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Protein

Ras-related protein Rab-28

Gene

Rab28

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 27GTPBy similarity9
Nucleotide bindingi68 – 72GTPBy similarity5
Nucleotide bindingi129 – 132GTPBy similarity4
Nucleotide bindingi159 – 161GTPBy similarity3

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: RGD
  • GTP binding Source: RGD

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-28
Gene namesi
Name:Rab28
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi620891. Rab28.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001212292 – 218Ras-related protein Rab-28Add BLAST217
PropeptideiPRO_0000396724219 – 221Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei8PhosphoserineBy similarity1
Modified residuei218Cysteine methyl esterBy similarity1
Lipidationi218S-farnesyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PRIDEiP51158.

PTM databases

iPTMnetiP51158.
PhosphoSitePlusiP51158.

Expressioni

Tissue specificityi

Testis, brain, and to much lower levels heart, skeletal muscle and fat cells. Expressed in the retina.1 Publication

Gene expression databases

BgeeiENSRNOG00000017074.
ExpressionAtlasiP51158. baseline and differential.
GenevisibleiP51158. RN.

Structurei

3D structure databases

ProteinModelPortaliP51158.
SMRiP51158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 49Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

GeneTreeiENSGT00800000124173.
HOGENOMiHOG000233968.
HOVERGENiHBG101090.
InParanoidiP51158.
KOiK07915.
OMAiYKQTIGV.
OrthoDBiEOG091G11JJ.
PhylomeDBiP51158.
TreeFamiTF313852.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51158-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSEEESQD RQLKIVVLGD GTSGKTSLAT CFAQETFGKQ YKQTIGLDFF
60 70 80 90 100
LRRITLPGNL NVTLQVWDIG GQTIGGKMLD KYIYGAQGIL LVYDITNYQS
110 120 130 140 150
FENLEDWYSV VKTVSEESET QPLVALVGNK IDLEHMRTVK PDKHLRFCQE
160 170 180 190 200
NGFSSHFVSA KTGDSVFLCF QKVAAEILGI KLNKAEIEQS QRVVKADIVN
210 220
YNQEPMSRTV NPPRSSMCAV Q
Length:221
Mass (Da):24,772
Last modified:October 1, 1996 - v1
Checksum:i2220A1F0B0EBFFB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78606 mRNA. Translation: CAA55340.1.
PIRiS65476.
RefSeqiNP_446430.1. NM_053978.1.
UniGeneiRn.4023.

Genome annotation databases

EnsembliENSRNOT00000081033; ENSRNOP00000071725; ENSRNOG00000017074.
GeneIDi117049.
KEGGirno:117049.

Similar proteinsi

Entry informationi

Entry nameiRAB28_RAT
AccessioniPrimary (citable) accession number: P51158
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 22, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families