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P51148

- RAB5C_HUMAN

UniProt

P51148 - RAB5C_HUMAN

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Protein

Ras-related protein Rab-5C

Gene

RAB5C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi28 – 358GTPBy similarity
Nucleotide bindingi76 – 805GTPBy similarity
Nucleotide bindingi134 – 1374GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: UniProtKB
  2. GTPase activity Source: UniProtKB
  3. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. endosome organization Source: Ensembl
  2. GTP catabolic process Source: UniProtKB
  3. plasma membrane to endosome transport Source: UniProtKB
  4. protein transport Source: UniProtKB-KW
  5. regulation of endocytosis Source: Ensembl
  6. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_19400. Golgi Associated Vesicle Biogenesis.
SignaLinkiP51148.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-5C
Alternative name(s):
L1880
RAB5L
Gene namesi
Name:RAB5C
Synonyms:RABL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:9785. RAB5C.

Subcellular locationi

Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity. Early endosome membrane By similarity; Lipid-anchor By similarity. Melanosome 1 Publication
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

GO - Cellular componenti

  1. endocytic vesicle Source: Ensembl
  2. endosome Source: UniProtKB-KW
  3. extracellular vesicular exosome Source: UniProtKB
  4. intracellular membrane-bounded organelle Source: HPA
  5. lipid particle Source: UniProtKB
  6. lysosomal membrane Source: UniProtKB
  7. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34145.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Ras-related protein Rab-5CPRO_0000121110Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi213 – 2131S-geranylgeranyl cysteineBy similarity
Lipidationi214 – 2141S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

MaxQBiP51148.
PaxDbiP51148.
PeptideAtlasiP51148.
PRIDEiP51148.

PTM databases

PhosphoSiteiP51148.

Expressioni

Gene expression databases

BgeeiP51148.
CleanExiHS_RAB5C.
ExpressionAtlasiP51148. baseline and differential.
GenevestigatoriP51148.

Organism-specific databases

HPAiHPA003426.

Interactioni

Subunit structurei

Binds EEA1.

Protein-protein interaction databases

BioGridi111816. 25 interactions.
IntActiP51148. 10 interactions.
MINTiMINT-4999312.
STRINGi9606.ENSP00000345689.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4KYIX-ray3.08B/D/F/H18-182[»]
ProteinModelPortaliP51148.
SMRiP51148. Positions 19-182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi50 – 589Effector regionSequence Analysis

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP51148.
KOiK07889.
OMAiANLLFFE.
PhylomeDBiP51148.
TreeFamiTF300199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P51148-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGRGGAARP NGPAAGNKIC QFKLVLLGES AVGKSSLVLR FVKGQFHEYQ
60 70 80 90 100
ESTIGAAFLT QTVCLDDTTV KFEIWDTAGQ ERYHSLAPMY YRGAQAAIVV
110 120 130 140 150
YDITNTDTFA RAKNWVKELQ RQASPNIVIA LAGNKADLAS KRAVEFQEAQ
160 170 180 190 200
AYADDNSLLF METSAKTAMN VNEIFMAIAK KLPKNEPQNA TGAPGRNRGV
210
DLQENNPASR SQCCSN
Length:216
Mass (Da):23,483
Last modified:October 31, 2003 - v2
Checksum:iAA42096C6EED77ED
GO
Isoform 2 (identifier: P51148-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MELSWRSPSPLSASLHSTSPHPHALWTTTAGRAM

Note: No experimental confirmation available.

Show »
Length:249
Mass (Da):27,036
Checksum:iCAF9CB42B04DBDEF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81A → R(PubMed:8646882)Curated
Sequence conflicti8 – 81A → R(PubMed:7951316)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401R → H in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036414

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MELSWRSPSPLSASLHSTSP HPHALWTTTAGRAM in isoform 2. 1 PublicationVSP_046035

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18420 mRNA. Translation: AAB08927.1.
U11293 mRNA. Translation: AAA74081.1.
AF141304 mRNA. Translation: AAF66594.1.
AF498938 mRNA. Translation: AAM21086.1.
AK310234 mRNA. No translation available.
CR541901 mRNA. Translation: CAG46699.1.
BT019484 mRNA. Translation: AAV38291.1.
AC003104 Genomic DNA. No translation available.
AC099811 Genomic DNA. No translation available.
AC105024 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60805.1.
BC106039 mRNA. Translation: AAI06040.1.
BC114439 mRNA. Translation: AAI14440.1.
CCDSiCCDS11419.1. [P51148-1]
CCDS58551.1. [P51148-2]
PIRiI38703.
RefSeqiNP_001238968.1. NM_001252039.1. [P51148-2]
NP_004574.2. NM_004583.3. [P51148-1]
NP_958842.1. NM_201434.2. [P51148-1]
UniGeneiHs.650382.

