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Protein

Ras-related protein Rab-9A

Gene

RAB9A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transport of proteins between the endosomes and the trans Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei155GTP; via amide nitrogenCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 22GTPCombined sources1 Publication9
Nucleotide bindingi62 – 66GTPBy similarity5
Nucleotide bindingi124 – 127GTPCombined sources1 Publication4

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB

GO - Biological processi

  • negative regulation by host of symbiont molecular function Source: AgBase
  • positive regulation of exocytosis Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • regulation of protein localization Source: AgBase
  • retrograde transport, endosome to Golgi Source: GO_Central
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123595-MONOMER.
ReactomeiR-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.
R-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-9A
Gene namesi
Name:RAB9A
Synonyms:RAB9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:9792. RAB9A.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • late endosome Source: MGI
  • lysosome Source: MGI
  • melanosome Source: UniProtKB
  • phagocytic vesicle Source: UniProtKB
  • phagocytic vesicle membrane Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB-SubCell
  • trans-Golgi network membrane Source: Reactome
  • transport vesicle Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi40I → L: Loss of interaction with HPS4; when associated with L-66. 1 Publication1
Mutagenesisi44F → L: Loss of interaction with HPS4; when associated with L-66. 1 Publication1
Mutagenesisi61W → L: Loss of interaction with HPS4; when associated with L-66. 1 Publication1
Mutagenesisi66Q → L: Loss of interaction with HPS4; when associated with L-40 or L-44 or L-61. 1 Publication1

Organism-specific databases

DisGeNETi9367.
OpenTargetsiENSG00000123595.
PharmGKBiPA34152.

Chemistry databases

ChEMBLiCHEMBL1293294.
DrugBankiDB03793. Benzoic Acid.

Polymorphism and mutation databases

BioMutaiRAB9A.
DMDMi1710003.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001211392 – 201Ras-related protein Rab-9AAdd BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei179PhosphoserineCombined sources1
Modified residuei187PhosphothreonineCombined sources1
Lipidationi200S-geranylgeranyl cysteineBy similarity1
Lipidationi201S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

EPDiP51151.
MaxQBiP51151.
PaxDbiP51151.
PeptideAtlasiP51151.
PRIDEiP51151.

PTM databases

iPTMnetiP51151.
PhosphoSitePlusiP51151.

Expressioni

Gene expression databases

BgeeiENSG00000123595.
CleanExiHS_RAB9A.
ExpressionAtlasiP51151. baseline and differential.
GenevisibleiP51151. HS.

Organism-specific databases

HPAiCAB016411.
HPA003094.

Interactioni

Subunit structurei

Interacts (preferentially in its GTP-bound form) with GCC2 (via its GRIP domain) (PubMed:18243103, PubMed:16885419). Interacts (GTP-bound form) with SGSM1; the GDP-bound form has much lower affinity for SGSM1 (PubMed:22637480). Interacts with SGSM2 (PubMed:21808068). The GTP-bound form but not the GDP-bound form interacts with HPS4 and BLOC-3 complex (heterodimer of HPS1 and HPS4) but does not interact with HPS1 alone (PubMed:20048159).5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NISCHQ9Y2I15EBI-4401353,EBI-2688731
PLEKHM2Q8IWE54EBI-4401353,EBI-726484

Protein-protein interaction databases

BioGridi114768. 25 interactors.
DIPiDIP-46409N.
IntActiP51151. 7 interactors.
STRINGi9606.ENSP00000420127.

Structurei

Secondary structure

1201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 13Combined sources9
Helixi20 – 29Combined sources10
Beta strandi41 – 51Combined sources11
Beta strandi54 – 62Combined sources9
Helixi67 – 69Combined sources3
Helixi70 – 73Combined sources4
Helixi74 – 77Combined sources4
Beta strandi81 – 88Combined sources8
Helixi92 – 96Combined sources5
Helixi98 – 109Combined sources12
Turni114 – 116Combined sources3
Beta strandi119 – 124Combined sources6
Helixi135 – 144Combined sources10
Beta strandi150 – 152Combined sources3
Turni155 – 157Combined sources3
Helixi161 – 173Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WMSX-ray1.25A/B1-177[»]
ProteinModelPortaliP51151.
SMRiP51151.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP51151.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 44Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0394. Eukaryota.
ENOG410XNZV. LUCA.
GeneTreeiENSGT00760000119125.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP51151.
KOiK07899.
OMAiKIDINER.
OrthoDBiEOG091G0JIV.
PhylomeDBiP51151.
TreeFamiTF326442.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51151-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKSSLFKV ILLGDGGVGK SSLMNRYVTN KFDTQLFHTI GVEFLNKDLE
60 70 80 90 100
VDGHFVTMQI WDTAGQERFR SLRTPFYRGS DCCLLTFSVD DSQSFQNLSN
110 120 130 140 150
WKKEFIYYAD VKEPESFPFV ILGNKIDISE RQVSTEEAQA WCRDNGDYPY
160 170 180 190 200
FETSAKDATN VAAAFEEAVR RVLATEDRSD HLIQTDTVNL HRKPKPSSSC

