ID   RAB9A_HUMAN             Reviewed;         201 AA.
AC   P51151; A8K390; Q6ICN1;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-JAN-2012, entry version 124.
DE   RecName: Full=Ras-related protein Rab-9A;
GN   Name=RAB9A; Synonyms=RAB9;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=97271569; PubMed=9126495; DOI=10.1006/geno.1997.4644;
RA   Davies J.P., Cotter P.D., Ioannou Y.A.;
RT   "Cloning and mapping of human Rab7 and Rab9 cDNA sequences and
RT   identification of a Rab9 pseudogene.";
RL   Genomics 41:131-134(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RA   Puhl H.L. III, Ikeda S.R., Aronstam R.S.;
RT   "cDNA clones of human proteins involved in signal transduction
RT   sequenced by the Guthrie cDNA resource center (www.cdna.org).";
RL   Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Cervix carcinoma;
RX   PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA   Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,
RA   Mann M.;
RT   "Global, in vivo, and site-specific phosphorylation dynamics in
RT   signaling networks.";
RL   Cell 127:635-648(2006).
RN   [8]
RP   INTERACTION WITH GCC2.
RX   PubMed=16885419; DOI=10.1091/mbc.E06-02-0153;
RA   Reddy J.V., Burguete A.S., Sridevi K., Ganley I.G., Nottingham R.M.,
RA   Pfeffer S.R.;
RT   "A functional role for the GCC185 golgin in mannose 6-phosphate
RT   receptor recycling.";
RL   Mol. Biol. Cell 17:4353-4363(2006).
RN   [9]
RP   INTERACTION WITH GCC2.
RX   PubMed=18243103; DOI=10.1016/j.cell.2007.11.048;
RA   Burguete A.S., Fenn T.D., Brunger A.T., Pfeffer S.R.;
RT   "Rab and Arl GTPase family members cooperate in the localization of
RT   the golgin GCC185.";
RL   Cell 132:286-298(2008).
RN   [10]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [11]
RP   X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) OF 1-177 IN COMPLEX WITH GDP.
RX   PubMed=15263003; DOI=10.1074/jbc.M407114200;
RA   Chen L., DiGiammarino E., Zhou X.E., Wang Y., Toh D., Hodge T.W.,
RA   Meehan E.J.;
RT   "High resolution crystal structure of human Rab9 GTPase: a novel
RT   antiviral drug target.";
RL   J. Biol. Chem. 279:40204-40208(2004).
CC   -!- FUNCTION: Involved in the transport of proteins between the
CC       endosomes and the trans Golgi network.
CC   -!- SUBUNIT: Interacts (preferentially in its GTP-bound form) with
CC       GCC2 (via its GRIP domain).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic
CC       side (Potential). Endoplasmic reticulum membrane (Potential).
CC       Golgi apparatus membrane (Potential).
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
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DR   EMBL; U44103; AAC51200.1; -; mRNA.
DR   EMBL; AF498944; AAM21092.1; -; mRNA.
DR   EMBL; CR450362; CAG29358.1; -; mRNA.
DR   EMBL; AK290505; BAF83194.1; -; mRNA.
DR   EMBL; CH471074; EAW98826.1; -; Genomic_DNA.
DR   EMBL; BC017265; AAH17265.1; -; mRNA.
DR   IPI; IPI00016372; -.
DR   PIR; G02361; G02361.
DR   RefSeq; NP_001182257.1; NM_001195328.1.
DR   RefSeq; NP_004242.1; NM_004251.4.
DR   UniGene; Hs.495704; -.
DR   UniGene; Hs.728400; -.
DR   PDB; 1WMS; X-ray; 1.25 A; A/B=1-177.
DR   PDBsum; 1WMS; -.
DR   ProteinModelPortal; P51151; -.
DR   SMR; P51151; 1-173.
DR   DIP; DIP-46409N; -.
DR   STRING; P51151; -.
DR   PhosphoSite; P51151; -.
