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P51158 (RAB28_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein Rab-28
Gene names
Name:Rab28
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length221 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential. Cytoplasmcytoskeletoncilium basal body. Note: Expressed in the basal body and ciliary rootlet of the photoreceptors. Ref.2

Tissue specificity

Testis, brain, and to much lower levels heart, skeletal muscle and fat cells. Expressed in the retina. Ref.2

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 218217Ras-related protein Rab-28
PRO_0000121229
Propeptide219 – 2213Removed in mature form By similarity
PRO_0000396724

Regions

Nucleotide binding19 – 279GTP By similarity
Nucleotide binding68 – 725GTP By similarity
Nucleotide binding129 – 1324GTP By similarity
Nucleotide binding159 – 1613GTP By similarity
Motif41 – 499Effector region By similarity

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue81Phosphoserine By similarity
Modified residue2181Cysteine methyl ester By similarity
Lipidation2181S-farnesyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P51158 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 2220A1F0B0EBFFB8

FASTA22124,772
        10         20         30         40         50         60 
MSDSEEESQD RQLKIVVLGD GTSGKTSLAT CFAQETFGKQ YKQTIGLDFF LRRITLPGNL 

        70         80         90        100        110        120 
NVTLQVWDIG GQTIGGKMLD KYIYGAQGIL LVYDITNYQS FENLEDWYSV VKTVSEESET 

       130        140        150        160        170        180 
QPLVALVGNK IDLEHMRTVK PDKHLRFCQE NGFSSHFVSA KTGDSVFLCF QKVAAEILGI 

       190        200        210        220 
KLNKAEIEQS QRVVKADIVN YNQEPMSRTV NPPRSSMCAV Q 

« Hide

References

[1]"Alternative mRNA splicing of the novel GTPase Rab28 generates isoforms with different C-termini."
Brauers A., Schuermann A., Massmann S., Muehl-Zuerbes P., Becker W., Kainulainen H., Lie C., Joost H.-G.
Eur. J. Biochem. 237:833-840(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
[2]"Mutations in RAB28, encoding a farnesylated small GTPase, are associated with autosomal-recessive cone-rod dystrophy."
European Retinal Disease Consortium
Roosing S., Rohrschneider K., Beryozkin A., Sharon D., Weisschuh N., Staller J., Kohl S., Zelinger L., Peters T.A., Neveling K., Strom T.M., van den Born L.I., Hoyng C.B., Klaver C.C., Roepman R., Wissinger B., Banin E., Cremers F.P., den Hollander A.I.
Am. J. Hum. Genet. 93:110-117(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X78606 mRNA. Translation: CAA55340.1.
PIRS65476.
RefSeqNP_446430.1. NM_053978.1.
UniGeneRn.4023.

3D structure databases

ProteinModelPortalP51158.
SMRP51158. Positions 8-184.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000023176.

PTM databases

PhosphoSiteP51158.

Proteomic databases

PaxDbP51158.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID117049.
KEGGrno:117049.

Organism-specific databases

CTD9364.
RGD620891. Rab28.

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000233968.
HOVERGENHBG101090.
InParanoidP51158.
KOK07915.
PhylomeDBP51158.
TreeFamTF313852.

Gene expression databases

GenevestigatorP51158.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio619871.
PROP51158.

Entry information

Entry nameRAB28_RAT
AccessionPrimary (citable) accession number: P51158
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families