C
Length:201
Mass (Da):22,838
Last modified:October 1, 1996 - v1
Checksum:i65B502C21E97DB72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44103 mRNA. Translation: AAC51200.1.
AF498944 mRNA. Translation: AAM21092.1.
CR450362 mRNA. Translation: CAG29358.1.
AK290505 mRNA. Translation: BAF83194.1.
CH471074 Genomic DNA. Translation: EAW98826.1.
BC017265 mRNA. Translation: AAH17265.1.
CCDSiCCDS14156.1.
PIRiG02361.
RefSeqiNP_001182257.1. NM_001195328.1.
NP_004242.1. NM_004251.4.
XP_016885453.1. XM_017029964.1.
UniGeneiHs.495704.

Genome annotation databases

EnsembliENST00000464506; ENSP00000420127; ENSG00000123595.
ENST00000618931; ENSP00000480777; ENSG00000123595.
GeneIDi9367.
KEGGihsa:9367.
UCSCiuc004cvm.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44103 mRNA. Translation: AAC51200.1.
AF498944 mRNA. Translation: AAM21092.1.
CR450362 mRNA. Translation: CAG29358.1.
AK290505 mRNA. Translation: BAF83194.1.
CH471074 Genomic DNA. Translation: EAW98826.1.
BC017265 mRNA. Translation: AAH17265.1.
CCDSiCCDS14156.1.
PIRiG02361.
RefSeqiNP_001182257.1. NM_001195328.1.
NP_004242.1. NM_004251.4.
XP_016885453.1. XM_017029964.1.
UniGeneiHs.495704.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WMSX-ray1.25A/B1-177[»]
ProteinModelPortaliP51151.
SMRiP51151.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114768. 25 interactors.
DIPiDIP-46409N.
IntActiP51151. 7 interactors.
STRINGi9606.ENSP00000420127.

Chemistry databases

ChEMBLiCHEMBL1293294.
DrugBankiDB03793. Benzoic Acid.

PTM databases

iPTMnetiP51151.
PhosphoSitePlusiP51151.

Polymorphism and mutation databases

BioMutaiRAB9A.
DMDMi1710003.

Proteomic databases

EPDiP51151.
MaxQBiP51151.
PaxDbiP51151.
PeptideAtlasiP51151.
PRIDEiP51151.

Protocols and materials databases

DNASUi9367.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000464506; ENSP00000420127; ENSG00000123595.
ENST00000618931; ENSP00000480777; ENSG00000123595.
GeneIDi9367.
KEGGihsa:9367.
UCSCiuc004cvm.5. human.

Organism-specific databases

CTDi9367.
DisGeNETi9367.
GeneCardsiRAB9A.
HGNCiHGNC:9792. RAB9A.
HPAiCAB016411.
HPA003094.
MIMi300284. gene.
neXtProtiNX_P51151.
OpenTargetsiENSG00000123595.
PharmGKBiPA34152.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0394. Eukaryota.
ENOG410XNZV. LUCA.
GeneTreeiENSGT00760000119125.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP51151.
KOiK07899.
OMAiKIDINER.
OrthoDBiEOG091G0JIV.
PhylomeDBiP51151.
TreeFamiTF326442.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123595-MONOMER.
ReactomeiR-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.
R-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Miscellaneous databases

EvolutionaryTraceiP51151.
GeneWikiiRAB9A.
GenomeRNAii9367.
PROiP51151.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123595.
CleanExiHS_RAB9A.
ExpressionAtlasiP51151. baseline and differential.
GenevisibleiP51151. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB9A_HUMAN
AccessioniPrimary (citable) accession number: P51151
Secondary accession number(s): A8K390, Q6ICN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 174 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.