF00287 Na_K-ATPase, 1 hit
TIGRFAMsiTIGR01107 Na_K_ATPase_bet, 1 hit
PROSITEiView protein in PROSITE
PS00390 ATPASE_NA_K_BETA_1, 1 hit
PS00391 ATPASE_NA_K_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P51164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALQEKKTC GQRMEEFQRY CWNPDTGQML GRTLSRWVWI SLYYVAFYVV
60 70 80 90 100
MTGLFALCLY VLMQTVDPYT PDYQDQLRSP GVTLRPDVYG EKGLEIVYNV
110 120 130 140 150
SDNRTWADLT QTLHAFLAGY SPAAQEDSIN CTSEQYFFQE SFRAPNHTKF
160 170 180 190 200
SCKFTADMLQ NCSGLADPNF GFEEGKPCFI IKMNRIVKFL PSNGSAPRVD
210 220 230 240 250
CAFLDQPREL GQPLQVKYYP PNGTFSLHYF PYYGKKAQPH YSNPLVAAKL
260 270 280 290
LNIPRNAEVA IVCKVMAEHV TFNNPHDPYE GKVEFKLKIE K
Length:291
Mass (Da):33,367
Last modified:October 1, 1996 - v1
Checksum:i573F6D729CED1C3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75110 mRNA Translation: AAA35987.1
BX537316 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09221.1
BC029059 mRNA Translation: AAH29059.1
AB008783 Genomic DNA Translation: BAA23425.1
CCDSiCCDS9539.1
PIRiJH0480
RefSeqiNP_000696.1, NM_000705.3
UniGeneiHs.434202

Genome annotation databases

EnsembliENST00000335288; ENSP00000334216; ENSG00000186009
GeneIDi496
KEGGihsa:496
UCSCiuc001vtz.5 human

Similar proteinsi

Entry informationi

Entry nameiATP4B_HUMAN
AccessioniPrimary (citable) accession number: P51164
Secondary accession number(s): B1B0N8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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