Reviewed, UniProtKB/Swiss-Prot P51164 (ATP4B_HUMAN)

Names and origin

Protein names

Recommended name:
    Potassium-transporting ATPase subunit beta
Alternative name(s):
    Proton pump beta chain
    Gastric H(+)/K(+) ATPase subunit beta

Gene names

Name:

ATP4B

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Composed of two subunits: alpha (catalytic) and beta.
Subcellular location	Membrane; Single-pass type II membrane protein.
Sequence similarities	Belongs to the X(+)/potassium ATPases subunit beta family.

Ontologies

Keywords
Biological process	Hydrogen ion transport Ion transport Potassium transport Transport
Cellular component	Membrane
Domain	Signal-anchor Transmembrane
Ligand	Potassium
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro potassium ion transport Inferred from electronic annotation. Source: UniProtKB-KW proton transport Inferred from electronic annotation. Source: UniProtKB-KW sodium ion transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hydrogen:potassium-exchanging ATPase activity Ref.1 Traceable author statement. Source: ProtInc potassium ion binding Inferred from electronic annotation. Source: UniProtKB-KW sodium:potassium-exchanging ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 291	291	Potassium-transporting ATPase subunit beta		PRO_0000219091
Regions
	Topological domain	1 – 36	36	Cytoplasmic Potential
	Transmembrane	37 – 57	21	Signal-anchor for type II membrane protein Potential
	Topological domain	58 – 291	234	Extracellular Potential
Amino acid modifications
	Glycosylation	99	1	N-linked (GlcNAc...) Potential
	Glycosylation	103	1	N-linked (GlcNAc...) Potential
	Glycosylation	130	1	N-linked (GlcNAc...) Potential
	Glycosylation	146	1	N-linked (GlcNAc...) Potential
	Glycosylation	161	1	N-linked (GlcNAc...) Potential
	Glycosylation	193	1	N-linked (GlcNAc...) Potential
	Glycosylation	222	1	N-linked (GlcNAc...) Potential
	Disulfide bond	131 ↔ 152		By similarity
	Disulfide bond	162 ↔ 178		By similarity
	Disulfide bond	201 ↔ 263		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P51164-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 573F6D729CED1C3D	FASTA	291	33,367
	10 20 30 40 50 60 MAALQEKKTC GQRMEEFQRY CWNPDTGQML GRTLSRWVWI SLYYVAFYVV MTGLFALCLY 70 80 90 100 110 120 VLMQTVDPYT PDYQDQLRSP GVTLRPDVYG EKGLEIVYNV SDNRTWADLT QTLHAFLAGY 130 140 150 160 170 180 SPAAQEDSIN CTSEQYFFQE SFRAPNHTKF SCKFTADMLQ NCSGLADPNF GFEEGKPCFI 190 200 210 220 230 240 IKMNRIVKFL PSNGSAPRVD CAFLDQPREL GQPLQVKYYP PNGTFSLHYF PYYGKKAQPH 250 260 270 280 290 YSNPLVAAKL LNIPRNAEVA IVCKVMAEHV TFNNPHDPYE GKVEFKLKIE K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning of the beta-subunit of the human gastric H,K-ATPase." Ma J.-Y., Song Y.-H., Sjoestrand S.E., Rask L., Maardh S. Biochem. Biophys. Res. Commun. 180:39-45(1991) [PubMed: 1656976] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[5]	"GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells." Yoshida T., Sato R., Mahmood S., Kawasaki S., Futai M., Maeda M. FEBS Lett. 414:333-337(1997) [PubMed: 9315713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-14. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M75110 mRNA. Translation: AAA35987.1. BX537316 Genomic DNA. Translation: CAM28358.1. CH471085 Genomic DNA. Translation: EAX09221.1. BC029059 mRNA. Translation: AAH29059.1. AB008783 Genomic DNA. Translation: BAA23425.1.
IPI	IPI00016421.
PIR	JH0480.
RefSeq	NP_000696.1.
UniGene	Hs.434202
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P51164.
Protein family/group databases
TCDB	3.A.3.1.2. P-type ATPase (P-ATPase) superfamily.
Proteomic databases
PRIDE	P51164.
Genome annotation databases
Ensembl	ENST00000335288; ENSP00000334216; ENSG00000186009; Homo sapiens. [Genome view]
GeneID	496.
KEGG	hsa:496.
UCSC	uc001vtz.1. human.
Organism-specific databases
CTD	496.
GeneCards	GC13M113351.
H-InvDB	HIX0019013.
HGNC	HGNC:820. ATP4B.
HPA	CAB005598.
MIM	137217. gene.
PharmGKB	PA25114.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG446583.
HOVERGEN	P51164.
InParanoid	P51164.
OMA	MNRIVKF.
OrthoDB	EOG9J9QJ4.
Gene expression databases
ArrayExpress	P51164.
Bgee	P51164.
CleanEx	HS_ATP4B.
Genevestigator	P51164.
GermOnline	ENSG00000186009. Homo sapiens.
Family and domain databases
InterPro	IPR000402. ATPase_P-typ_cation-exchng_bsu. [Graphical view]
PANTHER	PTHR11523. ATPase_H_Na/K_b. 1 hit.
Pfam	PF00287. Na_K-ATPase. 1 hit. [Graphical view]
PROSITE	PS00390. ATPASE_NA_K_BETA_1. 1 hit. PS00391. ATPASE_NA_K_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB01129. Rabeprazole.
NextBio	2083.
SOURCE	Search...

Entry information

Entry name

ATP4B_HUMAN

Accession

Primary (citable) accession number: P51164
Secondary accession number(s): B1B0N8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	December 15, 2009
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.