DR   DMDM; 1710003; -.
DR   PeptideAtlas; P51151; -.
DR   PRIDE; P51151; -.
DR   Ensembl; ENST00000464506; ENSP00000420127; ENSG00000123595.
DR   GeneID; 9367; -.
DR   KEGG; hsa:9367; -.
DR   UCSC; uc004cvm.1; human.
DR   CTD; 9367; -.
DR   GeneCards; GC0XP013707; -.
DR   H-InvDB; HIX0203301; -.
DR   HGNC; HGNC:9792; RAB9A.
DR   HPA; CAB016411; -.
DR   HPA; HPA003094; -.
DR   MIM; 300284; gene.
DR   neXtProt; NX_P51151; -.
DR   PharmGKB; PA34152; -.
DR   eggNOG; prNOG06590; -.
DR   GeneTree; ENSGT00600000084038; -.
DR   HOGENOM; HBG745225; -.
DR   HOVERGEN; HBG009351; -.
DR   InParanoid; P51151; -.
DR   OMA; VDISERQ; -.
DR   OrthoDB; EOG4R7VBS; -.
DR   PhylomeDB; P51151; -.
DR   NextBio; 35080; -.
DR   ArrayExpress; P51151; -.
DR   Bgee; P51151; -.
DR   CleanEx; HS_RAB9A; -.
DR   Genevestigator; P51151; -.
DR   GermOnline; ENSG00000123595; Homo sapiens.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005770; C:late endosome; IDA:MGI.
DR   GO; GO:0005764; C:lysosome; IDA:MGI.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019003; F:GDP binding; IDA:UniProtKB.
DR   GO; GO:0005525; F:GTP binding; IDA:UniProtKB.
DR   GO; GO:0003924; F:GTPase activity; IDA:UniProtKB.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0045921; P:positive regulation of exocytosis; IMP:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003579; Small_GTPase_Rab_type.
DR   KO; K07899; -.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00175; RAB; 1.
DR   TIGRFAMs; TIGR00231; Small_GTP; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell membrane; Complete proteome; Endoplasmic reticulum;
KW   Golgi apparatus; GTP-binding; Lipoprotein; Membrane;
KW   Nucleotide-binding; Phosphoprotein; Prenylation; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN         1    201       Ras-related protein Rab-9A.
FT                                /FTId=PRO_0000121139.
FT   NP_BIND      14     22       GTP.
FT   NP_BIND      62     66       GTP (By similarity).
FT   NP_BIND     124    127       GTP.
FT   NP_BIND     154    156       GTP.
FT   MOTIF        36     44       Effector region (By similarity).
FT   MOD_RES     179    179       Phosphoserine.
FT   LIPID       200    200       S-geranylgeranyl cysteine (By
FT                                similarity).
FT   LIPID       201    201       S-geranylgeranyl cysteine (By
FT                                similarity).
FT   STRAND        5     13
FT   HELIX        20     29
FT   STRAND       41     51
FT   STRAND       54     62
FT   HELIX        67     69
FT   HELIX        70     73
FT   HELIX        74     77
FT   STRAND       81     88
FT   HELIX        92     96
FT   HELIX        98    109
FT   TURN        114    116
FT   STRAND      119    124
FT   HELIX       135    144
FT   STRAND      150    152
FT   TURN        155    157
FT   HELIX       161    173
SQ   SEQUENCE   201 AA;  22838 MW;  65B502C21E97DB72 CRC64;
     MAGKSSLFKV ILLGDGGVGK SSLMNRYVTN KFDTQLFHTI GVEFLNKDLE VDGHFVTMQI
     WDTAGQERFR SLRTPFYRGS DCCLLTFSVD DSQSFQNLSN WKKEFIYYAD VKEPESFPFV
     ILGNKIDISE RQVSTEEAQA WCRDNGDYPY FETSAKDATN VAAAFEEAVR RVLATEDRSD
     HLIQTDTVNL HRKPKPSSSC C
//