Genome annotation databases

EnsembliENST00000346213; ENSP00000345689; ENSG00000108774. [P51148-1]
ENST00000393860; ENSP00000377440; ENSG00000108774. [P51148-1]
ENST00000547517; ENSP00000447053; ENSG00000108774. [P51148-2]
GeneIDi5878.
KEGGihsa:5878.
UCSCiuc002hyz.3. human. [P51148-1]

Polymorphism databases

DMDMi38258923.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18420 mRNA. Translation: AAB08927.1 .
U11293 mRNA. Translation: AAA74081.1 .
AF141304 mRNA. Translation: AAF66594.1 .
AF498938 mRNA. Translation: AAM21086.1 .
AK310234 mRNA. No translation available.
CR541901 mRNA. Translation: CAG46699.1 .
BT019484 mRNA. Translation: AAV38291.1 .
AC003104 Genomic DNA. No translation available.
AC099811 Genomic DNA. No translation available.
AC105024 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60805.1 .
BC106039 mRNA. Translation: AAI06040.1 .
BC114439 mRNA. Translation: AAI14440.1 .
CCDSi CCDS11419.1. [P51148-1 ]
CCDS58551.1. [P51148-2 ]
PIRi I38703.
RefSeqi NP_001238968.1. NM_001252039.1. [P51148-2 ]
NP_004574.2. NM_004583.3. [P51148-1 ]
NP_958842.1. NM_201434.2. [P51148-1 ]
UniGenei Hs.650382.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4KYI X-ray 3.08 B/D/F/H 18-182 [» ]
ProteinModelPortali P51148.
SMRi P51148. Positions 19-182.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111816. 25 interactions.
IntActi P51148. 10 interactions.
MINTi MINT-4999312.
STRINGi 9606.ENSP00000345689.

PTM databases

PhosphoSitei P51148.

Polymorphism databases

DMDMi 38258923.

Proteomic databases

MaxQBi P51148.
PaxDbi P51148.
PeptideAtlasi P51148.
PRIDEi P51148.

Protocols and materials databases

DNASUi 5878.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000346213 ; ENSP00000345689 ; ENSG00000108774 . [P51148-1 ]
ENST00000393860 ; ENSP00000377440 ; ENSG00000108774 . [P51148-1 ]
ENST00000547517 ; ENSP00000447053 ; ENSG00000108774 . [P51148-2 ]
GeneIDi 5878.
KEGGi hsa:5878.
UCSCi uc002hyz.3. human. [P51148-1 ]

Organism-specific databases

CTDi 5878.
GeneCardsi GC17M040276.
HGNCi HGNC:9785. RAB5C.
HPAi HPA003426.
MIMi 604037. gene.
neXtProti NX_P51148.
PharmGKBi PA34145.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00760000119101.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi P51148.
KOi K07889.
OMAi ANLLFFE.
PhylomeDBi P51148.
TreeFami TF300199.

Enzyme and pathway databases

Reactomei REACT_19400. Golgi Associated Vesicle Biogenesis.
SignaLinki P51148.

Miscellaneous databases

GeneWikii RAB5C.
GenomeRNAii 5878.
NextBioi 22840.
PROi P51148.
SOURCEi Search...

Gene expression databases

Bgeei P51148.
CleanExi HS_RAB5C.
ExpressionAtlasi P51148. baseline and differential.
Genevestigatori P51148.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and mapping of a human gene (RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene."
    Han H.J., Sudo K., Inazawa J., Nakamura Y.
    Cytogenet. Cell Genet. 73:137-139(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate."
    Clemens D.L., Lee B.-Y., Horwitz M.A.
    Infect. Immun. 68:2671-2684(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lung.
  4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  11. "Determinants of Rab5 interaction with the N-terminus of early endosome antigen 1."
    Merithew E., Stone C., Eathiraj S., Lambright D.G.
    J. Biol. Chem. 278:8494-8500(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EEA1.
  12. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Melanoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-40.

Entry informationi

Entry nameiRAB5C_HUMAN
AccessioniPrimary (citable) accession number: P51148
Secondary accession number(s): F8W1H5, Q6FH55, Q9P0Y5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 31, 2003
Last modified: October 29, 2014
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3