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P51163

- HEM4_MOUSE

UniProt

P51163 - HEM4_MOUSE

Protein

Uroporphyrinogen-III synthase

Gene

Uros

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) By similarity.By similarity

    Catalytic activityi

    Hydroxymethylbilane = uroporphyrinogen III + H2O.

    Pathwayi

    GO - Molecular functioni

    1. cofactor binding Source: Ensembl
    2. uroporphyrinogen-III synthase activity Source: MGI

    GO - Biological processi

    1. cellular response to amine stimulus Source: Ensembl
    2. cellular response to arsenic-containing substance Source: Ensembl
    3. porphyrin-containing compound biosynthetic process Source: MGI
    4. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
    5. response to antibiotic Source: Ensembl
    6. uroporphyrinogen III biosynthetic process Source: Ensembl

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Heme biosynthesis, Porphyrin biosynthesis

    Enzyme and pathway databases

    BRENDAi4.2.1.75. 3474.
    ReactomeiREACT_203298. Heme biosynthesis.
    UniPathwayiUPA00251; UER00320.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uroporphyrinogen-III synthase (EC:4.2.1.75)
    Short name:
    UROIIIS
    Short name:
    UROS
    Alternative name(s):
    Hydroxymethylbilane hydrolyase [cyclizing]
    Uroporphyrinogen-III cosynthase
    Gene namesi
    Name:Uros
    Synonyms:Uros3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:98917. Uros.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. mitochondrion Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 265265Uroporphyrinogen-III synthasePRO_0000135252Add
    BLAST

    Proteomic databases

    MaxQBiP51163.
    PaxDbiP51163.
    PRIDEiP51163.

    PTM databases

    PhosphoSiteiP51163.

    Expressioni

    Gene expression databases

    ArrayExpressiP51163.
    BgeeiP51163.
    CleanExiMM_UROS.
    GenevestigatoriP51163.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    IntActiP51163. 1 interaction.
    MINTiMINT-4097372.

    Structurei

    3D structure databases

    ProteinModelPortaliP51163.
    SMRiP51163. Positions 1-260.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1587.
    HOGENOMiHOG000007209.
    HOVERGENiHBG000492.
    InParanoidiP51163.
    KOiK01719.
    OMAiDKGIAME.
    OrthoDBiEOG7K3TMH.
    PhylomeDBiP51163.
    TreeFamiTF324092.

    Family and domain databases

    InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
    [Graphical view]
    PfamiPF02602. HEM4. 1 hit.
    [Graphical view]
    SUPFAMiSSF69618. SSF69618. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P51163-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVLLLKDAK EDDSGLDPYI QELRLCGLEA TLIPVLSFEF MSLPSLSEKL    50
    SHPEGFGGLI FTSPRAVEAV KLCLEKDNKT EAWEKSLKDR WNAKSVYVVG 100
    SATASLVNKI GLDAEGAGSG NAEKLAEYIC SKPSSELPLL FPCGTIKGDT 150
    LPKMLKDKGI PMESMHVYQT VPHPGIQGSL KSYYEDQGIP ASITFFSPSG 200
    LKYSLEYIQA LSGSSFDQIK FIAIGPSTTR AMAAKGLPVS CTAESPTPQA 250
    LAAGIRNVLK PNHCC 265
    Length:265
    Mass (Da):28,504
    Last modified:October 1, 1996 - v1
    Checksum:i45BD2A6BD709A126
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18867 mRNA. Translation: AAA74742.1.
    U16216 mRNA. Translation: AAA79978.1.
    U04439 mRNA. Translation: AAA81898.1.
    BC068161 mRNA. Translation: AAH68161.1.
    CCDSiCCDS21934.1.
    PIRiA56838.
    RefSeqiNP_033505.1. NM_009479.2.
    XP_006507643.1. XM_006507580.1.
    XP_006507644.1. XM_006507581.1.
    XP_006507645.1. XM_006507582.1.
    UniGeneiMm.3160.

    Genome annotation databases

    EnsembliENSMUST00000033276; ENSMUSP00000033276; ENSMUSG00000030979.
    ENSMUST00000106145; ENSMUSP00000101751; ENSMUSG00000030979.
    ENSMUST00000106146; ENSMUSP00000101752; ENSMUSG00000030979.
    GeneIDi22276.
    KEGGimmu:22276.
    UCSCiuc009kdf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18867 mRNA. Translation: AAA74742.1 .
    U16216 mRNA. Translation: AAA79978.1 .
    U04439 mRNA. Translation: AAA81898.1 .
    BC068161 mRNA. Translation: AAH68161.1 .
    CCDSi CCDS21934.1.
    PIRi A56838.
    RefSeqi NP_033505.1. NM_009479.2.
    XP_006507643.1. XM_006507580.1.
    XP_006507644.1. XM_006507581.1.
    XP_006507645.1. XM_006507582.1.
    UniGenei Mm.3160.

    3D structure databases

    ProteinModelPortali P51163.
    SMRi P51163. Positions 1-260.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P51163. 1 interaction.
    MINTi MINT-4097372.

    PTM databases

    PhosphoSitei P51163.

    Proteomic databases

    MaxQBi P51163.
    PaxDbi P51163.
    PRIDEi P51163.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033276 ; ENSMUSP00000033276 ; ENSMUSG00000030979 .
    ENSMUST00000106145 ; ENSMUSP00000101751 ; ENSMUSG00000030979 .
    ENSMUST00000106146 ; ENSMUSP00000101752 ; ENSMUSG00000030979 .
    GeneIDi 22276.
    KEGGi mmu:22276.
    UCSCi uc009kdf.1. mouse.

    Organism-specific databases

    CTDi 7390.
    MGIi MGI:98917. Uros.

    Phylogenomic databases

    eggNOGi COG1587.
    HOGENOMi HOG000007209.
    HOVERGENi HBG000492.
    InParanoidi P51163.
    KOi K01719.
    OMAi DKGIAME.
    OrthoDBi EOG7K3TMH.
    PhylomeDBi P51163.
    TreeFami TF324092.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00320 .
    BRENDAi 4.2.1.75. 3474.
    Reactomei REACT_203298. Heme biosynthesis.

    Miscellaneous databases

    NextBioi 302397.
    PROi P51163.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51163.
    Bgeei P51163.
    CleanExi MM_UROS.
    Genevestigatori P51163.

    Family and domain databases

    InterProi IPR003754. 4pyrrol_synth_uPrphyn_synth.
    [Graphical view ]
    Pfami PF02602. HEM4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69618. SSF69618. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Uroporphyrinogen-III synthase: molecular cloning, nucleotide sequence, expression of a mouse full-length cDNA, and its localization on mouse chromosome 7."
      Xu W., Kozak C.A., Desnick R.J.
      Genomics 26:556-562(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X CBA.
      Tissue: Liver.
    2. "The cDNA sequence of mouse uroporphyrinogen III synthase and assignment to mouse chromosome 7."
      Bensidhoum M., Ged C.M., Poirier C., Guenet J.-L., de Verneuil H.
      Mamm. Genome 5:728-730(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiHEM4_MOUSE
    AccessioniPrimary (citable) accession number: P51163
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3