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P51163

- HEM4_MOUSE

UniProt

P51163 - HEM4_MOUSE

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Protein

Uroporphyrinogen-III synthase

Gene
Uros, Uros3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) By similarity.

Catalytic activityi

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathwayi

GO - Molecular functioni

  1. cofactor binding Source: Ensembl
  2. uroporphyrinogen-III synthase activity Source: MGI

GO - Biological processi

  1. cellular response to amine stimulus Source: Ensembl
  2. cellular response to arsenic-containing substance Source: Ensembl
  3. porphyrin-containing compound biosynthetic process Source: MGI
  4. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
  5. response to antibiotic Source: Ensembl
  6. uroporphyrinogen III biosynthetic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Enzyme and pathway databases

BRENDAi4.2.1.75. 3474.
ReactomeiREACT_203298. Heme biosynthesis.
UniPathwayiUPA00251; UER00320.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III synthase (EC:4.2.1.75)
Short name:
UROIIIS
Short name:
UROS
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene namesi
Name:Uros
Synonyms:Uros3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:98917. Uros.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. mitochondrion Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Uroporphyrinogen-III synthasePRO_0000135252Add
BLAST

Proteomic databases

MaxQBiP51163.
PaxDbiP51163.
PRIDEiP51163.

PTM databases

PhosphoSiteiP51163.

Expressioni

Gene expression databases

ArrayExpressiP51163.
BgeeiP51163.
CleanExiMM_UROS.
GenevestigatoriP51163.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

IntActiP51163. 1 interaction.
MINTiMINT-4097372.

Structurei

3D structure databases

ProteinModelPortaliP51163.
SMRiP51163. Positions 1-260.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1587.
HOGENOMiHOG000007209.
HOVERGENiHBG000492.
InParanoidiP51163.
KOiK01719.
OMAiDKGIAME.
OrthoDBiEOG7K3TMH.
PhylomeDBiP51163.
TreeFamiTF324092.

Family and domain databases

InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMiSSF69618. SSF69618. 1 hit.

Sequencei

Sequence statusi: Complete.

P51163-1 [UniParc]FASTAAdd to Basket

« Hide

MKVLLLKDAK EDDSGLDPYI QELRLCGLEA TLIPVLSFEF MSLPSLSEKL    50
SHPEGFGGLI FTSPRAVEAV KLCLEKDNKT EAWEKSLKDR WNAKSVYVVG 100
SATASLVNKI GLDAEGAGSG NAEKLAEYIC SKPSSELPLL FPCGTIKGDT 150
LPKMLKDKGI PMESMHVYQT VPHPGIQGSL KSYYEDQGIP ASITFFSPSG 200
LKYSLEYIQA LSGSSFDQIK FIAIGPSTTR AMAAKGLPVS CTAESPTPQA 250
LAAGIRNVLK PNHCC 265
Length:265
Mass (Da):28,504
Last modified:October 1, 1996 - v1
Checksum:i45BD2A6BD709A126
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18867 mRNA. Translation: AAA74742.1.
U16216 mRNA. Translation: AAA79978.1.
U04439 mRNA. Translation: AAA81898.1.
BC068161 mRNA. Translation: AAH68161.1.
CCDSiCCDS21934.1.
PIRiA56838.
RefSeqiNP_033505.1. NM_009479.2.
XP_006507643.1. XM_006507580.1.
XP_006507644.1. XM_006507581.1.
XP_006507645.1. XM_006507582.1.
UniGeneiMm.3160.

Genome annotation databases

EnsembliENSMUST00000033276; ENSMUSP00000033276; ENSMUSG00000030979.
ENSMUST00000106145; ENSMUSP00000101751; ENSMUSG00000030979.
ENSMUST00000106146; ENSMUSP00000101752; ENSMUSG00000030979.
GeneIDi22276.
KEGGimmu:22276.
UCSCiuc009kdf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18867 mRNA. Translation: AAA74742.1 .
U16216 mRNA. Translation: AAA79978.1 .
U04439 mRNA. Translation: AAA81898.1 .
BC068161 mRNA. Translation: AAH68161.1 .
CCDSi CCDS21934.1.
PIRi A56838.
RefSeqi NP_033505.1. NM_009479.2.
XP_006507643.1. XM_006507580.1.
XP_006507644.1. XM_006507581.1.
XP_006507645.1. XM_006507582.1.
UniGenei Mm.3160.

3D structure databases

ProteinModelPortali P51163.
SMRi P51163. Positions 1-260.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P51163. 1 interaction.
MINTi MINT-4097372.

PTM databases

PhosphoSitei P51163.

Proteomic databases

MaxQBi P51163.
PaxDbi P51163.
PRIDEi P51163.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033276 ; ENSMUSP00000033276 ; ENSMUSG00000030979 .
ENSMUST00000106145 ; ENSMUSP00000101751 ; ENSMUSG00000030979 .
ENSMUST00000106146 ; ENSMUSP00000101752 ; ENSMUSG00000030979 .
GeneIDi 22276.
KEGGi mmu:22276.
UCSCi uc009kdf.1. mouse.

Organism-specific databases

CTDi 7390.
MGIi MGI:98917. Uros.

Phylogenomic databases

eggNOGi COG1587.
HOGENOMi HOG000007209.
HOVERGENi HBG000492.
InParanoidi P51163.
KOi K01719.
OMAi DKGIAME.
OrthoDBi EOG7K3TMH.
PhylomeDBi P51163.
TreeFami TF324092.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00320 .
BRENDAi 4.2.1.75. 3474.
Reactomei REACT_203298. Heme biosynthesis.

Miscellaneous databases

NextBioi 302397.
PROi P51163.
SOURCEi Search...

Gene expression databases

ArrayExpressi P51163.
Bgeei P51163.
CleanExi MM_UROS.
Genevestigatori P51163.

Family and domain databases

InterProi IPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view ]
Pfami PF02602. HEM4. 1 hit.
[Graphical view ]
SUPFAMi SSF69618. SSF69618. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Uroporphyrinogen-III synthase: molecular cloning, nucleotide sequence, expression of a mouse full-length cDNA, and its localization on mouse chromosome 7."
    Xu W., Kozak C.A., Desnick R.J.
    Genomics 26:556-562(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Liver.
  2. "The cDNA sequence of mouse uroporphyrinogen III synthase and assignment to mouse chromosome 7."
    Bensidhoum M., Ged C.M., Poirier C., Guenet J.-L., de Verneuil H.
    Mamm. Genome 5:728-730(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiHEM4_MOUSE
AccessioniPrimary (citable) accession number: P51163
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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