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P51158

- RAB28_RAT

UniProt

P51158 - RAB28_RAT

Protein

Ras-related protein Rab-28

Gene

Rab28

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 279GTPBy similarity
    Nucleotide bindingi68 – 725GTPBy similarity
    Nucleotide bindingi129 – 1324GTPBy similarity
    Nucleotide bindingi159 – 1613GTPBy similarity

    GO - Molecular functioni

    1. GDP binding Source: UniProtKB
    2. GTPase activity Source: RGD
    3. GTP binding Source: UniProtKB

    GO - Biological processi

    1. GTP catabolic process Source: GOC
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-28
    Gene namesi
    Name:Rab28
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620891. Rab28.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated. Cytoplasmcytoskeletoncilium basal body 1 Publication
    Note: Expressed in the basal body and ciliary rootlet of the photoreceptors.

    GO - Cellular componenti

    1. ciliary basal body Source: UniProtKB
    2. ciliary rootlet Source: UniProtKB
    3. cytoplasm Source: UniProtKB-KW
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 218217Ras-related protein Rab-28PRO_0000121229Add
    BLAST
    Propeptidei219 – 2213Removed in mature formBy similarityPRO_0000396724

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei8 – 81PhosphoserineBy similarity
    Modified residuei218 – 2181Cysteine methyl esterBy similarity
    Lipidationi218 – 2181S-farnesyl cysteineBy similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

    Proteomic databases

    PaxDbiP51158.

    PTM databases

    PhosphoSiteiP51158.

    Expressioni

    Tissue specificityi

    Testis, brain, and to much lower levels heart, skeletal muscle and fat cells. Expressed in the retina.1 Publication

    Gene expression databases

    GenevestigatoriP51158.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000023176.

    Structurei

    3D structure databases

    ProteinModelPortaliP51158.
    SMRiP51158. Positions 8-184.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 499Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    HOVERGENiHBG101090.
    InParanoidiP51158.
    KOiK07915.
    PhylomeDBiP51158.
    TreeFamiTF313852.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P51158-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDSEEESQD RQLKIVVLGD GTSGKTSLAT CFAQETFGKQ YKQTIGLDFF    50
    LRRITLPGNL NVTLQVWDIG GQTIGGKMLD KYIYGAQGIL LVYDITNYQS 100
    FENLEDWYSV VKTVSEESET QPLVALVGNK IDLEHMRTVK PDKHLRFCQE 150
    NGFSSHFVSA KTGDSVFLCF QKVAAEILGI KLNKAEIEQS QRVVKADIVN 200
    YNQEPMSRTV NPPRSSMCAV Q 221
    Length:221
    Mass (Da):24,772
    Last modified:October 1, 1996 - v1
    Checksum:i2220A1F0B0EBFFB8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78606 mRNA. Translation: CAA55340.1.
    PIRiS65476.
    RefSeqiNP_446430.1. NM_053978.1.
    UniGeneiRn.4023.

    Genome annotation databases

    GeneIDi117049.
    KEGGirno:117049.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78606 mRNA. Translation: CAA55340.1 .
    PIRi S65476.
    RefSeqi NP_446430.1. NM_053978.1.
    UniGenei Rn.4023.

    3D structure databases

    ProteinModelPortali P51158.
    SMRi P51158. Positions 8-184.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000023176.

    PTM databases

    PhosphoSitei P51158.

    Proteomic databases

    PaxDbi P51158.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 117049.
    KEGGi rno:117049.

    Organism-specific databases

    CTDi 9364.
    RGDi 620891. Rab28.

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    HOVERGENi HBG101090.
    InParanoidi P51158.
    KOi K07915.
    PhylomeDBi P51158.
    TreeFami TF313852.

    Miscellaneous databases

    NextBioi 619871.
    PROi P51158.

    Gene expression databases

    Genevestigatori P51158.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Alternative mRNA splicing of the novel GTPase Rab28 generates isoforms with different C-termini."
      Brauers A., Schuermann A., Massmann S., Muehl-Zuerbes P., Becker W., Kainulainen H., Lie C., Joost H.-G.
      Eur. J. Biochem. 237:833-840(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiRAB28_RAT
    AccessioniPrimary (citable) accession number: P51158
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3