Ras-related protein Rab-9A - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot P51151 (RAB9A_HUMAN)

Last modified June 16, 2009. Version 96. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Ras-related protein Rab-9A
Short name=Rab-9A

Gene names

Name:	RAB9A
Synonyms:	RAB9

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Involved in the transport of proteins between the endosomes and the trans Golgi network.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential. Endoplasmic reticulum membrane Potential. Golgi apparatus membrane Potential.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

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Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cell membrane Endoplasmic reticulum Golgi apparatus Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Phosphoprotein Prenylation
Technical term	3D-structure
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell late endosome Inferred from direct assay. Source: MGI lysosome Inferred from direct assay. Source: MGI plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 201

201

Ras-related protein Rab-9A

PRO_0000121139

Regions

Nucleotide binding

14 – 21

GTP By similarity

Nucleotide binding

62 – 66

GTP By similarity

Nucleotide binding

124 – 127

GTP By similarity

Motif

36 – 44

Effector region By similarity

Amino acid modifications

Modified residue

179

Phosphoserine Ref.5

Lipidation

200

S-geranylgeranyl cysteine By similarity

Lipidation

201

S-geranylgeranyl cysteine By similarity

Secondary structure

201

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

P51151-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 65B502C21E97DB72
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FASTA

201

22,838

        10         20         30         40         50         60 
MAGKSSLFKV ILLGDGGVGK SSLMNRYVTN KFDTQLFHTI GVEFLNKDLE VDGHFVTMQI 

        70         80         90        100        110        120 
WDTAGQERFR SLRTPFYRGS DCCLLTFSVD DSQSFQNLSN WKKEFIYYAD VKEPESFPFV 

       130        140        150        160        170        180 
ILGNKIDISE RQVSTEEAQA WCRDNGDYPY FETSAKDATN VAAAFEEAVR RVLATEDRSD 

       190        200 
HLIQTDTVNL HRKPKPSSSC C

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene." Davies J.P., Cotter P.D., Ioannou Y.A. Genomics 41:131-134(1997) [PubMed: 9126495] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
[5]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179, MASS SPECTROMETRY. Tissue: Epithelium.
[6]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

U44103 mRNA. Translation: AAC51200.1.
AF498944 mRNA. Translation: AAM21092.1.
CR450362 mRNA. Translation: CAG29358.1.
BC017265 mRNA. Translation: AAH17265.1.

IPI

IPI00016372.

PIR

G02361.

RefSeq

NP_004242.1.

UniGene

Hs.495704

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WMS	X-ray	1.25	A/B	1-177	[»]

ModBase

Search...

PTM databases

PhosphoSite

P51151.

Proteomic databases

PeptideAtlas

P51151.

PRIDE

P51151.

Genome annotation databases

Ensembl

ENSG00000123595. Homo sapiens. [Contig view]

GeneID

9367.

KEGG

hsa:9367.

Organism-specific databases

GeneCards

GC0XP013617.

H-InvDB

HIX0020661.

HGNC

HGNC:9792. RAB9A.

HPA

CAB016411.
HPA003094.

MIM

300284. gene.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

P51151.

OMA

P51151. VDISERQ.

Gene expression databases

ArrayExpress

P51151.

Bgee

P51151.

CleanEx

HS_RAB9A.

GermOnline

ENSG00000123595. Homo sapiens.

Family and domain databases

InterPro

IPR003579. GTPase_Rab.
IPR013753. Ras.
IPR001806. Ras_GTPase.
IPR005225. Small_GTP_bd.
[Graphical view]

Pfam

PF00071. Ras. 1 hit.
[Graphical view]

PRINTS

PR00449. RASTRNSFRMNG.

SMART

SM00175. RAB. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00231. small_GTP. 1 hit.

PROSITE

PS51419. RAB. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

35080.

SOURCE

Search...

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Entry information

Entry name

RAB9A_HUMAN

Accession

Primary (citable) accession number: P51151
Secondary accession number(s): Q6ICN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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