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Protein

Ras-related protein Rab-26

Gene

Rab26

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach (By similarity). Plays a role in the secretion of amylase from acinar granules in the parotid gland.By similarity2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi71 – 799GTPBy similarity
Nucleotide bindingi120 – 1245GTPBy similarity
Nucleotide bindingi178 – 1814GTPBy similarity
Nucleotide bindingi208 – 2103GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: GO_Central
  2. GMP binding Source: UniProtKB
  3. GTPase activity Source: RGD
  4. GTP binding Source: UniProtKB

GO - Biological processi

  1. exocrine system development Source: UniProtKB
  2. Golgi to plasma membrane protein transport Source: UniProtKB
  3. GTP catabolic process Source: GOC
  4. intracellular protein transport Source: GO_Central
  5. protein localization to plasma membrane Source: GO_Central
  6. protein secretion Source: GO_Central
  7. Rab protein signal transduction Source: GO_Central
  8. regulated secretory pathway Source: UniProtKB
  9. regulation of exocytosis Source: UniProtKB
  10. vesicle docking involved in exocytosis Source: GO_Central
  11. vesicle-mediated transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-26
Gene namesi
Name:Rab26
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi620890. Rab26.

Subcellular locationi

Cytoplasmic vesiclesecretory vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
Note: Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location (By similarity). Localized immediately around secretory granules in the acinar cells of the parotid gland. Not localized in plasma membranes.By similarity

GO - Cellular componenti

  1. endosome Source: GO_Central
  2. Golgi membrane Source: UniProtKB
  3. intrinsic component of plasma membrane Source: UniProtKB
  4. secretory granule membrane Source: UniProtKB
  5. transport vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Ras-related protein Rab-26PRO_0000121220Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi254 – 2541S-geranylgeranyl cysteineBy similarity
Lipidationi255 – 2551S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

PaxDbiP51156.
PRIDEiP51156.

PTM databases

PhosphoSiteiP51156.

Expressioni

Tissue specificityi

Expressed in pancreas, kidney, brain, submandibular gland, and lung.1 Publication

Gene expression databases

GenevestigatoriP51156.

Interactioni

Subunit structurei

Interacts with ADRA2B. Interacts with RIMS1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004249.

Structurei

3D structure databases

ProteinModelPortaliP51156.
SMRiP51156. Positions 59-228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi94 – 1029Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118937.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP51156.
KOiK07913.
OMAiNKVDSAH.
OrthoDBiEOG7Q2N5Z.
PhylomeDBiP51156.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51156-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRKKTPKSK GGSVPAASTL PAAANGPRLA HPRTARPGPE APPNGPPQSG
60 70 80 90 100
RPSLGGTGDF YDVAFKVMLV GDSGVGKTCL LVRFKDGAFL AGTFISTVGI
110 120 130 140 150
DFRNKVLDVD GMKVKLQIWD TAGQERFRSV THAYYRDAHA LLLLYDITNK
160 170 180 190 200
DSFDNIQAWL TEIQEYAQQD VVLMLLGNKV DSTQERVVKR EDGEKLAKEY
210 220 230 240 250
GLPFMETSAK SGLNVDLAFT AIAKELKQRS TKAPSEPRFR LHDYVKREGR

GVSCCRL
Length:257
Mass (Da):28,203
Last modified:September 27, 2005 - v2
Checksum:i3C4A12A2B8333474
GO

Sequence cautioni

The sequence AAA69955.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061984 mRNA. Translation: AAH61984.1.
U18771 mRNA. Translation: AAA69955.1. Different initiation.
PIRiJC2528.
RefSeqiNP_598264.1. NM_133580.1.
UniGeneiRn.10975.

Genome annotation databases

EnsembliENSRNOT00000004249; ENSRNOP00000004249; ENSRNOG00000042086.
GeneIDi171111.
KEGGirno:171111.
UCSCiRGD:620890. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061984 mRNA. Translation: AAH61984.1.
U18771 mRNA. Translation: AAA69955.1. Different initiation.
PIRiJC2528.
RefSeqiNP_598264.1. NM_133580.1.
UniGeneiRn.10975.

3D structure databases

ProteinModelPortaliP51156.
SMRiP51156. Positions 59-228.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004249.

PTM databases

PhosphoSiteiP51156.

Proteomic databases

PaxDbiP51156.
PRIDEiP51156.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004249; ENSRNOP00000004249; ENSRNOG00000042086.
GeneIDi171111.
KEGGirno:171111.
UCSCiRGD:620890. rat.

Organism-specific databases

CTDi25837.
RGDi620890. Rab26.

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118937.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP51156.
KOiK07913.
OMAiNKVDSAH.
OrthoDBiEOG7Q2N5Z.
PhylomeDBiP51156.

Miscellaneous databases

NextBioi621820.
PROiP51156.

Gene expression databases

GenevestigatoriP51156.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  2. "Molecular cloning of a new member of the Rab protein family, Rab 26, from rat pancreas."
    Wagner A.C.C., Strowski M.Z., Goeke B., Williams J.A.
    Biochem. Biophys. Res. Commun. 207:950-956(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 63-257, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Pancreas.
  3. "Expression, characterization, and localization of Rab26, a low molecular weight GTP-binding protein, in the rat parotid gland."
    Yoshie S., Imai A., Nashida T., Shimomura H.
    Histochem. Cell Biol. 113:259-263(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Parotid gland.
  4. "Relation of Rab26 to the amylase release from rat parotid acinar cells."
    Nashida T., Imai A., Shimomura H.
    Arch. Oral Biol. 51:89-95(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiRAB26_RAT
AccessioniPrimary (citable) accession number: P51156
Secondary accession number(s): Q6P6W7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 27, 2005
Last modified: February 4, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.