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P51156 (RAB26_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein Rab-26
Gene names
Name:Rab26
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach By similarity. Plays a role in the secretion of amylase from acinar granules in the parotid gland. Ref.3 Ref.4

Subunit structure

Interacts with ADRA2B. Interacts with RIMS1 By similarity.

Subcellular location

Cytoplasmic vesiclesecretory vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side By similarity. Note: Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location By similarity. Localized immediately around secretory granules in the acinar cells of the parotid gland. Not localized in plasma membranes. Ref.3 Ref.4

Tissue specificity

Expressed in pancreas, kidney, brain, submandibular gland, and lung. Ref.2

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence caution

The sequence AAA69955.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257Ras-related protein Rab-26
PRO_0000121220

Regions

Nucleotide binding71 – 799GTP By similarity
Nucleotide binding120 – 1245GTP By similarity
Nucleotide binding178 – 1814GTP By similarity
Nucleotide binding208 – 2103GTP By similarity
Motif94 – 1029Effector region By similarity

Amino acid modifications

Lipidation2541S-geranylgeranyl cysteine By similarity
Lipidation2551S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P51156 [UniParc].

Last modified September 27, 2005. Version 2.
Checksum: 3C4A12A2B8333474

FASTA25728,203
        10         20         30         40         50         60 
MSRKKTPKSK GGSVPAASTL PAAANGPRLA HPRTARPGPE APPNGPPQSG RPSLGGTGDF 

        70         80         90        100        110        120 
YDVAFKVMLV GDSGVGKTCL LVRFKDGAFL AGTFISTVGI DFRNKVLDVD GMKVKLQIWD 

       130        140        150        160        170        180 
TAGQERFRSV THAYYRDAHA LLLLYDITNK DSFDNIQAWL TEIQEYAQQD VVLMLLGNKV 

       190        200        210        220        230        240 
DSTQERVVKR EDGEKLAKEY GLPFMETSAK SGLNVDLAFT AIAKELKQRS TKAPSEPRFR 

       250 
LHDYVKREGR GVSCCRL 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
[2]"Molecular cloning of a new member of the Rab protein family, Rab 26, from rat pancreas."
Wagner A.C.C., Strowski M.Z., Goeke B., Williams J.A.
Biochem. Biophys. Res. Commun. 207:950-956(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 63-257, TISSUE SPECIFICITY.
Strain: Sprague-Dawley.
Tissue: Pancreas.
[3]"Expression, characterization, and localization of Rab26, a low molecular weight GTP-binding protein, in the rat parotid gland."
Yoshie S., Imai A., Nashida T., Shimomura H.
Histochem. Cell Biol. 113:259-263(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
Tissue: Parotid gland.
[4]"Relation of Rab26 to the amylase release from rat parotid acinar cells."
Nashida T., Imai A., Shimomura H.
Arch. Oral Biol. 51:89-95(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC061984 mRNA. Translation: AAH61984.1.
U18771 mRNA. Translation: AAA69955.1. Different initiation.
PIRJC2528.
RefSeqNP_598264.1. NM_133580.1.
UniGeneRn.10975.

3D structure databases

ProteinModelPortalP51156.
SMRP51156. Positions 59-228.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000004249.

PTM databases

PhosphoSiteP51156.

Proteomic databases

PaxDbP51156.
PRIDEP51156.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000004249; ENSRNOP00000004249; ENSRNOG00000042086.
GeneID171111.
KEGGrno:171111.
UCSCRGD:620890. rat.

Organism-specific databases

CTD25837.
RGD620890. Rab26.

Phylogenomic databases

eggNOGCOG1100.
GeneTreeENSGT00750000117504.
HOGENOMHOG000233968.
HOVERGENHBG009351.
KOK07913.
OMANKVDSAH.
OrthoDBEOG7Q2N5Z.
PhylomeDBP51156.

Gene expression databases

GenevestigatorP51156.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio621820.
PROP51156.

Entry information

Entry nameRAB26_RAT
AccessionPrimary (citable) accession number: P51156
Secondary accession number(s): Q6P6W7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 27, 2005
Last modified: May 14, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families