P51156 (RAB26_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-26

Gene names

Name:

Rab26

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach By similarity. Plays a role in the secretion of amylase from acinar granules in the parotid gland. Ref.3 Ref.4
Subunit structure	Interacts with ADRA2B. Interacts with RIMS1 By similarity.
Subcellular location	Cytoplasmic vesicle › secretory vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side By similarity. Note: Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location By similarity. Localized immediately around secretory granules in the acinar cells of the parotid gland. Not localized in plasma membranes. Ref.3 Ref.4
Tissue specificity	Expressed in pancreas, kidney, brain, submandibular gland, and lung. Ref.2
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.
Sequence caution	The sequence AAA69955.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasmic vesicle Golgi apparatus Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Golgi to plasma membrane protein transport Inferred from sequence or structural similarity. Source: UniProtKB exocrine system development Inferred from direct assay Ref.3. Source: UniProtKB regulated secretory pathway Inferred from sequence or structural similarity. Source: UniProtKB regulation of exocytosis Inferred from direct assay Ref.3. Source: UniProtKB small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	Golgi membrane Inferred from sequence or structural similarity. Source: UniProtKB intrinsic to plasma membrane Inferred from direct assay Ref.3. Source: UniProtKB secretory granule membrane Inferred from sequence or structural similarity. Source: UniProtKB transport vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GMP binding Inferred from sequence or structural similarity. Source: UniProtKB GTP binding Inferred from direct assay Ref.3. Source: UniProtKB GTPase activity Traceable author statement Ref.2. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Ras-related protein Rab-26		PRO_0000121220
Regions
	Nucleotide binding	71 – 79	9	GTP By similarity
	Nucleotide binding	120 – 124	5	GTP By similarity
	Nucleotide binding	178 – 181	4	GTP By similarity
	Nucleotide binding	208 – 210	3	GTP By similarity
	Motif	94 – 102	9	Effector region By similarity
Amino acid modifications
	Lipidation	254	1	S-geranylgeranyl cysteine By similarity
	Lipidation	255	1	S-geranylgeranyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P51156 [UniParc]. Last modified September 27, 2005. Version 2. Checksum: 3C4A12A2B8333474	FASTA	257	28,203
	10 20 30 40 50 60 MSRKKTPKSK GGSVPAASTL PAAANGPRLA HPRTARPGPE APPNGPPQSG RPSLGGTGDF 70 80 90 100 110 120 YDVAFKVMLV GDSGVGKTCL LVRFKDGAFL AGTFISTVGI DFRNKVLDVD GMKVKLQIWD 130 140 150 160 170 180 TAGQERFRSV THAYYRDAHA LLLLYDITNK DSFDNIQAWL TEIQEYAQQD VVLMLLGNKV 190 200 210 220 230 240 DSTQERVVKR EDGEKLAKEY GLPFMETSAK SGLNVDLAFT AIAKELKQRS TKAPSEPRFR 250 LHDYVKREGR GVSCCRL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[2]	"Molecular cloning of a new member of the Rab protein family, Rab 26, from rat pancreas." Wagner A.C.C., Strowski M.Z., Goeke B., Williams J.A. Biochem. Biophys. Res. Commun. 207:950-956(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 63-257, TISSUE SPECIFICITY. Strain: Sprague-Dawley. Tissue: Pancreas.
[3]	"Expression, characterization, and localization of Rab26, a low molecular weight GTP-binding protein, in the rat parotid gland." Yoshie S., Imai A., Nashida T., Shimomura H. Histochem. Cell Biol. 113:259-263(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION. Tissue: Parotid gland.
[4]	"Relation of Rab26 to the amylase release from rat parotid acinar cells." Nashida T., Imai A., Shimomura H. Arch. Oral Biol. 51:89-95(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC061984 mRNA. Translation: AAH61984.1. U18771 mRNA. Translation: AAA69955.1. Different initiation.
IPI	IPI00199248.
PIR	JC2528.
RefSeq	NP_598264.1. NM_133580.1.
UniGene	Rn.10975.
3D structure databases
ProteinModelPortal	P51156.
SMR	P51156. Positions 59-228.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000004249.
PTM databases
PhosphoSite	P51156.
Proteomic databases
PaxDb	P51156.
PRIDE	P51156.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000004249; ENSRNOP00000004249; ENSRNOG00000042086.
GeneID	171111.
KEGG	rno:171111.
UCSC	RGD:620890. rat.
Organism-specific databases
CTD	25837.
RGD	620890. Rab26.
Phylogenomic databases
eggNOG	COG1100.
GeneTree	ENSGT00700000104031.
HOGENOM	HOG000233968.
HOVERGEN	HBG009351.
KO	K07913.
Gene expression databases
ArrayExpress	P51156.
Genevestigator	P51156.
GermOnline	ENSRNOG00000003131. Rattus norvegicus.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	621820.

Entry information

Entry name

RAB26_RAT

Accession

Primary (citable) accession number: P51156
Secondary accession number(s): Q6P6W7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	September 27, 2005
Last modified:	May 1, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program