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Protein

Ras-related protein Rab-5C

Gene

RAB5C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 36GTPBy similarity9
Nucleotide bindingi47 – 53GTPBy similarity7
Nucleotide bindingi76 – 80GTPBy similarity5
Nucleotide bindingi134 – 137GTPBy similarity4
Nucleotide bindingi164 – 166GTPBy similarity3

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • plasma membrane to endosome transport Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • regulation of endocytosis Source: GO_Central
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108774-MONOMER.
ReactomeiR-HSA-432722. Golgi Associated Vesicle Biogenesis.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-8856828. Clathrin-mediated endocytosis.
R-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.
SignaLinkiP51148.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-5C
Alternative name(s):
L1880
RAB5L
Gene namesi
Name:RAB5C
Synonyms:RABL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:9785. RAB5C.

Subcellular locationi

GO - Cellular componenti

  • early endosome Source: GO_Central
  • early endosome membrane Source: UniProtKB-SubCell
  • endocytic vesicle Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • intracellular membrane-bounded organelle Source: HPA
  • lipid particle Source: UniProtKB
  • lysosomal membrane Source: UniProtKB
  • melanosome Source: UniProtKB-SubCell
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5878.
OpenTargetsiENSG00000108774.
PharmGKBiPA34145.

Polymorphism and mutation databases

BioMutaiRAB5C.
DMDMi38258923.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211101 – 216Ras-related protein Rab-5CAdd BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi213S-geranylgeranyl cysteineBy similarity1
Lipidationi214S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

EPDiP51148.
MaxQBiP51148.
PaxDbiP51148.
PeptideAtlasiP51148.
PRIDEiP51148.
TopDownProteomicsiP51148-1. [P51148-1]

PTM databases

iPTMnetiP51148.
PhosphoSitePlusiP51148.
SwissPalmiP51148.

Expressioni

Gene expression databases

BgeeiENSG00000108774.
CleanExiHS_RAB5C.
ExpressionAtlasiP51148. baseline and differential.
GenevisibleiP51148. HS.

Organism-specific databases

HPAiHPA003426.
HPA004167.

Interactioni

Subunit structurei

Binds EEA1.

Binary interactionsi

WithEntry#Exp.IntActNotes
APPL2Q8NEU85EBI-1054923,EBI-741261

Protein-protein interaction databases

BioGridi111816. 147 interactors.
IntActiP51148. 120 interactors.
MINTiMINT-4999312.
STRINGi9606.ENSP00000345689.

Structurei

Secondary structure

1216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi20 – 27Combined sources8
Helixi34 – 41Combined sources8
Beta strandi55 – 65Combined sources11
Beta strandi68 – 77Combined sources10
Helixi81 – 86Combined sources6
Helixi87 – 91Combined sources5
Beta strandi95 – 102Combined sources8
Helixi106 – 122Combined sources17
Beta strandi128 – 134Combined sources7
Helixi139 – 141Combined sources3
Helixi146 – 155Combined sources10
Beta strandi159 – 162Combined sources4
Turni165 – 168Combined sources4
Helixi171 – 181Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KYIX-ray3.08B/D/F/H18-182[»]
ProteinModelPortaliP51148.
SMRiP51148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi50 – 58Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0092. Eukaryota.
ENOG410YCCP. LUCA.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP51148.
KOiK07889.
OMAiTTNNCCK.
OrthoDBiEOG091G0HKN.
PhylomeDBiP51148.
TreeFamiTF300199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P51148-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGRGGAARP NGPAAGNKIC QFKLVLLGES AVGKSSLVLR FVKGQFHEYQ
60 70 80 90 100
ESTIGAAFLT QTVCLDDTTV KFEIWDTAGQ ERYHSLAPMY YRGAQAAIVV
110 120 130 140 150
YDITNTDTFA RAKNWVKELQ RQASPNIVIA LAGNKADLAS KRAVEFQEAQ
160 170 180 190 200
AYADDNSLLF METSAKTAMN VNEIFMAIAK KLPKNEPQNA TGAPGRNRGV
210
DLQENNPASR SQCCSN
Length:216
Mass (Da):23,483
Last modified:October 31, 2003 - v2
Checksum:iAA42096C6EED77ED
GO
Isoform 2 (identifier: P51148-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MELSWRSPSPLSASLHSTSPHPHALWTTTAGRAM

