P51148 (RAB5C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-5C

Alternative name(s):
L1880
RAB5L

Gene names

Name:	RAB5C
Synonyms:	RABL

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Protein transport. Probably involved in vesicular traffic By similarity.
Subunit structure	Binds EEA1.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side By similarity. Early endosome membrane; Lipid-anchor By similarity. Melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Ref.10
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cell membrane Endosome Membrane
Coding sequence diversity	Polymorphism
Ligand	GTP-binding Nucleotide-binding
PTM	Acetylation Lipoprotein Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	early endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 216	215	Ras-related protein Rab-5C		PRO_0000121110
Regions
	Nucleotide binding	28 – 35	8	GTP By similarity
	Nucleotide binding	76 – 80	5	GTP By similarity
	Nucleotide binding	134 – 137	4	GTP By similarity
	Motif	50 – 58	9	Effector region Potential
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.11
	Lipidation	213	1	S-geranylgeranyl cysteine By similarity
	Lipidation	214	1	S-geranylgeranyl cysteine By similarity
Natural variations
	Natural variant	40	1	R → H in a colorectal cancer sample; somatic mutation. Ref.13		VAR_036414
Experimental info
	Sequence conflict	8	1	A → R Ref.1
	Sequence conflict	8	1	A → R Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P51148 [UniParc]. Last modified October 31, 2003. Version 2. Checksum: AA42096C6EED77ED	FASTA	216	23,483
	10 20 30 40 50 60 MAGRGGAARP NGPAAGNKIC QFKLVLLGES AVGKSSLVLR FVKGQFHEYQ ESTIGAAFLT 70 80 90 100 110 120 QTVCLDDTTV KFEIWDTAGQ ERYHSLAPMY YRGAQAAIVV YDITNTDTFA RAKNWVKELQ 130 140 150 160 170 180 RQASPNIVIA LAGNKADLAS KRAVEFQEAQ AYADDNSLLF METSAKTAMN VNEIFMAIAK 190 200 210 KLPKNEPQNA TGAPGRNRGV DLQENNPASR SQCCSN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and mapping of a human gene (RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene." Han H.J., Sudo K., Inazawa J., Nakamura Y. Cytogenet. Cell Genet. 73:137-139(1996) [PubMed: 8646882] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21." Albertsen H.M., Smith S.A., Mazoyer S., Fujimoto E., Stevens J., Williams B., Rodriguez P., Cropp C.S., Slijepcevic P., Carlson M., Robertson M., Bradley P., Lawrence E., Harrington T., Sheng Z.M., Hoopes R., Sternberg N., Brothman A. , Callahan R., Ponder B.A.J., White R. Nat. Genet. 7:472-479(1994) [PubMed: 7951316] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate." Clemens D.L., Lee B.-Y., Horwitz M.A. Infect. Immun. 68:2671-2684(2000) [PubMed: 10768959] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[4]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[9]	"Determinants of Rab5 interaction with the N-terminus of early endosome antigen 1." Merithew E., Stone C., Eathiraj S., Lambright D.G. J. Biol. Chem. 278:8494-8500(2003) [PubMed: 12493736] [Abstract] Cited for: INTERACTION WITH EEA1.
[10]	"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes." Chi A., Valencia J.C., Hu Z.-Z., Watabe H., Yamaguchi H., Mangini N.J., Huang H., Canfield V.A., Cheng K.C., Yang F., Abe R., Yamagishi S., Shabanowitz J., Hearing V.J., Wu C., Appella E., Hunt D.F. J. Proteome Res. 5:3135-3144(2006) [PubMed: 17081065] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Tissue: Melanoma.
[11]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-40.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U18420 mRNA. Translation: AAB08927.1. U11293 mRNA. Translation: AAA74081.1. AF141304 mRNA. Translation: AAF66594.1. AF498938 mRNA. Translation: AAM21086.1. CR541901 mRNA. Translation: CAG46699.1. BT019484 mRNA. Translation: AAV38291.1. CH471152 Genomic DNA. Translation: EAW60805.1. BC106039 mRNA. Translation: AAI06040.1. BC114439 mRNA. Translation: AAI14440.1.
IPI	IPI00016339.
PIR	I38703.
RefSeq	NP_001238968.1. NM_001252039.1. NP_004574.2. NM_004583.3. NP_958842.1. NM_201434.2.
UniGene	Hs.650382.
3D structure databases
ProteinModelPortal	P51148.
SMR	P51148. Positions 19-182.
ModBase	Search...
Protein-protein interaction databases
IntAct	P51148. 6 interactions.
STRING	P51148.
PTM databases
PhosphoSite	P51148.
Polymorphism databases
DMDM	38258923.
Proteomic databases
PeptideAtlas	P51148.
PRIDE	P51148.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000346213; ENSP00000345689; ENSG00000108774. ENST00000393860; ENSP00000377440; ENSG00000108774.
GeneID	5878.
KEGG	hsa:5878.
UCSC	uc002hyz.1. human.
Organism-specific databases
CTD	5878.
GeneCards	GC17M040276.
H-InvDB	HIX0039065.
HGNC	HGNC:9785. RAB5C.
HPA	HPA003426.
MIM	604037. gene.
neXtProt	NX_P51148.
PharmGKB	PA34145.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07543.
GeneTree	ENSGT00550000074186.
HOGENOM	HBG745225.
HOVERGEN	HBG009351.
InParanoid	P51148.
OMA	QESNPAS.
OrthoDB	EOG4Z0B6M.
PhylomeDB	P51148.
Enzyme and pathway databases
Reactome	REACT_11123. Membrane Trafficking.
Gene expression databases
ArrayExpress	P51148.
Bgee	P51148.
CleanEx	HS_RAB5C.
Genevestigator	P51148.
GermOnline	ENSG00000108774. Homo sapiens.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
KO	K07889.
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. Small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	22840.
SOURCE	Search...

Entry information

Entry name

RAB5C_HUMAN

Accession

Primary (citable) accession number: P51148
Secondary accession number(s): Q6FH55, Q9P0Y5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 31, 2003
Last modified:	January 25, 2012
This is version 112 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.