Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uroporphyrinogen-III synthase

Gene

Uros

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) (By similarity).By similarity

Catalytic activityi

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Delta-aminolevulinic acid dehydratase (Alad)
  2. Porphobilinogen deaminase (Hmbs)
  3. Uroporphyrinogen-III synthase (Uros)
  4. Uroporphyrinogen decarboxylase (Urod)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

  • cofactor binding Source: Ensembl
  • uroporphyrinogen-III synthase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processHeme biosynthesis, Porphyrin biosynthesis

Enzyme and pathway databases

BRENDAi4.2.1.75 3474
ReactomeiR-MMU-189451 Heme biosynthesis
UniPathwayiUPA00251; UER00320

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III synthase (EC:4.2.1.75)
Short name:
UROIIIS
Short name:
UROS
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene namesi
Name:Uros
Synonyms:Uros3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:98917 Uros

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001352521 – 265Uroporphyrinogen-III synthaseAdd BLAST265

Proteomic databases

EPDiP51163
PaxDbiP51163
PeptideAtlasiP51163
PRIDEiP51163

PTM databases

iPTMnetiP51163
PhosphoSitePlusiP51163

Expressioni

Gene expression databases

BgeeiENSMUSG00000030979
CleanExiMM_UROS
ExpressionAtlasiP51163 baseline and differential
GenevisibleiP51163 MM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiP51163, 1 interactor
MINTiP51163
STRINGi10090.ENSMUSP00000033276

Structurei

3D structure databases

ProteinModelPortaliP51163
SMRiP51163
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4132 Eukaryota
COG1587 LUCA
GeneTreeiENSGT00390000009853
HOGENOMiHOG000007209
HOVERGENiHBG000492
InParanoidiP51163
KOiK01719
OMAiDQIKFAA
OrthoDBiEOG091G0F70
PhylomeDBiP51163
TreeFamiTF324092

Family and domain databases

CDDicd06578 HemD, 1 hit
InterProiView protein in InterPro
IPR036108 4pyrrol_syn_uPrphyn_synt_sf
IPR003754 4pyrrol_synth_uPrphyn_synth
PfamiView protein in Pfam
PF02602 HEM4, 1 hit
SUPFAMiSSF69618 SSF69618, 1 hit

Sequencei

Sequence statusi: Complete.

P51163-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLLLKDAK EDDSGLDPYI QELRLCGLEA TLIPVLSFEF MSLPSLSEKL
60 70 80 90 100
SHPEGFGGLI FTSPRAVEAV KLCLEKDNKT EAWEKSLKDR WNAKSVYVVG
110 120 130 140 150
SATASLVNKI GLDAEGAGSG NAEKLAEYIC SKPSSELPLL FPCGTIKGDT
160 170 180 190 200
LPKMLKDKGI PMESMHVYQT VPHPGIQGSL KSYYEDQGIP ASITFFSPSG
210 220 230 240 250
LKYSLEYIQA LSGSSFDQIK FIAIGPSTTR AMAAKGLPVS CTAESPTPQA
260
LAAGIRNVLK PNHCC
Length:265
Mass (Da):28,504
Last modified:October 1, 1996 - v1
Checksum:i45BD2A6BD709A126
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18867 mRNA Translation: AAA74742.1
U16216 mRNA Translation: AAA79978.1
U04439 mRNA Translation: AAA81898.1
BC068161 mRNA Translation: AAH68161.1
CCDSiCCDS21934.1
PIRiA56838
RefSeqiNP_001289014.1, NM_001302085.1
NP_001289016.1, NM_001302087.1
NP_033505.1, NM_009479.3
XP_006507645.1, XM_006507582.3
UniGeneiMm.3160

Genome annotation databases

EnsembliENSMUST00000033276; ENSMUSP00000033276; ENSMUSG00000030979
ENSMUST00000106145; ENSMUSP00000101751; ENSMUSG00000030979
ENSMUST00000106146; ENSMUSP00000101752; ENSMUSG00000030979
GeneIDi22276
KEGGimmu:22276
UCSCiuc009kdf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiHEM4_MOUSE
AccessioniPrimary (citable) accession number: P51163
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health