Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P51156

- RAB26_RAT

UniProt

P51156 - RAB26_RAT

Protein

Ras-related protein Rab-26

Gene

Rab26

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (27 Sep 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach By similarity. Plays a role in the secretion of amylase from acinar granules in the parotid gland.By similarity2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi71 – 799GTPBy similarity
    Nucleotide bindingi120 – 1245GTPBy similarity
    Nucleotide bindingi178 – 1814GTPBy similarity
    Nucleotide bindingi208 – 2103GTPBy similarity

    GO - Molecular functioni

    1. GMP binding Source: UniProtKB
    2. GTPase activity Source: RGD
    3. GTP binding Source: UniProtKB

    GO - Biological processi

    1. exocrine system development Source: UniProtKB
    2. Golgi to plasma membrane protein transport Source: UniProtKB
    3. GTP catabolic process Source: GOC
    4. regulated secretory pathway Source: UniProtKB
    5. regulation of exocytosis Source: UniProtKB
    6. small GTPase mediated signal transduction Source: InterPro
    7. vesicle-mediated transport Source: RGD

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-26
    Gene namesi
    Name:Rab26
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi620890. Rab26.

    Subcellular locationi

    Cytoplasmic vesiclesecretory vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
    Note: Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location By similarity. Localized immediately around secretory granules in the acinar cells of the parotid gland. Not localized in plasma membranes.By similarity

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB
    2. intrinsic component of plasma membrane Source: UniProtKB
    3. secretory granule membrane Source: UniProtKB
    4. transport vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257Ras-related protein Rab-26PRO_0000121220Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi254 – 2541S-geranylgeranyl cysteineBy similarity
    Lipidationi255 – 2551S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Prenylation

    Proteomic databases

    PaxDbiP51156.
    PRIDEiP51156.

    PTM databases

    PhosphoSiteiP51156.

    Expressioni

    Tissue specificityi

    Expressed in pancreas, kidney, brain, submandibular gland, and lung.1 Publication

    Gene expression databases

    GenevestigatoriP51156.

    Interactioni

    Subunit structurei

    Interacts with ADRA2B. Interacts with RIMS1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000004249.

    Structurei

    3D structure databases

    ProteinModelPortaliP51156.
    SMRiP51156. Positions 59-228.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi94 – 1029Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00750000117504.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    KOiK07913.
    OMAiNKVDSAH.
    OrthoDBiEOG7Q2N5Z.
    PhylomeDBiP51156.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51156-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRKKTPKSK GGSVPAASTL PAAANGPRLA HPRTARPGPE APPNGPPQSG    50
    RPSLGGTGDF YDVAFKVMLV GDSGVGKTCL LVRFKDGAFL AGTFISTVGI 100
    DFRNKVLDVD GMKVKLQIWD TAGQERFRSV THAYYRDAHA LLLLYDITNK 150
    DSFDNIQAWL TEIQEYAQQD VVLMLLGNKV DSTQERVVKR EDGEKLAKEY 200
    GLPFMETSAK SGLNVDLAFT AIAKELKQRS TKAPSEPRFR LHDYVKREGR 250
    GVSCCRL 257
    Length:257
    Mass (Da):28,203
    Last modified:September 27, 2005 - v2
    Checksum:i3C4A12A2B8333474
    GO

    Sequence cautioni

    The sequence AAA69955.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC061984 mRNA. Translation: AAH61984.1.
    U18771 mRNA. Translation: AAA69955.1. Different initiation.
    PIRiJC2528.
    RefSeqiNP_598264.1. NM_133580.1.
    UniGeneiRn.10975.

    Genome annotation databases

    EnsembliENSRNOT00000004249; ENSRNOP00000004249; ENSRNOG00000042086.
    GeneIDi171111.
    KEGGirno:171111.
    UCSCiRGD:620890. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC061984 mRNA. Translation: AAH61984.1 .
    U18771 mRNA. Translation: AAA69955.1 . Different initiation.
    PIRi JC2528.
    RefSeqi NP_598264.1. NM_133580.1.
    UniGenei Rn.10975.

    3D structure databases

    ProteinModelPortali P51156.
    SMRi P51156. Positions 59-228.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000004249.

    PTM databases

    PhosphoSitei P51156.

    Proteomic databases

    PaxDbi P51156.
    PRIDEi P51156.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000004249 ; ENSRNOP00000004249 ; ENSRNOG00000042086 .
    GeneIDi 171111.
    KEGGi rno:171111.
    UCSCi RGD:620890. rat.

    Organism-specific databases

    CTDi 25837.
    RGDi 620890. Rab26.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00750000117504.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    KOi K07913.
    OMAi NKVDSAH.
    OrthoDBi EOG7Q2N5Z.
    PhylomeDBi P51156.

    Miscellaneous databases

    NextBioi 621820.
    PROi P51156.

    Gene expression databases

    Genevestigatori P51156.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    2. "Molecular cloning of a new member of the Rab protein family, Rab 26, from rat pancreas."
      Wagner A.C.C., Strowski M.Z., Goeke B., Williams J.A.
      Biochem. Biophys. Res. Commun. 207:950-956(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 63-257, TISSUE SPECIFICITY.
      Strain: Sprague-Dawley.
      Tissue: Pancreas.
    3. "Expression, characterization, and localization of Rab26, a low molecular weight GTP-binding protein, in the rat parotid gland."
      Yoshie S., Imai A., Nashida T., Shimomura H.
      Histochem. Cell Biol. 113:259-263(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
      Tissue: Parotid gland.
    4. "Relation of Rab26 to the amylase release from rat parotid acinar cells."
      Nashida T., Imai A., Shimomura H.
      Arch. Oral Biol. 51:89-95(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiRAB26_RAT
    AccessioniPrimary (citable) accession number: P51156
    Secondary accession number(s): Q6P6W7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3