Note: No experimental confirmation available.
Show »
Length:249
Mass (Da):27,036
Checksum:iCAF9CB42B04DBDEF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8A → R (PubMed:8646882).Curated1
Sequence conflicti8A → R (PubMed:7951316).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03641440R → H in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0460351M → MELSWRSPSPLSASLHSTSP HPHALWTTTAGRAM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18420 mRNA. Translation: AAB08927.1.
U11293 mRNA. Translation: AAA74081.1.
AF141304 mRNA. Translation: AAF66594.1.
AF498938 mRNA. Translation: AAM21086.1.
AK310234 mRNA. No translation available.
CR541901 mRNA. Translation: CAG46699.1.
BT019484 mRNA. Translation: AAV38291.1.
AC003104 Genomic DNA. No translation available.
AC099811 Genomic DNA. No translation available.
AC105024 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60805.1.
BC106039 mRNA. Translation: AAI06040.1.
BC114439 mRNA. Translation: AAI14440.1.
CCDSiCCDS11419.1. [P51148-1]
CCDS58551.1. [P51148-2]
PIRiI38703.
RefSeqiNP_001238968.1. NM_001252039.1. [P51148-2]
NP_004574.2. NM_004583.3. [P51148-1]
NP_958842.1. NM_201434.2. [P51148-1]
XP_011523392.1. XM_011525090.1. [P51148-1]
XP_011523393.1. XM_011525091.1. [P51148-1]
UniGeneiHs.650382.

Genome annotation databases

EnsembliENST00000346213; ENSP00000345689; ENSG00000108774. [P51148-1]
ENST00000393860; ENSP00000377440; ENSG00000108774. [P51148-1]
ENST00000547517; ENSP00000447053; ENSG00000108774. [P51148-2]
GeneIDi5878.
KEGGihsa:5878.
UCSCiuc002hza.4. human. [P51148-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18420 mRNA. Translation: AAB08927.1.
U11293 mRNA. Translation: AAA74081.1.
AF141304 mRNA. Translation: AAF66594.1.
AF498938 mRNA. Translation: AAM21086.1.
AK310234 mRNA. No translation available.
CR541901 mRNA. Translation: CAG46699.1.
BT019484 mRNA. Translation: AAV38291.1.
AC003104 Genomic DNA. No translation available.
AC099811 Genomic DNA. No translation available.
AC105024 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60805.1.
BC106039 mRNA. Translation: AAI06040.1.
BC114439 mRNA. Translation: AAI14440.1.
CCDSiCCDS11419.1. [P51148-1]
CCDS58551.1. [P51148-2]
PIRiI38703.
RefSeqiNP_001238968.1. NM_001252039.1. [P51148-2]
NP_004574.2. NM_004583.3. [P51148-1]
NP_958842.1. NM_201434.2. [P51148-1]
XP_011523392.1. XM_011525090.1. [P51148-1]
XP_011523393.1. XM_011525091.1. [P51148-1]
UniGeneiHs.650382.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KYIX-ray3.08B/D/F/H18-182[»]
ProteinModelPortaliP51148.
SMRiP51148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111816. 147 interactors.
IntActiP51148. 120 interactors.
MINTiMINT-4999312.
STRINGi9606.ENSP00000345689.

PTM databases

iPTMnetiP51148.
PhosphoSitePlusiP51148.
SwissPalmiP51148.

Polymorphism and mutation databases

BioMutaiRAB5C.
DMDMi38258923.

Proteomic databases

EPDiP51148.
MaxQBiP51148.
PaxDbiP51148.
PeptideAtlasiP51148.
PRIDEiP51148.
TopDownProteomicsiP51148-1. [P51148-1]

Protocols and materials databases

DNASUi5878.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346213; ENSP00000345689; ENSG00000108774. [P51148-1]
ENST00000393860; ENSP00000377440; ENSG00000108774. [P51148-1]
ENST00000547517; ENSP00000447053; ENSG00000108774. [P51148-2]
GeneIDi5878.
KEGGihsa:5878.
UCSCiuc002hza.4. human. [P51148-1]

Organism-specific databases

CTDi5878.
DisGeNETi5878.
GeneCardsiRAB5C.
HGNCiHGNC:9785. RAB5C.
HPAiHPA003426.
HPA004167.
MIMi604037. gene.
neXtProtiNX_P51148.
OpenTargetsiENSG00000108774.
PharmGKBiPA34145.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0092. Eukaryota.
ENOG410YCCP. LUCA.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP51148.
KOiK07889.
OMAiTTNNCCK.
OrthoDBiEOG091G0HKN.
PhylomeDBiP51148.
TreeFamiTF300199.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108774-MONOMER.
ReactomeiR-HSA-432722. Golgi Associated Vesicle Biogenesis.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-8856828. Clathrin-mediated endocytosis.
R-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.
SignaLinkiP51148.

Miscellaneous databases

ChiTaRSiRAB5C. human.
GeneWikiiRAB5C.
GenomeRNAii5878.
PROiP51148.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108774.
CleanExiHS_RAB5C.
ExpressionAtlasiP51148. baseline and differential.
GenevisibleiP51148. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB5C_HUMAN
AccessioniPrimary (citable) accession number: P51148
Secondary accession number(s): F8W1H5, Q6FH55, Q9P0Y5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 31, 2003
Last modified: November 30, 2016
This is version 166 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.