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P51163 (HEM4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen-III synthase
Short name=UROIIIS
Short name=UROS
EC=4.2.1.75
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene names
Name:Uros
Synonyms:Uros3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) By similarity.

Catalytic activity

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the uroporphyrinogen-III synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Uroporphyrinogen-III synthase
PRO_0000135252

Sequences

Sequence LengthMass (Da)Tools
P51163 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 45BD2A6BD709A126

FASTA26528,504
        10         20         30         40         50         60 
MKVLLLKDAK EDDSGLDPYI QELRLCGLEA TLIPVLSFEF MSLPSLSEKL SHPEGFGGLI 

        70         80         90        100        110        120 
FTSPRAVEAV KLCLEKDNKT EAWEKSLKDR WNAKSVYVVG SATASLVNKI GLDAEGAGSG 

       130        140        150        160        170        180 
NAEKLAEYIC SKPSSELPLL FPCGTIKGDT LPKMLKDKGI PMESMHVYQT VPHPGIQGSL 

       190        200        210        220        230        240 
KSYYEDQGIP ASITFFSPSG LKYSLEYIQA LSGSSFDQIK FIAIGPSTTR AMAAKGLPVS 

       250        260 
CTAESPTPQA LAAGIRNVLK PNHCC

« Hide

References

« Hide 'large scale' references
[1]"Uroporphyrinogen-III synthase: molecular cloning, nucleotide sequence, expression of a mouse full-length cDNA, and its localization on mouse chromosome 7."
Xu W., Kozak C.A., Desnick R.J.
Genomics 26:556-562(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6 X CBA.
Tissue: Liver.
[2]"The cDNA sequence of mouse uroporphyrinogen III synthase and assignment to mouse chromosome 7."
Bensidhoum M., Ged C.M., Poirier C., Guenet J.-L., de Verneuil H.
Mamm. Genome 5:728-730(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U18867 mRNA. Translation: AAA74742.1.
U16216 mRNA. Translation: AAA79978.1.
U04439 mRNA. Translation: AAA81898.1.
BC068161 mRNA. Translation: AAH68161.1.
IPIIPI00119087.
PIRA56838.
RefSeqNP_033505.1. NM_009479.2.
UniGeneMm.3160.

3D structure databases

ProteinModelPortalP51163.
SMRP51163. Positions 1-260.
ModBaseSearch...

PTM databases

PhosphoSiteP51163.

Proteomic databases

PaxDbP51163.
PRIDEP51163.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033276; ENSMUSP00000033276; ENSMUSG00000030979.
ENSMUST00000106145; ENSMUSP00000101751; ENSMUSG00000030979.
ENSMUST00000106146; ENSMUSP00000101752; ENSMUSG00000030979.
GeneID22276.
KEGGmmu:22276.

Organism-specific databases

CTD7390.
MGIMGI:98917. Uros.

Phylogenomic databases

eggNOGCOG1587.
HOGENOMHOG000007209.
HOVERGENHBG000492.
InParanoidP51163.
KOK01719.
OMADDCGQDP.
OrthoDBEOG45B1GF.

Enzyme and pathway databases

BRENDA4.2.1.75. 3474.
UniPathwayUPA00251; UER00320.

Gene expression databases

ArrayExpressP51163.
BgeeP51163.
CleanExMM_UROS.
GenevestigatorP51163.
GermOnlineENSMUSG00000030979. Mus musculus.

Family and domain databases

InterProIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMSSF69618. HEM4_synth. 1 hit.
ProtoNetSearch...

Other

NextBio302397.
SOURCESearch...

Entry information

Entry nameHEM4_MOUSE
AccessionPrimary (citable) accession number: P51163
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 3, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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