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Protein

Gastrotropin

Gene

Fabp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (PubMed:23251388). Stimulates gastric acid and pepsinogen secretion (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • bile acid metabolic process Source: MGI
  • lipid transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-159418. Recycling of bile acids and salts.
R-MMU-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrotropin
Short name:
GT
Alternative name(s):
Fatty acid-binding protein 6
Ileal lipid-binding protein
Short name:
ILBP
Gene namesi
Name:Fabp6
Synonyms:Illbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96565. Fabp6.

Subcellular locationi

  • Cytoplasm By similarity
  • Membrane; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 128127GastrotropinPRO_0000067381Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP51162.
PaxDbiP51162.
PeptideAtlasiP51162.
PRIDEiP51162.

PTM databases

PhosphoSiteiP51162.

Expressioni

Tissue specificityi

Expressed in ovary granulosa and luteal cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000020405.
GenevisibleiP51162. MM.

Interactioni

Protein-protein interaction databases

IntActiP51162. 1 interaction.
STRINGi10090.ENSMUSP00000020672.

Structurei

3D structure databases

ProteinModelPortaliP51162.
SMRiP51162. Positions 2-128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Can bind at least two ligands per molecule, however, the stoichiometry is debated.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00390000012034.
HOGENOMiHOG000004830.
HOVERGENiHBG005633.
InParanoidiP51162.
KOiK08755.
OMAiTVKMEGG.
OrthoDBiEOG091G16BV.
PhylomeDBiP51162.
TreeFamiTF330348.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031257. Gastrotropin.
IPR031259. iLBP.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF69. PTHR11955:SF69. 1 hit.
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51162-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFSGKYEFE SEKNYDEFMK RLGLPGDVIE RGRNFKIITE VQQDGQDFTW
60 70 80 90 100
SQSYSGGNIM SNKFTIGKEC EMQTMGGKKF KATVKMEGGK VVAEFPNYHQ
110 120
TSEVVGDKLV EISTIGDVTY ERVSKRLA
Length:128
Mass (Da):14,486
Last modified:January 23, 2007 - v2
Checksum:i9FF64BDD0AFA2909
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00938 Genomic DNA. Translation: AAC27352.1.
AL670472 Genomic DNA. Translation: CAI24826.1.
CH466575 Genomic DNA. Translation: EDL33855.1.
BC119289 mRNA. Translation: AAI19290.1.
BC120767 mRNA. Translation: AAI20768.1.
CCDSiCCDS24560.1.
PIRiA54797.
RefSeqiNP_032401.1. NM_008375.2.
UniGeneiMm.142716.

Genome annotation databases

EnsembliENSMUST00000020672; ENSMUSP00000020672; ENSMUSG00000020405.
GeneIDi16204.
KEGGimmu:16204.
UCSCiuc007imt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00938 Genomic DNA. Translation: AAC27352.1.
AL670472 Genomic DNA. Translation: CAI24826.1.
CH466575 Genomic DNA. Translation: EDL33855.1.
BC119289 mRNA. Translation: AAI19290.1.
BC120767 mRNA. Translation: AAI20768.1.
CCDSiCCDS24560.1.
PIRiA54797.
RefSeqiNP_032401.1. NM_008375.2.
UniGeneiMm.142716.

3D structure databases

ProteinModelPortaliP51162.
SMRiP51162. Positions 2-128.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP51162. 1 interaction.
STRINGi10090.ENSMUSP00000020672.

PTM databases

PhosphoSiteiP51162.

Proteomic databases

MaxQBiP51162.
PaxDbiP51162.
PeptideAtlasiP51162.
PRIDEiP51162.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020672; ENSMUSP00000020672; ENSMUSG00000020405.
GeneIDi16204.
KEGGimmu:16204.
UCSCiuc007imt.2. mouse.

Organism-specific databases

CTDi2172.
MGIiMGI:96565. Fabp6.

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00390000012034.
HOGENOMiHOG000004830.
HOVERGENiHBG005633.
InParanoidiP51162.
KOiK08755.
OMAiTVKMEGG.
OrthoDBiEOG091G16BV.
PhylomeDBiP51162.
TreeFamiTF330348.

Enzyme and pathway databases

ReactomeiR-MMU-159418. Recycling of bile acids and salts.
R-MMU-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Miscellaneous databases

PROiP51162.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020405.
GenevisibleiP51162. MM.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031257. Gastrotropin.
IPR031259. iLBP.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF69. PTHR11955:SF69. 1 hit.
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFABP6_MOUSE
AccessioniPrimary (citable) accession number: P51162
Secondary accession number(s): Q5SRT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.