Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P51158

- RAB28_RAT

UniProt

P51158 - RAB28_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ras-related protein Rab-28

Gene

Rab28

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 279GTPBy similarity
Nucleotide bindingi68 – 725GTPBy similarity
Nucleotide bindingi129 – 1324GTPBy similarity
Nucleotide bindingi159 – 1613GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: UniProtKB
  2. GTPase activity Source: RGD
  3. GTP binding Source: UniProtKB

GO - Biological processi

  1. GTP catabolic process Source: GOC
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-28
Gene namesi
Name:Rab28
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620891. Rab28.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated. Cytoplasmcytoskeletoncilium basal body 1 Publication
Note: Expressed in the basal body and ciliary rootlet of the photoreceptors.

GO - Cellular componenti

  1. ciliary basal body Source: UniProtKB
  2. ciliary rootlet Source: UniProtKB
  3. cytoplasm Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 218217Ras-related protein Rab-28PRO_0000121229Add
BLAST
Propeptidei219 – 2213Removed in mature formBy similarityPRO_0000396724

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei8 – 81PhosphoserineBy similarity
Modified residuei218 – 2181Cysteine methyl esterBy similarity
Lipidationi218 – 2181S-farnesyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiP51158.

PTM databases

PhosphoSiteiP51158.

Expressioni

Tissue specificityi

Testis, brain, and to much lower levels heart, skeletal muscle and fat cells. Expressed in the retina.1 Publication

Gene expression databases

GenevestigatoriP51158.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023176.

Structurei

3D structure databases

ProteinModelPortaliP51158.
SMRiP51158. Positions 8-184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 499Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
HOVERGENiHBG101090.
InParanoidiP51158.
KOiK07915.
PhylomeDBiP51158.
TreeFamiTF313852.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51158-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDSEEESQD RQLKIVVLGD GTSGKTSLAT CFAQETFGKQ YKQTIGLDFF
60 70 80 90 100
LRRITLPGNL NVTLQVWDIG GQTIGGKMLD KYIYGAQGIL LVYDITNYQS
110 120 130 140 150
FENLEDWYSV VKTVSEESET QPLVALVGNK IDLEHMRTVK PDKHLRFCQE
160 170 180 190 200
NGFSSHFVSA KTGDSVFLCF QKVAAEILGI KLNKAEIEQS QRVVKADIVN
210 220
YNQEPMSRTV NPPRSSMCAV Q
Length:221
Mass (Da):24,772
Last modified:October 1, 1996 - v1
Checksum:i2220A1F0B0EBFFB8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78606 mRNA. Translation: CAA55340.1.
PIRiS65476.
RefSeqiNP_446430.1. NM_053978.1.
UniGeneiRn.4023.

Genome annotation databases

GeneIDi117049.
KEGGirno:117049.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78606 mRNA. Translation: CAA55340.1 .
PIRi S65476.
RefSeqi NP_446430.1. NM_053978.1.
UniGenei Rn.4023.

3D structure databases

ProteinModelPortali P51158.
SMRi P51158. Positions 8-184.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000023176.

PTM databases

PhosphoSitei P51158.

Proteomic databases

PaxDbi P51158.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 117049.
KEGGi rno:117049.

Organism-specific databases

CTDi 9364.
RGDi 620891. Rab28.

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233968.
HOVERGENi HBG101090.
InParanoidi P51158.
KOi K07915.
PhylomeDBi P51158.
TreeFami TF313852.

Miscellaneous databases

NextBioi 619871.
PROi P51158.

Gene expression databases

Genevestigatori P51158.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Alternative mRNA splicing of the novel GTPase Rab28 generates isoforms with different C-termini."
    Brauers A., Schuermann A., Massmann S., Muehl-Zuerbes P., Becker W., Kainulainen H., Lie C., Joost H.-G.
    Eur. J. Biochem. 237:833-840(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiRAB28_RAT
AccessioniPrimary (citable) accession number: P51158
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3