P51151 (RAB9A_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 137.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ras-related protein Rab-9A | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Reference proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 201 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Involved in the transport of proteins between the endosomes and the trans Golgi network. |
| Subunit structure | Interacts (preferentially in its GTP-bound form) with GCC2 (via its GRIP domain). Ref.9 Ref.10 |
| Subcellular location | Cell membrane; Lipid-anchor; Cytoplasmic side Potential. Endoplasmic reticulum membrane Potential. Golgi apparatus membrane Potential. Late endosome. Cytoplasmic vesicle › phagosome membrane; Lipid-anchor; Cytoplasmic side By similarity. Cytoplasmic vesicle › phagosome. Note: Co-localizes with OSBPL1A at the late endosome. Recruited to phagosomes containing S.aureus or M.tuberculosis. Ref.7 Ref.14 |
| Sequence similarities | Belongs to the small GTPase superfamily. Rab family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 201 | 201 | Ras-related protein Rab-9A | PRO_0000121139 | |||||||||||||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||||||||||||
| Nucleotide binding | 14 – 22 | 9 | GTP | ||||||||||||||||||||||||||||||||||||
| Nucleotide binding | 62 – 66 | 5 | GTP By similarity | ||||||||||||||||||||||||||||||||||||
| Nucleotide binding | 124 – 127 | 4 | GTP | ||||||||||||||||||||||||||||||||||||
| Nucleotide binding | 154 – 156 | 3 | GTP | ||||||||||||||||||||||||||||||||||||
| Motif | 36 – 44 | 9 | Effector region By similarity | ||||||||||||||||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||||||||||||||||
| Modified residue | 179 | 1 | Phosphoserine Ref.8 | ||||||||||||||||||||||||||||||||||||
| Lipidation | 200 | 1 | S-geranylgeranyl cysteine By similarity | ||||||||||||||||||||||||||||||||||||
| Lipidation | 201 | 1 | S-geranylgeranyl cysteine By similarity | ||||||||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||||||||
| Beta strand | 5 – 13 | 9 | |||||||||||||||||||||||||||||||||||||
| Helix | 20 – 29 | 10 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 41 – 51 | 11 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 54 – 62 | 9 | |||||||||||||||||||||||||||||||||||||
| Helix | 67 – 69 | 3 | |||||||||||||||||||||||||||||||||||||
| Helix | 70 – 73 | 4 | |||||||||||||||||||||||||||||||||||||
| Helix | 74 – 77 | 4 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 81 – 88 | 8 | |||||||||||||||||||||||||||||||||||||
| Helix | 92 – 96 | 5 | |||||||||||||||||||||||||||||||||||||
| Helix | 98 – 109 | 12 | |||||||||||||||||||||||||||||||||||||
| Turn | 114 – 116 | 3 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 119 – 124 | 6 | |||||||||||||||||||||||||||||||||||||
| Helix | 135 – 144 | 10 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 150 – 152 | 3 | |||||||||||||||||||||||||||||||||||||
| Turn | 155 – 157 | 3 | |||||||||||||||||||||||||||||||||||||
| Helix | 161 – 173 | 13 | |||||||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene." Davies J.P., Cotter P.D., Ioannou Y.A. Genomics 41:131-134(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [3] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [5] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle. |
| [7] | "The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments." Johansson M., Lehto M., Tanhuanpaeae K., Cover T.L., Olkkonen V.M. Mol. Biol. Cell 16:5480-5492(2005) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION. |
| [8] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [9] | "A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling." Reddy J.V., Burguete A.S., Sridevi K., Ganley I.G., Nottingham R.M., Pfeffer S.R. Mol. Biol. Cell 17:4353-4363(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH GCC2. |
| [10] | "Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185." Burguete A.S., Fenn T.D., Brunger A.T., Pfeffer S.R. Cell 132:286-298(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH GCC2. |
| [11] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma. |
| [12] | "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma. |
| [13] | "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
| [14] | "Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes." Seto S., Tsujimura K., Koide Y. Traffic 12:407-420(2011) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION. |
| [15] | "High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target." Chen L., DiGiammarino E., Zhou X.E., Wang Y., Toh D., Hodge T.W., Meehan E.J. J. Biol. Chem. 279:40204-40208(2004) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) OF 1-177 IN COMPLEX WITH GDP. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | U44103 mRNA. Translation: AAC51200.1. AF498944 mRNA. Translation: AAM21092.1. CR450362 mRNA. Translation: CAG29358.1. AK290505 mRNA. Translation: BAF83194.1. CH471074 Genomic DNA. Translation: EAW98826.1. BC017265 mRNA. Translation: AAH17265.1. | ||||||||||||
| IPI | IPI00016372. | ||||||||||||
| PIR | G02361. | ||||||||||||
| RefSeq | NP_001182257.1. NM_001195328.1. NP_004242.1. NM_004251.4. | ||||||||||||
| UniGene | Hs.495704. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
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| ProteinModelPortal | P51151. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| DIP | DIP-46409N. | ||||||||||||
| STRING | 9606.ENSP00000420127. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | P51151. | ||||||||||||
Polymorphism databases | |||||||||||||
| DMDM | 1710003. | ||||||||||||
Proteomic databases | |||||||||||||
| PaxDb | P51151. | ||||||||||||
| PeptideAtlas | P51151. | ||||||||||||
| PRIDE | P51151. | ||||||||||||
Protocols and materials databases | |||||||||||||
| DNASU | 9367. | ||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000464506; ENSP00000420127; ENSG00000123595. | ||||||||||||
| GeneID | 9367. | ||||||||||||
| KEGG | hsa:9367. | ||||||||||||
| UCSC | uc004cvm.3. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 9367. | ||||||||||||
| GeneCards | GC0XP013707. | ||||||||||||
| HGNC | HGNC:9792. RAB9A. | ||||||||||||
| HPA | CAB016411. HPA003094. | ||||||||||||
| MIM | 300284. gene. | ||||||||||||
| neXtProt | NX_P51151. | ||||||||||||
| PharmGKB | PA34152. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | COG1100. | ||||||||||||
| HOGENOM | HOG000233968. | ||||||||||||
| HOVERGEN | HBG009351. | ||||||||||||
| InParanoid | P51151. | ||||||||||||
| KO | K07899. | ||||||||||||
| OMA | LIPTDTV. | ||||||||||||
| OrthoDB | EOG4R7VBS. | ||||||||||||
| PhylomeDB | P51151. | ||||||||||||
Gene expression databases | |||||||||||||
| Bgee | P51151. | ||||||||||||
| CleanEx | HS_RAB9A. | ||||||||||||
| Genevestigator | P51151. | ||||||||||||
| GermOnline | ENSG00000123595. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view] | ||||||||||||
| Pfam | PF00071. Ras. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR00449. RASTRNSFRMNG. | ||||||||||||
| SMART | SM00175. RAB. 1 hit. [Graphical view] | ||||||||||||
| TIGRFAMs | TIGR00231. small_GTP. 1 hit. | ||||||||||||
| PROSITE | PS51419. RAB. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other | |||||||||||||
| ChEMBL | CHEMBL1293294. | ||||||||||||
| EvolutionaryTrace | P51151. | ||||||||||||
| GenomeRNAi | 9367. | ||||||||||||
| NextBio | 35080. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | RAB9A_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P51151 Secondary accession number(s): A8K390, Q6ICN1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with
