Reviewed,
UniProtKB/Swiss-Prot P51151 (RAB9A_HUMAN)
Last modified
June 16, 2009.
Version 96.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ras-related protein Rab-9A Short name=Rab-9A | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 201 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Involved in the transport of proteins between the endosomes and the trans Golgi network. |
| Subcellular location | Cell membrane; Lipid-anchor; Cytoplasmic side Potential. Endoplasmic reticulum membrane Potential. Golgi apparatus membrane Potential. |
| Sequence similarities | Belongs to the small GTPase superfamily. Rab family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein transport Transport |
| Cellular component | Cell membrane Endoplasmic reticulum Golgi apparatus Membrane |
| Ligand | GTP-binding Nucleotide-binding |
| PTM | Lipoprotein Phosphoprotein Prenylation |
| Technical term | 3D-structure |
| Gene Ontology (GO) | |
| Biological process | protein transport Inferred from electronic annotation. Source: UniProtKB-KW small GTPase mediated signal transductionInferred from electronic annotation. Source: InterPro |
| Cellular component | Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum membraneInferred from electronic annotation. Source: UniProtKB-SubCell late endosomeInferred from direct assay. Source: MGI lysosomeInferred from direct assay. Source: MGI plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Ref.1Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 201 | 201 | Ras-related protein Rab-9A | PRO_0000121139 | |||||||||||||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||||||||||||
| Nucleotide binding | 14 – 21 | 8 | GTP By similarity | ||||||||||||||||||||||||||||||||||||
| Nucleotide binding | 62 – 66 | 5 | GTP By similarity | ||||||||||||||||||||||||||||||||||||
| Nucleotide binding | 124 – 127 | 4 | GTP By similarity | ||||||||||||||||||||||||||||||||||||
| Motif | 36 – 44 | 9 | Effector region By similarity | ||||||||||||||||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||||||||||||||||
| Modified residue | 179 | 1 | Phosphoserine Ref.5 | ||||||||||||||||||||||||||||||||||||
| Lipidation | 200 | 1 | S-geranylgeranyl cysteine By similarity | ||||||||||||||||||||||||||||||||||||
| Lipidation | 201 | 1 | S-geranylgeranyl cysteine By similarity | ||||||||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||||||||
| Beta strand | 5 – 13 | 9 | |||||||||||||||||||||||||||||||||||||
| Helix | 20 – 29 | 10 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 41 – 51 | 11 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 54 – 62 | 9 | |||||||||||||||||||||||||||||||||||||
| Helix | 67 – 69 | 3 | |||||||||||||||||||||||||||||||||||||
| Helix | 70 – 73 | 4 | |||||||||||||||||||||||||||||||||||||
| Helix | 74 – 77 | 4 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 81 – 88 | 8 | |||||||||||||||||||||||||||||||||||||
| Helix | 92 – 96 | 5 | |||||||||||||||||||||||||||||||||||||
| Helix | 98 – 109 | 12 | |||||||||||||||||||||||||||||||||||||
| Turn | 114 – 116 | 3 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 119 – 124 | 6 | |||||||||||||||||||||||||||||||||||||
| Helix | 135 – 144 | 10 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 150 – 152 | 3 | |||||||||||||||||||||||||||||||||||||
| Turn | 155 – 157 | 3 | |||||||||||||||||||||||||||||||||||||
| Helix | 161 – 173 | 13 | |||||||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene." Davies J.P., Cotter P.D., Ioannou Y.A. Genomics 41:131-134(1997) [PubMed: 9126495] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [3] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle. |
| [5] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179, MASS SPECTROMETRY. Tissue: Epithelium. |
| [6] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| U44103 mRNA. Translation: AAC51200.1. AF498944 mRNA. Translation: AAM21092.1. CR450362 mRNA. Translation: CAG29358.1. BC017265 mRNA. Translation: AAH17265.1. | |||||||||||||
| IPI | IPI00016372. | ||||||||||||
| PIR | G02361. | ||||||||||||
| RefSeq | NP_004242.1. | ||||||||||||
| UniGene | Hs.495704 | ||||||||||||
3D structure databases | |||||||||||||
| |||||||||||||
| ModBase | Search... | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | P51151. | ||||||||||||
Proteomic databases | |||||||||||||
| PeptideAtlas | P51151. | ||||||||||||
| PRIDE | P51151. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSG00000123595. Homo sapiens. [Contig view] | ||||||||||||
| GeneID | 9367. | ||||||||||||
| KEGG | hsa:9367. | ||||||||||||
Organism-specific databases | |||||||||||||
| GeneCards | GC0XP013617. | ||||||||||||
| H-InvDB | HIX0020661. | ||||||||||||
| HGNC | HGNC:9792. RAB9A. | ||||||||||||
| HPA | CAB016411. HPA003094. | ||||||||||||
| MIM | 300284. gene. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOVERGEN | P51151. | ||||||||||||
| OMA | P51151. VDISERQ. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | P51151. | ||||||||||||
| Bgee | P51151. | ||||||||||||
| CleanEx | HS_RAB9A. | ||||||||||||
| GermOnline | ENSG00000123595. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR003579. GTPase_Rab. IPR013753. Ras. IPR001806. Ras_GTPase. IPR005225. Small_GTP_bd. [Graphical view] | ||||||||||||
| Pfam | PF00071. Ras. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR00449. RASTRNSFRMNG. | ||||||||||||
| SMART | SM00175. RAB. 1 hit. [Graphical view] | ||||||||||||
| TIGRFAMs | TIGR00231. small_GTP. 1 hit. | ||||||||||||
| PROSITE | PS51419. RAB. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 35080. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | RAB9A_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P51151 Secondary accession number(s): Q6ICN1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


